Pernilla Videhult Pierre
Adjunkt
E-postadress: pernilla.videhult-pierre@ki.se
Telefon: +46852483867
Besöksadress: Enheten för audiologi, Alfred Nobels Allé 10, plan 5, 14152 Huddinge
Postadress: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Audiologi, 141 52 Huddinge
Om mig
- Medicine doktor, apotekare, adjunkt och forskare
*Samarbeten utanför Enheten för audiologi*
Filip Asp, med dr, civilingenjör, Karolinska universitetssjukhuset,
Stockholm
Cecilia Engmér Berglin, medicine doktor, specialistläkare i
öron-näsa-hals, Karolinska universitetssjukhuset, Stockholm.
Anders Fridberger, professor i neurovetenskap, Institutionen för klinisk och
experimentell medicin, Cellbiologi, Linköpings universitet, Linköping.
Christina Forshell Hederstierna, medicine doktor, överläkare i audiologi,
Karolinska universitetssjukhuset, Stockholm.
Mikael Hedeland, professor i analytisk farmaceutisk kemi, Uppsala
universitet, Uppsala .
Göran Laurell, professor i öron-näs-halssjukdomar, Uppsala universitet,
överläkare, Akademiska sjukhuset, Uppsala.
Curt Pettersson, professor emeritus i analytisk farmaceutisk kemi, Uppsala
universitet, Uppsala.
Ulf Rosenhall, professor emeritus i klinisk audiologi, överläkare,
Karolinska universitetssjukhuset, Stockholm.
Henrik Smeds, med dr, överläkare i öron-näsa-hals, Karolinska
universitetssjukhuset.
*Publikationer*
/*Vetenskapliga originalartiklar*/
1. *Videhult Pierre P*, Fransson A, Kisiel A. M., Laurell G. Hydrogen Gas
Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo
Study. Accepterad av Ann Otol Rhinol Laryngol 2022.
2. Fransson A, *Videhult Pierre P*, Risling M, Laurell G. Inhalation of
molecular hydrogen, a rescue treatment for noise-induced hearing loss. Front
Cell Neurosci 2021. DOI: 10.3389/fncel.2021.658662
3. *Videhult Pierre P*, Rasmussen JE, Nikkhou Aski S, Damberg P, Laurell G.
High-dose furosemide enhances the magnetic resonance signal of systemic
gadolinium in the mammalian cochlea. Otol Neurotol 2020.
https://doi.org/10.1097/MAO.0000000000002571
4. *Videhult Pierre P*, Eklöf M, Smeds H, Asp F. Cochlear implantation with
the CI512 and CI532 pre-curved electrode arrays: one year speech recognition
and intraoperative thresholds of electrically evoked compound action
potentials. Audiol Neurotol 2019 - 24: 299-308. DOI: 10.1159/000504592
5. Pirttilä K, *Videhult Pierre P*, Haglöf J, Engskog M, Hedeland M,
Laurell G, Arvidsson T, Pettersson C. An LCMS-based untargeted metabolomics
protocol for cochlear perilymph: highlighting metabolic effects of hydrogen
gas on the inner ear of noise exposed Guinea pigs.
Metabolomics 2019 - 15(10):138. DOI: 10.1007/s11306-019-1595-1
6. *Videhult Pierre P*, Fransson A, Kisiel MA, Damberg P, Nikkhou Aski S,
Andersson M, et al. Middle Ear Administration of a Particulate Chitosan Gel
in an in vivo Model of Cisplatin Ototoxicity. Front Cell
Neurosci 2019 - 13:268. DOI: 10.3389/fncel.2019.00268
7. Fransson AE, Kisiel M, Pirttilä K, Pettersson C, *Videhult Pierre P*,
Laurell GFE. Hydrogen inhalation protects against ototoxicity induced by
intravenous cisplatin in the guinea pig. Front Cell Neurosci 2017 Sep
13 - 11:280. DOI: 10.3389/fncel.2017.00280.
8. *Videhult Pierre P*, Haglöf J, Linder B, Engskog MKR, Arvidsson T,
Pettersson C, Fransson A, Laurell G. Cisplatin-induced metabolome changes in
serum: an experimental approach to identify markers for ototoxicity. Acta
Otolaryngol 2017 Oct - 137(10):1024-1030. DOI: 10.1080/00016489.2017.1325006.
9. Engmér Berglin C, *Videhult Pierre P*, Ekborn A, Bramer T, Edsman K,
Hultcrantz M, Laurell G. Local treatment of the inner ear: a study of three
different polymers aimed for middle ear administration. Acta
Otolaryngol 2015 - 135(10):985-94. DOI: 10.3109/00016489.2015.1058534.
