Pekka Katajisto

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: CELL REPORTS. 2023;42(8):112970
Aberrant metabolite trafficking and fuel sensitivity in human pluripotent stem cell-derived islets.
Barsby T; Vähäkangas E; Ustinov J; Montaser H; Ibrahim H; Lithovius V; Kuuluvainen E; Chandra V; Saarimäki-Vire J; Katajisto P; Hietakangas V; Otonkoski T
Journal article: JOURNAL OF CELL BIOLOGY. 2023;222(8):e202303107
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
Hakanpaa L; Abouelezz A; Lenaerts A-S; Culfa S; Algie M; Barlund J; Katajisto P; McMahon H; Almeida-Souza L
Article: DISEASE MODELS & MECHANISMS. 2023;16(4):dmm049692
Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth
Lemmetyinen TT; Viitala EW; Wartiovaara L; Kaprio T; Hagstrom J; Haglund C; Katajisto P; Wang TC; Domenech-Moreno E; Ollila S
Article: SCIENCE ADVANCES. 2023;9(2):eadd5163
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto HAK; Kuusela M; Heikkinen A; Muniandy M; van der Kolk BW; Gopalakrishnan S; Pollanen N; Sandvik M; Schmidt MS; Heinonen S; Saari S; Kuula J; Hakkarainen A; Tampio J; Saarinen T; Taskinen M-R; Lundbom N; Groop P-H; Tiirola M; Katajisto P; Lehtonen M; Brenner C; Kaprio J; Pekkala S; Ollikainen M; Pietilainen KH; Pirinen E
Article: JOURNAL OF CELL SCIENCE. 2022;135(23):jcs260232
Laminin matrix adhesion regulates basal mammary epithelial cell identity
Englund JI; Bui H; Dinc DD; Paavolainen O; McKenna T; Laitinen S; Munne P; Klefstrom J; Peuhu E; Katajisto P
Article: SCIENCE ADVANCES. 2022;8(41):eabm1847
Cellular shape reinforces niche to stem cell signaling in the small intestine
Pentinmikko N; Lozano R; Scharaw S; Andersson S; Englund JI; Castillo-Azofeifa D; Gallagher A; Broberg M; Song K-Y; Carvajal AS; Speidel AT; Sundstrom M; Allbritton N; Stevens MM; Klein OD; Teixeira A; Katajisto P
Article: NATURE. 2022;607(7919):548-554
Retrograde movements determine effective stem cell numbers in the intestine
Azkanaz M; Corominas-Murtra B; Ellenbroek SIJ; Bruens L; Webb AT; Laskaris D; Oost KC; Lafirenze SJA; Annusver K; Messal HA; Iqbal S; Flanagan DJ; Huels DJ; Rojas-Rodriguez F; Vizoso M; Kasper M; Sansom OJ; Snippert HJ; Liberali P; Simons BD; Katajisto P; Hannezo E; van Rheenen J
Article: NATURE BIOTECHNOLOGY. 2022;40(7):1042-1055
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
Balboa D; Barsby T; Lithovius V; Saarimaki-Vire J; Omar-Hmeadi M; Dyachok O; Montaser H; Lund P-E; Yang M; Ibrahim H; Naatanen A; Chandra V; Vihinen H; Jokitalo E; Kvist J; Ustinov J; Nieminen AI; Kuuluvainen E; Hietakangas V; Katajisto P; Lau J; Carlsson P-O; Barg S; Tengholm A; Otonkoski T
Article: NATURE CELL BIOLOGY. 2022;24(2):148-154
Metabolic determination of cell fate through selective inheritance of mitochondria
Dohla J; Kuuluvainen E; Gebert N; Amaral A; Englund JI; Gopalakrishnan S; Konovalova S; Nieminen AI; Salminen ES; Munumer RT; Ahlqvist K; Yang Y; Bui H; Otonkoski T; Kakela R; Hietakangas V; Tyynismaa H; Ori A; Katajisto P
Journal article: FRONTIERS IN COMPUTER SCIENCE. 2022;4:777458
"Tonga": A Novel Toolbox for Straightforward Bioimage Analysis
Ritchie A; Laitinen S; Katajisto P; Englund JI
Article: HUMAN MOLECULAR GENETICS. 2021;30(24):2429-2440
WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas
Aavikko M; Kaasinen E; Andersson N; Pentinmikko N; Sulo P; Donner I; Pihlajamaa P; Kuosmanen A; Bramante S; Katainen R; Sipila LJ; Martin S; Arola J; Carpen O; Heiskanen I; Mecklin J-P; Taipale J; Ristimaki A; Lehti K; Gucciardo E; Katajisto P; Schalin-Jantti C; Vahteristo P; Aaltonen LA
Article: NATURE COMMUNICATIONS. 2021;12(1):6741
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage
Martin-Alonso M; Iqbal S; Vornewald PM; Lindholm HT; Damen MJ; Martinez F; Hoel S; Diez-Sanchez A; Altelaar M; Katajisto P; Arroyo AG; Oudhoff MJ
Article: CELL REPORTS: METHODS. 2021;1(5):100059
An image analysis method for regionally defined cellular phenotyping of the Drosophila midgut.
