Rainer Heuchel
Senior Forskare | Docent
E-postadress: rainer.heuchel@ki.se
Besöksadress: Hälsovägen, Enheten för kirurgi C1:77, 14186 Stockholm
Postadress: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Kirurgi och onkologi, 141 52 Huddinge
Om mig
- Rainer Heuchel har gjort sin doktorsavhandling om transkriptionella enhancer
vid Universitetet av Zürich / Schweiz under handledningen av professor
Walter Schaffner. Han gick sedan till Ludwig Institutet för Cancerforskning,
ledd av Carl-Henrik Heldin, där hans forskning fokuserade på PDGF och
TGF-beta signalering med hjälp av genetiskt modifierade musmodeller. År
2008 började han hos professor Matthias Löhr vid Karolinska Institutet,
där han leder labbet för bukspottkörtel forskningen. R.H. är docent i
cell och molekylärbiologi sedan December 2021.
*Undervisningsområden*
Molekylärbiologi, cellbiologi, djur modeller av humana sjukdomer.
Forskningsbeskrivning
- *Forskningsområden*
Inflammatoriska och cancerösa sjukdomar i bukspottkörteln
Akut och kronisk pankreatit är mycket svår behandlade sjukdomar. Kronisk
pankreatit har också identifierats som en riskfaktor för utveckling av
cancer i bukspottskörteln. Vi använder olika musmodeller som rekapitulera
dessa två former av mänsklig pankreatit för att bättre förstå
grundläggande biologi av dessa sjukdomar och för att identifiera nya
mål/targets för läkemedelsutveckling och behandling.
Enligt Cancerfonds Rapporten 2012 har pankreas duktal adenokarcinom (PDAC)
gått upp från femte till fjärde vanligaste dödsorsaken av cancer i
Sverige, men det är inte ens bland de 10 vanligaste formerna av cancer. Det
faktum att PDAC har bytt plats med bröstcancer är emellertid inte på grund
av en ökning i PDAC incidens, utan är baserat på de förbättringar som
gjorts vid behandling av bröstcancer. Detta indikerar dilemma med PDAC,
eftersom det inte finns någon biomarkör och diagnosen av tumören sker
sent. När den identifierats är den nästan helt resistent mot konventionell
kemo-och strålterapi. Den ökade terapi motståndet beror främst på att
det enorma fibrotiska svar (desmoplasi = överdriven kollagen disposition
jämförbar med ärrvävnad), inducerad av stromacellerna. Eftersom
tumörvävnad av en "genomsnittlig" PDAC består till minst 50% av
tumörstroma (främst aktiverade stellatceller celler, makrofage, kollagen
etc.), betyder det ett stort hinder för tillträde av potentiella läkemedel
mot de skyddade cancercellerna.
Många läkemedel har utvecklats, som kan bekämpa cancerceller
framgångsrikt i 2-dimensionell cellodling och xenotransplantat experiment
(subkutan injektion av cancerceller) i nakna möss. Dessa metoder har de
kritiska nackdelar att de inte tar hänsyn till kollagenrika stroman (2-D
kultur och xenograft), avsaknaden av ett fungerande immunförsvar (nakna
möss) och fel placering av tumören (subkutant jämfört med i
bukspottkörteln). För att kringgå dessa systematiska problem har vi
utvecklat 3-dimensionella avaskulära minitumörer som innehåller
cancerceller omgiven av aktiverade stellat celler, som kan identifiera dessa
läkemedel, som är effektiva bara i 2-D kultur och därmed har mycket liten
chans att någonsin arbeta i en patient. Läkemedel med bevisad anti-cancer
potential i vårt 3-D model testas sedan i genetiskt definierade
mustumörmodeller, som inte bara efterliknar preneoplastiskt utvecklingen av
det mänskliga PDAC, men kännetecknas av samma kollagenrika stroma. Dessa
förvånande likheter mellan mus och människa grunda sig mest sannolikt på
det faktum att musens PDAC induceras av samma gener (KRAS, TP53) som har
funnits muterad i majoriteten av patienterna. Förutom läkemedeltest / ny
terapi använder vi pre-kliniska musmodeller också för att 1) identifiera
nya biomarkörer och droger, 2) identifiera och karaktisera cancer stamceller
och 3) karakterisering av ytterligare mutationer i tumörutvecklingen och
metastasering.
