Pontus Plaven Sigray

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About me

My research is primarily focused on developing biomarkers and new treatments for neurodegenerative diseases by applying neuroimaging techniques, such as MRI and PET. Me, my group and my collaborators are currently running the ERAP phase IIa trial (clinicaltrial.gov ID: NCT06022068), where we evaluate the effect of the drug sirolimus/rapamycin on human neurodegeneration and aging.
My work also involves creating and assessing biomarkers of aging that can be used as endpoints in clinical trials of geroprotective compounds. To this end, my group applies machine learning models to large batches of multi-modal imaging data to estimate the biological age of different organ-systems in the human body.

Articles

Article: GEROSCIENCE. 2024;46(5):4123-4133
Multimodal brain age prediction using machine learning: combining structural MRI and 5-HT2AR PET-derived features
Doerfel RP; Arenas-Gomez JM; Svarer C; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
Article: JAMA PSYCHIATRY. 2024;81(5):468-476
Cognitive Function and Variability in Antipsychotic Drug-Naive Patients With First-Episode Psychosis
Lee M; Cernvall M; Borg J; Plaven-Sigray P; Larsson C; Erhardt S; Sellgren CM; Fatouros-Bergman H; Cervenka S
Article: BMC NEUROLOGY. 2024;24(1):111
Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
Article: HUMAN BRAIN MAPPING. 2023;44(17):6139-6148
Prediction of brain age using structural magnetic resonance imaging: A comparison of accuracy and test-retest reliability of publicly available software packages
Dorfel RP; Arenas-Gomez JM; Fisher PM; Ganz M; Knudsen GM; Svensson JE; Plaven-Sigray P
Article: MOLECULAR PSYCHIATRY. 2023;28(10):4272-4279
Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial
Johansen A; Armand S; Plaven-Sigray P; Nasser A; Ozenne B; Petersen IN; Keller SH; Madsen J; Beliveau V; Moller K; Vassilieva A; Langley C; Svarer C; Stenbaek DS; Sahakian BJ; Knudsen GM
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2023;43(9):1544-1556
Kinetic models for estimating occupancy from single-scan PET displacement studies
Laurell GL; Plaven-Sigray P; Johansen A; Raval NR; Nasser A; Madsen CA; Madsen J; Hansen HD; Donovan LL; Knudsen GM; Lammertsma AA; Ogden RT; Svarer C; Schain M
Article: ADDICTION. 2023;118(6):1053-1061
Striatal dopamine D2 receptor availability as a predictor of subsequent alcohol use in social drinkers
Jangard S; Jayaram-Lindstrom N; Isacsson NH; Matheson GJ; Plaven-Sigray P; Franck J; Borg J; Farde L; Cervenka S
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(4):241-248
Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [¹¹C]AZ10419369 Positron Emission Tomography Study
Tangen A; Veldman ER; Svensson J; Tiger M; Nord M; Sorjonen K; Andersson M; Plaven-Sigray P; Varrone A; Halldin C; Varnas K; Borg J; Lundberg J
Article: NUCLEAR MEDICINE AND BIOLOGY. 2022;114-115:42-48
Evaluation of the α-synuclein PET radiotracer (d3)-[11C]MODAG-001 in pigs.
Raval NR; Madsen CA; Shalgunov V; Nasser A; Battisti UM; Beaman EE; Juhl M; Jørgensen LM; Herth MM; Hansen HD; Plavén-Sigray P; Knudsen GM
Article: NEUROIMAGE. 2022;263:119620
Designing drug occupancy studies with PET neuroimaging: Sample size, occupancy ranges and analytical methods
Laurell GL; Plaven-Sigray P; Svarer C; Ogden RT; Knudsen GM; Schain M
Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(10):1863-1868
In vivo correlation of serotonin transporter and 1B receptor availability in the human brain: a PET study
Svensson JE; Tiger M; Plaven-Sigray P; Halldin C; Schain M; Lundberg J
Article: MOLECULAR PSYCHIATRY. 2022;27(2):1233-1240
Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
Plaven-Sigray P; Ikonen Victorsson P; Santillo A; Matheson GJ; Lee M; Collste K; Fatouros-Bergman H; Sellgren CM; Erhardt S; Agartz I; Halldin C; Farde L; Cervenka S
Article: FRONTIERS IN NEUROSCIENCE. 2022;16:847074
An in vivo Pig Model for Testing Novel Positron Emission Tomography Radioligands Targeting Cerebral Protein Aggregates
Raval NR; Nasser A; Madsen CA; Beschorner N; Beaman EE; Juhl M; Lehel S; Palner M; Svarer C; Plaven-Sigray P; Jorgensen LM; Knudsen GM
Article: NPJ SCHIZOPHRENIA. 2021;7(1):46
No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
Lee M; Fatouros-Bergman H; Plaven-Sigray P; Victorsson PI; Sellgren CM; Erhardt S; Flyckt L; Farde L; Cervenka S
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):264
Serotonin transporter availability increases in patients recovering from a depressive episode
Svensson JE; Svanborg C; Plaven-Sigray P; Kaldo V; Halldin C; Schain M; Lundberg J
Article: JOURNAL OF NUCLEAR MEDICINE. 2021;62(3):412-417
