Per Uhlén

EDUCATION
University Studies
Master of Science in Engineering Physics, Royal Institute of Technology (KTH),
Stockholm, Sweden (1993–1998)
Doctoral (PhD) Studies
Karolinska Institutet, Department of Women’s and Children’s Health (KBH),
Stockholm, Sweden (1998–2002)
Postdoctoral Studies
Yale University School of Medicine, Dept of Pharmacology
New Haven, CT, USA (2003–2005)
Marine Biological Laboratory (MBL), Dept of Neuroscience
Woods Hole, MA, USA (2004)
Assistant Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2005–2008)
Docent
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2008–)

POSITIONS
Assistant Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2005–2008)
Associate Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2008–)
Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2014–)
Adjunct Researcher
RIKEN Brain Science Institute, Hirosawa, Wako, Saitama, Japan (2017–2018)
Guest Professor
Keio University School of Medicine, Shinanomachi, Tokyo, Japan (2017–2020)

My research group explores various cell signaling phenomena and their impact on critical biological and medical processes at both cellular and organ levels, with a primary focus on neuroscience and cancer. We develop innovative tissue preparation methods and utilize state-of-the-art imaging techniques, including 3D light-sheet microscopy and spatial transcriptomics, alongside advanced analytical tools such as Fourier transform and deep learning. Additionally, we employ modern cell and genetic technologies, including iPS cells, organoids, transgenic animals, single-cell RNA sequencing, and CRISPR-Cas, to study and manipulate a variety of biological and medical processes. Our primary interest lies in elucidating the mechanisms of intracellular signaling and their roles in development and disease. A key objective of our work is to uncover how cells regulate and interpret the frequency and amplitude of intracellular calcium oscillations to coordinate essential biological functions.