Sophia Brismar Wendel

Sophia Brismar Wendel

Adjungerad Lektor | Docent
E-postadress: sophia.brismar@ki.se
Besöksadress: Entrévägen 2, 18257 Danderyd
Postadress: D1 Kliniska vetenskaper, Danderyds sjukhus, D1 Ob o gy Obstetrik, 171 77 Stockholm
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Om mig

  • Jag studerade medicin vid Karolinska Institutet från 1992 till 1998, blev legitimerad läkare 2000 och specialist i gynekologi och obstetrik 2005. Jag disputerade vid KI 2009. Jag arbetar som medicinskt ledningsansvarig överläkare på förlossningen, Kvinnokliniken, Danderyds sjukhus. Jag är anknuten till forskning som adjungerad universitetslektor och docent vid Institutionen för Kliniska Vetenskaper, KIDS. Jag har handlett tre och bi-handlett två doktorander till disputation. Just nu handleder jag fyra och bihandleder fem doktorander. 

Forskningsbeskrivning

  • Mina huvudsakliga forskningsområden rör kliniska prövningar, epidemiologisk och viss experimentell forskning.

    1.                          Kliniska prövningar avser interventioner för att förhindra graviditetskomplikationer eller intrapartala komplikationer såsom bäckenbottenskada vid förlossning (EVA), allvarlig blödning vid kejsarsnitt (ACT), fosterdöd vid prolongerad graviditet (SWEPIS), heminduktion (OPTION), förbättrade neonatala resultat vid akut kejsarsnitt (SUCCECS) och förlossning (PICRINO) med mera.

    2.                          Epidemiologiska studier inkluderar registerdata och kliniska patientkohorter, till exempel covid-19 under graviditet och tidig barndom, obstetriska analsfinkterskador, intervall mellan graviditeter och sätesförlossning.

    3.                          Experimentell forskning inkluderar AI för att förbättra tolkningen av CTG.

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 December 2024 - 30 November 2028
    Purpose: To reduce severe postpartum hemorrhage (PPH), causing maternal morbidity and mortality worldwide. Aim: To assess if manual external aortic compression is effective and safe to prevent severe PPH in cesarean section. Severe PPH is maternal blood loss &gt
    1000 ml at childbirth, more common in cesarean (14%) than vaginal births (7%). External aortic compression is used to temporize heavy blood loss, however never tested as a preventive method. A Cochrane review stated in 2020 that mechanical methods for the prevention and treatment of PPH, including aortic compression, urgently need scientific evaluation. We will assess the efficacy and safety of manual external aortic compression in a multicenter superiority randomized controlled trial including 2246 patients over three years. Population: Patients undergoing planned cesarean section. Intervention: Preventive manual external aortic compression. Control: No preventive aortic compression (standard care). Outcomes: Primary: Calculated blood loss &gt
    1000 ml or blood transfusion within 48 hours (binary). Secondary: gravimetric blood loss, maternal and neonatal morbidity and death, use of uterotonics and treatment for bleeding, transfer to higher level care, women´s sense of wellbeing, acceptability and satisfaction with the intervention, breastfeeding, and adverse effects. Direct patient benefits include reduced morbidity and mortality from severe PPH worldwide, using a simple, low-cost, and well-known method in a new way.
  • Swedish Research Council
    1 December 2024 - 30 November 2028
    The purpose of the SUCCECS study is to improve neonatal health and survival after emergency Cesarean section.  We aim to perform a multicenter study to evaluate a new approach to resuscitation of non-breathing neonates born by Cesarean section. Study design: Multicenter study with stepped wedge cluster randomization.- Population: Singleton term neonates born by emergency Cesarean section.- Intervention: When in need of life support, the neonate will be put on a platform with the cord intact, close to the mother. The neonatal team will give respiratory support with sustained cord circulation, following neonatal CPR guidelines. Cord clamping will be performed after respiration has been established and at the earliest after three minutes.- Control: Management according to standard care, including immediate cord clamping.- Outcome: Composite outcome of admission to neonatal care for predefined criteria (asphyxia at birth, respiratory distress, hypoxic-ischemic encephalopathy, hypoglycemia) and death before admission. Short and long-term neonatal outcomes and adverse maternal and neonatal outcomes will be evaluated.Importance: A reduction in neonatal admissions can benefit both the neonate and their parents, while also yielding positive economic implications for healthcare systems.Time plan: Preparations started in 2022, supported by the SRC planning grant no. 2021-06581. Training of staff will begin in early 2025, while the initial intervention rollout is planned for 2025.
  • Swedish Research Council
    1 January 2024 - 31 December 2027
    The overall aim is to evaluate the impacts on neonatal and maternal outcomes of adopting one of two different guidelines for monitoring labor: 1) the newly developed World Health Organization (WHO) Labour Care Guide (LCG)
    and 2) the currently used standard care guidelines. The LCG promotes woman-centered care, includes new definitions of onset and progress of labor, and emphasizes the monitoring of supportive care. However, no randomized controlled trials (RCTs) to date have compared the LCG with standard care with regards to safety and other key outcomes of labor in a high-resource setting.Study design: A national multicenter stepped wedge cluster RCT. Outcome data will be collected from Swedish Health Registers, questionnaires, and interviews.  Population: Women in active labor at 24 participating Swedish maternity wards, randomized to 6 clusters.Intervention: Use of the LCGControl: Use of standard care guidelines.Outcomes: Primary: 1) a neonatal core outcome set
    and 2) the rate of intrapartum Cesarean section.Secondary: neonatal and maternal outcomes, women’s and partner’s experiences of childbirth, obstetric staff experiences of LCG, economic evaluation, implementation determinants and outcomes.The main clinical benefit of introducing LCG is expected to be a reduction of adverse neonatal outcomes and decreased numbers of Cesarean sections during labor. In addition, we expect to see a higher degree of satisfaction among the participating women, partners, and providers.
  • Swedish Research Council
    1 January 2022 - 31 December 2023
  • Swedish Research Council
    1 January 2022 - 31 December 2023
  • Swedish Research Council
    1 January 2022 - 31 December 2023
  • Swedish Research Council
    1 December 2021 - 30 November 2025
  • Swedish Research Council
    1 January 2019 - 31 December 2021
  • Swedish Research Council
    1 January 2017 - 31 December 2019

Anställningar

  • Adjungerad Lektor, Kliniska vetenskaper, Danderyds sjukhus, Karolinska Institutet, 2024-2026

Examina och utbildning

  • Docent, obstetrik och gynekologi, Karolinska Institutet, 2021
  • Medicine Doktorsexamen, Institutionen för klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2009
  • Läkarexamen, Karolinska Institutet, 1998

Handledning

Nyheter från KI

Kalenderhändelser från KI