Pontus Plaven Sigray

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: TRIALS. 2024;25(1):648
Effects of cognitive training under hypoxia on cognitive proficiency and neuroplasticity in remitted patients with mood disorders and healthy individuals: ALTIBRAIN study protocol for a randomized controlled trial.
Miskowiak KW; Damgaard V; Schandorff JM; Macoveanu J; Knudsen GM; Johansen A; Plaven-Sigray P; Svarer C; Fussing CB; Cramer K; Jørgensen MB; Kessing LV; Ehrenreich H
Article: JOURNAL OF NEUROSCIENCE. 2024;44(33):e1750232024
An In Vivo High-Resolution Human Brain Atlas of Synaptic Density
Johansen A; Beliveau V; Colliander E; Raval NR; Dam VH; Gillings N; Aznar S; Svarer C; Plaven-Sigray P; Knudsen GM
Article: JAMA PSYCHIATRY. 2024;81(5):468-476
Cognitive Function and Variability in Antipsychotic Drug-Naive Patients With First-Episode Psychosis A Systematic Review and Meta-Analysis
Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
Article: GEROSCIENCE. 2024;46(5):4123-4133
Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features
Doerfel RP; Arenas-Gomez JM; Svarer C; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
Article: BMC NEUROLOGY. 2024;24(1):111
Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
Article: HUMAN BRAIN MAPPING. 2023;44(17):6139-6148
Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test-retest reliability of publicly available software packages
Dorfel RP; Arenas-Gomez JM; Fisher PM; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
Article: MOLECULAR PSYCHIATRY. 2023;28(10):4272-4279
Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial
Johansen A; Armand S; Plaven-Sigray P; Nasser A; Ozenne B; Petersen IN; Keller SH; Madsen J; Beliveau V; Moller K; Vassilieva A; Langley C; Svarer C; Stenbaek DS; Sahakian BJ; Knudsen GM
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(9):1544-1556
Kinetic models for estimating occupancy from single-scan PET displacement studies
Laurell GL; Plaven-Sigray P; Johansen A; Raval NR; Nasser A; Madsen CA; Madsen J; Hansen HD; Donovan LL; Knudsen GM; Lammertsma AA; Ogden RT; Svarer C; Schain M
Article: ADDICTION. 2023;118(6):1053-1061
Striatal dopamine D2 receptor availability as a predictor of subsequent alcohol use in social drinkers
Jangard S; Jayaram-Lindstrom N; Isacsson NH; Matheson GJ; Plaven-Sigray P; Franck J; Borg J; Farde L; Cervenka S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248
Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [¹¹C]AZ10419369 Positron Emission Tomography Study
Tangen A; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plaven-Sigray P; Varrone A; Halldin C; Varnas K; Borg J; Lundberg J
Article: NEUROIMAGE. 2022;263:119620
Designing drug occupancy studies with PET neuroimaging: Sample size, occupancy ranges and analytical methods
Laurell GL; Plaven-Sigray P; Svarer C; Ogden RT; Knudsen GM; Schain M
Article: NUCLEAR MEDICINE AND BIOLOGY. 2022;114-115:42-48
Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs.
Raval NR; Madsen CA; Shalgunov V; Nasser A; Battisti UM; Beaman EE; Juhl M; Jørgensen LM; Herth MM; Hansen HD; Plavén-Sigray P; Knudsen GM
Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868
In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study
Svensson JE; Tiger M; Plaven-Sigray P; Halldin C; Schain M; Lundberg J
Article: FRONTIERS IN NEUROSCIENCE. 2022;16:847074
An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Raval NR; Nasser A; Madsen CA; Beschorner N; Beaman EE; Juhl M; Lehel S; Palner M; Svarer C; Plaven-Sigray P; Jorgensen LM; Knudsen GM
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
Plaven-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: FRONTIERS IN SYNAPTIC NEUROSCIENCE. 2021;13:715811
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson's Disease
Raval NR; Gudmundsen F; Juhl M; Andersen IV; Speth N; Videbaek A; Petersen IN; Mikkelsen JD; Fisher PM; Herth MM; Plaven-Sigray P; Knudsen GM; Palner M
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46
No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
