Peter Zaphiropoulos

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i molekylärbiologi sedan 2009.

Utbildning
- Master of Science, The University of Michigan, Ann Arbor, MI, USA, 1983
- Ph.D., The University of Michigan, Ann Arbor, MI, USA, 1985

Artiklar

Article: CANCERS. 2022;14(13):3134

Circular and Fusion RNAs in Medulloblastoma Development

Azatyan A; Zaphiropoulos PG
Article: CANCERS. 2021;13(20):5138

Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors

Azatyan A; Zhang S; Darabi A; Siesjoe P; Wang T; Zaphiropoulos PG
Article: CANCER LETTERS. 2019;442:341-350

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism

Azatyan A; Gallo-Oller G; Diao Y; Selivanova G; Johnsen JI; Zaphiropoulos PG
Article: MOLECULAR ONCOLOGY. 2018;12(10):1718-1734

Identification of novel GLI1 target genes and regulatory circuits in human cancer cells

Diao Y; Rahman MF-U; Vyatkin Y; Azatyan A; St Laurent G; Kapranov P; Zaphiropoulos PG
Article: ONCOTARGET. 2016;7(44):71580-71593

Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells

Diao Y; Azatyan A; Rahman MF-U; Zhao C; Zhu J; Dahlman-Wright K; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(3):308

Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling

Villegas VE; Rondon-Lagos M; Annaratone L; Castellano I; Grismaldo A; Sapino A; Zaphiropoulos PG
Article: DISCOVERIES (CRAIOVA). 2015;3(3):e50

An updated h-index measures both the primary and total scientific output of a researcher.

Bucur O; Almasan A; Zubarev R; Friedman M; Nicolson GL; Sumazin P; Leabu M; Nikolajczyk BS; Avram D; Kunej T; Calin GA; Godwin AK; Adami H-O; Zaphiropoulos PG; Richardson DR; Schmitt-Ulms G; Westerblad H; Keniry M; Grau GER; Carbonetto S; Stan RV; Popa-Wagner A; Takhar K; Baron BW; Galardy PJ; Yang F; Data D; Fadare O; Yeo KJ; Gabreanu GR; Andrei S; Soare GR; Nelson MA; Liehn EA
Article: BMC CANCER. 2014;14:600

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling

Diao Y; Rahman MF-U; Villegas VE; Wickstrom M; Johnsen JI; Zaphiropoulos PG
Article: MOLECULAR ONCOLOGY. 2014;8(5):912-926

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1

Villegas VE; Rahman MF-U; Fernandez-Barrena MG; Diao Y; Liapi E; Sonkoly E; Stahle M; Pivarcsi A; Annaratone L; Sapino A; Ramirez Clavijo S; Burglin TR; Shimokawa T; Ramachandran S; Kapranov P; Fernandez-Zapico ME; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

Wickstrom M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevag OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
Article: RNA BIOLOGY. 2013;10(2):321-333

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling

Shimokawa T; Rahman MF-U; Tostar U; Sonkoly E; Stahle M; Pivarcsi A; Palaniswamy R; Zaphiropoulos PG
Article: ONCOGENESIS. 2012;1(3):e3

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma

Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: FRONTIERS IN GENETICS. 2012;3:119

Genetic variations and alternative splicing: the Glioma associated oncogene 1, GLI1.

Zaphiropoulos PG
Article: PLOS ONE. 2012;7(5):e37761

Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant

Tostar U; Finta C; Rahman MF-U; Shimokawa T; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF DERMATOLOGY. 2011;50(7):838-843

PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas

Santos DCC; Zaphiropoulos PG; Neto CF; Pimentel ERA; Sanches JAJ; Ruiz IRG
Article: FRONTIERS IN GENETICS. 2011;2:92

Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?

