Sebastien Talbot

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Mitt laboratorium integrerar neurovetenskap och immunologi, vilket är ett nytt och mycket dynamiskt område, och kombinerar tekniker inom molekylär- och cellbiologi, optogenetik, vävnadsrening och avbildning, elektrofysiologi, neuroanatomi, beteende och genetik. Mitt mål är att identifiera de mekanismer och molekyler som reglerar samspelet mellan immunsystemet och det sensoriska nervsystemet i fysiologi och patologi. Bland annat kommer jag att undersöka rollen av nociceptor-neuron i cancer-immunövervakning.

Artiklar

Journal article: NATURE REVIEWS CANCER. 2025;25(8):573-589
Neuro-immune cross-talk in cancer
Amit M; Eichwald T; Roger A; Anderson J; Chang A; Vermeer PD; Dixon KO; Scheff NN; Talbot S
Article: CELL REPORTS. 2024;43(12):115045
Cytokines reprogram airway sensory neurons in asthma
Crosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2024;12(11):e009962
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma
Mcilvried LA; Martel Matos AA; Yuan MM; Atherton MA; Obuekwe F; Nilsen ML; Nikpoor AR; Talbot S; Bruno TC; Taggart DN; Johnson LK; Ferris RL; Zandberg DP; Scheff NN
Article: BIORXIV. 2024;:2023.10.18.562990
Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer.
Barr J; Walz A; Restaino AC; Amit M; Barclay SM; Vichaya EG; Spanos WC; Dantzer R; Talbot S; Vermeer PD
Journal article: CANCER RESEARCH. 2024;84(7_Supplement):sy31-02-sy31-02
Abstract SY31-02: Nociceptor neurons control anti-tumor immunity
Eichwald T; Balood M; Ahmadi M; Roversi K; Wong D; Mandl J; Rafei M; Ghasemlou N; Vermeer P; Amit M; Talbot S
Article: CANCER SCIENCE. 2024;115(4):1102-1113
An engineered Accum-E7 protein-based vaccine with dual anti-cervical cancer activity.
Bikorimana J-P; Abusarah J; Gonçalves M; Farah R; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
Article: ISCIENCE. 2024;27(3):109248
A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses.
Gonçalves MP; Farah R; Bikorimana J-P; Abusarah J; El-Hachem N; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
Article: SCIENCE ADVANCES. 2023;9(19):eade4443
Functional neuronal circuits promote disease progression in cancer
Restaino AC; Walz A; Vermeer SJ; Barr J; Kovacs A; Fettig RR; Vermeer DW; Reavis H; Williamson CS; Lucido CT; Eichwald T; Omran DK; Jung E; Schwartz LE; Bell M; Muirhead DM; Hooper JE; Spanos WC; Drapkin R; Talbot S; Vermeer PD
Article: CELLS. 2023;12(8):1189
A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages
Foster SL; Dutton AJ; Yerzhan A; March LB; Barry K; Seehus CR; Huang X; Talbot S; Woolf CJ
Article: ISCIENCE. 2022;25(12):105537
The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells
Bikorimana J-P; El-Hachem N; Abusarah J; Eliopoulos N; Talbot S; Shammaa R; Rafei M
Article: BIO-PROTOCOL. 2022;12(19):e4527
LIST: A Newly Developed Laser-assisted Cell Bioprinting Technology
Roversi K; Orimi HE; Erfanian M; Talbot S; Boutopoulos C
Article: CELLS. 2022;11(15):2263
CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties
Bikorimana J-P; Saad W; Abusarah J; Lahrichi M; Talbot S; Shammaa R; Rafei M
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2022;67(1):e1-18
Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report
Rahimi RA; Cho JL; Jakubzick CV; Khader SA; Lambrecht BN; Lloyd CM; Molofsky AB; Talbot S; Bonham CA; Drake WP; Sperling AI; Singer BD
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;(184)
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
Ahmadi A; Balood M; Roversi K; Ahmadi M; Rafei M; Talbot S
Article: CELLS. 2022;11(11):1816
LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response
Mardani F; Saad W; El-Hachem N; Bikorimana J-P; Kurdi M; Shammaa R; Talbot S; Rafei M
Article: BIOELECTRONIC MEDICINE. 2022;8(1):7
Anatomical differences in nociceptor neurons sensitivity.
Crosson T; Talbot S
Article: SMALL. 2022;18(14):e2103364
Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons
Roversi K; Tabatabaei M; Desjardins-Lecavalier N; Balood M; Crosson T; Costantino S; Griffith M; Talbot S; Boutopoulos C
Article: CELL REPORTS MEDICINE. 2022;3(3):100534
Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity
Bikorimana J-P; Salame N; Beaudoin S; Balood M; Crosson T; Abusarah J; Talbot S; Lobenberg R; Plouffe S; Rafei M
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2506:297-314
Analysis of Airway Vagal Neurons.
