Rolf Ohlsson

Kaneda A; Wang CJ; Cheong R; Timp W; Onyango P; Wen B; Iacobuzio-Donahue CA; Ohlsson R; Andraos R; Pearson MA; Sharov AA; Longo DL; Ko MSH; Levchenko A; Feinberg AP

Article: CURRENT OPINION IN CELL BIOLOGY. 2007;19(3):321-325

The 4C technique:: the 'Rosetta stone' for genome biology in 3D?

Ohlsson R; Gondor A

Article: MOLECULAR AND CELLULAR BIOLOGY. 2007;27(5):1631-1648

CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide.

Chernukhin I; Shamsuddin S; Kang SY; Bergström R; Kwon Y-W; Yu W; Whitehead J; Mukhopadhyay R; Docquier F; Farrar D; Morrison I; Vigneron M; Wu S-Y; Chiang C-M; Loukinov D; Lobanenkov V; Ohlsson R; Klenova E

Article: CELL CYCLE. 2007;6(4):450-454

CTCF regulates asynchronous replication of the imprinted H19/Igf2 domain.

Bergström R; Whitehead J; Kurukuti S; Ohlsson R

Article: HUMAN MOLECULAR GENETICS. 2007;16(3):343-354

A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis.

Hancock AL; Brown KW; Moorwood K; Moon H; Holmgren C; Mardikar SH; Dallosso AR; Klenova E; Loukinov D; Ohlsson R; Lobanenkov VV; Malik K

Article: NATURE GENETICS. 2006;38(11):1341-1347

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions

Zhao Z; Tavoosidana G; Sjolinder M; Gondor A; Mariano P; Wang S; Kanduri C; Lezcano M; Sandhu KS; Singh U; Pant V; Tiwari V; Kurukuti S; Ohlsson R

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(28):10684-10689

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2.

Kurukuti S; Tiwari VK; Tavoosidana G; Pugacheva E; Murrell A; Zhao Z; Lobanenkov V; Reik W; Ohlsson R

Article: EMBO JOURNAL. 2005;24(18):3291-3300

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin.

Burke LJ; Zhang R; Bartkuhn M; Tiwari VK; Tavoosidana G; Kurukuti S; Weth C; Leers J; Galjart N; Ohlsson R; Renkawitz R

Article: HUMAN MOLECULAR GENETICS. 2005;14(7):953-965

Familial cases of point mutations in the XIST promoter reveal a correlation between CTCF binding and pre-emptive choices of X chromosome inactivation.

Pugacheva EM; Tiwari VK; Abdullaev Z; Vostrov AA; Flanagan PT; Quitschke WW; Loukinov DI; Ohlsson R; Lobanenkov VV

Article: SCIENCE. 2005;307(5717):1976-1978

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.

Sakatani T; Kaneda A; Iacobuzio-Donahue CA; Carter MG; de Boom Witzel S; Okano H; Ko MSH; Ohlsson R; Longo DL; Feinberg AP

Article: EMBO REPORTS. 2005;6(2):165-170

CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator.

Moon H; Filippova G; Loukinov D; Pugacheva E; Chen Q; Smith ST; Munhall A; Grewe B; Bartkuhn M; Arnold R; Burke LJ; Renkawitz-Pohl R; Ohlsson R; Zhou J; Renkawitz R; Lobanenkov V

Article: NATURE GENETICS. 2004;36(10):1105-1110

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.

Yu W; Ginjala V; Pant V; Chernukhin I; Whitehead J; Docquier F; Farrar D; Tavoosidana G; Mukhopadhyay R; Kanduri C; Oshimura M; Feinberg AP; Lobanenkov V; Klenova E; Ohlsson R

Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(18):7855-7862

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region

Thakur N; Tiwari VK; Thomassin H; Pandey RR; Göndör A; Grange T; Ohlsson R; Kanduri C

Article: GENOME RESEARCH. 2004;14(8):1594-1602

The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide.

Mukhopadhyay R; Yu W; Whitehead J; Xu J; Lezcano M; Pack S; Kanduri C; Kanduri M; Ginjala V; Vostrov A; Quitschke W; Chernukhin I; Klenova E; Lobanenkov V; Ohlsson R

Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(8):3497-3504

Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.

Pant V; Kurukuti S; Pugacheva E; Shamsuddin S; Mariano P; Renkawitz R; Klenova E; Lobanenkov V; Ohlsson R

Article: GENES & DEVELOPMENT. 2003;17(5):586-590

The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains

Pant V; Mariano P; Kanduri C; Mattsson A; Lobanenkov V; Heuchel R; Ohlsson R

Article: GENE THERAPY. 2003;10(6):513-522

Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors.