Sammanfattningsvis har vi inrättat en progressiv selektionsstrategi för
anti-PDAC läkemedel (2D till 3D in vitro system följt av genetiskt
modifierade musmodeller) som avsevärt kommer att minska antalet möss som
krävs i drogtester och förhoppningsvis öka effekten av läkemedel i human
fas-I kliniska prövningar för PDAC.
Artiklar
- Article: SCIENTIFIC REPORTS. 2025;15(1):9694Varela JC; Harish AV; Maniewski P; Gibbon T; Tudoran O; Heuchel R; Lohr M; Margulis W; Russom A; Laurell F
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(17):9369Guendel B; Liu X; Pfutzenreuter A; Engelsberger V; Weiskirchen R; Loehr J-M; Heuchel R
- Article: BIOMEDICINES. 2023;11(11):3061Aval NA; Lahchaichi E; Tudoran O; Fayazbakhsh F; Heuchel R; Lohr M; Pettersson T; Russom A
- Journal article: PANCREATOLOGY. 2023;23:e140-e141Gündel B; Heuchel R; Liu X; Löhr M
- Journal article: PANCREATOLOGY. 2023;23:e140Gündel B; Heuchel R; Löhr M
- Article: NATURE COMMUNICATIONS. 2023;14(1):5024Moro CF; Geyer N; Harrizi S; Hamidi Y; Soderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martin-Bernabe A; Dhanjal S; Navis AC; Villard C; del Valle AC; Bozoky L; Sparrelid E; Dirix L; Strell C; Ostman A; Schmierer B; Vermeulen PB; Engstrand J; Bozoky B; Gerling M
- Article: CANCER RESEARCH. 2023;83(10):1628-1645He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
- Article: ISCIENCE. 2022;25(11):105317Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
- Journal article: PANCREATOLOGY. 2022;22:e81Liu X; Gündel B; Engelsberger V; Löhr M; Heuchel R
- Journal article: PANCREATOLOGY. 2022;22:e70Gündel B; Heuchel R; Gündel A; Liu X
- Journal article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2022;7(1):364Moustakas A; Lohr JM; Heuchel RL
- Article: NEOPLASIA. 2021;23(12):1300-1306Bozoky B; Moro CF; Strell C; Geyer N; Heuchel RL; Lohr JM; Ernberg I; Szekely L; Gerling M; Bozoky B
- Article: PANCREAS. 2021;50(10):1427-1434Li X; Nania S; Kleiter I; Löhr J-M; Heuchel RL
- Article: CANCERS. 2021;13(21):5338Li J; Wu X; Schiffmann L; MacVicar T; Zhou C; Wang Z; Li D; Camacho OV; Heuchel R; Odenthal M; Hillmer A; Quaas A; Zhao Y; Bruns CJ; Popp FC
- Article: TRANSLATIONAL ONCOLOGY. 2021;14(7):101107Liu X; Gundel B; Li X; Liu J; Wright A; Lohr M; Arvidsson G; Heuchel R
- Journal article: PANCREATOLOGY. 2021;21:s72Liu X; Gündel B; Li X; Liu J; Wright A; Löhr M; Arvidsson G; Heuchel R
- Article: ACS APPLIED MATERIALS & INTERFACES. 2020;12(48):53665-53681Zhao Y; Ye F; Brismar TB; Li X; He R; Heuchel R; El-Sayed R; Feliu N; Zheng W; Oerther S; Dutta J; Parak WJ; Muhammed M; Hassan M
- Journal article: PANCREATOLOGY. 2020;20:s129Liu X; Arvidsson G; Li X; Liu J; Wright A; Löhr M; Heuchel R
- Article: SCIENTIFIC REPORTS. 2020;10(1):17444Gorchs L; Ahmed S; Mayer C; Knauf A; Moro CF; Svensson M; Heuchel R; Rangelova E; Bergman P; Kaipe H
- Article: BMC CANCER. 2020;20(1):475Norberg KJ; Liu X; Moro CF; Strell C; Nania S; Bluemel M; Balboni A; Bozoky B; Heuchel RL; Loehr JM
- Article: PANCREATOLOGY. 2019;19(7):963-970Held T; Verbeke CS; Strobel O; Rutkowski W; Villard C; Moro CF; Del Chiaro M; Buechler M; Heuchel R; Lohr M
