Sean Rudd
Principal Researcher | Docent
E-mail: sean.rudd@ki.se
Visiting address: SciLifeLab, Tomtebodavägen 23, 17165 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Rudd, 171 77 Stockholm
About me
I am an Associate Professor (Docent) and Group Leader at the Department of Oncology-Pathology with my research group located at SciLifeLab Stockholm.
Research
I lead a curiosity-driven research group investigating nucleotide metabolism and molecular pharmacology. Our goal is to uncover the mechanisms that shape response to cancer therapies and to use these insights to guide more precise and effective treatment strategies.
For more info, check out our external site – www.seanruddlab.com
Teaching
• Supervision of BSc & MSc thesis projects
• Lecturing on cancer biology, cancer drug discovery, and drug mechanism of action
• Co-organise doctoral course on Genome Instability in Cancer Development and Therapy
Selected publications
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2026;302(3):111214Allosteric targeting with antiviral nucleotide analogs allows fine-tuning of SAMHD1 dNTPase activityDirks C; Schlotterbeck A-K; Pettersson P; Leppert A; Landreh M; Zhang SM; Rudd SG
- Article: MOLECULAR ONCOLOGY. 2026Yague-Capilla M; Dirks C; Eiden C; Fesenmayer SK; Hormann FM; Klootsema Y; Lilienthal I; Zhang SM; Herold N; Rudd SG
- Review: LEUKEMIA. 2025;39(3):531-542Hormann FM; Rudd SG
- Review: DISEASE MODELS & MECHANISMS. 2024;17(8):dmm050775Yague-Capilla M; Rudd SG
- Article: ISCIENCE. 2024;27(2):108907Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Articles
- Article: CELL CYCLE. 2026;25(1):1-19Klootsema Y; Tsesmetzis N; Sharma S; Hofmann S; Thier J; Dirks C; Hormann FM; Yague-Capilla M; Bohlin A; Bengtzen S; Lehmann S; Chabes A; Jadersten M; Lundin V; Rudd SG; Lilienthal I; Herold N
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2026;27(4):1953Hall B; Castelli L; Higginbottom A; He J; Zou L-N; Walker H; Yague-Capilla M; Wong KE; Burrows DJ; George J; Hamer K; Tanner JM; Kyrgiou-Balli E; Ross R; Garland H; Tonkiss E; George R; Webster CP; Smith EF; Timmons HO; Allsop J; Stefanidis N; Ward BD; Lin Y-H; Highley JR; Azzouz M; West RJH; Rudd SG; De Vos KJ; Shaw PJ; Hautbergue GM; Allen SP
- Article: FUNDAMENTAL & CLINICAL PHARMACOLOGY. 2025;39(5):e70044Wang J; Pouryaghoub N; Strauss R; Bartek J; Zhang SM; Rudd SG
- Article: CHEMISTRY-A EUROPEAN JOURNAL. 2025;31(33):e202500382Kehler M; Zhou K; Kemas AM; del Prado A; Hutchinson ES; Nairn EH; Varga M; Plattner Y; Zhong Y; Purewal-Sidhu O; Haslam J; Wiita E; Gildie H; Singerova K; Szaruga Z; Almloef I; Hormann FM; Liu K-C; Wallner O; Ortis F; Homan EJ; Gileadi O; Rudd SG; Stenmark P; de Vega M; Helleday T; D'Arcy-Evans ND; Lauschke VM; Michel M
- Article: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2024;43(8):831-836Dirks C; Bwanika HC; Jemth A-S; Zhang SM; Rudd SG
- Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
- Article: CELL DEATH & DISEASE. 2021;12(7):709Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(170)Yague-Capilla M; Rudd SG
- Article: BMC RESEARCH NOTES. 2021;14(1):27Makela P; Zhang SM; Rudd SG
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
- Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
- Article: CANCER RESEARCH. 2020;80(17):3530-3541Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
- Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
- Article: BLOOD CANCER JOURNAL. 2018;8(11):98Rassidakis GZ; Herold N; Myrberg IH; Tsesmetzis N; Rudd SG; Henter J-I; Schaller T; Ng S-B; Chng WJ; Yan B; Ng CH; Ravandi F; Andreeff M; Kantarjian HM; Medeiros LJ; Xagoraris I; Khoury JD
