Peter Zaphiropoulos

About me
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About me

Professor of Molecular Biology since 2009.

Utbildning
Master of Science, The University of Michigan, Ann Arbor, MI, USA, 1983
Ph.D., The University of Michigan, Ann Arbor, MI, USA, 1985

Articles

Article: CANCERS. 2022;14(13):3134
Circular and Fusion RNAs in Medulloblastoma Development
Azatyan A; Zaphiropoulos PG
Article: CANCERS. 2021;13(20):5138
Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors
Azatyan A; Zhang S; Darabi A; Siesjoe P; Wang T; Zaphiropoulos PG
Article: CANCER LETTERS. 2019;442:341-350
RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism
Azatyan A; Gallo-Oller G; Diao Y; Selivanova G; Johnsen JI; Zaphiropoulos PG
Article: MOLECULAR ONCOLOGY. 2018;12(10):1718-1734
Identification of novel GLI1 target genes and regulatory circuits in human cancer cells
Diao Y; Rahman MF-U; Vyatkin Y; Azatyan A; St Laurent G; Kapranov P; Zaphiropoulos PG
Article: ONCOTARGET. 2016;7(44):71580-71593
Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells
Diao Y; Azatyan A; Rahman MF-U; Zhao C; Zhu J; Dahlman-Wright K; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(3):308
Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling
Villegas VE; Rondon-Lagos M; Annaratone L; Castellano I; Grismaldo A; Sapino A; Zaphiropoulos PG
Article: DISCOVERIES (CRAIOVA). 2015;3(3):e50
An updated h-index measures both the primary and total scientific output of a researcher.
Bucur O; Almasan A; Zubarev R; Friedman M; Nicolson GL; Sumazin P; Leabu M; Nikolajczyk BS; Avram D; Kunej T; Calin GA; Godwin AK; Adami H-O; Zaphiropoulos PG; Richardson DR; Schmitt-Ulms G; Westerblad H; Keniry M; Grau GER; Carbonetto S; Stan RV; Popa-Wagner A; Takhar K; Baron BW; Galardy PJ; Yang F; Data D; Fadare O; Yeo KJ; Gabreanu GR; Andrei S; Soare GR; Nelson MA; Liehn EA
Article: BMC CANCER. 2014;14:600
The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
Diao Y; Rahman MF-U; Villegas VE; Wickstrom M; Johnsen JI; Zaphiropoulos PG
Article: MOLECULAR ONCOLOGY. 2014;8(5):912-926
Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1
Villegas VE; Rahman MF-U; Fernandez-Barrena MG; Diao Y; Liapi E; Sonkoly E; Stahle M; Pivarcsi A; Annaratone L; Sapino A; Ramirez Clavijo S; Burglin TR; Shimokawa T; Ramachandran S; Kapranov P; Fernandez-Zapico ME; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
Wickstrom M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevag OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
Article: RNA BIOLOGY. 2013;10(2):321-333
RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
Shimokawa T; Rahman MF-U; Tostar U; Sonkoly E; Stahle M; Pivarcsi A; Palaniswamy R; Zaphiropoulos PG
Article: ONCOGENESIS. 2012;1(3):e3
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: FRONTIERS IN GENETICS. 2012;3:119
Genetic variations and alternative splicing: the Glioma associated oncogene 1, GLI1.
Zaphiropoulos PG
Article: PLOS ONE. 2012;7(5):e37761
Novel Mechanism of Action on Hedgehog Signaling by a Suppressor of Fused Carboxy Terminal Variant
Tostar U; Finta C; Rahman MF-U; Shimokawa T; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF DERMATOLOGY. 2011;50(7):838-843
PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas
Santos DCC; Zaphiropoulos PG; Neto CF; Pimentel ERA; Sanches JAJ; Ruiz IRG
Article: FRONTIERS IN GENETICS. 2011;2:92
Trans-splicing in Higher Eukaryotes: Implications for Cancer Development?
Zaphiropoulos PG
Article: GENES AND CANCER. 2010;1(9):941-951
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.
Tostar U; Toftgård R; Zaphiropoulos PG; Shimokawa T
Article: BMC MOLECULAR BIOLOGY. 2010;11:32
Genetic variations regulate alternative splicing in the 5′ untranslated regions of the mouse glioma-associated oncogene 1, Gli1
Palaniswamy R; Teglund S; Lauth M; Zaphiropoulos PG; Shimokawa T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14345-14354
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal
Shimokawa T; Tostar U; Lauth M; Palaniswamy R; Kasper M; Toftgard R; Zaphiropoulos PG
Article: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. 2008;198(2):231.e1-231.e7
Lack of aneuploidy for chromosomes 15, 16, and 18 in placentas from small-for-gestational-age liveborn infants
Papadogiannakis N; Iwarsson E; Taimi T; Zaphiropoulos PG; Westgren M
Article: ONCOGENE. 2007;26(34):4889-4896
Distinct roles of first exon variants of the tumor-suppressor Patched1 in Hedgehog signaling
Shimokawa T; Svard J; Heby-Henricson K; Teglund S; Toftgard R; Zaphiropoulos PG
Article: BIOCHEMICAL JOURNAL. 2006;394(Pt 1):19-26
Inhibition of GLI1 gene activation by patched1
Rahnama F; Shimokawa T; Lauth M; Finta C; Kogerman P; Teglund S; Toftgård R; Zaphiropoulos PG
Article: FEBS LETTERS. 2004;578(1-2):157-162
A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions
Shimokawa T; Rahnama F; Zaphiropoulos PG
Article: BMC GENOMICS. 2004;5(1):49
The FU gene and its possible protein isoforms -: art. no. 49