Viitanen A; Gullmets J; Morikka J; Katajisto P; Mattila J; Hietakangas V
Article: NATURE. 2021;594(7863):430-435
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
Flanagan DJ; Pentinmikko N; Luopajarvi K; Willis NJ; Gilroy K; Raven AP; Mcgarry L; Englund JI; Webb AT; Scharaw S; Nasreddin N; Hodder MC; Ridgway RA; Minnee E; Sphyris N; Gilchrist E; Najumudeen AK; Romagnolo B; Perret C; Williams AC; Clevers H; Nummela P; Lahde M; Alitalo K; Hietakangas V; Hedley A; Clark W; Nixon C; Kirschner K; Jones EY; Ristimaki A; Leedham SJ; Fish PV; Vincent J-P; Katajisto P; Sansom OJ
Article: DEVELOPMENT. 2021;148(12):dev199281
Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk
Englund JI; Ritchie A; Blaas L; Cojoc H; Pentinmikko N; Dohla J; Iqbal S; Patarroyo M; Katajisto P
Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (CMGH). 2021;12(3):873-889
Polycomb Repressive Complex 2 Regulates Genes Necessary for Intestinal Microfold Cell (M Cell) Development
George JJ; Oittinen M; Martin-Diaz L; Zapilko V; Iqbal S; Rintakangas T; Martins FTA; Niskanen H; Katajisto P; Kaikkonen MU; Viiri K
Article: CANCER LETTERS. 2020;492:54-62
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2020;191:111330
The role of stem cell niche in intestinal aging
Pentinmikko N; Katajisto P
Article: GASTROENTEROLOGY. 2020;158(5):1389-1401.e10
LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate
Gao Y; Yan Y; Tripathi S; Pentinmikko N; Amaral A; Paivinen P; Domenech-Moreno E; Andersson S; Wong IPL; Clevers H; Katajisto P; Makela TP
Article: AGING. 2019;11(22):9971-9981
Latest advances in aging research and drug discovery
Bakula D; Ablasser A; Aguzzi A; Antebi A; Barzilai N; Bittner M-I; Jensen MB; Calkhoven CF; Chen D; de Grey ADNJ; Feige JN; Georgievskaya A; Gladyshev VN; Golato T; Gudkov AV; Hoppe T; Kaeberlein M; Katajisto P; Kennedy BK; Lal U; Martin-Villalba A; Moskalev AA; Ozerov I; Petr MA; Reason; Rubinsztein DC; Tyshkovskiy A; Vanhaelen Q; Zhavoronkov A; Scheibye-Knudsen M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(11):2272-2280.e12
Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins
Sola-Carvajal A; Revechon G; Helgadottir HT; Whisenant D; Hagblom R; Dohla J; Katajisto P; Brodin D; Fagerstrom-Billai F; Viceconte N; Eriksson M
Article: NATURE. 2019;571(7765):398-402
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Pentinmikko N; Iqbal S; Mana M; Andersson S; Cognetta ABIII; Suciu RM; Roper J; Luopajarvi K; Markelin E; Gopalakrishnan S; Smolander O-P; Naranjo S; Saarinen T; Juuti A; Pietilainen K; Auvinen P; Ristimaki A; Gupta N; Tammela T; Jacks T; Sabatini DM; Cravatt BF; Yilmaz OH; Katajisto P
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA - BIOENERGETICS. 2018;1859:e19
Selective segregation of mitochondria by stem cells
Katajisto PA
Article: CELL STEM CELL. 2018;22(5):769-778.e4
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
Mihaylova MM; Cheng C-W; Cao AQ; Tripathi S; Mana MD; Bauer-Rowe KE; Abu-Remaileh M; Clavain L; Erdemir A; Lewis CA; Freinkman E; Dickey AS; La Spada AR; Huang Y; Bell GW; Deshpande V; Carmeliet P; Katajisto P; Sabatini DM; Yilmaz OH
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(1):402-414
Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway
Ollila S; Domenech-Moreno E; Laajanen K; Wong IPL; Tripathi S; Pentinmikko N; Gao Y; Yan Y; Niemela EH; Wang TC; Viollet B; Leone G; Katajisto P; Vaahtomeri K; Makela TP