- Article: FEBS OPEN BIO. 2019;9(10):1756-1768Li X; Clappier C; Kleiter I; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s28-s29Li X; Wallmann T; Nania S; Hornung L; Kleiter I; Löhr J-M; Rolny C; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s107Held T; Verbeke CS; Strobel O; Rutkowski W; Villard C; Moro CF; Del Chiaro M; Büchler MW; Heuchel R; Löhr J-M
- Journal article: PANCREATOLOGY. 2019;19:s80Liu X; Arvidsson G; Li X; Liu J; Wright A; Löhr J-M; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s117Mailian E; Kordes M; Russom A; Heuchel R; Eriksson L; Löhr J-M
- Article: CANCERS. 2019;11(5):E638-638Firuzi O; Che PP; El Hassouni B; Buijs M; Coppola S; Lohr M; Funel N; Heuchel R; Carnevale I; Schmidt T; Mantini G; Avan A; Saso L; Peters GJ; Giovannetti E
- Article: PANCREATOLOGY. 2018;18(7):734-741Norberg KJ; Nania S; Li X; Gao H; Szatmary P; Segersvard R; Haas S; Wagman A; Arnelo U; Sutton R; Heuchel RL; Lohr JM
- Journal article: ESMO OPEN. 2018;3:a336Firuzi O; Che PP; Buijs M; Hassouni BE; Stefano C; Löhr M; Heuchel R; Saso L; Peters GJ; Giovannetti E
- Article: ADVANCED FUNCTIONAL MATERIALS. 2018;28(21)Zhou XC; Haraldsson T; Nania S; Ribet F; Palano G; Heuchel R; Loehr M; van der Wijngaart W
- Journal article: EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT. 2018;3(3):189-195Lohr J-M; Kordes M; Rutkowski W; Heuchel R; Gustafsson-Liljefors M; Russom A; Nilsson M
- Article: GUT. 2018;67(3):497-507Hessmann E; Patzak MS; Klein L; Chen N; Kari V; Ramu I; Bapiro TE; Frese KK; Gopinathan A; Richards FM; Jodrell DI; Verbeke C; Li X; Heuchel R; Lohr JM; Johnsen SA; Gress TM; Ellenrieder V; Neesse A
- Article: MOLECULAR ONCOLOGY. 2017;11(10):1413-1429Malgerud L; Lindberg J; Wirta V; Gustafsson-Liljefors M; Karimi M; Moro CF; Stecker K; Picker A; Huelsewig C; Stein M; Bohnert R; Del Chiaro M; Haas SL; Heuchel RL; Permert J; Maeurer MJ; Brock S; Verbeke CS; Engstrand L; Jackson DB; Gronberg H; Lohr J-M
- Article: SCIENTIFIC REPORTS. 2017;7(1):7031Zhao M; Rabieifar P; Costa TDF; Zhuang T; Minden A; Lohr M; Heuchel R; Stromblad S
- Journal article: PANCREATOLOGY. 2017;17(3):s34Norberg J; Strell C; Balboni A; Östman A; Heuchel R; Löhr M
- Journal article: PANCREATOLOGY. 2017;17(3):s27Li X; Hornung L; Nania S; Verbeke C; Löhr M; Heuchel R
- Article: BRITISH JOURNAL OF CANCER. 2017;117(1):65-77Strell C; Norberg KJ; Mezheyeuski A; Schnittert J; Kuninty PR; Moro CF; Paulsson J; Schultz NA; Calatayud D; Lohr JM; Frings O; Verbeke CS; Heuchel RL; Prakash J; Johansen JS; Ostman A
- Article: JOURNAL OF IMMUNOTHERAPY. 2017;40(4):132-139Omazic B; Ayoglu B; Lohr M; Segersvard R; Verbeke C; Magalhaes I; Potacova Z; Mattsson J; Terman A; Ghazi S; Albiin N; Kartalis N; Nilsson P; Poiret T; Liu Z; Heuchel R; Schwenk JM; Permert J; Maeurer MJ; Ringden O
- Journal article: PLOS ONE. 2017;12(1):e0171283Moro CF; Fernandez-Woodbridge A; D'souza MA; Zhang Q; Bozoky B; Vasan SK; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Bjornstedt M; Lohr JM; Isaksson B; Verbeke C; Bozoky B
