Rainer Heuchel
Principal Researcher | Docent
E-mail: rainer.heuchel@ki.se
Visiting address: Hälsovägen, Enheten för kirurgi C1:77, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Kirurgi och onkologi, 141 52 Huddinge
About me
- Rainer Heuchel has done his PhD on transcriptional enhancers at the
University of Zuerich/Switzterland under the supervision of Prof. Walter
Schaffner. He then joined the Ludwig Institute for Cancer Reseach headed by
Carl-Henrik Heldin where his research focussed on PDGF- and TGF-beta
signaling using genetically engineered mouse models. In 2008 he joined Prof.
Matthias Löhr at Karolinska Institutet where he heads the pancreas research
lab. In December 2021, he became associate professor in cell and molecular
biology.
*Teaching interest*
Cancer biology, molecular biology, animal models of human diseases.
Research
- *Research interests*
Inflammatory and cancerous diseases of the pancreas.
Acute and chronic pancreatitis are very difficult to treat diseases. Chronic
pancreatitis has also been identified as a risk factor for the development of
pancreatic cancer. We use different mouse models recapitulating these two
forms of human pancreatitis in order to better understand the basic biology
of these diseases and to identify new targets for drug and treatment
development.
According to the Cancerfonds Rapporten 2012, pancreatic ductal adenocarcinoma
(PDAC) has raised from the fifth to the fourth most frequent cause of death
by cancer in Sweden, although it is not even among the 10 most common forms
of cancer. The fact that PDAC has changed place with breast cancer is,
however, not due to an increase in PDAC incidence, but is based on the
improvements made in the treatment of breast cancer. This indicates the
dilemma of PDAC, in that there is no diagnostic biomarker, the diagnosis is
late and the tumor, once identified is almost completely resistant towards
conventional chemo- and radiation therapy. The increased therapy resistance
is mainly due to the enormous fibrotic response (desmoplasia), seen as
excessive collagen disposition (comparable to scar tissue), induced by the
stromal cells. Therefore the stroma of an "average" PDAC is consisting to at
least 50% of tumor stroma (mainly activated stellate cells, macrophages
etc.), which is hindering the access of potential anti-cancer drugs to the
actual cancer cells.
Many drugs have been developed, which fight cancer cells successfully in
2-dimensional cell culture and xenograft experiments (subcutaneous injection
of cancer cells) in nude mice. These approaches have the critical
disadvantages that they do not take into account the collagen-rich stroma
(2-D culture and xenograft), the lack of a functioning immune system (nude
mice) and the wrong placing of the tumor (subcutaneous vs. into the
pancreas). In order to circumvent these systematic problems we have developed
3-dimensional stroma-containing cancer cell cultures (avascular minitumors),
which are able to identify those drugs, which only work in 2-D culture and
thus have very little chance to ever work in a patient. Drugs with proven
anti-cancer potential in our 3-D setup are then tested in genetically defined
mouse tumor models, which not only mimic the preneoplastic development of
human PDAC, but are characterized by the same collagen-rich stroma. These
astonishing similarities between mouse and man are most probably based on the
fact that the mouse PDAC is induced by the same genes (KRAS, TP53) that have
been found mutated in the majority of patients. Besides drug/therapy testing,
we use the pre-clinical mouse models also to 1) identify new biomarkers and
drug targets, 2) identify and chararcterize cancer stem cells and to 3)
characterize the impact of additional mutations in tumor development and
metastasis formation.
In conclusion, we have set up a progressive filter strategy for anti-PDAC
drugs (2D to 3D in vitro systems followed floowoed by genetically engineered
mouse models) which will significantly reduce the number of mice required in
drug testing and hopefully increase the efficacy of drugs entering human
phase-I clinical trials for PDAC.