Article: NATURE BIOTECHNOLOGY. 2017;35(6):569-576
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
Roper J; Tammela T; Cetinbas NM; Akkad A; Roghanian A; Rickelt S; Almeqdadi M; Wu K; Oberli MA; Sanchez-Rivera F; Park YK; Liang X; Eng G; Taylor MS; Azimi R; Kedrin D; Neupane R; Beyaz S; Sicinska ET; Suarez Y; Yoo J; Chen L; Zukerberg L; Katajisto P; Deshpande V; Bass AJ; Tsichlis PN; Lees J; Langer R; Hynes RO; Chen J; Bhutkar A; Jacks T; Yilmaz OH
Article: NATURE. 2017;545(7654):355-359
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
Tammela T; Sanchez-Rivera FJ; Cetinbas NM; Wu K; Joshi NS; Helenius K; Park Y; Azimi R; Kerper NR; Wesselhoeft RAL; Gu X; Schmidt L; Cornwall-Brady M; Yilmaz OH; Xue W; Katajisto P; Bhutkar A; Jacks T
Article: SCIENCE. 2015;348(6232):340-343
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
Katajisto P; Doehla J; Chaffer CL; Pentinmikko N; Marjanovic N; Iqbal S; Zoncu R; Chen W; Weinberg RA; Sabatini DM
Article: AGING CELL. 2014;13(5):911-917
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan
Lamming DW; Mihaylova MM; Katajisto P; Baar EL; Yilmaz OH; Hutchins A; Gultekin Y; Gaither R; Sabatini DM
Article: NATURE. 2012;486(7404):490-495
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Yilmaz OH; Katajisto P; Lamming DW; Gueltekin Y; Bauer-Rowe KE; Sengupta S; Birsoy K; Dursun A; Yilmaz VO; Selig M; Nielsen GP; Mino-Kenudson M; Zukerberg LR; Bhan AK; Deshpande V; Sabatini DM
Article: SCIENCE. 2012;335(6076):1638-1643
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Lamming DW; Ye L; Katajisto P; Goncalves MD; Saitoh M; Stevens DM; Davis JG; Salmon AB; Richardson A; Ahima RS; Guertin DA; Sabatini DM; Baur JA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(7):E388-E397
Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
Partanen JI; Tervonen TA; Myllynen M; Lind E; Imai M; Katajisto P; Dijkgraaf GJP; Kovanen PE; Makela TP; Werb Z; Klefstrom J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(5):2467-2476
Impaired Gastric Gland Differentiation in Peutz-Jeghers Syndrome
Udd L; Katajisto P; Kyyronen M; Ristimaki AP; Makela TP
Article: DEVELOPMENT. 2008;135(13):2331-2338
LKB1 in endothelial cells is required for angiogenesis and TGFβ-mediated vascular smooth muscle cell recruitment
Londesborough A; Vaahtomeri K; Tiainen M; Katajisto P; Ekman N; Vallenius T; Makela TP
Article: NATURE GENETICS. 2008;40(4):455-459
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Katajisto P; Vaahtomeri K; Ekman N; Ventela E; Ristimaki A; Bardeesy N; Feil R; DePinho RA; Makela TP
Article: BRITISH JOURNAL OF CANCER. 2005;92(6):1126-1129
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADα, and MO25α, in Peutz-Jeghers syndrome
Alhopuro P; Katajisto P; Lehtonen R; Ylisaukko-oja SK; Näätsaari L; Karhu A; Westerman AM; Wilson JHP; de Rooij FWM; Vogel T; Moeslein G; Tomlinson IP; Aaltonen LA; Mäkelä TP; Launonen V
Article: GASTROENTEROLOGY. 2004;127(4):1030-1037
Supression of Peutx-Jeghers polyposis by inhibition of cyclooxygenase-2
Udd L; Katajisto P; Rossi DJ; Lepistö A; Lahesmaa AM; Ylikorkala A; Järvinen HJ; Ristimäki AP; Mäkelä TP
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Preprint: BIORXIV. 2023;BIORXIV
Golgi organization is a determinant of stem cell function in the small intestine.