- Article: METABOLOMICS. 2017;13(5):61Lindahl A; Heuchel R; Forshed J; Lehtio J; Lohr M; Nordstrom A
- Article: PLOS ONE. 2016;11(11):e0166067Moro CF; Fernandez-Woodbridge A; D'souza MA; Zhang Q; Bozoky B; Kandaswamy SV; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Bjornstedt M; Lohr JM; Isaksson B; Verbeke C; Bozoky B
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(9):1839-1846Li X; Nania S; Fejzibegovic N; Moro CF; Klopp-Schulze L; Verbeke C; Lohr J-M; Heuchel RL
- Journal article: PANCREATOLOGY. 2016;16(3):s24Heuchel R; Li X; Yu Y; Nania S; Verbeke C; Löhr M
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2015;50(11):1419-1427Haraldsson E; Swahn F; Verbeke C; Mattsson JSM; Enochsson L; Ung K-A; Lundell L; Heuchel R; Lohr J-M; Arnelo U
- Article: CLINICAL CHEMISTRY. 2015;61(11):1408-1416Huang J; Lohr J-M; Nilsson M; Segersvard R; Matsson H; Verbeke C; Heuchel R; Kere J; Iafrate AJ; Zheng Z; Ye W
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;464(3):737-742Barrefelt A; Zhao Y; Larsson MK; Egri G; Kuiper RV; Hamm J; Saghafian M; Caidahl K; Brismar TB; Aspelin P; Heuchel R; Muhammed M; Dahne L; Hassan M
- Article: EXPERIMENTAL GERONTOLOGY. 2014;57:149-154Marschallinger J; Krampert M; Couillard-Despres S; Heuchel R; Bogdahn U; Aigner L
- Article: THERANOSTICS. 2014;4(6):604-613Gerling M; Zhao Y; Nania S; Norberg KJ; Verbeke CS; Englert B; Kuiper RV; Bergstrom A; Hassan M; Neesse A; Lohr JM; Heuchel RL
- Article: DEVELOPMENTAL BIOLOGY. 2013;382(2):375-384Estrada KD; Wang W; Retting KN; Chien CT; Elkhoury FE; Heuchel R; Lyons KM
- Article: JOURNAL OF PATHOLOGY. 2013;230(4):441-452Wang J; Zhao J; Chu ESH; Mok MTS; Go MYY; Man K; Heuchel R; Lan HY; Chang Z; Sung JJY; Yu J
- Article: PLOS ONE. 2013;8(7):e70195Wei LH; Huang XR; Zhang Y; Li YQ; Chen H-Y; Heuchel R; Yan BP; Yu C-M; Lan HY
- Article: BMC CANCER. 2013;13:95Longati P; Jia X; Eimer J; Wagman A; Witt M-R; Rehnmark S; Verbeke C; Toftgard R; Lohr M; Heuchel RL
- Article: PLOS ONE. 2013;8(1):e53573Liu G-X; Li Y-Q; Huang XR; Wei L; Chen H-Y; Shi Y-J; Heuchel RL; Lan HY
- Article: CELL STEM CELL. 2011;9(5):433-446Lonardo E; Hermann PC; Mueller M-T; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Roderiguez-Arabaolaza I; Carlos Ramirez J; Torres-Ruiz R; Garcia E; Hidalgo M; Alvaro Cebrian D; Heuchel R; Lohr M; Berger F; Bartenstein P; Aicher A; Heeschen C
- Article: PLOS ONE. 2011;6(6):e20203Pazirandeh A; Sultana T; Mirza M; Rozell B; Hultenby K; Wallis K; Vennstrom B; Davis B; Arner A; Heuchel R; Lohr M; Philipson L; Sollerbrant K
- Article: PULMONARY CIRCULATION. 2011;1(2):259-268Dahal BK; Heuchel R; Pullamsetti SS; Wilhelm J; Ghofrani HA; Weissmann N; Seeger W; Grimminger F; Schermuly RT
- Article: DIABETES. 2011;60(2):590-601Chen HY; Huang XR; Wang W; Li JH; Heuchel RL; Chung ACK; Lan HY
- Article: EMBO JOURNAL. 2010;29(14):2421-2432Shimokawa N; Haglund K; Hoelter SM; Grabbe C; Kirkin V; Koibuchi N; Schultz C; Rozman J; Hoeller D; Qiu C-H; Londono MB; Ikezawa J; Jedlicka P; Stein B; Schwarzacher SW; Wolfer DP; Ehrhardt N; Heuchel R; Nezis I; Brech A; Schmidt MHH; Fuchs H; Gailus-Durner V; Klingenspor M; Bogler O; Wurst W; Deller T; de Angelis MH; Dikic I