Wang J-C; Crosson T; Talbot S
Article: JCI INSIGHT. 2021;6(24):e148510
Nociceptor neurons promote IgE class switch in B cells
Mathur S; Wang J-C; Seehus CR; Poirier F; Crosson T; Hsieh Y-C; Doyle B; Lee S; Woolf CJ; Foster SL; Talbot S
Article: CELL REPORTS MEDICINE. 2021;2(12):100455
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
Abusarah J; Khodayarian F; El-Hachem N; Salame N; Olivier M; Balood M; Roversi K; Talbot S; Bikorimana J-P; Chen J; Jolicoeur M; Trudeau L-E; Kamyabiazar S; Annabi B; Robert F; Pelletier J; El-Kadiry A-E; Shammaa R; Rafei M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(19):3905-3923
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker
Tochitsky I; Jo S; Andrews N; Kotoda M; Doyle B; Shim J; Talbot S; Roberson D; Lee J; Haste L; Jordan SM; Levy BD; Bean BP; Woolf CJ
Article: MICROMACHINES. 2021;12(8):865
Bioprinting of Adult Dorsal Root Ganglion (DRG) Neurons Using Laser-Induced Side Transfer (LIST)
Roversi K; Ebrahimi Orimi H; Falchetti M; Lummertz da Rocha E; Talbot S; Boutopoulos C
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(6):2330-2342
FcεR1-expressing nociceptors trigger allergic airway inflammation
Crosson T; Wang J-C; Doyle B; Merrison H; Balood M; Parrin A; Pascal M; Mindt BC; Seehus CR; Ozcan A; Huang X; Semenara E; Lai NYY; Majdoubi A; Abdulnour R-EE; Rajchgot T; Rafei M; Foster SL; Thibodeau J; Fritz JH; Levy BD; Woolf CJ; Talbot S
Article: NATURE BIOTECHNOLOGY. 2021;39(2):179-185
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Michoud F; Seehus C; Schoenle P; Brun N; Taub D; Zhang Z; Jain A; Furfaro I; Akouissi O; Moon R; Meier P; Galan K; Doyle B; Tetreault M; Talbot S; Browne LE; Huang Q; Woolf CJ; Lacour SP
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(6):1693-1696.e4
Vagal sensory neurons drive mucous cell metaplasia
Talbot S; Doyle B; Huang J; Wang J-C; Ahmadi M; Roberson DP; Yekkirala A; Foster SL; Browne LE; Bean BP; Levy BD; Woolf CJ
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:237
A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties
El-Kadiry AE-H; Abusarah J; Cui YE; El-Hachem N; Hammond-Martel I; Wurtele H; Thomas S; Ahmadi M; Balood M; Talbot S; Rafei M
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1953
Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice
Majdoubi A; Lee JS; Kishta OA; Balood M; Moulefera MA; Ishido S; Talbot S; Cheong C; Alquier T; Thibodeau J
Article: JOURNAL OF IMMUNOLOGY. 2019;203(11):2887-2898
Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206⁺ Dendritic Cells to Skin-Draining Lymph Nodes
Majdoubi A; Lee JS; Balood M; Sabourin A; DeMontigny A; Kishta OA; Moulefera MA; Galbas T; Yun TJ; Talbot S; Ishido S; Cheong C; Thibodeau J
Article: ELIFE. 2019;8:e48118
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation
Lee S; Jo S; Talbot S; Zhang H-XB; Kotoda M; Andrews NA; Puopolo M; Liu PW; Jacquemont T; Pascal M; Heckman LM; Jain A; Lee J; Woolf CJ; Bean BP
Journal article: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):268-289
Profiling of how nociceptor neurons detect danger - new and old foes
Crosson T; Roversi K; Balood M; Othman R; Ahmadi M; Wang J-C; Pereira PJS; Tabatabaei M; Couture R; Eichwald T; Latini A; Prediger RD; Rangachari M; Seehus CR; Fosters SL; Talbot S
Article: STEM CELL REPORTS. 2019;12(1):29-41
Neurite Collapse and Altered ER Ca²⁺ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
Korecka JA; Talbot R; Osborn TM; de Leeuw SM; Levy SA; Ferrari EJ; Moskites A; Atkinson E; Jodelka FM; Hinrich AJ; Hastings ML; Woolf CJ; Hallett PJ; Isacson O
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:3115
Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background
Yeola AP; Doss PMIA; Baillargeon J; Akbar I; Mailhot B; Balood M; Talbot S; Anderson AC; Lacroix S; Rangachari M
Article: NATURE. 2018;563(7732):564-568
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; Scheffer DDL; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):447-453.e3
Substance P activates Mas-related G protein-coupled receptors to induce itch
Azimi E; Reddy VB; Seadi Pereira PJ; Talbot S; Woolf CJ; Lerner EA
Article: JCI INSIGHT. 2016;1(16):e89362
Dual action of neurokinin-1 antagonists on Mas-related GPCRs
Azimi E; Reddy VB; Shade K-TC; Anthony RM; Talbot S; Pereira PJS; Lerner EA
Article: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2016;94(7):752-757
Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats
Talbot S; Dias JP; El Midaoui A; Couture R
Article: BIOELECTRONIC MEDICINE. 2016;3:18-28
Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes.
Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16272-16281
GRPR/PI3Kγ: Partners in Central Transmission of Itch
Pereira PJS; Machado GDB; Danesi GM; Canevese FF; Reddy VB; Pereira TCB; Bogo MR; Cheng Y-C; Laedermann C; Talbot S; Lerner EA; Campos MM
Article: NEURON. 2015;87(2):341-354
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
Talbot S; Abdulnour R-EE; Burkett PR; Lee S; Cronin SJF; Pascal MA; Laedermann C; Foster SL; Tran JV; Lai N; Chiu IM; Ghasemlou N; DiBiase M; Roberson D; Von Hehn C; Agac B; Haworth O; Seki H; Penninger JM; Kuchroo VK; Bean BP; Levy BD; Woolf CJ
Article: J DIABETES METAB. 2015;6(6):1-7
Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats.
Midaoui AE; Talbot S; Lahjouji K; Dias JP; Fantus IG; Couture R
Article: BEHAVIOURAL BRAIN RESEARCH. 2013;241:17-26
Brain kinin B₁ receptor contributes to the onset of stereotypic nocifensive behavior in rat
Gariepy HDB; Talbot S; Senecal J; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:214
Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat
Talbot S; Gariepy HDB; Saint-Denis J; Couture R
Article: EXPERIMENTAL NEUROLOGY. 2012;234(2):373-381
Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy
Talbot S; Couture R
Article: TOXICOLOGY. 2012;293(1-3):125-131
An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase
Lin JC-J; Roy J-P; Verreault J; Talbot S; Cote F; Couture R; Morin A
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:16
Activation of TRPV1 by capsaicin induces functional Kinin B₁ receptor in rat spinal cord microglia
Talbot S; Dias JP; Lahjouji K; Bogo MR; Campos MM; Gaudreau P; Couture R
Article: PLOS ONE. 2012;7(3):e33864
Ocular Application of the Kinin B₁ Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats
Pouliot M; Talbot S; Senecal J; Dotigny F; Vaucher E; Couture R
Article: PEPTIDES. 2011;32(7):1447-1456
Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells
Talbot S; Lin JC-J; Lahjouji K; Roy J-P; Senecal J; Morin A; Couture R
Article: PEPTIDES. 2010;31(10):1940-1945
Mechanism of cigarette smoke-induced kinin B₁ receptor expression in rat airways
Lin JC-J; Talbot S; Lahjouji K; Roy J-P; Senecal J; Couture R; Morin A
Article: PLOS ONE. 2010;5(9):e12622
Kinin B₁ Receptor Enhances the Oxidative Stress in a Rat Model of Insulin Resistance: Outcome in Hypertension, Allodynia and Metabolic Complications
Dias JP; Talbot S; Senecal J; Carayon P; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2010;7(1):36
Key role for spinal dorsal horn microglial kinin B₁ receptor in early diabetic pain neuropathy
Talbot S; Chahmi E; Dias JP; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2009;6:11
Cellular localization of kinin B₁ receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [N^α-Bodipy]-des-Arg⁹-bradykinin
Talbot S; Theberge-Turmel P; Liazoghli D; Senecal J; Gaudreau P; Couture R
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2008;52(3):278-285
Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats
Richard C; Lauzier B; Delemasure S; Talbot S; Ghibu S; Collin B; Senecal J; Menetrier F; Vergely C; Couture R; Rochette L
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;589(1-3):66-72
Blockade of sensory abnormalities and kinin B₁ receptor expression by N-Acetyl-L-Cysteine and ramipril in a rat model of insulin resistance
Ismael MA; Talbot S; Carbonneau CL; Beausejour CM; Couture R
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(1):136-143
Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors
Abdouh M; Talbot S; Couture R; Hassessian HM
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;557(2-3):115-123
Differential regulation of the signaling and trafficking of the two prostaglandin D₂ receptors, prostanoid DP receptor and CRTH2
Gallant MA; Slipetz D; Hamelin E; Rochdi MD; Talbot S; de Brum-Fernandes AJ; Parent J-L
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