Sean Rudd

Sean Rudd

Principal Researcher
Visiting address: SciLifeLab, Tomtebodavägen 23, 17165 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Rudd, 171 77 Stockholm

About me

  • Assistant Professor & Group Leader at the Department of Oncology-Pathology & SciLifeLab

Research

  • The Rudd Group aims to provide cancer patients with better treatment options. We believe one way this can be achieved in a timely manner is by focusing research efforts upon commonly used chemotherapeutic agents. These therapies, which form standard-of-care for many cancers, typically kill tumour cells by targeting pan-essential pathways, principally metabolism of the DNA molecule or its nucleotide building blocks (deoxynucleoside triphosphates, dNTPs). In our research program we aim to define the molecular underpinnings of why some cancers respond to these therapies whilst others do not. This information can provide the basis for rational therapy improvements through the identification of biomarkers and therapeutic targets together with the design of mechanism-based drug combinations. We employ a multidisciplinary approach in our research – centred upon biochemical, biophysical, and cell-based methods – and use both hypothesis-driven and hypothesis-free approaches in our efforts to define and exploit the molecular mechanisms underpinning clinical efficacy of chemotherapeutic agents.

Teaching

  • • Supervision of undergraduate & MSc thesis projects
    • Lecturing on cancer biology, cancer drug discovery, and drug mechanism of action
    • Co-organise doctoral course on Genome Instability in Cancer Development and Therapy

Articles

All other publications

Grants

Employments

  • Principal Researcher, Department of Oncology-Pathology, Karolinska Institutet, 2024-
  • Assistant Professor, Department of Oncology-Pathology, Karolinska Institutet, 2019-2024

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