Jouvenot Y; Ginjala V; Zhang L; Liu P-Q; Oshimura M; Feinberg AP; Wolffe AP; Ohlsson R; Gregory PD

Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):389-398

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms.

Feinberg AP; Cui H; Ohlsson R

Article: CANCER RESEARCH. 2002;62(16):4545-4548

The kinetics of deregulation of expression by de novo methylation of the h19 imprinting control region in cancer cells.

Kanduri C; Kanduri M; Liu L; Thakur N; Pfeifer S; Ohlsson R

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(20):18106-18110

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.

Kanduri C; Fitzpatrick G; Mukhopadhyay R; Kanduri M; Lobanenkov V; Higgins M; Ohlsson R

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(10):6806-6811

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.

Loukinov DI; Pugacheva E; Vatolin S; Pack SD; Moon H; Chernukhin I; Mannan P; Larsson E; Kanduri C; Vostrov AA; Cui H; Niemitz EL; Rasko JEJ; Docquier FM; Kistler M; Breen JJ; Zhuang Z; Quitschke WW; Renkawitz R; Klenova EM; Feinberg AP; Ohlsson R; Morse HC; Lobanenkov VV

Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(10):3339-3344

Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region.

Kanduri M; Kanduri C; Mariano P; Vostrov AA; Quitschke W; Lobanenkov V; Ohlsson R

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(8):5707-5710

Multiple cis elements within the Igf2/H19 insulator domain organize a distance-dependent silencer. A cautionary note.

Ginjala V; Holmgren C; Ullerås E; Kanduri C; Pant V; Lobanenkov V; Franklin G; Ohlsson R

Article: CURRENT BIOLOGY. 2001;11(14):1128-1130

CpG methylation regulates the Igf2/H19 insulator.

Holmgren C; Kanduri C; Dell G; Ward A; Mukhopadhya R; Kanduri M; Lobanenkov V; Ohlsson R

Article: TRENDS IN GENETICS. 2001;17(3):136-141

Did genomic imprinting and X chromosome inactivation arise from stochastic expression?

Ohlsson R; Paldi A; Graves JA

Article: METHODS IN MOLECULAR BIOLOGY. 2001;181:153-167

Allele-specific in situ hybridization (ASISH).

Ohlsson R; Svensson K; Cui H; Malmikumpu H; Adam G

Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2000;44(7):785-790

Dynamic readjustment of parental methylation patterns of the 5'-flank of the mouse H19 gene during in vitro organogenesis.

Liang L; Kanduri C; Pilartz M; Svensson K; Song JH; Wentzel P; Eriksson U; Ohlsson R

Article: CURRENT BIOLOGY. 2000;10(14):853-856

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive.

Kanduri C; Pant V; Loukinov D; Pugacheva E; Qi CF; Wolffe A; Ohlsson R; Lobanenkov VV

Article: CURRENT BIOLOGY. 2000;10(8):449-457

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.

Kanduri C; Holmgren C; Pilartz M; Franklin G; Kanduri M; Liu L; Ginjala V; Ullerås E; Mattsson R; Ohlsson R

Article: MAMMALIAN GENOME. 1999;10(12):1150-1159

A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.

Frank D; Mendelsohn CL; Ciccone E; Svensson K; Ohlsson R; Tycko B

Article: CANCER RESEARCH. 1999;59(16):3889-3892

Mosaic allelic insulin-like growth factor 2 expression patterns reveal a link between Wilms' tumorigenesis and epigenetic heterogeneity.

Ohlsson R; Cui H; He L; Pfeifer S; Malmikumpu H; Jiang S; Feinberg AP; Hedborg F

Article: DEVELOPMENTAL BIOLOGY. 1999;212(1):124-136

PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.

Ohlsson R; Falck P; Hellström M; Lindahl P; Boström H; Franklin G; Ahrlund-Richter L; Pollard J; Soriano P; Betsholtz C

Article: MECHANISMS OF DEVELOPMENT. 1999;82(1-2):195-197

The genotype and epigenotype synergize to diversify the spatial pattern of expression of the imprinted H19 gene.

Lin WL; He XB; Svensson K; Adam G; Li YM; Tang TW; Paldi A; Pfeifer S; Ohlsson R

Article: DEVELOPMENT GENES AND EVOLUTION. 1999;209(2):113-119

Random monoallelic expression of the imprinted IGF2 and H19 genes in the absence of discriminative parental marks

Ohlsson R; Flam F; Fisher R; Miller S; Cui HM; Pfeifer S; Adam GIR

Article: CURRENT SCIENCE. 1999;77(4):539-544

Genes without protein products:: Is H19 the norm or the exception?