Lee M; Fatouros-Bergman H; Plaven-Sigray P; Victorsson PI; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264
Serotonin transporter availability increases in patients recovering from a depressive episode
Svensson JE; Svanborg C; Plaven-Sigray P; Kaldo V; Halldin C; Schain M; Lundberg J
Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417
Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies
Laurell GL; Plaven-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
Article: NEUROIMAGE. 2021;226:117523
Low convergent validity of [¹¹C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [¹¹C]FLB 457
Freiburghaus T; Svensson JE; Matheson GJ; Plaven-Sigray P; Lundberg J; Farde L; Cervenka S
Article: SCHIZOPHRENIA RESEARCH. 2020;222:175-184
Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness
Matheson GJ; Plaven-Sigray P; Louzolo A; Borg J; Farde L; Petrovic P; Cervenka S
Article: NEUROIMAGE. 2019;202:116143
Validity and reliability of extrastriatal [¹¹C]raclopride binding quantification in the living human brain
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338
Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [¹¹C]PBR28 HRRT PET study
Tuisku J; Plaven-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Bruck A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamaki P; Rissanen E; Sucksdorff M; Varrone A; Collste K; Gallezot J-D; Hillmer A; Huang Y; Hoglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
Article: NEUROIMAGE. 2019;188:102-110
Accuracy and reliability of [¹¹C]PBR28 specific binding estimated without the use of a reference region
Plaven-Sigray P; Schain M; Zanderigo F; Farde L; Halldin C; Forsberg A; Varrone A; Jucaite A; Cervenka S; Stenkrona P; Collste K; Kander M; Kosek E; Lampa J; Hoglund CO; Rabiner EA; Gunn RN; Ogden RT; Cervenk S
Article: PLOS ONE. 2018;13(12):e0209584
Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men
Caravaggio F; Plaven-Sigray P; Matheson GJ; Plitman E; Chakravarty MM; Borg J; Graff-Guerrero A; Cervenka S
Article: EJNMMI RESEARCH. 2018;8(1):102
Test-retest reliability and convergent validity of (R)-[¹¹C]PK11195 outcome measures without arterial input function
Plaven-Sigray P; Matheson GJ; Cselenyi Z; Jucaite A; Farde L; Cervenka S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(6):433-442
Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data
Plaven-Sigray P; Matheson GJ; Collste K; Ashok AH; Coughlin JM; Howes OD; Mizrahi R; Pomper MG; Rusjan P; Veronese M; Wang Y; Cervenka S
Article: EJNMMI RESEARCH. 2018;8(1):74
[¹¹C]SCH23390 binding to the D₁-dopamine receptor in the human brain-a comparison of manual and automated methods for image analysis
Stenkrona P; Matheson GJ; Cervenka S; Sigray PP; Halldin C; Farde L
Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(5):e1006196
Simulations to benchmark time-varying connectivity methods for fMRI
Thompson WH; Richter CG; Plaven-Sigray P; Fransson P
Article: PLOS ONE. 2018;13(3):e0193770
Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study
Plaven-Sigray P; Matheson GJ; Gustavsson P; Stenkrona P; Halldin C; Farde L; Cervenka S
Article: ELIFE. 2017;6:e27725
The readability of scientific texts is decreasing over time
Plaven-Sigray P; Matheson GJ; Schiffler BC; Thompson WH
Article: EJNMMI RESEARCH. 2017;7(1):58
Assessment of simplified ratio-based approaches for quantification of PET [¹¹C] PBR28 data
Matheson GJ; Plaven-Sigray P; Forsberg A; Varrone A; Farde L; Cervenka S
Article: NEUROIMAGE. 2017;155:344-353
Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [¹¹C] SCH-23390
Matheson GJ; Stenkrona P; Cselenyi Z; Plaven-Sigray P; Halldin C; Farde L; Cervenka S
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
Plaven-Sigray P; Hedman E; Victorsson P; Matheson GJ; Forsberg A; Djurfeldt DR; Ruck C; Halldin C; Lindefors N; Cervenka S
Article: NEUROIMAGE. 2014;102:590-595
Dopamine D1 receptor availability is related to social behavior: A positron emission tomography study
Plaven-Sigray P; Gustavsson P; Farde L; Borg J; Stenkrona P; Nyberg L; Backman L; Cervenka S
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Alla övriga publikationer