Nondisplaceable Binding Is a Potential Confounding Factor in ¹¹C-PBR28 Translocator Protein PET Studies
Laurell GL; Plaven-Sigray P; Jucaite A; Varrone A; Cosgrove KP; Svarer C; Knudsen GM; Ogden RT; Zanderigo F; Cervenka S; Hillmer AT; Schain M
Article: NEUROIMAGE. 2021;226:117523
Low convergent validity of [¹¹C]raclopride binding in extrastriatal brain regions: A PET study of within-subject correlations with [¹¹C]FLB 457
Freiburghaus T; Svensson JE; Matheson GJ; Plaven-Sigray P; Lundberg J; Farde L; Cervenka S
Article: FRONTIERS IN SYNAPTIC NEUROSCIENCE. 2021;13:715811
Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson's Disease
Raval NR; Gudmundsen F; Juhl M; Andersen IV; Speth N; Videbaek A; Petersen IN; Mikkelsen JD; Fisher PM; Herth MM; Plaven-Sigray P; Knudsen GM; Palner M
Article: SCHIZOPHRENIA RESEARCH. 2020;222:175-184
Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness
Matheson GJ; Plaven-Sigray P; Louzolo A; Borg J; Farde L; Petrovic P; Cervenka S
Article: NEUROIMAGE. 2019;202:116143
Validity and reliability of extrastriatal [¹¹C]raclopride binding quantification in the living human brain
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338
Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [¹¹C]PBR28 HRRT PET study
Tuisku J; Plaven-Sigray P; Gaiser EC; Airas L; Al-Abdulrasul H; Bruck A; Carson RE; Chen M-K; Cosgrove KP; Ekblad L; Esterlis I; Farde L; Forsberg A; Halldin C; Helin S; Kosek E; Lekander M; Lindgren N; Marjamaki P; Rissanen E; Sucksdorff M; Varrone A; Collste K; Gallezot J-D; Hillmer A; Huang Y; Hoglund CO; Johansson J; Jucaite A; Lampa J; Nabulsi N; Pittman B; Sandiego CM; Stenkrona P; Rinne J; Matuskey D; Cervenka S
Article: NEUROIMAGE. 2019;188:102-110
Accuracy and reliability of [¹¹C]PBR28 specific binding estimated without the use of a reference region
Plaven-Sigray P; Schain M; Zanderigo F; Farde L; Halldin C; Forsberg A; Varrone A; Jucaite A; Cervenka S; Stenkrona P; Collste K; Kander M; Kosek E; Lampa J; Hoglund CO; Rabiner EA; Gunn RN; Ogden RT; Cervenk S
Article: EJNMMI RESEARCH. 2018;8(1):102
Test-retest reliability and convergent validity of (R)-[¹¹C]PK11195 outcome measures without arterial input function
Plaven-Sigray P; Matheson GJ; Cselenyi Z; Jucaite A; Farde L; Cervenka S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(6):433-442
Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data
Plaven-Sigray P; Matheson GJ; Collste K; Ashok AH; Coughlin JM; Howes OD; Mizrahi R; Pomper MG; Rusjan P; Veronese M; Wang Y; Cervenka S
Article: EJNMMI RESEARCH. 2018;8(1):74
[¹¹C]SCH23390 binding to the D₁-dopamine receptor in the human brain-a comparison of manual and automated methods for image analysis
Stenkrona P; Matheson GJ; Cervenka S; Sigray PP; Halldin C; Farde L
Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(5):e1006196
Simulations to benchmark time-varying connectivity methods for fMRI
Thompson WH; Richter CG; Plaven-Sigray P; Fransson P
Article: PLOS ONE. 2018;13(3):e0193770
Is dopamine D1 receptor availability related to social behavior? A positron emission tomography replication study
Plaven-Sigray P; Matheson GJ; Gustavsson P; Stenkrona P; Halldin C; Farde L; Cervenka S
Article: PLOS ONE. 2018;13(12):e0209584
Trait impulsivity is not related to post-commissural putamen volumes: A replication study in healthy men
Caravaggio F; Plaven-Sigray P; Matheson GJ; Plitman E; Chakravarty MM; Borg J; Graff-Guerrero A; Cervenka S
Article: EJNMMI RESEARCH. 2017;7(1):58
Assessment of simplified ratio-based approaches for quantification of PET [¹¹C] PBR28 data
Matheson GJ; Plaven-Sigray P; Forsberg A; Varrone A; Farde L; Cervenka S
Article: ELIFE. 2017;6:e27725
The readability of scientific texts is decreasing over time
Plaven-Sigray P; Matheson GJ; Schiffler BC; Thompson WH
Article: NEUROIMAGE. 2017;155:344-353
Reliability of volumetric and surface-based normalisation and smoothing techniques for PET analysis of the cortex: A test-retest analysis using [¹¹C] SCH-23390
Matheson GJ; Stenkrona P; Cselenyi Z; Plaven-Sigray P; Halldin C; Farde L; Cervenka S
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856
Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [¹¹C]PBR28
Collste K; Plaven-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(5):462-469
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
Plaven-Sigray P; Hedman E; Victorsson P; Matheson GJ; Forsberg A; Djurfeldt DR; Ruck C; Halldin C; Lindefors N; Cervenka S
Article: NEUROIMAGE. 2014;102:590-595
Dopamine D1 receptor availability is related to social behavior: A positron emission tomography study
Plaven-Sigray P; Gustavsson P; Farde L; Borg J; Stenkrona P; Nyberg L; Backman L; Cervenka S
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All other publications

Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(11):2805-2819
Early stopping in clinical PET studies: How to reduce expense and exposure
Svensson JE; Schain M; Knudsen GM; Ogden RT; Plaven-Sigray P
Letter: BIOLOGICAL PSYCHIATRY. 2021;89(3):e5-e8
Meta-analysis of the Glial Marker TSPO in Psychosis Revisited: Reconciling Inconclusive Findings of Patient-Control Differences
Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; De Picker L; Rusjan P; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(1_SUPPL):228-229
Meta-analysis of the glial marker TSPO in psychosis revisited: Reconciling inconclusive findings of patient-control differences
Plaven-Sigray P; Matheson GJ; Coughlin JM; Hafizi S; Laurikainen H; Ottoy J; de'Picker L; Rusjan PM; Hietala J; Howes OD; Mizrahi R; Morrens M; Pomper MG; Cervenka S
Letter: NEUROIMAGE. 2020;207:116371
In response to the letter "[¹¹C]raclopride and extrastriatal binding to D2/3 receptors"
Svensson JE; Schain M; Plaven-Sigray P; Cervenka S; Tiger M; Nord M; Halldin C; Farde L; Lundberg J
Letter: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2020;47(2):502-504
Clinical brain PET research must embrace multi-centre collaboration and data sharing or risk its demise
Matheson GJ; Plaven-Sigray P; Tuisku J; Rinne J; Matuskey D; Cervenka S
Editorial comment: PSYCHOLOGICAL MEDICINE. 2019;49(10):1624-1628
Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears? A commentary on 'Neuroinflammation in schizophrenia: metaanalysis of in-vivo microglial imaging' by Marques et al.
Plaven-Sigray P; Cervenka S
Corrigendum: PSYCHOLOGICAL MEDICINE. 2019;49(9):1583-1584
Meta-analytic studies of the glial cell marker TSPO in psychosis - a question of apples and pears?: A commentary on 'Neuroinflammation in schizophrenia: metaanalysis of in-vivo microglial imaging' (vol 49, pg 1624, 2019)
Plaven-Sigray P; Cervenka S
Thesis / dissertation: 2018
Positron emission tomography : development, evaluation and application of quantification methods
Plavén-Sigray, Pontus
Review: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2018;373(1744):20170156
Brain neuroreceptor density and personality traits: towards dimensional biomarkers for psychiatric disorders
Farde L; Plaven-Sigray P; Borg J; Cervenka S

Selected grants

The search for an aging biomarker: in vivo quantification of age-related proteins using Positron Emission Tomography in humans
Impetus Longevity Grant

Grants

Swedish Research Council - International post-doc grant
Swedish Research Council
Lundbeck Foundation post-doc grant
Lundbeck Foundation
Fonden för psykisk hälsa research grant
Fonden för psykisk hälsa
Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography
Demensförbundet - Demensfonden
Evaluating rapamycin treatment in Alzheimer’s disease using positron emission tomography
Åhlénstiftelsen Medical Research grant
Swedish Society for Medical Research - postdoc stipend
Swedish Society for Medical Research
Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography: a pilot study
Loo and Hans Osterman Foundation for Medical Research

Employments

Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025
Postdoc, Neurobiology Research Unit, Copenhagen University Hospital, 2019-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2019
Degree Of Master Of Science In Psychology, Karolinska Institutet, 2013

About me

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