Kanduri C; Pfeifer S; Li YM; Ohlsson R

Article: NATURE MEDICINE. 1998;4(11):1276-1280

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability.

Cui H; Horon IL; Ohlsson R; Hamilton SR; Feinberg AP

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(43):28247-28252

The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans.

Li YM; Franklin G; Cui HM; Svensson K; He XB; Adam G; Ohlsson R; Pfeifer S

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(21):12208-12213

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Bertilsson G; Heidrich J; Svensson K; Åsman M; Jendeberg L; Sydow-Bäckman M; Ohlsson R; Postlind H; Blomquist P; Berkenstam A

Article: ONCOGENE. 1998;16(1):113-119

Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells.

He L; Cui H; Walsh C; Mattsson R; Lin W; Anneren G; Pfeifer-Ohlsson S; Ohlsson R

Article: DEVELOPMENT. 1998;125(1):61-69

The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns.

Svensson K; Mattsson R; James TC; Wentzel P; Pilartz M; MacLaughlin J; Miller SJ; Olsson T; Eriksson UJ; Ohlsson R

Article: CANCER RESEARCH. 1997;57(20):4469-4473

Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis

Cui HM; Hedborg F; He LM; Sandstedt B; PfeiferOhlsson S; Ohlsson R

Article: DEVELOPMENT. 1996;122(3):839-847

Allele-specific in situ hybridization (ASISH) analysis: A novel technique which resolves differential allelic usage of H19 within the same cell lineage during human placental development

Adam GIR; Cui HM; Miller SJ; Flam F; Ohlsson R

Article: MECHANISMS OF DEVELOPMENT. 1996;54(2):211-223

Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis

Pettersson K; Svensson K; Mattsson R; Carlsson B; Ohlsson R; Berkenstam A

Article: ONCOGENE. 1995;11(9):1873-1884

An Inr-containing sequence flanking the TATA box of the human c-sis (PDGF-B) proto-oncogene promoter functions in cis as a co-activator for its intronic enhancer.

Franklin GC; Adam GI; Miller SJ; Moncrieff CL; Ullerås E; Ohlsson R

Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):869-876

Normal development and neoplasia: the imprinting connection.

Ohlsson R; Franklin G

Article: ONCOGENE. 1995;11(2):221-229

EXPRESSION, PROMOTER USAGE AND PARENTAL IMPRINTING STATUS OF INSULIN-LIKE GROWTH-FACTOR-II (IGF2) IN HUMAN HEPATOBLASTOMA - UNCOUPLING OF IGF2 AND H19 IMPRINTING

LI XR; ADAM G; CUI HM; SANDSTEDT B; OHLSSON R; EKSTROM TJ

Article: MOLECULAR REPRODUCTION AND DEVELOPMENT. 1995;41(2):177-183

MONOALLELIC EXPRESSION OF IGF2 AT THE HUMAN FETAL MATERNAL BOUNDARY

EKSTROM TJ; CUI HM; NYSTROM A; RUTANEN EM; OHLSSON R

Article: MECHANISMS OF DEVELOPMENT. 1995;51(1):31-37

H19 is imprinted in the choroid plexus and leptomeninges of the mouse foetus.

Svensson K; Walsh C; Fundele R; Ohlsson R

Article: AMERICAN JOURNAL OF PATHOLOGY. 1995;146(4):833-847

IGF2 EXPRESSION IS A MARKER FOR PARAGANGLIONIC SIF CELL-DIFFERENTIATION IN NEUROBLASTOMA

HEDBORG F; OHLSSON R; SANDSTEDT B; GRIMELIUS T; HOEHNER JC; PAHLMAN S

Article: CANCER RESEARCH. 1995;55(5):1111-1116

PATERNALLY DERIVED H19 IS DIFFERENTIALLY EXPRESSED IN MALIGNANT AND NONMALIGNANT TROPHOBLAST

WALSH C; MILLER SJ; FLAM F; FISHER RA; OHLSSON R

Article: DEVELOPMENT. 1995;121(2):309-316

PROMOTER-SPECIFIC IGF2 IMPRINTING STATUS AND ITS PLASTICITY DURING HUMAN LIVER DEVELOPMENT

EKSTROM TJ; CUI HM; OHLSSON R

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