Preprint: MEDRXIV. 2025;MEDRXIV
Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages.
Dörfel RP; Ozenne B; Ganz M; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Svensson JE; Plavén-Sigray P
Review: GEROSCIENCE. 2025;47(3):2721-2737
In vivo medical imaging for assessing geroprotective interventions in humans
Svensson JE; Schain M; Plaven-Sigray P
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022;42(1_SUPPL):80-81
Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs
Raval N; Madsen C; Shalgunov V; Nasser A; Battisti U; Beaman E; Juhl M; Jorgensen L; Herth M; Hansen H; Plaven-Sigray P; Knudsen G
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):228-229
Meta-analysis of the glial marker TSPO in psychosis revisited: Reconciling inconclusive findings of patient-control differences
Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; de'Picker L; Rusjan PM; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(11):2805-2819
Early stopping in clinical PET studies: How to reduce expense and exposure
Svensson JE; Schain M; Knudsen GM; Ogden RT; Plaven-Sigray P
Letter: BIOLOGICAL PSYCHIATRY. 2021;89(3):e5-e8
Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences
Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; De Picker L; Rusjan P; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Letter: NEUROIMAGE. 2020;207:116371
In response to the letter "[¹¹C]raclopride and extrastriatal binding to D2/3 receptors"
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(2):502-504
Clinical brain PET research must embrace multi-centre collaboration and data sharing or risk its demise
Matheson GJ; Plaven-Sigray P; Tuisku J; Rinne J; Matuskey D; Cervenka S
Corrigendum: PSYCHOLOGICAL MEDICINE. 2019;49(9):1583-1584
Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears?: A commentary on 'Neuroinflammation in schizophrenia: metaanalysis of in-vivo microglial imaging' (vol 49, pg 1624, 2019)
Plaven-Sigray P; Cervenka S
Editorial comment: PSYCHOLOGICAL MEDICINE. 2019;49(10):1624-1628
Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears? A commentary on 'Neuroinflammation in schizophrenia: metaanalysis of in-vivo microglial imaging' by Marques et al.
Plaven-Sigray P; Cervenka S
Doctoral thesis: 2018
Positron emission tomography : development, evaluation and application of quantification methods
Plaven Sigray P
Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2018;373(1744):20170156
Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders
Farde L; Plaven-Sigray P; Borg J; Cervenka S

Utvalda forskningsbidrag

The search for an aging biomarker: in vivo quantification of age-related proteins using Positron Emission Tomography in humans
Impetus Longevity Grant

Forskningsbidrag

mTOR inhibition as a neuroprotective treatment in Alzheimer’s Disease
Hjärnfonden
mTOR inhibition as a neuroprotective treatment
Åke Wibergs Stiftelse
VR internationell postdok
Vetenskapsrådet
Lundbeck Fonden postdok
Lundbeck Fonden
Rapamycinbehandling vid Alzheimers sjukdom utvärderat med hjälp av positronemissionstomografi
Demensförbundet - Demensfonden
Rapamycinbehandling vid Alzheimers sjukdom utvärderat med hjälp av positronemissionstomografi
Åhlénstiftelsen Medicinsk Forskning
Fonden för psykisk hälsa projektbidrag
Fonden för psykisk hälsa
SSMF postdok stipendium
Svenska Sällskapet för Medicinsk Forskning (SSMF)
Rapamycinbehandling vid Alzheimers sjukdom, effektutvärdering med hjälp av positronemissionstomografi: en pilotstudie
Loo och Hans Osterman Stiftelse för Medicinsk Forskning

Anställningar

Postdoktorala Studier, Klinisk neurovetenskap, Karolinska Institutet, 2025-2028
Postdoktor, Klinisk neurovetenskap, Karolinska Institutet, 2022-2025
Postdoktor, Neurobiologisk Foskningsenhet, Rigshospitalet, 2019-2025

Examina och utbildning

Medicine Doktorsexamen, Institutionen för klinisk neurovetenskap, Karolinska Institutet, 2019
Psykologexamen, Karolinska Institutet, 2013

Artiklar

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Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI