Shanie Saghafian-Hedengren

Om mig
Publikationer
Populärvetenskap och samverkan

Forskningsbeskrivning

*ÅTERHÄMTNING AV IMMUNSYSTEM OCH INFEKTIONSSKYDD HOS BARN SOM GENOMGÅR
CANCERBEHANDLING. *Vår vision är att barn som gått igenom cancerterapi
får en bra livskvalité genom att ha ett robust skydd mot pågående och
framtida infektioner. Våra projekt undersöker i detalj, ex vivo och in
vitro, hur cellgiftsbehandling påverkar barnets B- och T-cellers svar mot
infektioner – akut såväl som långsiktigt. En annan målsättning med
gruppens forskning är att på klinisk nivå kartlägga vaccinationsskydd
samt förekomst och typ av infektioner hos friska individer och barn som har
bakomliggande sjukdomar.
För mer information om våra projekt
se: /https://ki.se/kbh/aterhamtning-av-immunsystem-och-infektionsskydd-hos-barn-som-genomgar-cancerbehandling/

Artiklar

Article: JOURNAL OF VIROLOGY. 2022;96(22):e0131022-e01322
Four-Parameter FluoroSpot Assay Reveals That the Varicella Zoster Virus Elicits a Robust Memory T Cell IL-10 Response throughout Childhood
Nilsson A; Hobinger A; Jahnmatz P; Tiselius E; Laestadius A; Melen E; Bjorkander S; Saghafian-Hedengren S
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(15):5305
The Feasibility of Host Transcriptome Profiling as a Diagnostic Tool for Microbial Etiology in Childhood Cancer Patients with Febrile Neutropenia
Wahlund M; Sinha I; Broliden K; Saghafian-Hedengren S; Nilsson A; Berggren A
Article: VACCINE. 2019;37(28):3685-3693
Altered proportions of circulating CXCR5+helper T cells do not dampen influenza vaccine responses in children with rheumatic disease
Laestadius A; Ingelman-Sundberg HM; Myrberg IH; Verme A; Sundberg E; Schweiger B; Saghafian-Hedengren S; Nilsson A
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2017;36(1):102-108
Assessment of Cytokine and Chemokine Signatures as Potential Biomarkers of Childhood Community-acquired Pneumonia Severity A Nested Cohort Study in India
Saghafian-Hedengren S; Mathew JL; Hagel E; Singhi S; Ray P; Ygberg S; Nilsson A
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1865
Epstein-Barr Virus, but Not Cytomegalovirus, Latency Accelerates the Decay of Childhood Measles and Rubella Vaccine Responses-A 10-Year Follow-up of a Swedish Birth Cohort
Lasaviciute G; Bjorkander S; Carvalho-Queiroz C; Myrberg IH; Nussbaum B; Nilsson C; Bemark M; Nilsson A; Sverremark-Ekstrom E; Saghafian-Hedengren S
Article: FRONTIERS IN PEDIATRICS. 2016;4:93
Associations between EBV and CMV Seropositivity, Early Exposures, and Gut Microbiota in a Prospective Birth Cohort: A 10-Year Follow-up
Carvalho-Queiroz C; Johansson MA; Persson J-O; Jortso E; Kjerstadius T; Nilsson C; Saghafian-Hedengren S; Sverremark-Ekstrom E
Article: JOURNAL OF GLOBAL HEALTH. 2015;5(2):050418-232
Etiology of community acquired pneumonia among children in India: prospective, cohort study
Mathew JL; Singhi S; Ray P; Hagel E; Saghafian-Hedengren S; Bansal A; Ygberg S; Sodhi KS; Kumar BVR; Nilsson A
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;71(2):178-188
Pre-Eclampsia Affects Cord Blood NK Cell Expression of Activation Receptors and Serum Cytokine Levels but Not CB Monocyte Characteristics
Sohlberg E; Saghafian-Hedengren S; Bachmayer N; Hamad RR; Bremme K; Holmlund U
Article: JOURNAL OF VIROLOGY. 2013;87(24):13446-13455
Epstein-Barr Virus Coinfection in Children Boosts Cytomegalovirus-Induced Differentiation of Natural Killer Cells
Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson YT; Sverremark-Ekstrom E
Article: CLINICAL IMMUNOLOGY. 2013;149(3):421-431
A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27⁻IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation.
Bemark M; Friskopp L; Saghafian-Hedengren S; Koethe S; Fasth A; Abrahamsson J; Sverremark-Ekström E; Andersson BA; Mellgren K
Article: JOURNAL OF IMMUNOLOGY. 2013;191(11):5669-5676
Cytomegalovirus-Seropositive Children Show Inhibition of In Vitro EBV Infection That Is Associated with CD8⁺CD57⁺ T Cell Enrichment and IFN-γ
Sohlberg E; Saghafian-Hedengren S; Rasul E; Marchini G; Nilsson C; Klein E; Nagy N; Sverremark-Ekstrom E
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2012;1(3):136-138
Age at Epstein-Barr virus infection and Epstein-Barr virus nuclear antigen-1 antibodies in Swedish children
Simon KC; Saghafian-Hedengren S; Sverremark-Ekstrom E; Nilsson C; Ascherio A
Article: PLOS ONE. 2012;7(11):e49315
Early-Life Gut Bacteria Associate with IL-4-, IL-10-and IFN-γ Production at Two Years of Age
Johansson MA; Saghafian-Hedengren S; Haileselassie Y; Roos S; Troye-Blomberg M; Nilsson C; Sverremark-Ekstrom E
Article: IMMUNOLOGY. 2011;133(1):41-50
Cord blood monocyte subsets are similar to adult and show potent peptidoglycan-stimulated cytokine responses
Sohlberg E; Saghafian-Hedengren S; Bremme K; Sverremark-Ekstrom E
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;125(2):433-438
Early-life EBV infection protects against persistent IgE sensitization
Saghafian-Hedengren S; Sverremark-Ekstrom E; Linde A; Lilja G; Nilsson C
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):2511-2517
Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-γ Production
Saghafian-Hedengren S; Sundstrom Y; Sohlberg E; Nilsson C; Linde A; Troye-Blomberg M; Berg L; Sverremark-Ekstrom E
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2009;155(3):387-394
Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children
Amoudruz P; Holmlund U; Saghafian-Hedengren S; Nilsson C; Sverremark-Ekstrom E
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2008;38(3):449-457
Maternal allergy influences p38-mitogen-activated protein kinase activity upon microbial challenge in CD14⁺ monocytes from 2-year-old children
Saghafian-Hedengren S; Holmlund U; Amoudruz P; Nilsson C; Sverremark-Ekstroem E

Alla övriga publikationer

Review: FRONTIERS IN IMMUNOLOGY. 2021;12:582539
T Cell Subsets During Early Life and Their Implication in the Treatment of Childhood Acute Lymphoblastic Leukemia
Saghafian-Hedengren S; Sverremark-Ekstrom E; Nilsson A
Review: BLOOD REVIEWS. 2018;32(1):71-80
Insights into defective serological memory after acute lymphoblastic leukaemia treatment: The role of the plasma cell survival niche, memory B-cells and gut microbiota in vaccine responses
Saghafian-Hedengren S; Soderstrom I; Sverremark-Ekstrom E; Nilsson A
Letter: HAEMATOLOGICA. 2015;100(4):e158-e161
Selective loss of vaccine-specific memory B cells in a rhesus macaque model of chemotherapy: influence of doxorubicin on immunological memory
Ingelman-Sundberg HM; Saghafian-Hedengren S; Jahnmatz M; Eksborg S; Jonker M; Nilsson A

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

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Kalenderhändelser från KI