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2010;30(14):3685-3694Krampert M; Chirasani SR; Wachs F-P; Aigner R; Bogdahn U; Yingling JM; Heldin C-H; Aigner L; Heuchel R
- Article: MATRIX BIOLOGY. 2010;29(3):166-176Lu N; Carracedo S; Ranta J; Heuchel R; Soininen R; Gullberg D
- Article: ADVANCED ENGINEERING MATERIALS. 2009;11(8):B129-B135Lohr JM; Heuchel R; Jesnowski R; Wallrapp C
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(5):1443-1454Chung ACK; Huang XR; Zhou L; Heuchel R; Lai KN; Lan HY
- Article: LABORATORY INVESTIGATION. 2008;88(11):1204-1214Krampert M; Heldin C-H; Heuchel RL
- Article: BMC CANCER. 2007;7:224Suzuki S; Heldin C-H; Heuchel RL
- Article: HEPATOLOGY. 2007;46(4):1257-1270Weng H-L; Ciuclan L; Liu Y; Hamzavi J; Godoy P; Gaitantzi H; Kanzler S; Heuchel R; Ueberham U; Gebhardt R; Breitkopf K; Dooley S
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(10):2142-2149Magnusson PU; Looman C; Ahgren A; Wu Y; Claesson-Welsh L; Heuchel RL
- Article: PLACENTA. 2007;28(5-6):412-420Singh U; Sun T; Looman C; Heuchel R; Elliott R; Freichel A; Meissner A; Flockerzi V; Fundele R
- Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2007;51(5):361-370Looman C; Sun T; Yu Y; Zieba A; Ahgren A; Feinstein R; Forsberg H; Hellberg C; Heldin C-H; Zhang X-Q; Forsberg-Nilsson K; Khoo N; Fundele R; Heuchel R
- Article: BLOOD. 2006;108(6):1877-1886Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
- Article: JOURNAL OF IMMUNOLOGY. 2006;176(11):6777-6784Li R; Rosendahl A; Brodin G; Cheng AM; Ahgren A; Sundquist C; Kulkarni S; Pawson T; Heldin C-H; Heuchel RL
- Article: MATRIX BIOLOGY. 2006;25(2):118-129Lu N; Heuchel R; Barczyk M; Zhang WM; Gullberg D
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(41):42516-42527Chiara F; Goumans MJ; Forsberg H; Ahgrén A; Rasola A; Aspenström P; Wernstedt C; Hellberg C; Heldin CH; Heuchel R
- Article: CANCER RESEARCH. 2004;64(8):2725-2733Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin CH; Östman A
- Article: GENES & DEVELOPMENT. 2003;17(5):586-590Pant V; Mariano P; Kanduri C; Mattsson A; Lobanenkov V; Heuchel R; Ohlsson R
- Article: MOLECULAR BIOLOGY OF THE CELL. 2003;14(2):529-544Edlund S; Bu SH; Schuster N; Aspenström P; Heuchel R; Heldin NE; ten Dijke P; Heldin CH; Landström M
- Article: ONCOGENE. 2003;22(3):412-425Arsura M; Panta GR; Bilyeu JD; Cavin LG; Sovak MA; Oliver AA; Factor V; Heuchel R; MErcurio F; Thorgeirsson SS; Sonenshein GE
- Article: GENES & DEVELOPMENT. 2000;14(24):3179-3190Tallquist MD; Klinghoffer RA; Heuchel R; Mueting-Nelsen PF; Corrin PD; Heldin CH; Johnson RJ; Soriano P
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(37):29023-29030Brodin G; Åhgren A; ten Dijke P; Heldin CH; Heuchel R
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(20):11410-11415Heuchel R; Berg A; Tallquist M; Åhlén K; Reed RK; Rubin K; Claesson-Welsh L; Heldin CH; Soriano P
- Article: EMBO JOURNAL. 1998;17(10):2846-2854Günes Ç; Heuchel R; Georgiev O; Müller KH; Lichtlen P; Blüthmann H; Marino S; Aguzzi A; Schaffner W
- Article: NATURE. 1997;389(6651):631-635Nakao A; Afrakhte M; Moren A; Nakayama T; Christian JL; Heuchel R; Itoh S; Kawabata N; Heldin NE; Heldin CH; tenDijke P
- Article: EXPERIENTIA. 1995;51(6):606-611WAN M; HEUCHEL R; RADTKE F; HUNZIKER PE; KAGI JHR
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Alla övriga publikationer
- Review: INFLAMMATORY BOWEL DISEASES. 2023;29(4):647-660Schuler C; Foti F; Perren L; Mamie C; Weder B; Stokmaier M; de Valliere C; Heuchel R; Ruiz PA; Rogler G; Hausmann M
- Conference publication: 2022;00:912-914Iseri E; Kaya K; Heuchel R; van der Wijngaart W
- Preprint: SSRN ELECTRONIC JOURNAL. 2022Sarhan D; Eisinger S; Pelicano C; Fei H; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
- Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9:A927Sarhan D; He F; Calandigary A; Malki E; Moro CF; Kaisso M; Olofsson-Sahl P; Melssen M; Lohr M; Karlsson M; Heuchel R
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:741162Guendel B; Liu X; Loehr M; Heuchel R
- Conference publication: ANNALS OF ONCOLOGY. 2018;29:vi31Kordes M; Lohr M; Malgerud L; Kaduthanam S; Frodin J-E; Karimi M; Yachnin J; Moro CF; Ghazi S; Heuchel R; Wirta V; Huelsewig C; Stecker K; Del Chiaro M; Ostman A; Engstrand L; Brock S; Gustafsson-Liljefors M
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2018;36(15):e16214Loehr M; Kordes M; Malgerud L; Kaduthanam S; Frodin JE; Karimi M; Yachnin J; Moro CF; Ghazi S; Heuchel RL; Wirta V; Huelsewig C; Stecker K; Del Chiaro M; Ostman A; Lars E; Brock S; Gustavsson-Liljefors M
- Review: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;56:140-154Valentini D; Rao M; Rane L; Rahman S; Axelsson-Robertson R; Heuchel R; Lohr M; Hoft D; Brighenti S; Zumla A; Maeurer M
- Review: CANCERS. 2014;6(4):2137-2154Schober M; Jesenofsky R; Faissner R; Weidenauer C; Hagmann W; Michl P; Heuchel RL; Haas SL; Lohr J-M
- Corrigendum: CELL STEM CELL. 2012;10(1):104Lonardo E; Hermann PC; Mueller M-T; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Rodriguez-Arabaolaza I; Carlos Ramirez J; Torres-Ruiz R; Garcia E; Hidaldo M; Alvaro Cebrian D; Heuchel R; Loehr M; Berger F; Bartenstein P; Aicher A; Heeschen C
- Published conference paper: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2008;12(5B):2130-2144Hamzavi J; Ehnert S; Godoy P; Ciuclan L; Weng H; Mertens PR; Heuchel R; Dooley S
- Corrigendum: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008;28(2):E11Magnusson PU; Looman C; Agren A; Wu Y; Claesson-Welsh L; Heuchel RL
Forskningsbidrag
- Desmoplastic stroma (fibrotic connective tissue) is the common denominator of pancreatic ductal adenocarcinoma and chronic pancreatitis.Swedish Cancer Society1 January 2018Pancreatic ductal adenocarcinoma (BDAK) is the fourth most common cancer-related death cause characterized by an unusually high content of fibrotic scar-like connective tissue (desmoplasia) similar to histological chronic pancreatitis (KP), which is also, ultimately, a fatal disease. The fibrotic stroma / desmoplasia in BDAK is responsible for the chemo and radiation resistance. In most cases of BDAK, chronic pancreatitis occurs in the surrounding pancreatic tissue, which has led to the pre-genomic honor that PDAC was misdiagnosed as KP. In our research, we investigate the reactive, fibrotic stromal in PDAC and CP, by modulating the signaling of a growth factor (TGF-beta) responsible for the fibrotic scar-like connective tissue of BDAK and KP. We use genetically modified mice, where we can alter the TGF-beta signaling in the various cell types in the pancreas, namely epithelial cells, macrophages and stellate cells / fibroblasts, and look at their role in the onset of desmoplasia. In addition, we investigate the TGF-beta's tumor-inhibiting role during the onset of BDAK and its later, driving role in the emergence of daughter tumors. The purpose of this project is to gain a better understanding of the reactive torch in KP and BDAK, with particular emphasis on TGF-beta signaling. Finally, we hope that our results will give us new ideas on how we can use the modulation of TGF-beta signaling to defeat the stroma-based chemoresistence in PDAC and to change the lethal fate BDAK develops.
- Desmoplastic stroma (fibrotic connective tissue) is the common denominator of pancreatic ductal adenocarcinoma and chronic pancreatitis.Swedish Cancer Society1 January 2017Pancreatic ductal adenocarcinoma (BDAK) is the fourth most common cancer-related death cause characterized by an unusually high content of fibrotic scar-like connective tissue (desmoplasia) similar to histological chronic pancreatitis (KP), which is also, ultimately, a fatal disease. The fibrotic stroma / desmoplasia in BDAK is responsible for the chemo and radiation resistance. In most cases of BDAK, chronic pancreatitis occurs in the surrounding pancreatic tissue, which has led to the pre-genomic honor that PDAC was misdiagnosed as KP. In our research, we investigate the reactive, fibrotic stromal in PDAC and CP, by modulating the signaling of a growth factor (TGF-beta) responsible for the fibrotic scar-like connective tissue of BDAK and KP. We use genetically modified mice, where we can alter the TGF-beta signaling in the various cell types in the pancreas, namely epithelial cells, macrophages and stellate cells / fibroblasts, and look at their role in the onset of desmoplasia. In addition, we investigate the TGF-beta's tumor-inhibiting role during the onset of BDAK and its later, driving role in the emergence of daughter tumors. The purpose of this project is to gain a better understanding of the reactive torch in KP and BDAK, with particular emphasis on TGF-beta signaling. Finally, we hope that our results will give us new ideas on how we can use the modulation of TGF-beta signaling to defeat the stroma-based chemoresistence in PDAC and to change the lethal fate BDAK develops.
- Swedish Research Council1 January 2013 - 31 December 2015
Anställningar
- Senior Forskare, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2021