Per Uhlén
About me
EDUCATION
University Studies
Master of Science in Engineering Physics, Royal Institute of Technology (KTH),
Stockholm, Sweden (1993–1998)
Doctoral (PhD) Studies
Karolinska Institutet, Department of Women’s and Children’s Health (KBH)
Stockholm, Sweden (1998–2002)
Postdoctoral Studies
Yale University School of Medicine, Dept of Pharmacology
New Haven, CT, USA (2003–2005)
Marine Biological Laboratory (MBL), Dept of Neuroscience
Woods Hole, MA, USA (2004)
Assistant Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2005–2008)
Docent
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2008–)POSITIONS
Assistant Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2005–2008)
Associate Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2008–)
Professor
Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),
Stockholm, Sweden (2014–)
Adjunct Researcher
RIKEN Brain Science Institute, Hirosawa, Wako, Saitama, Japan (2017–2018)
Guest Professor
Keio University School of Medicine, Shinanomachi, Tokyo, Japan (2017–2020)
Research
My research group explores various cell signaling phenomena and their impact on critical biological and medical processes at both cellular and organ levels, with a primary focus on neuroscience and cancer. We develop innovative tissue preparation methods and utilize state-of-the-art imaging techniques, including 3D light-sheet microscopy and spatial transcriptomics, alongside advanced analytical tools such as Fourier transform and deep learning. Additionally, we employ modern cell and genetic technologies, including iPS cells, organoids, transgenic animals, single-cell RNA sequencing, and CRISPR-Cas, to study and manipulate a variety of biological and medical processes. Our primary interest lies in elucidating the mechanisms of intracellular signaling and their roles in development and disease. A key objective of our work is to uncover how cells regulate and interpret the frequency and amplitude of intracellular calcium oscillations to coordinate essential biological functions.
Selected publications
- Article: SCIENCE. 2024;386(6724):907-915
- Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020
- Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231
- Preprint: BIORXIV. 2022
- Editorial comment: NATURE METHODS. 2022;19(5):527-529
- Article: NATURE COMMUNICATIONS. 2022;13(1):1537
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119
- Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888
- Editorial comment: TRENDS IN CANCER. 2018;4(5):337-341
- Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
- Article: FRONTIERS IN NEURAL CIRCUITS. 2014;8:111
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(7):2212-2217
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(7):2160-2165
- Article: NATURE. 2000;405(6787):694-697
Articles
- Article: JCI INSIGHT. 2024;9(14):e175751
- Article: WORLD JOURNAL OF UROLOGY. 2023;41(12):3405-3411
- Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674
- Article: ACS APPLIED BIO MATERIALS. 2023;6(9):3790-3797
- Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_7):vii35
- Article: ENVIRONMENTAL TOXICOLOGY. 2022;37(8):2044-2057
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(18):e2118927119
- Article: FRONTIERS IN MATERIALS. 2021;7:560372
- Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156
- Article: STEM CELLS AND DEVELOPMENT. 2020;29(17):1160-1177
- Article: STEM CELL RESEARCH AND THERAPY. 2020;11(1):320
- Article: CELL REPORTS. 2020;31(9):107699
- Article: CELL CALCIUM. 2020;88:102210
- Article: WORLD JOURNAL OF UROLOGY. 2019;37(11):2297-2302
- Article: EXPERIMENTAL CELL RESEARCH. 2019;383(1):111469
- Article: NEUROSCIENCE. 2019;402:78-89
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(6):2328-2337
- Article: MOLECULAR ONCOLOGY. 2019;13(2):202-211
- Article: JOURNAL OF NEUROSCIENCE METHODS. 2019;311:259-266
- Article: CANCER MEDICINE. 2018;7(12):6193-6204
- Article: BRITISH JOURNAL OF CANCER. 2018;118(7):995-999
- Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2018;97(3):190-203
- Article: GLIA. 2018;66(1):94-107
- Article: COMMUNICATIONS BIOLOGY. 2018;1:75
- Article: PLOS PATHOGENS. 2017;13(12):e1006739
- Article: EXPERIMENTAL CELL RESEARCH. 2017;357(2):236-242
- Article: BIOINFORMATICS. 2017;33(16):2547-2554
- Article: STEM CELLS AND DEVELOPMENT. 2017;26(12):876-887
- Article: CANCER RESEARCH. 2017;77(7):1741-1752