- Article: NATURE COMMUNICATIONS. 2018;9(1):250Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
- Article: EXPERIMENTAL HEMATOLOGY. 2017;52:32-39Herold N; Rudd SG; Sanjiv K; Kutzner J; Myrberg IH; Paulin CBJ; Olsen TK; Helleday T; Henter J-I; Schaller T
- Article: CELL CYCLE. 2017;16(11):1029-1038Herold N; Rudd SG; Sanjiv K; Kutzner J; Bladh J; Paulin CBJ; Helleday T; Henter J-I; Schaller T
- Article: MOLECULAR & CELLULAR ONCOLOGY. 2017;4(2):e1287554Rudd SG; Schaller T; Herold N
- Article: NATURE MEDICINE. 2017;23(2):256-263Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
- Article: ONCOGENESIS. 2016;5(12):e275Eshtad S; Mavajian Z; Rudd SG; Visnes T; Bostrom J; Altun M; Helleday T
- Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
- Article: NUCLEIC ACIDS RESEARCH. 2015;43(2):1056-1068Guilliam TA; Jozwiakowski SK; Ehlinger A; Barnes RP; Rudd SG; Bailey LJ; Skehel JM; Eckert KA; Chazin WJ; Doherty AJ
- Article: MOLECULAR CELL. 2013;52(4):566-573Bianchi J; Rudd SG; Jozwiakowski SK; Bailey LJ; Soura V; Taylor E; Stevanovic I; Green AJ; Stracker TH; Lindsay HD; Doherty AJ
- Article: MOLECULAR CELL. 2013;52(4):554-565Rudd SG; Glover L; Jozwiakowski SK; Horn D; Doherty AJ
- Article: BIOCHEMICAL JOURNAL. 2011;435(1):113-125Goodfellow SJ; Rebello MR; Toska E; Zeef LAH; Rudd SG; Medler KF; Roberts SGE
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All other publications
- Preprint: BIORXIV. 2025Valerie NCK; Alam S; Hormann F; Martens U; Lundgren B; Gaetani M; Boström J; Rudd S; Arvidsson P; Altun M
- Preprint: BIORXIV. 2025Shu H; Sharm S; Alam S; Frank L; Tampere M; van Kuilenburg ABP; Valerie NCK; Altun M; Chabes A; Rudd S; Zhang SM
- Preprint: CHEMRXIV. 2025Kehler M; Zhou K; Kemas A; del Prado A; Scaletti Hutchinson E; Hesslefors Nairn E; Varga M; Plattner Y; Zong Y; Purewal-Sidhu O; Haslam J; Wiita E; Gildie H; Singerova K; Szaruga Z; Almlöf I; Hormann F; Liu K-C; Wallner O; Ortis F; Homan E; Gileadi O; Rudd S; Stenmark P; de Vega M; Helleday T; D'Arcy-Evans N; Lauschke V; Michel M
- Preprint: BIORXIV. 2024Wang J; Strauss R; Bartek J; Rudd SG
- Review: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2023;92(4):241-251Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunitiesRudd SG
- Preprint: BIORXIV. 2023Zhang SM; Paulin CBJ; Michel M; Marttila P; Yagüe-Capilla M; Bwanika HC; Shu H; Vekatram RP; Wiita E; Jemth A-S; Almlöf I; Loseva O; Ortis F; Dirks C; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Strömberg K; Homan E; Scobie M; Lundbäck T; Helleday T; Rudd S
- Review: MOLECULAR ONCOLOGY. 2022;16(21):3792-3810Helleday T; Rudd SG
- Corrigendum: CELL DEATH & DISEASE. 2022;13(8):672Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
- Review: PEERJ. 2022;10:e13141Wang J; Hao S; Gu J; Rudd SG; Wang Y
- Preprint: BIORXIV. 2020Mäkelä P; Zhang SM; Rudd S
- Preprint: BIORXIV. 2020Zhang SM; Calderón-Montaño J; Rudd S
- Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5050Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
- Review: CANCERS. 2018;10(7):E240-240Tsesmetzis N; Paulin CBJ; Rudd SG; Herold N
- Review: DNA REPAIR. 2016;44:193-204Rudd SG; Valerie NCK; Helleday T
- Review: MOLECULAR & CELLULAR ONCOLOGY. 2014;1(2):e960754Rudd SG; Bianchi J; Doherty AJ
Employments
- Principal Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2024-
- Assistant Professor, Department of Oncology-Pathology, Karolinska Institutet, 2019-2024
Degrees and Education
- Docent, Karolinska Institutet, 2026
- PhD, Genome Damage and Stability Centre, University of Sussex, 2013