Zaphiropoulos PG
Article: GENES AND CANCER. 2010;1(9):941-951

Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

Tostar U; Toftgård R; Zaphiropoulos PG; Shimokawa T
Article: BMC MOLECULAR BIOLOGY. 2010;11:32

Genetic variations regulate alternative splicing in the 5′ untranslated regions of the mouse glioma-associated oncogene 1, Gli1

Palaniswamy R; Teglund S; Lauth M; Zaphiropoulos PG; Shimokawa T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14345-14354

Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal

Shimokawa T; Tostar U; Lauth M; Palaniswamy R; Kasper M; Toftgard R; Zaphiropoulos PG
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2008;198(2):231.e1-231.e7

Lack of aneuploidy for chromosomes 15, 16, and 18 in placentas from small-for-gestational-age liveborn infants

Papadogiannakis N; Iwarsson E; Taimi T; Zaphiropoulos PG; Westgren M
Article: ONCOGENE. 2007;26(34):4889-4896

Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling

Shimokawa T; Svard J; Heby-Henricson K; Teglund S; Toftgard R; Zaphiropoulos PG
Article: BIOCHEMICAL JOURNAL. 2006;394(Pt 1):19-26

Inhibition of GLI1 gene activation by patched1

Rahnama F; Shimokawa T; Lauth M; Finta C; Kogerman P; Teglund S; Toftgård R; Zaphiropoulos PG
Article: FEBS LETTERS. 2004;578(1-2):157-162

A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions

Shimokawa T; Rahnama F; Zaphiropoulos PG
Article: BMC GENOMICS. 2004;5(1):49

The FU gene and its possible protein isoforms -: art. no. 49

Osterlund T; Everman DB; Betz RC; Mosca M; Nöthen MM; Schwartz CE; Zaphiropoulos PG; Toftgård R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):325-334

Distinct roles of PTCH2 splice variants in Hedgehog signalling

Rahnama F; Toftgård R; Zaphiropoulos PG
Article: MITOCHONDRIAL DNA. 2003;14(3):155-162

A map of the mouse Cyp3a locus

Zaphiropoulos PG
Article: ONCOGENE. 2002;21(39):6007-6016

Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein

Kogerman P; Krause D; Rahnama F; Kogerman L; Undén AB; Zaphiropoulos PG; Toftgård R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(8):5882-5890

Intergenic mRNA molecules resulting from trans-splicing

Finta C; Zaphiropoulos PG
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2001;18(10):1841-1848

Intergenic transcripts containing a novel human cytochrome P4502C exon 1 spliced to sequences from the CYP2C9 gene

Warner SC; Finta C; Zaphiropoulos PG
Article: MOLECULAR PHARMACOLOGY. 2001;59(2):386-392

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450

Domanski TL; Finta C; Halpert JR; Zaphiropoulos PG
Article: GENE. 2000;260(1-2):13-23

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons

Finta C; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2000;16(5):943-949

Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors

Jögi A; Abel F; Sjöberg RM; Toftgård R; Zaphiropoulos PG; Påhlman S; Martinsson T; Axelson H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3438-3443

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

Nilsson M; Undèn AB; Krause D; Malmqwist U; Raza K; Zaphiropoulos PG; Toftgård R
Article: GENOMICS. 2000;63(3):433-438

The human CYP2C locus:: A prototype for intergenic and exon repetition splicing events

Finta C; Zaphiropoulos PG
Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;104(6):751-760

The kidney cytochrome P-4502C23 arachidonic acid epoxygenase is upregulated during dietary salt loading

Holla VR; Makita K; Zaphiropoulos PG; Capdevila JH
Article: NATURE CELL BIOLOGY. 1999;1(5):312-319

Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1

Kogerman P; Grimm T; Kogerman L; Krause D; Undén AB; Sandstedt B; Toftgård R; Zaphiropoulos PG
Article: NUCLEIC ACIDS RESEARCH. 1999;27(13):2585-2590

RNA molecules containing exons originating from different members of the cytochrome P4502C gene subfamily (CYP2C) in human epidermis and liver