Articles
- Article: SCIENTIFIC REPORTS. 2025;15(1):9694Varela JC; Harish AV; Maniewski P; Gibbon T; Tudoran O; Heuchel R; Lohr M; Margulis W; Russom A; Laurell F
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(17):9369Guendel B; Liu X; Pfutzenreuter A; Engelsberger V; Weiskirchen R; Loehr J-M; Heuchel R
- Article: BIOMEDICINES. 2023;11(11):3061Aval NA; Lahchaichi E; Tudoran O; Fayazbakhsh F; Heuchel R; Lohr M; Pettersson T; Russom A
- Journal article: PANCREATOLOGY. 2023;23:e140-e141Gündel B; Heuchel R; Liu X; Löhr M
- Journal article: PANCREATOLOGY. 2023;23:e140Gündel B; Heuchel R; Löhr M
- Article: NATURE COMMUNICATIONS. 2023;14(1):5024Moro CF; Geyer N; Harrizi S; Hamidi Y; Soderqvist S; Kuznyecov D; Tidholm Qvist E; Salmonson Schaad M; Hermann L; Lindberg A; Heuchel RL; Martin-Bernabe A; Dhanjal S; Navis AC; Villard C; del Valle AC; Bozoky L; Sparrelid E; Dirix L; Strell C; Ostman A; Schmierer B; Vermeulen PB; Engstrand J; Bozoky B; Gerling M
- Article: CANCER RESEARCH. 2023;83(10):1628-1645He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
- Article: ISCIENCE. 2022;25(11):105317Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
- Journal article: PANCREATOLOGY. 2022;22:e81Liu X; Gündel B; Engelsberger V; Löhr M; Heuchel R
- Journal article: PANCREATOLOGY. 2022;22:e70Gündel B; Heuchel R; Gündel A; Liu X
- Journal article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2022;7(1):364Moustakas A; Lohr JM; Heuchel RL
- Article: NEOPLASIA. 2021;23(12):1300-1306Bozoky B; Moro CF; Strell C; Geyer N; Heuchel RL; Lohr JM; Ernberg I; Szekely L; Gerling M; Bozoky B
- Article: PANCREAS. 2021;50(10):1427-1434Li X; Nania S; Kleiter I; Löhr J-M; Heuchel RL
- Article: CANCERS. 2021;13(21):5338Li J; Wu X; Schiffmann L; MacVicar T; Zhou C; Wang Z; Li D; Camacho OV; Heuchel R; Odenthal M; Hillmer A; Quaas A; Zhao Y; Bruns CJ; Popp FC
- Article: TRANSLATIONAL ONCOLOGY. 2021;14(7):101107Liu X; Gundel B; Li X; Liu J; Wright A; Lohr M; Arvidsson G; Heuchel R
- Journal article: PANCREATOLOGY. 2021;21:s72Liu X; Gündel B; Li X; Liu J; Wright A; Löhr M; Arvidsson G; Heuchel R
- Article: ACS APPLIED MATERIALS & INTERFACES. 2020;12(48):53665-53681Zhao Y; Ye F; Brismar TB; Li X; He R; Heuchel R; El-Sayed R; Feliu N; Zheng W; Oerther S; Dutta J; Parak WJ; Muhammed M; Hassan M
- Journal article: PANCREATOLOGY. 2020;20:s129Liu X; Arvidsson G; Li X; Liu J; Wright A; Löhr M; Heuchel R
- Article: SCIENTIFIC REPORTS. 2020;10(1):17444Gorchs L; Ahmed S; Mayer C; Knauf A; Moro CF; Svensson M; Heuchel R; Rangelova E; Bergman P; Kaipe H
- Article: BMC CANCER. 2020;20(1):475Norberg KJ; Liu X; Moro CF; Strell C; Nania S; Bluemel M; Balboni A; Bozoky B; Heuchel RL; Loehr JM
- Article: PANCREATOLOGY. 2019;19(7):963-970Held T; Verbeke CS; Strobel O; Rutkowski W; Villard C; Moro CF; Del Chiaro M; Buechler M; Heuchel R; Lohr M
