Per Uhlén

Per Uhlén

Professor | Docent
Visiting address: Solnavägen 9, 6C, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Uhlén, 171 77 Stockholm
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About me

  • EDUCATION
    University Studies
    Master of Science in Engineering Physics, Royal Institute of Technology (KTH),  


  • Stockholm, Sweden (1993–1998)
    Doctoral (PhD) Studies
    Karolinska Institutet, Department of Women’s and Children’s Health (KBH) 

  • Stockholm, Sweden (1998–2002)
    Postdoctoral Studies
    Yale University School of Medicine, Dept of Pharmacology
    New Haven, CT, USA (2003–2005)
    Marine Biological Laboratory (MBL), Dept of Neuroscience
    Woods Hole, MA, USA (2004)
    Assistant Professor
    Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),  

  • Stockholm, Sweden (2005–2008)
    Docent
    Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),  

  • Stockholm, Sweden (2008–)

     

  • POSITIONS
    Assistant Professor
    Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),  


  • Stockholm, Sweden (2005–2008)
    Associate Professor
    Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),  

  • Stockholm, Sweden (2008–)
    Professor
    Karolinska Institutet, Dept of Medical Biochemistry and Biophysics (MBB),  

  • Stockholm, Sweden (2014–)
    Adjunct Researcher
    RIKEN Brain Science Institute, Hirosawa, Wako, Saitama, Japan (2017–2018)
    Guest Professor
    Keio University School of Medicine, Shinanomachi, Tokyo, Japan (2017–2020)

Research

  • My research group explores various cell signaling phenomena and their impact on critical biological and medical processes at both cellular and organ levels, with a primary focus on neuroscience and cancer. We develop innovative tissue preparation methods and utilize state-of-the-art imaging techniques, including 3D light-sheet microscopy and spatial transcriptomics, alongside advanced analytical tools such as Fourier transform and deep learning. Additionally, we employ modern cell and genetic technologies, including iPS cells, organoids, transgenic animals, single-cell RNA sequencing, and CRISPR-Cas, to study and manipulate a variety of biological and medical processes. Our primary interest lies in elucidating the mechanisms of intracellular signaling and their roles in development and disease. A key objective of our work is to uncover how cells regulate and interpret the frequency and amplitude of intracellular calcium oscillations to coordinate essential biological functions.

Selected publications

Articles

All other publications

Grants

  • Three-Dimensional Mapping of Molecular Mechanisms After Spinal Cord Injury
    The Swedish Brain Foundation
    1 July 2024 - 30 June 2027
  • Spatial Single-Cell Analysis of Proteins and RNAs in the Tumor Microenvironment by 3D Imaging
    The Swedish Cancer Society
    1 January 2023 - 31 December 2025
  • Exploration of Intratumoral Heterogeneity with Multimodal 3D Imaging at Single-Cell Resolution to Improve Precision Medicine for Cancer
    Swedish Research Council
    1 January 2022 - 31 December 2025

Employments

  • Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2014-

Degrees and Education

  • Docent, Karolinska Institutet, 2008
  • Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2002

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