Pontus Plaven Sigray
Postdoctoral Researcher
E-mail: pontus.plaven.sigray@ki.se
Visiting address: Akademiska Stråket 1, Bioclinicum, J4-14, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 CPF Lundberg, 171 77 Stockholm
About me
My research is primarily focused on developing biomarkers and new treatments for neurodegenerative diseases by applying neuroimaging techniques, such as MRI and PET. Me, my group and my collaborators are currently running the ERAP phase IIa trial (clinicaltrial.gov ID: NCT06022068), where we evaluate the effect of the drug sirolimus/rapamycin on human neurodegeneration and aging.
My work also involves creating and assessing biomarkers of aging that can be used as endpoints in clinical trials of geroprotective compounds. To this end, my group applies machine learning models to large batches of multi-modal imaging data to estimate the biological age of different organ-systems in the human body.
Articles
- Article: GEROSCIENCE. 2024;46(5):4123-4133
- Article: JAMA PSYCHIATRY. 2024;81(5):468-476
- Article: BMC NEUROLOGY. 2024;24(1):111
- Article: HUMAN BRAIN MAPPING. 2023;44(17):6139-6148
- Article: MOLECULAR PSYCHIATRY. 2023;28(10):4272-4279
- Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(9):1544-1556
- Article: ADDICTION. 2023;118(6):1053-1061
- Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248
- Article: NUCLEAR MEDICINE AND BIOLOGY. 2022;114-115:42-48
- Article: NEUROIMAGE. 2022;263:119620
- Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868
- Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
- Article: FRONTIERS IN NEUROSCIENCE. 2022;16:847074
- Article: NPJ SCHIZOPHRENIA. 2021;7(1):46
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264
- Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417
- Article: NEUROIMAGE. 2021;226:117523
- Article: FRONTIERS IN SYNAPTIC NEUROSCIENCE. 2021;13:715811
- Article: SCHIZOPHRENIA RESEARCH. 2020;222:175-184
- Article: NEUROIMAGE. 2019;202:116143
- Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338
- Article: NEUROIMAGE. 2019;188:102-110
- Article: EJNMMI RESEARCH. 2018;8(1):102
- Article: BIOLOGICAL PSYCHIATRY. 2018;84(6):433-442
- Article: EJNMMI RESEARCH. 2018;8(1):74
- Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(5):e1006196
- Article: PLOS ONE. 2018;13(3):e0193770
- Article: PLOS ONE. 2018;13(12):e0209584
- Article: EJNMMI RESEARCH. 2017;7(1):58
- Article: ELIFE. 2017;6:e27725
- Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
- Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469
- Article: NEUROIMAGE. 2014;102:590-595
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All other publications
- Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(11):2805-2819
- Letter: BIOLOGICAL PSYCHIATRY. 2021;89(3):e5-e8
- Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):228-229
- Letter: NEUROIMAGE. 2020;207:116371
- Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(2):502-504
- Editorial comment: PSYCHOLOGICAL MEDICINE. 2019;49(10):1624-1628
- Corrigendum: PSYCHOLOGICAL MEDICINE. 2019;49(9):1583-1584
- Thesis / dissertation: 2018
- Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 2018;373(1744):20170156
Selected grants
- The search for an aging biomarker: in vivo quantification of age-related proteins using Positron Emission Tomography in humansImpetus Longevity Grant
Grants
- Swedish Research Council - International post-doc grantSwedish Research Council
- Lundbeck Foundation post-doc grantLundbeck Foundation
- Fonden för psykisk hälsa research grantFonden för psykisk hälsa
- Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomographyDemensförbundet - Demensfonden
- Evaluating rapamycin treatment in Alzheimer’s disease using positron emission tomographyÅhlénstiftelsen Medical Research grant
- Swedish Society for Medical Research - postdoc stipendSwedish Society for Medical Research
- Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography: a pilot studyLoo and Hans Osterman Foundation for Medical Research
Employments
- Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025
- Postdoc, Neurobiology Research Unit, Copenhagen University Hospital, 2019-2025
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2019
- Degree Of Master Of Science In Psychology, Karolinska Institutet, 2013