- Article: FEBS OPEN BIO. 2019;9(10):1756-1768Li X; Clappier C; Kleiter I; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s28-s29Li X; Wallmann T; Nania S; Hornung L; Kleiter I; Löhr J-M; Rolny C; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s107Held T; Verbeke CS; Strobel O; Rutkowski W; Villard C; Moro CF; Del Chiaro M; Büchler MW; Heuchel R; Löhr J-M
- Journal article: PANCREATOLOGY. 2019;19:s80Liu X; Arvidsson G; Li X; Liu J; Wright A; Löhr J-M; Heuchel R
- Journal article: PANCREATOLOGY. 2019;19:s117Mailian E; Kordes M; Russom A; Heuchel R; Eriksson L; Löhr J-M
- Article: CANCERS. 2019;11(5):E638-638Firuzi O; Che PP; El Hassouni B; Buijs M; Coppola S; Lohr M; Funel N; Heuchel R; Carnevale I; Schmidt T; Mantini G; Avan A; Saso L; Peters GJ; Giovannetti E
- Article: PANCREATOLOGY. 2018;18(7):734-741Norberg KJ; Nania S; Li X; Gao H; Szatmary P; Segersvard R; Haas S; Wagman A; Arnelo U; Sutton R; Heuchel RL; Lohr JM
- Journal article: ESMO OPEN. 2018;3:a336Firuzi O; Che PP; Buijs M; Hassouni BE; Stefano C; Löhr M; Heuchel R; Saso L; Peters GJ; Giovannetti E
- Article: ADVANCED FUNCTIONAL MATERIALS. 2018;28(21)Zhou XC; Haraldsson T; Nania S; Ribet F; Palano G; Heuchel R; Loehr M; van der Wijngaart W
- Journal article: EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT. 2018;3(3):189-195Lohr J-M; Kordes M; Rutkowski W; Heuchel R; Gustafsson-Liljefors M; Russom A; Nilsson M
- Article: GUT. 2018;67(3):497-507Hessmann E; Patzak MS; Klein L; Chen N; Kari V; Ramu I; Bapiro TE; Frese KK; Gopinathan A; Richards FM; Jodrell DI; Verbeke C; Li X; Heuchel R; Lohr JM; Johnsen SA; Gress TM; Ellenrieder V; Neesse A
- Article: MOLECULAR ONCOLOGY. 2017;11(10):1413-1429Malgerud L; Lindberg J; Wirta V; Gustafsson-Liljefors M; Karimi M; Moro CF; Stecker K; Picker A; Huelsewig C; Stein M; Bohnert R; Del Chiaro M; Haas SL; Heuchel RL; Permert J; Maeurer MJ; Brock S; Verbeke CS; Engstrand L; Jackson DB; Gronberg H; Lohr J-M
- Article: SCIENTIFIC REPORTS. 2017;7(1):7031Zhao M; Rabieifar P; Costa TDF; Zhuang T; Minden A; Lohr M; Heuchel R; Stromblad S
- Journal article: PANCREATOLOGY. 2017;17(3):s34Norberg J; Strell C; Balboni A; Östman A; Heuchel R; Löhr M
- Journal article: PANCREATOLOGY. 2017;17(3):s27Li X; Hornung L; Nania S; Verbeke C; Löhr M; Heuchel R
- Article: BRITISH JOURNAL OF CANCER. 2017;117(1):65-77Strell C; Norberg KJ; Mezheyeuski A; Schnittert J; Kuninty PR; Moro CF; Paulsson J; Schultz NA; Calatayud D; Lohr JM; Frings O; Verbeke CS; Heuchel RL; Prakash J; Johansen JS; Ostman A
- Article: JOURNAL OF IMMUNOTHERAPY. 2017;40(4):132-139Omazic B; Ayoglu B; Lohr M; Segersvard R; Verbeke C; Magalhaes I; Potacova Z; Mattsson J; Terman A; Ghazi S; Albiin N; Kartalis N; Nilsson P; Poiret T; Liu Z; Heuchel R; Schwenk JM; Permert J; Maeurer MJ; Ringden O
- Journal article: PLOS ONE. 2017;12(1):e0171283Moro CF; Fernandez-Woodbridge A; D'souza MA; Zhang Q; Bozoky B; Vasan SK; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Bjornstedt M; Lohr JM; Isaksson B; Verbeke C; Bozoky B
- Article: METABOLOMICS. 2017;13(5):61Lindahl A; Heuchel R; Forshed J; Lehtio J; Lohr M; Nordstrom A
- Article: PLOS ONE. 2016;11(11):e0166067Moro CF; Fernandez-Woodbridge A; D'souza MA; Zhang Q; Bozoky B; Kandaswamy SV; Catalano P; Heuchel R; Shtembari S; Del Chiaro M; Danielsson O; Bjornstedt M; Lohr JM; Isaksson B; Verbeke C; Bozoky B
- Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(9):1839-1846Li X; Nania S; Fejzibegovic N; Moro CF; Klopp-Schulze L; Verbeke C; Lohr J-M; Heuchel RL
- Journal article: PANCREATOLOGY. 2016;16(3):s24Heuchel R; Li X; Yu Y; Nania S; Verbeke C; Löhr M
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2015;50(11):1419-1427Haraldsson E; Swahn F; Verbeke C; Mattsson JSM; Enochsson L; Ung K-A; Lundell L; Heuchel R; Lohr J-M; Arnelo U
- Article: CLINICAL CHEMISTRY. 2015;61(11):1408-1416Huang J; Lohr J-M; Nilsson M; Segersvard R; Matsson H; Verbeke C; Heuchel R; Kere J; Iafrate AJ; Zheng Z; Ye W
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;464(3):737-742Barrefelt A; Zhao Y; Larsson MK; Egri G; Kuiper RV; Hamm J; Saghafian M; Caidahl K; Brismar TB; Aspelin P; Heuchel R; Muhammed M; Dahne L; Hassan M
- Article: EXPERIMENTAL GERONTOLOGY. 2014;57:149-154Marschallinger J; Krampert M; Couillard-Despres S; Heuchel R; Bogdahn U; Aigner L
- Article: THERANOSTICS. 2014;4(6):604-613Gerling M; Zhao Y; Nania S; Norberg KJ; Verbeke CS; Englert B; Kuiper RV; Bergstrom A; Hassan M; Neesse A; Lohr JM; Heuchel RL
- Article: DEVELOPMENTAL BIOLOGY. 2013;382(2):375-384Estrada KD; Wang W; Retting KN; Chien CT; Elkhoury FE; Heuchel R; Lyons KM
- Article: JOURNAL OF PATHOLOGY. 2013;230(4):441-452Wang J; Zhao J; Chu ESH; Mok MTS; Go MYY; Man K; Heuchel R; Lan HY; Chang Z; Sung JJY; Yu J
- Article: PLOS ONE. 2013;8(7):e70195Wei LH; Huang XR; Zhang Y; Li YQ; Chen H-Y; Heuchel R; Yan BP; Yu C-M; Lan HY
- Article: BMC CANCER. 2013;13:95Longati P; Jia X; Eimer J; Wagman A; Witt M-R; Rehnmark S; Verbeke C; Toftgard R; Lohr M; Heuchel RL
- Article: PLOS ONE. 2013;8(1):e53573Liu G-X; Li Y-Q; Huang XR; Wei L; Chen H-Y; Shi Y-J; Heuchel RL; Lan HY
- Article: CELL STEM CELL. 2011;9(5):433-446Lonardo E; Hermann PC; Mueller M-T; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Roderiguez-Arabaolaza I; Carlos Ramirez J; Torres-Ruiz R; Garcia E; Hidalgo M; Alvaro Cebrian D; Heuchel R; Lohr M; Berger F; Bartenstein P; Aicher A; Heeschen C
- Article: PLOS ONE. 2011;6(6):e20203Pazirandeh A; Sultana T; Mirza M; Rozell B; Hultenby K; Wallis K; Vennstrom B; Davis B; Arner A; Heuchel R; Lohr M; Philipson L; Sollerbrant K
- Article: PULMONARY CIRCULATION. 2011;1(2):259-268Dahal BK; Heuchel R; Pullamsetti SS; Wilhelm J; Ghofrani HA; Weissmann N; Seeger W; Grimminger F; Schermuly RT
- Article: DIABETES. 2011;60(2):590-601Chen HY; Huang XR; Wang W; Li JH; Heuchel RL; Chung ACK; Lan HY
- Article: EMBO JOURNAL. 2010;29(14):2421-2432Shimokawa N; Haglund K; Hoelter SM; Grabbe C; Kirkin V; Koibuchi N; Schultz C; Rozman J; Hoeller D; Qiu C-H; Londono MB; Ikezawa J; Jedlicka P; Stein B; Schwarzacher SW; Wolfer DP; Ehrhardt N; Heuchel R; Nezis I; Brech A; Schmidt MHH; Fuchs H; Gailus-Durner V; Klingenspor M; Bogler O; Wurst W; Deller T; de Angelis MH; Dikic I