Scharaw S; Sola-Carvajal A; Belevich I; Webb AT; Das S; Andersson S; Pentinmikko N; Villablanca EJ; Goldenring JR; Jokitalo E; Coffey RJ; Katajisto P
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2023;34(2):258-259
Golgi organization is a determinant of stem cell signaling in the small intestine
Scharaw S; Cavajal AS; Webb A; Belevich I; Pentinmikko N; Das S; Jokitalo E; Coffey R; Katajisto P
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2023;34(2):802-803
Golgi organization is a determinant of stem cell signaling in the small intestine
Scharaw S; Cavajal AS; Webb A; Belevich I; Pentinmikko N; Das S; Jokitalo E; Coffey R; Katajisto P
Preprint: BIORXIV. 2022
Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer
Sur I; Zhao W; Zhang J; Pilström MK; Rozell B; Webb A; Cheng H; Ristimäki A; Katajisto P; Enge M; Rannikmae H; de la Roche M; Taipale J
Preprint: BIORXIV. 2022
Reticular Adhesion Formation is Mediated by Flat Clathrin Lattices and Opposed by Fibrillar Adhesions
Hakanpää L; Abouelezz A; Lenaerts A-S; Culfa S; Algie M; Bärlund J; Katajisto P; McMahon HT; Almeida-Souza L
Preprint: MEDRXIV. 2022
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota composition in a twin study
Lapatto H; Kuusela M; Heikkinen A; Muniandy M; van der Kolk BW; Gopalakrishnan S; Sandvik M; Schmidt MS; Heinonen S; Saari S; Pöllänen N; Kuula J; Hakkarainen A; Tampio J; Saarinen T; Taskinen M-R; Lundbom N; Groop P-H; Tiirola M; Katajisto P; Lehtonen M; Brenner C; Kaprio J; Pekkala S; Ollikainen M; Pietiläinen KH; Pirinen E
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52:107
The role of autophagy in the early rise of asymmetric T cell fates
Borsa M; Youdale T; Cantrell D; Katajisto P; Simon AK
Preprint: BIORXIV. 2021
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin
Iqbal S; Andersson S; Nestaite E; Pentinmikko N; Kumar A; Borshagovski D; Webb A; Saarinen T; Juuti A; Ori A; Varjosalo M; Pietiläinen KH; Jensen KB; Oudhoff M; Katajisto P
Preprint: BIORXIV. 2021
Functional, metabolic and transcriptional maturation of stem cell derived beta cells
Balboa D; Barsby T; Lithovius V; Saarimäki-Vire J; Omar-Hmeadi M; Dyachok O; Montaser H; Lund P-E; Yang M; Ibrahim H; Näätänen A; Chandra V; Vihinen H; Jokitalo E; Kvist J; Ustinov J; Nieminen AI; Kuuluvainen E; Hietakangas V; Katajisto P; Lau J; Carlsson P-O; Barg S; Tengholm A; Otonkoski T
Preprint: BIORXIV. 2021
LAM – an image analysis method for regionally defined organ-wide cellular phenotyping of the Drosophila midgut
Viitanen A; Gullmets J; Morikka J; Katajisto P; Mattila J; Hietakangas V
Preprint: SSRN ELECTRONIC JOURNAL. 2021
Alanine Catabolism of Paneth Cells Maintains Intestinal Stem Cell Function During Dietary Restriction
Kumar A; Iqbal S; Pentinmikko N; Broberg M; Morikka J; Hietakangas V; Katajisto P
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:89
Liver X receptor activation promotes intestinal repair while limiting tumorigenesis
Das S; Parigi SM; Scharaw S; Luo X; Diaz OE; Webb A; Zagami C; Pelczar P; De La Fuente M; Czarnewski P; Lopez Kostner F; Nylen S; Antonson P; Hermoso MA; Huber S; Gustafsson JA; Katajisto P; Villablanca EJ
Preprint: BIORXIV. 2020
Polycomb Repressive Complex 2-controlled Essrg regulates intestinal Microfold cell differentiation
George JJ; Oittinen M; Martin-Diaz L; Zapilko V; Iqbal S; Rintakangas T; Martins FTA; Niskanen H; Katajisto P; Kaikkonen M; Viiri K
Conference publication: CANCER RESEARCH. 2020;80(16):2081
Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes
Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Preprint: BIORXIV. 2020
Smooth muscle-specific MMP17 (MT4-MMP) defines the intestinal ECM niche
Martín-Alonso M; Lindholm HT; Iqbal S; Vornewald P; Hoel S; Damen MJ; Altelaar AFM; Katajisto P; Arroyo AG; Oudhoff MJ
Preprint: BIORXIV. 2019
Laminin alpha 5 is Necessary for Mammary Epithelial Growth and Function by Maintaining Luminal Epithelial Cell Identity
Englund JI; Cojoc H; Blaas L; Ritchie A; Pentinmikko N; Döhla J; Munne P; Patarroyo M; Klefström J; Ivaska J; Katajisto P
Conference publication: CANCER RESEARCH. 2018;78(10):73
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis.
Roper J; Tammela T; Cetinbas NM; Akkad A; Roghanian A; Rickelt S; Almeqdadi M; Wu K; Oberli M; Sanchez-Rivera F; Park Y; Liang X; Eng G; Taylor MS; Azimi R; Kedrin D; Neupane R; Beyaz S; Sicinska ET; Suarez Y; Yoo J; Chen L; Zukerberg L; Katajisto P; Deshpande V; Bass A; Tsichlis PN; Lees J; Langer R; Hynes RO; Chen J; Bhutkar AJ; Jacks T; Yilmaz OH
Other: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(5)
STEM CELLS AGE-DISCRIMINATE ORGANELLES TO MAINTAIN STEMNESS
Meeting abstract: CANCER RESEARCH. 2014;74(19):99
Wnt signaling promotes tumor propagation in a mouse model of lung adenocarcinoma
Tammela T; Kerper N; Xue W; Joshi N; Katajisto P; Jacks T
Review: JOURNAL OF CELL SCIENCE. 2008;121(21):3531-3540
Lkb1 is required for TGFβ-mediated myofibroblast differentiation
Vaahtomeri K; Ventelae E; Laajanen K; Katajisto P; Wipff P-J; Hinz B; Vallenius T; Tiainen M; Makela TP
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1775(1):63-75
The LKB1 tumor suppressor kinase in human disease
Katajisto P; Vallenius T; Vaahtomeri K; Ekman N; Udd L; Tiainen M; Makela TP
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Forskningsbidrag

Niche geometry in stem cell regulation and ageing
Swedish Research Council
1 January 2023 - 31 December 2027
Centre of Excellence in Stem Cell Metabolism
Academy of Finland
13 December 2022 - 31 December 2025
Center of Excellence in Stem Cell Metabolism
Academy of Finland
5 January 2020 - 31 December 2022
Levels of cell fate regulation
Academy of Finland
1 January 2020 - 31 December 2023
Niche-to-Stem Cell signaling in Tumorigenesis and treatment - Niche-to-Stem Cell signaling in Tumorigenesis and treatment
Cancer Foundation Finland
12 November 2019
The role of cellular metabolism in self-renewal and differentiation of stem cells
Swedish Research Council
1 January 2019 - 31 December 2022
Center of Excellence in Stem Cell Metabolism
Academy of Finland
1 January 2018 - 31 December 2020
Age-Selective Segregation of Organelles
European Research Council
1 May 2016 - 30 April 2021
Stem cell niche and asymmetric division in aging
Academy of Finland
9 January 2016 - 31 August 2018
Stem cell niche and asymmetric division in aging
Academy of Finland
9 January 2013 - 31 August 2016

Anställningar

Senior Forskare, Cell- och molekylärbiologi, Karolinska Institutet, 2024-

Handledare

Marjan Abbasi, Microtubule and Spindle Pole Body regulation in the budding yeast mitotic spindle

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