Per Uhlén
Professor | Docent
E-mail: per.uhlen@ki.se
Visiting address: Solnavägen 9, 6C, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Uhlén, 171 77 Stockholm
About me
- Per Uhlén is Professor of Cell Signaling in the Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet
Research
- Per Uhlén’s research group is studying cancer and developmental related processes in various types of cells. The biological platforms that we are applying are tumor samples, tissue slices, primary cell cultures, cell lines and stem cells. To study the processes of cell signaling, cell division, cell differentiation, and neural migration/networking we are applying state-of-the-art imaging techniques, such as 3D light-sheet microscopy and tissue clearing, advanced analysis tools, such as Fourier transform and deep learning, and modern genetic tools, such as transgenic animals. Our focus is to shed light on the intracellular cell signaling mechanisms and biological processes involved in disease and development. We are particularly interested in calcium signaling and how cells are modulating and decoding the frequency/amplitude of intracellular calcium oscillations.
Selected publications
- Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020
- Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231
- Preprint: BIORXIV. 2022
- Editorial comment: NATURE METHODS. 2022;19(5):527-529
- Article: NATURE COMMUNICATIONS. 2022;13(1):1537
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119
- Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888
- Editorial comment: TRENDS IN CANCER. 2018;4(5):337-341
- Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
- Article: FRONTIERS IN NEURAL CIRCUITS. 2014;8:111
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(7):2212-2217
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(7):2160-2165
- Article: NATURE. 2000;405(6787):694-697
Articles
- Article: WORLD JOURNAL OF UROLOGY. 2023;41(12):3405-3411
- Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674
- Article: ACS APPLIED BIO MATERIALS. 2023;6(9):3790-3797
- Article: ENVIRONMENTAL TOXICOLOGY. 2022;37(8):2044-2057
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(18):e2118927119
- Article: FRONTIERS IN MATERIALS. 2021;7:560372
- Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156
- Article: STEM CELLS AND DEVELOPMENT. 2020;29(17):1160-1177
- Article: STEM CELL RESEARCH AND THERAPY. 2020;11(1):320
- Article: CELL REPORTS. 2020;31(9):107699
- Article: CELL CALCIUM. 2020;88:102210
- Article: WORLD JOURNAL OF UROLOGY. 2019;37(11):2297-2302
- Article: EXPERIMENTAL CELL RESEARCH. 2019;383(1):111469
- Article: NEUROSCIENCE. 2019;402:78-89
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(6):2328-2337
- Article: MOLECULAR ONCOLOGY. 2019;13(2):202-211
- Article: JOURNAL OF NEUROSCIENCE METHODS. 2019;311:259-266
- Article: CANCER MEDICINE. 2018;7(12):6193-6204
- Article: BRITISH JOURNAL OF CANCER. 2018;118(7):995-999
- Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2018;97(3):190-203
- Article: GLIA. 2018;66(1):94-107
- Article: COMMUNICATIONS BIOLOGY. 2018;1:75
- Article: PLOS PATHOGENS. 2017;13(12):e1006739
- Article: EXPERIMENTAL CELL RESEARCH. 2017;357(2):236-242
- Article: BIOINFORMATICS. 2017;33(16):2547-2554
- Article: STEM CELLS AND DEVELOPMENT. 2017;26(12):876-887
- Article: CANCER RESEARCH. 2017;77(7):1741-1752
- Article: JCI INSIGHT. 2016;1(18):e83654
- Article: ELIFE. 2016;5:e14170
- Article: STEM CELL REPORTS. 2016;6(4):607-617
- Article: DEVELOPMENTAL CELL. 2016;36(2):164-178
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(36):E4985-E4994
- Article: DEVELOPMENTAL NEUROBIOLOGY. 2015;75(4):360-368
- Article: PLOS ONE. 2015;10(9):e0139104
- Article: PLOS ONE. 2015;10(3):e0120176
- Article: NATURE PROTOCOLS. 2014;9(9):2164-2179
- Article: NATURE COMMUNICATIONS. 2014;5:4557
- Article: THE FASEB JOURNAL. 2014;28(8):3456-3467
- Article: NATURE COMMUNICATIONS. 2014;5:3743
- Article: EMBO REPORTS. 2014;15(4):383-391
- Article: PLOS ONE. 2014;9(3):e92649
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
- Journal article: JOURNAL OF CELL SCIENCE. 2013;126(22):e1
- Article: DEVELOPMENT. 2013;140(22):4554-4564
- Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2013;6(4):e24788
- Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;269(1):51-60
- Article: BMC NEPHROLOGY. 2013;14:34
- Article: CIRCULATION RESEARCH. 2013;112(2):236-245
- Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
- Article: BRITISH JOURNAL OF CANCER. 2012;106(11):1807-1815
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5511-5516
- Article: BMC PHYSIOLOGY. 2012;12:3
- Article: PLOS ONE. 2012;7(2):e31258
- Article: TOXICOLOGICAL SCIENCES. 2011;124(1):192-201
- Article: NEUROCHEMICAL RESEARCH. 2011;36(7):1175-1185
- Article: EMBO JOURNAL. 2011;30(14):2762-2778
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2011;47(1):10-18
- Article: PLOS ONE. 2011;6(9):e23875
- Article: EMBO JOURNAL. 2010;29(22):3869-3878
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341
- Article: STEM CELLS AND DEVELOPMENT. 2010;19(9):1355-1364
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):28-32
- Article: JOURNAL OF ENDOCRINOLOGY. 2009;202(2):299-307
- Article: CIRCULATION RESEARCH. 2009;105(3):260-270
- Article: CELL DEATH AND DIFFERENTIATION. 2008;15(12):1857-1864
- Article: STEM CELLS. 2008;26(7):1891-1900
- Article: MATHEMATICAL BIOSCIENCES. 2006;204(2):232-249
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21954-21962
- Journal article: JOURNAL OF CELL SCIENCE. 2006;119(4):733-743
- Article: CELLULAR MICROBIOLOGY. 2005;7(6):779-788
- Journal article: JOURNAL OF NEUROSCIENCE. 2005;25(11):2853-2864
- Journal article: JOURNAL OF ENDOCRINOLOGY. 2005;184(2):371-379
- Journal article: SCIENCES STKE [ELECTRONIC RESOURCE] : SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. 2004;2004(258):pl15
- Journal article: BIOCHEMICAL JOURNAL. 2004;382(Pt 2):687-694
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(50):50355-50361
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(23):13420-13424
- Article: NATURE NEUROSCIENCE. 2000;3(3):226-230
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All other publications
- Preprint: BIORXIV. 2021
- Corrigendum: STEM CELL RESEARCH AND THERAPY. 2020;11(1):369
- Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2018;2(10):717-718
- Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
- Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:40-48
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(3):964-969
- Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191
- Conference publication: ANGIOGENESIS. 2013;16(1):246-247
- Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
- Review: CELL CALCIUM. 2011;49(5):350-356
- Conference publication: THE FASEB JOURNAL. 2006;20(5):A1238
- Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:514-518
- Thesis / dissertation: 2002
- Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2002;477(1-3):82-87
- Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2001;471(1-2):200-204
Employments
- Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2014-
Degrees and Education
- Docent, Karolinska Institutet, 2008
- Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2002