Sho Oasa

Sho Oasa

Biträdande Lektor
E-postadress: sho.oasa@ki.se
Besöksadress: L8:01, CMM, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postadress: K8 Klinisk neurovetenskap, K8 CPF Vukojevic, 171 77 Stockholm

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2026
    This interdisciplinary research proposal at the interface between biophysical chemistry, optics/photonics, cell biology and molecular medicine, aims to solidify instrumentation and further advance a new methodology for quantitative spatio-temporally resolved fluorescence microscopy imaging via massively parallel Fluorescence Correlation Spectroscopy (mpFCS) that we have recently developed. The methodology, which has the ultimate, single-molecule sensitivity, will be used in basic and translational studies to:Aim 1a. Dissect in live cells kinetic mechanisms through which gene transcription networks self-adjust their essential variables and control their own biological function.Aim 1b. Provide in live cells quantitative biophysical data and mechanistic insights on how the functional dynamics of oligodendrocyte transcription factor (OLIG2) can be rescued by treatment with novel prospective drug candidates. Aim 2.   Implement this new technology in a translational research study aiming to develop a reliable and affordable non-immune, blood-based assay for early diagnosis of amyloid diseases, such as Alzheimer’s disease (AD).Aim 3a. Development of a system for massively parallel dual-color Fluorescence Cross-Correlation Spectroscopy (mpFCCS).Aim 3b. Develop a fiber optic probe to allow parallelized FCS recordings in behaving animals.
  • Postdoctoral funding
    the Strategic Research Program in Neuroscience (StratNeuro)
    1 January 2020 - 31 December 2021

Anställningar

  • Biträdande Lektor, Klinisk neurovetenskap, Karolinska Institutet, 2021-2026
  • Postdoktor, Klinisk neurovetenskap, Karolinska Institutet, 2019-2021
  • Research Associate, Department of Clinical Neuroscience, Karolinska Institutet, 2017-2019
  • Postdoctoral Fellowship, Faculty of Advanced Life Science, Hokkaido University, 2016-2017

Examina och utbildning

  • Ph.D., Study on homodimer of glucocorticoid receptor and transcriptional regulation in single-cell level using fluorescence correlation spectroscopy and microwells., Graduate School of Life Science, Hokkaido University, 2016
  • Msc, Graduate School of Life Science, Hokkaido University, 2013
  • Bsc, Department of Science, Hokkaido University, 2011

Sakkunniggranskning för vetenskaplig tidskrift

  • Cell Reports
  • Plant, Cell & Environment

Konferenser och events

  • Poster-presentationer av egna accepterade abstract, The 21st IUPAB, 2024
  • Inbjuden föredragshållare, Bio-optics meeting, 2024
  • Inbjuden föredragshållare, The 7th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2023
  • Poster-presentationer av egna accepterade abstract, EBSA satellite meeting “Fluorescence fluctuation and single molecule spectroscopy”, 2023
  • Poster-presentationer av egna accepterade abstract, European Biophysics Society Association (EBSA), 2023
  • Poster-presentationer av egna accepterade abstract, Experimental Biology, Selected as oral 15 min talk as well, 2022
  • Poster-presentationer av egna accepterade abstract, Methods and Applications of Fluorescence, 2022
  • Inbjuden föredragshållare, The 6th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2021
  • Inbjuden föredragshållare, Photonica, 2021
  • Poster-presentationer av egna accepterade abstract, Annual meeting of Biophysics, 2020
  • Inbjuden föredragshållare, 5th Conference on the Therapeutic Potential of Kappa Opioids in Pain and Addiction, 2019
  • Poster-presentationer av egna accepterade abstract, The annual meeting of Biophysics of Japan, 2019
  • Poster-presentationer av egna accepterade abstract, The 54th Annual meeting of the Biophysical Society of Japan, 2016
  • Muntliga presentationer av egna accepterade abstract, The 3rd International International Life Life-Science Symposium for young scientists, 2015
  • Poster-presentationer av egna accepterade abstract, Single Protein Dynamics in Cellulo in Cellulo
  • SPDC2014, 2014
  • Poster-presentationer av egna accepterade abstract, The 52nd Annual meeting of Biophysical Society of Japan Annual meeting of Biophysical Society of Japan, 2014
  • Poster-presentationer av egna accepterade abstract, The 50th Annual meeting Annual meeting of the Biophysical Society of of the Biophysical Society of Japan, 2012

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