Pontus Plaven Sigray

Pontus Plaven Sigray

Postdoctoral Researcher
Visiting address: Akademiska Stråket 1, Bioclinicum, J4-14, 17176 Stockholm
Postal address: K8 Klinisk neurovetenskap, K8 CPF Lundberg, 171 77 Stockholm

About me

  • My research is primarily focused on developing biomarkers and new treatments for neurodegenerative diseases by applying neuroimaging techniques, such as MRI and PET. Me, my group and my collaborators are currently running the ERAP phase IIa trial (clinicaltrial.gov ID: NCT06022068), where we evaluate the effect of the drug sirolimus/rapamycin on human neurodegeneration and aging.

     

  • My work also involves creating and assessing biomarkers of aging that can be used as endpoints in clinical trials of geroprotective compounds. To this end, my group applies machine learning models to large batches of multi-modal imaging data to estimate the biological age of different organ-systems in the human body. 

Articles

All other publications

Selected grants

  • The search for an aging biomarker: in vivo quantification of age-related proteins using Positron Emission Tomography in humans
    Impetus Longevity Grant

Grants

  • Swedish Research Council - International post-doc grant
    Swedish Research Council
  • Lundbeck Foundation post-doc grant
    Lundbeck Foundation
  • Fonden för psykisk hälsa research grant
    Fonden för psykisk hälsa
  • Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography
    Demensförbundet - Demensfonden
  • Evaluating rapamycin treatment in Alzheimer’s disease using positron emission tomography
    Åhlénstiftelsen Medical Research grant
  • Swedish Society for Medical Research - postdoc stipend
    Swedish Society for Medical Research
  • Evaluating the effects of rapamycin treatment in Alzheimer’s disease using positron emission tomography: a pilot study
    Loo and Hans Osterman Foundation for Medical Research

Employments

  • Postdoctoral Researcher, Department of Clinical Neuroscience, Karolinska Institutet, 2022-2025
  • Postdoc, Neurobiology Research Unit, Copenhagen University Hospital, 2019-2025

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Clinical Neuroscience, Karolinska Institutet, 2019
  • Degree Of Master Of Science In Psychology, Karolinska Institutet, 2013

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