Osterlund T; Everman DB; Betz RC; Mosca M; Nöthen MM; Schwartz CE; Zaphiropoulos PG; Toftgård R
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 2):325-334
Distinct roles of PTCH2 splice variants in Hedgehog signalling
Rahnama F; Toftgård R; Zaphiropoulos PG
Article: MITOCHONDRIAL DNA. 2003;14(3):155-162
A map of the mouse Cyp3a locus
Zaphiropoulos PG
Article: ONCOGENE. 2002;21(39):6007-6016
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
Kogerman P; Krause D; Rahnama F; Kogerman L; Undén AB; Zaphiropoulos PG; Toftgård R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(8):5882-5890
Intergenic mRNA molecules resulting from trans-splicing
Finta C; Zaphiropoulos PG
Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2001;18(10):1841-1848
Intergenic transcripts containing a novel human cytochrome P4502C exon 1 spliced to sequences from the CYP2C9 gene
Warner SC; Finta C; Zaphiropoulos PG
Article: MOLECULAR PHARMACOLOGY. 2001;59(2):386-392
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome p450
Domanski TL; Finta C; Halpert JR; Zaphiropoulos PG
Article: GENE. 2000;260(1-2):13-23
The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons
Finta C; Zaphiropoulos PG
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2000;16(5):943-949
Patched 2, located in 1p32-34, is not mutated in high stage neuroblastoma tumors
Jögi A; Abel F; Sjöberg RM; Toftgård R; Zaphiropoulos PG; Påhlman S; Martinsson T; Axelson H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(7):3438-3443
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
Nilsson M; Undèn AB; Krause D; Malmqwist U; Raza K; Zaphiropoulos PG; Toftgård R
Article: GENOMICS. 2000;63(3):433-438
The human CYP2C locus:: A prototype for intergenic and exon repetition splicing events
Finta C; Zaphiropoulos PG
Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;104(6):751-760
The kidney cytochrome P-4502C23 arachidonic acid epoxygenase is upregulated during dietary salt loading
Holla VR; Makita K; Zaphiropoulos PG; Capdevila JH
Article: NATURE CELL BIOLOGY. 1999;1(5):312-319
Mammalian Suppressor-of-Fused modulates nuclear-cytoplasmic shuttling of GLI-1
Kogerman P; Grimm T; Kogerman L; Krause D; Undén AB; Sandstedt B; Toftgård R; Zaphiropoulos PG
Article: NUCLEIC ACIDS RESEARCH (NAR). 1999;27(13):2585-2590
RNA molecules containing exons originating from different members of the cytochrome P4502C gene subfamily (CYP2C) in human epidermis and liver
Zaphiropoulos PG
Article: CANCER RESEARCH. 1999;59(4):787-792
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
Zaphiropoulos PG; Undén AB; Rahnama F; Hollingsworth RE; Toftgård R
Article: NUCLEIC ACIDS RESEARCH (NAR). 1998;26(12):2843-2848
Non-homologous recombination mediated by Thermus aquaticus DNA polymerase I.: Evidence supporting a copy choice mechanism
Zaphiropoulos PG
Article: MOLECULAR CARCINOGENESIS. 1998;21(2):87-92
Mutation analysis of the human homologue of Drosophila patched and the xeroderma pigmentosum complementation group A genes in squamous cell carcinomas of the skin
Eklund LK; Lindström E; Undén AB; Lundh-Rozell B; Ståhle-Bäckdahl M; Zaphiropoulos PG; Toftgård R; Söderkvist P
Article: CANCER RESEARCH. 1997;57(12):2336-2340
Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma
Unden AB; Zaphiropoulos PG; Bruce K; Toftgard R; StahleBackdahl M
Article: MOLECULAR AND CELLULAR BIOLOGY. 1997;17(6):2985-2993
Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis
Zaphiropoulos PG
Article: DNA AND CELL BIOLOGY. 1996;15(12):1049-1056
cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region
Zaphiropoulos PG; Toftgard R
Article: CANCER RESEARCH. 1996;56(20):4562-4565
Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: Different in vivo mechanisms of PTCH inactivation
Unden AB; Holmberg E; LundhRozell B; StahleBackdahl M; Zaphiropoulos PG; Toftgard R; Vorechovsky I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(13):6536-6541
Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: Correlation with exon skipping
Zaphiropoulos PG
Article: CELL. 1996;85(6):841-851
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome
Hahn H; Wicking C; Zaphiropoulos PG; Gailani MR; Shanley S; Chidambaram A; Vorechovsky I; Holmberg E; Unden AB; Gillies S; Negus K; Smyth I; Pressman C; Leffell DJ; Gerrard B; Goldstein AM; Dean M; Toftgard R; ChenevixTrench G; Wainwright B; Bale AE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(21):12125-12128
A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities
Hahn H; Christiansen J; Wicking C; Zaphiropoulos PG; Chidambaram A; Gerrard B; Vorechovsky I; Bale AE; Toftgard R; Dean M; Wainwright B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1995;212(2):433-441
CYTOCHROME-P450 GENES EXPRESSED IN PORCINE OVARIES - IDENTIFICATION OF NOVEL FORMS, EVIDENCE FOR GENE CONVERSION, AND EVOLUTIONARY RELATIONSHIPS
ZAPHIROPOULOS PG; SKANTZ A; ELIASSON M; AHLBERG MB
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All other publications

Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(8):E1357-1357
Tamoxifen Resistance: Emerging Molecular Targets
Rondon-Lagos M; Villegas VE; Rangel N; Carolina Sanchez M; Zaphiropoulos PG
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2015;16(2):3251-3266
Neighboring Gene Regulation by Antisense Long Non-Coding RNAs
Villegas VE; Zaphiropoulos PG
Review: HUMAN MUTATION. 2006;27(3):215-219
PTCH mutations:: Distribution and analyses
Lindström E; Shimokawa T; Toftgård R; Zaphiropoulos PG
Letter: FEBS LETTERS. 2002;527(1-3):326
Template switching generated during reverse transcription?
Zaphiropoulos PG
Review: HISTOLOGY AND HISTOPATHOLOGY. 2002;17(2):677-682
Intergenic mRNAs. Minor gene products or tools of diversity?
Finta C; Warner SC; Zaphiropoulos PG
Letter: JOURNAL OF MOLECULAR EVOLUTION. 2001;53(2):160-162
A statistical view of genome transcription?
Finta C; Zaphiropoulos PG
Review: HISTOLOGY AND HISTOPATHOLOGY. 1998;13(2):585-589
Mechanisms of pre-mRNA splicing: Classical versus non-classical pathways
Zaphiropoulos PG
Letter: NATURE GENETICS. 1996;14(1):78-81
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
Gailani MR; StahleBackdahl M; Leffell DJ; Glynn M; Zaphiropoulos PG; Pressman C; Unden AB; Dean M; Brash DE; Bale AE; Toftgard R

Employments

Professor Emeritus/Emerita, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024

Degrees and Education

Docent, Karolinska Institutet, 1992

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