- Article: JCI INSIGHT. 2016;1(18):e83654
- Article: ELIFE. 2016;5:e14170
- Article: STEM CELL REPORTS. 2016;6(4):607-617
- Article: DEVELOPMENTAL CELL. 2016;36(2):164-178
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(36):E4985-E4994
- Article: DEVELOPMENTAL NEUROBIOLOGY. 2015;75(4):360-368
- Article: PLOS ONE. 2015;10(9):e0139104
- Article: PLOS ONE. 2015;10(3):e0120176
- Article: NATURE PROTOCOLS. 2014;9(9):2164-2179
- Article: NATURE COMMUNICATIONS. 2014;5:4557
- Article: THE FASEB JOURNAL. 2014;28(8):3456-3467
- Article: NATURE COMMUNICATIONS. 2014;5:3743
- Article: EMBO REPORTS. 2014;15(4):383-391
- Article: PLOS ONE. 2014;9(3):e92649
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
- Article: DEVELOPMENT. 2013;140(22):4554-4564
- Journal article: JOURNAL OF CELL SCIENCE. 2013;126(22):e1
- Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2013;6(4):e24788
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;269(1):51-60
- Article: BMC NEPHROLOGY. 2013;14:34
- Article: CIRCULATION RESEARCH. 2013;112(2):236-245
- Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
- Article: BRITISH JOURNAL OF CANCER. 2012;106(11):1807-1815
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5511-5516
- Article: BMC PHYSIOLOGY. 2012;12:3
- Article: PLOS ONE. 2012;7(2):e31258
- Article: TOXICOLOGICAL SCIENCES. 2011;124(1):192-201
- Article: NEUROCHEMICAL RESEARCH. 2011;36(7):1175-1185
- Article: EMBO JOURNAL. 2011;30(14):2762-2778
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2011;47(1):10-18
- Article: PLOS ONE. 2011;6(9):e23875
- Article: EMBO JOURNAL. 2010;29(22):3869-3878
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341
- Article: STEM CELLS AND DEVELOPMENT. 2010;19(9):1355-1364
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):28-32
- Article: JOURNAL OF ENDOCRINOLOGY. 2009;202(2):299-307
- Article: CIRCULATION RESEARCH. 2009;105(3):260-270
- Article: CELL DEATH AND DIFFERENTIATION. 2008;15(12):1857-1864
- Article: STEM CELLS. 2008;26(7):1891-1900
- Article: MATHEMATICAL BIOSCIENCES. 2006;204(2):232-249
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21954-21962
- Journal article: JOURNAL OF CELL SCIENCE. 2006;119(4):733-743
- Article: CELLULAR MICROBIOLOGY. 2005;7(6):779-788
- Journal article: JOURNAL OF NEUROSCIENCE. 2005;25(11):2853-2864
- Journal article: JOURNAL OF ENDOCRINOLOGY. 2005;184(2):371-379
- Journal article: SCIENCES STKE [ELECTRONIC RESOURCE] : SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. 2004;2004(258):pl15
- Journal article: BIOCHEMICAL JOURNAL. 2004;382(Pt 2):687-694
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(50):50355-50361
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(23):13420-13424
- Article: NATURE NEUROSCIENCE. 2000;3(3):226-230
- Show more
All other publications
- Editorial comment: NATURE NEUROSCIENCE. 2024;:2267-2268
- Preprint: BIORXIV. 2024;BIORXIV
- Preprint: BIORXIV. 2021
- Corrigendum: STEM CELL RESEARCH AND THERAPY. 2020;11(1):369
- Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2018;2(10):717-718
- Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
- Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:40-48
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(3):964-969
- Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191
- Conference publication: ANGIOGENESIS. 2013;16(1):246-247
- Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
- Review: CELL CALCIUM. 2011;49(5):350-356
- Conference publication: THE FASEB JOURNAL. 2006;20(5):A1238
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:514-518
- Thesis / dissertation: 2002
- Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2002;477(1-3):82-87
- Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2001;471(1-2):200-204
Grants
- Three-Dimensional Mapping of Molecular Mechanisms After Spinal Cord InjuryThe Swedish Brain Foundation1 July 2024 - 30 June 2027
- Spatial Single-Cell Analysis of Proteins and RNAs in the Tumor Microenvironment by 3D ImagingThe Swedish Cancer Society1 January 2023 - 31 December 2025
- Exploration of Intratumoral Heterogeneity with Multimodal 3D Imaging at Single-Cell Resolution to Improve Precision Medicine for CancerSwedish Research Council1 January 2022 - 31 December 2025
Employments
- Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2014-
Degrees and Education
- Docent, Karolinska Institutet, 2008
- Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2002