Zaphiropoulos PG
Article: CANCER RESEARCH. 1999;59(4):787-792

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas

Zaphiropoulos PG; Undén AB; Rahnama F; Hollingsworth RE; Toftgård R
Article: NUCLEIC ACIDS RESEARCH. 1998;26(12):2843-2848

Non-homologous recombination mediated by Thermus aquaticus DNA polymerase I.: Evidence supporting a copy choice mechanism

Zaphiropoulos PG
Article: MOLECULAR CARCINOGENESIS. 1998;21(2):87-92

Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin

Eklund LK; Lindström E; Undén AB; Lundh-Rozell B; Ståhle-Bäckdahl M; Zaphiropoulos PG; Toftgård R; Söderkvist P
Article: CANCER RESEARCH. 1997;57(12):2336-2340

Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma

Unden AB; Zaphiropoulos PG; Bruce K; Toftgard R; StahleBackdahl M
Article: MOLECULAR AND CELLULAR BIOLOGY. 1997;17(6):2985-2993

Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis

Zaphiropoulos PG
Article: DNA AND CELL BIOLOGY. 1996;15(12):1049-1056

cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region

Zaphiropoulos PG; Toftgard R
Article: CANCER RESEARCH. 1996;56(20):4562-4565

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PTCH inactivation

Unden AB; Holmberg E; LundhRozell B; StahleBackdahl M; Zaphiropoulos PG; Toftgard R; Vorechovsky I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(13):6536-6541

Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping

Zaphiropoulos PG
Article: CELL. 1996;85(6):841-851

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

Hahn H; Wicking C; Zaphiropoulos PG; Gailani MR; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden AB; Gillies S; Negus K; Smyth I; Pressman C; Leffell DJ; Gerrard B; Goldstein AM; Dean M; Toftgard R; ChenevixTrench G; Wainwright B; Bale AE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(21):12125-12128

A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities

Hahn H; Christiansen J; Wicking C; Zaphiropoulos PG; Chidambaram A; Gerrard B; Vorechovsky I; Bale AE; Toftgard R; Dean M; Wainwright B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1995;212(2):433-441

CYTOCHROME-P450 GENES EXPRESSED IN PORCINE OVARIES - IDENTIFICATION OF NOVEL FORMS, EVIDENCE FOR GENE CONVERSION, AND EVOLUTIONARY RELATIONSHIPS

ZAPHIROPOULOS PG; SKANTZ A; ELIASSON M; AHLBERG MB
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Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(8):E1357-1357

Tamoxifen Resistance: Emerging Molecular Targets

Rondon-Lagos M; Villegas VE; Rangel N; Carolina Sanchez M; Zaphiropoulos PG
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(2):3251-3266

Neighboring Gene Regulation by Antisense Long Non-Coding RNAs

Villegas VE; Zaphiropoulos PG
Review: HUMAN MUTATION. 2006;27(3):215-219

PTCH mutations:: Distribution and analyses

Lindström E; Shimokawa T; Toftgård R; Zaphiropoulos PG
Letter: FEBS LETTERS. 2002;527(1-3):326

Template switching generated during reverse transcription?

Zaphiropoulos PG
Review: HISTOLOGY AND HISTOPATHOLOGY. 2002;17(2):677-682

Intergenic mRNAs. Minor gene products or tools of diversity?

Finta C; Warner SC; Zaphiropoulos PG
Letter: JOURNAL OF MOLECULAR EVOLUTION. 2001;53(2):160-162

A statistical view of genome transcription?

Finta C; Zaphiropoulos PG
Review: HISTOLOGY AND HISTOPATHOLOGY. 1998;13(2):585-589

Mechanisms of pre-mRNA splicing: Classical versus non-classical pathways

Zaphiropoulos PG
Letter: NATURE GENETICS. 1996;14(1):78-81

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

Gailani MR; StahleBackdahl M; Leffell DJ; Glynn M; Zaphiropoulos PG; Pressman C; Unden AB; Dean M; Brash DE; Bale AE; Toftgard R

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