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2010;30(14):3685-3694Krampert M; Chirasani SR; Wachs F-P; Aigner R; Bogdahn U; Yingling JM; Heldin C-H; Aigner L; Heuchel R
- Article: MATRIX BIOLOGY. 2010;29(3):166-176Lu N; Carracedo S; Ranta J; Heuchel R; Soininen R; Gullberg D
- Article: ADVANCED ENGINEERING MATERIALS. 2009;11(8):B129-B135Lohr JM; Heuchel R; Jesnowski R; Wallrapp C
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(5):1443-1454Chung ACK; Huang XR; Zhou L; Heuchel R; Lai KN; Lan HY
- Article: LABORATORY INVESTIGATION. 2008;88(11):1204-1214Krampert M; Heldin C-H; Heuchel RL
- Article: BMC CANCER. 2007;7:224Suzuki S; Heldin C-H; Heuchel RL
- Article: HEPATOLOGY. 2007;46(4):1257-1270Weng H-L; Ciuclan L; Liu Y; Hamzavi J; Godoy P; Gaitantzi H; Kanzler S; Heuchel R; Ueberham U; Gebhardt R; Breitkopf K; Dooley S
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(10):2142-2149Magnusson PU; Looman C; Ahgren A; Wu Y; Claesson-Welsh L; Heuchel RL
- Article: PLACENTA. 2007;28(5-6):412-420Singh U; Sun T; Looman C; Heuchel R; Elliott R; Freichel A; Meissner A; Flockerzi V; Fundele R
- Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2007;51(5):361-370Looman C; Sun T; Yu Y; Zieba A; Ahgren A; Feinstein R; Forsberg H; Hellberg C; Heldin C-H; Zhang X-Q; Forsberg-Nilsson K; Khoo N; Fundele R; Heuchel R
- Article: BLOOD. 2006;108(6):1877-1886Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
- Article: JOURNAL OF IMMUNOLOGY. 2006;176(11):6777-6784Li R; Rosendahl A; Brodin G; Cheng AM; Ahgren A; Sundquist C; Kulkarni S; Pawson T; Heldin C-H; Heuchel RL
- Article: MATRIX BIOLOGY. 2006;25(2):118-129Lu N; Heuchel R; Barczyk M; Zhang WM; Gullberg D
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(41):42516-42527Chiara F; Goumans MJ; Forsberg H; Ahgrén A; Rasola A; Aspenström P; Wernstedt C; Hellberg C; Heldin CH; Heuchel R
- Article: CANCER RESEARCH. 2004;64(8):2725-2733Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin CH; Östman A
- Article: GENES & DEVELOPMENT. 2003;17(5):586-590Pant V; Mariano P; Kanduri C; Mattsson A; Lobanenkov V; Heuchel R; Ohlsson R
- Article: MOLECULAR BIOLOGY OF THE CELL. 2003;14(2):529-544Edlund S; Bu SH; Schuster N; Aspenström P; Heuchel R; Heldin NE; ten Dijke P; Heldin CH; Landström M
- Article: ONCOGENE. 2003;22(3):412-425Arsura M; Panta GR; Bilyeu JD; Cavin LG; Sovak MA; Oliver AA; Factor V; Heuchel R; MErcurio F; Thorgeirsson SS; Sonenshein GE
- Article: GENES & DEVELOPMENT. 2000;14(24):3179-3190Tallquist MD; Klinghoffer RA; Heuchel R; Mueting-Nelsen PF; Corrin PD; Heldin CH; Johnson RJ; Soriano P
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(37):29023-29030Brodin G; Åhgren A; ten Dijke P; Heldin CH; Heuchel R
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(20):11410-11415Heuchel R; Berg A; Tallquist M; Åhlén K; Reed RK; Rubin K; Claesson-Welsh L; Heldin CH; Soriano P
- Article: EMBO JOURNAL. 1998;17(10):2846-2854Günes Ç; Heuchel R; Georgiev O; Müller KH; Lichtlen P; Blüthmann H; Marino S; Aguzzi A; Schaffner W
