Pernilla Stridh

Pernilla Stridh

Forskare
E-postadress: pernilla.strid@ki.se
Besöksadress: L8:05, CMM Karolinska Universitetssjukhuset Solna, 17176 Solna
Postadress: K8 Klinisk neurovetenskap, K8 Neuro Kockum Stridh, 171 77 Stockholm
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Om mig

  • I work with complex genetics of inflammatory diseases as an Assistant
    Professor in the Genetic Epidemiology of Multiple Sclerosis group at Center
    for Molecular Medicine (CMM), which belongs to the Department of Clinical
    Neuroscience at Karolinska Institutet
    (https://ki.se/en/cns/ingrid-kockums-research-group). I focus on the role of
    genetic variants underlying a complex inflammatory disease, Multiple
    Sclerosis (MS), and specifically on developing and applying genome‐wide and
    sequence-level approaches to identify and characterize genetic variants that
    modify progression and severity of disease.
    For publications
    see: https://scholar.google.se/citations?hl=en&;user=tlg0XloAAAAJ

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • DFG
    1 January 2025 - 31 December 2028
    We hypothesise that the ability of neurons to survive and function under the inflammatory conditions is, to a considerable degree, under genetic control. Notably, identifying such genes will not only give insights into the molecular causes of neurodegeneration but also provide potential therapeutic targets to halt disease progression. Specifically, we aim to: • Identify candidate genes for MS severity for mechanistic studies (WP A) • Establish the role of the hallmark genes of inflamed neurons in MS development (WP B) • Evaluate the relative contribution of immune vs. CNS reactions to MS progression (WP C) We aim to characterize molecular targets that predispose for disease outcomes in persons with MS. For that purpose, we have built the most powerful cohorts and datasets for genetic and mediation analysis. Joining forces with NeuroFlame will provide highly relevant functional context for the mechanistic characterization of risk genes. We will utilize NeuroFlame’s epigenetic, transcriptomic and pathology data to fine-map risk loci. The NeuroFlame expertise will facilitate the prioritization of candidate genes and their functional characterization. In turn, we will investigate if the genes in hallmark pathways of inflamed neurons associate with MS outcomes, thus providing a strong link with their causal involvement in disease.

Anställningar

  • Forskare, Klinisk neurovetenskap, Karolinska Institutet, 2019-

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för klinisk neurovetenskap, Karolinska Institutet, 2010

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