10. *Videhult Pierre P*, Johnson AC, Fridberger A. Subjective and clinically
assessed hearing loss - a cross-sectional register-based study on a Swedish
population aged 18 through 50 years. PLoS One 2015 Apr 13 - 10(4):e0123290.
DOI: 10.1371/journal.pone.0123290.
11. *Pierre PV*, Fridberger A, Wikman A, Alexanderson K. Self-reported
hearing difficulties, main income sources, and socio-economic status - a
cross-sectional population-based study in Sweden. BMC Public Health 2012 Oct
15 - 12:874. DOI: 10.1186/1471-2458-12-874.
12. Berglin CE, *Pierre PV*, Bramer T, Edsman K, Ehrsson H, Eksborg S,
Laurell G. Prevention of cisplatin-induced hearing loss by administration of
a thiosulfate-containing gel to the middle ear in a guinea pig model. Cancer
Chemother Pharmacol 2011 Dec - 68(6):1547-56. DOI: 10.1007/s00280-011-1656-2.
13. *Pierre PV*, Wallin I, Eksborg S, Ehrsson H. Quantitative liquid
chromatographic determination of intact cisplatin in blood with
microwave-assisted post-column derivatization and UV detection. J Pharm
Biomed Anal 2011 Aug 25 - 56(1):126-30. DOI: 10.1016/j.jpba.2011.04.028.
14. *Pierre PV*, Engmér C, Wallin I, Laurell G, Ehrsson H. High
concentrations of thiosulfate in scala tympani perilymph after systemic
administration in the guinea pig. Acta Otolaryngol 2009 Feb - 129(2):132-7.
DOI: 10.1080/00016480802116232.
15. *Videhult P*, Laurell G, Wallin I, Ehrsson H. Kinetics of Cisplatin and
its monohydrated complex with sulfur-containing compounds designed for local
otoprotective administration. Exp Biol Med (Maywood) 2006
Nov - 231(10):1638-45. DOI: 10.1177/153537020623101009
16. *Videhult P*, Yachnin J, Jerremalm E, Lewensohn R, Ehrsson H. Synthesis
and cytotoxicity of the dihydrated complex of oxaliplatin. Cancer Lett 2002
Jun 28 - 180(2):191-4. DOI: 10.1016/s0304- 3835(02)00002-2
17. Jerremalm E, *Videhult P*, Alvelius G, Griffiths WJ, Bergman T, Eksborg
S, Ehrsson H. Alkaline hydrolysis of oxaliplatin--isolation and
identification of the oxalato monodentate intermediate. J Pharm Sci 2002
Oct - 91(10):2116-21. DOI: 10.1002/jps.10201
*/Vetenskapliga översiktsartiklar/*
Cortés Fuentes IA, *Videhult Pierre P*, Engmér Berglin C. Improving
clinical outcomes in cochlear implantation using glucocorticoid therapy: a
review. Ear Hear 2019, Apr 30. doi: 10.1097/AUD.0000000000000740.
/*Bokkapitel*/
Laurell G, *Videhult Pierre P*. Hearing loss after cisplatin: oxidative
stress pathways and potential for protection. I: Armstrong D, redaktör. Free
Radicals in ENT Pathology. New York: Springer - 2015. s. 217-241.
/*Avhandling*/
*Videhult Pierre P*. Doktorsavhandling: Cisplatin, a platinum-containing
antineoplastic drug: perspectives on analytical chemistry and prevention of
ototoxicity. Karolinska Institutet 2010, Stockholm.
Artiklar
- Article: ANNALS OF OTOLOGY, RHINOLOGY AND LARYNGOLOGY. 2023;132(8):865-872
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2021;15:658662
- Article: OTOLOGY AND NEUROTOLOGY. 2020;41(4):545-553
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13:268
- Article: AUDIOLOGY AND NEUROTOLOGY. 2019;24(6):299-308
- Article: ACTA OTO-LARYNGOLOGICA. 2017;137(10):1024-1030
- Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2017;11:280
- Article: ACTA OTO-LARYNGOLOGICA. 2015;135(10):985-994
- Article: PLOS ONE. 2015;10(4):e0123290
- Article: BMC PUBLIC HEALTH. 2012;12:874
- Article: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2011;68(6):1547-1556
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2011;56(1):126-130
- Article: ACTA OTO-LARYNGOLOGICA. 2009;129(2):132-137
- Article: EXPERIMENTAL BIOLOGY AND MEDICINE. 2006;231(10):1638-1645
- Article: JOURNAL OF PHARMACEUTICAL SCIENCES. 2002;91(10):2116-2121
- Article: CANCER LETTERS. 2002;180(2):191-194
Alla övriga publikationer
- Review: EAR AND HEARING. 2020;41(1):17-24
Anställningar
- Adjunkt, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2019-
Examina och utbildning
- Medicine Doktorsexamen, Institutionen för onkologi-patologi, Karolinska Institutet, 2010