Sebastien Talbot

Sebastien Talbot

Senior Forskare
Besöksadress: Solnavägen 9, Biomedicum, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa M Neuroimmunologi, 171 77 Stockholm
Del av:

Om mig

  • Mitt laboratorium integrerar neurovetenskap och immunologi, vilket är ett nytt och mycket dynamiskt område, och kombinerar tekniker inom molekylär- och cellbiologi, optogenetik, vävnadsrening och avbildning, elektrofysiologi, neuroanatomi, beteende och genetik. Mitt mål är att identifiera de mekanismer och molekyler som reglerar samspelet mellan immunsystemet och det sensoriska nervsystemet i fysiologi och patologi. Bland annat kommer jag att undersöka rollen av nociceptor-neuron i cancer-immunövervakning.

Utvalda publikationer

  • Article: NATURE. 2022;611(7935):405-412
    Balood M; Ahmadi M; Eichwald T; Ahmadi A; Majdoubi A; Roversi K; Roversi K; Lucido CT; Restaino AC; Huang S; Ji L; Huang K-C; Semerena E; Thomas SC; Trevino AE; Merrison H; Parrin A; Doyle B; Vermeer DW; Spanos WC; Williamson CS; Seehus CR; Foster SL; Dai H; Shu CJ; Rangachari M; Thibodeau J; Del RSV; Drapkin R; Rafei M; Ghasemlou N; Vermeer PD; Woolf CJ; Talbot S

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2027
    Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis
  • Swedish Research Council
    1 January 2023
    Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis

Nyheter från KI

Kalenderhändelser från KI