- Article: NATURE. 1997;389(6651):631-635Nakao A; Afrakhte M; Moren A; Nakayama T; Christian JL; Heuchel R; Itoh S; Kawabata N; Heldin NE; Heldin CH; tenDijke P
- Article: EXPERIENTIA. 1995;51(6):606-611WAN M; HEUCHEL R; RADTKE F; HUNZIKER PE; KAGI JHR
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All other publications
- Review: INFLAMMATORY BOWEL DISEASES. 2023;29(4):647-660Schuler C; Foti F; Perren L; Mamie C; Weder B; Stokmaier M; de Valliere C; Heuchel R; Ruiz PA; Rogler G; Hausmann M
- Conference publication: 2022;00:912-914Iseri E; Kaya K; Heuchel R; van der Wijngaart W
- Preprint: SSRN ELECTRONIC JOURNAL. 2022Sarhan D; Eisinger S; Pelicano C; Fei H; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
- Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9:A927Sarhan D; He F; Calandigary A; Malki E; Moro CF; Kaisso M; Olofsson-Sahl P; Melssen M; Lohr M; Karlsson M; Heuchel R
- Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:741162Guendel B; Liu X; Loehr M; Heuchel R
- Conference publication: ANNALS OF ONCOLOGY. 2018;29:vi31Kordes M; Lohr M; Malgerud L; Kaduthanam S; Frodin J-E; Karimi M; Yachnin J; Moro CF; Ghazi S; Heuchel R; Wirta V; Huelsewig C; Stecker K; Del Chiaro M; Ostman A; Engstrand L; Brock S; Gustafsson-Liljefors M
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2018;36(15):e16214Loehr M; Kordes M; Malgerud L; Kaduthanam S; Frodin JE; Karimi M; Yachnin J; Moro CF; Ghazi S; Heuchel RL; Wirta V; Huelsewig C; Stecker K; Del Chiaro M; Ostman A; Lars E; Brock S; Gustavsson-Liljefors M
- Review: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;56:140-154Valentini D; Rao M; Rane L; Rahman S; Axelsson-Robertson R; Heuchel R; Lohr M; Hoft D; Brighenti S; Zumla A; Maeurer M
- Review: CANCERS. 2014;6(4):2137-2154Schober M; Jesenofsky R; Faissner R; Weidenauer C; Hagmann W; Michl P; Heuchel RL; Haas SL; Lohr J-M
- Corrigendum: CELL STEM CELL. 2012;10(1):104Lonardo E; Hermann PC; Mueller M-T; Huber S; Balic A; Miranda-Lorenzo I; Zagorac S; Alcala S; Rodriguez-Arabaolaza I; Carlos Ramirez J; Torres-Ruiz R; Garcia E; Hidaldo M; Alvaro Cebrian D; Heuchel R; Loehr M; Berger F; Bartenstein P; Aicher A; Heeschen C
- Published conference paper: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2008;12(5B):2130-2144Hamzavi J; Ehnert S; Godoy P; Ciuclan L; Weng H; Mertens PR; Heuchel R; Dooley S
- Corrigendum: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2008;28(2):E11Magnusson PU; Looman C; Agren A; Wu Y; Claesson-Welsh L; Heuchel RL
Grants
- Desmoplastic stroma (fibrotic connective tissue) is the common denominator of pancreatic ductal adenocarcinoma and chronic pancreatitis.Swedish Cancer Society1 January 2018Pancreatic ductal adenocarcinoma (BDAK) is the fourth most common cancer-related death cause characterized by an unusually high content of fibrotic scar-like connective tissue (desmoplasia) similar to histological chronic pancreatitis (KP), which is also, ultimately, a fatal disease. The fibrotic stroma / desmoplasia in BDAK is responsible for the chemo and radiation resistance. In most cases of BDAK, chronic pancreatitis occurs in the surrounding pancreatic tissue, which has led to the pre-genomic honor that PDAC was misdiagnosed as KP. In our research, we investigate the reactive, fibrotic stromal in PDAC and CP, by modulating the signaling of a growth factor (TGF-beta) responsible for the fibrotic scar-like connective tissue of BDAK and KP. We use genetically modified mice, where we can alter the TGF-beta signaling in the various cell types in the pancreas, namely epithelial cells, macrophages and stellate cells / fibroblasts, and look at their role in the onset of desmoplasia. In addition, we investigate the TGF-beta's tumor-inhibiting role during the onset of BDAK and its later, driving role in the emergence of daughter tumors. The purpose of this project is to gain a better understanding of the reactive torch in KP and BDAK, with particular emphasis on TGF-beta signaling. Finally, we hope that our results will give us new ideas on how we can use the modulation of TGF-beta signaling to defeat the stroma-based chemoresistence in PDAC and to change the lethal fate BDAK develops.
- Desmoplastic stroma (fibrotic connective tissue) is the common denominator of pancreatic ductal adenocarcinoma and chronic pancreatitis.Swedish Cancer Society1 January 2017Pancreatic ductal adenocarcinoma (BDAK) is the fourth most common cancer-related death cause characterized by an unusually high content of fibrotic scar-like connective tissue (desmoplasia) similar to histological chronic pancreatitis (KP), which is also, ultimately, a fatal disease. The fibrotic stroma / desmoplasia in BDAK is responsible for the chemo and radiation resistance. In most cases of BDAK, chronic pancreatitis occurs in the surrounding pancreatic tissue, which has led to the pre-genomic honor that PDAC was misdiagnosed as KP. In our research, we investigate the reactive, fibrotic stromal in PDAC and CP, by modulating the signaling of a growth factor (TGF-beta) responsible for the fibrotic scar-like connective tissue of BDAK and KP. We use genetically modified mice, where we can alter the TGF-beta signaling in the various cell types in the pancreas, namely epithelial cells, macrophages and stellate cells / fibroblasts, and look at their role in the onset of desmoplasia. In addition, we investigate the TGF-beta's tumor-inhibiting role during the onset of BDAK and its later, driving role in the emergence of daughter tumors. The purpose of this project is to gain a better understanding of the reactive torch in KP and BDAK, with particular emphasis on TGF-beta signaling. Finally, we hope that our results will give us new ideas on how we can use the modulation of TGF-beta signaling to defeat the stroma-based chemoresistence in PDAC and to change the lethal fate BDAK develops.
- Swedish Research Council1 January 2013 - 31 December 2015
Employments
- Principal Researcher, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2021