Pekka Katajisto
Principal Researcher
E-mail: pekka.katajisto@ki.se
Telephone: +46852481171
Visiting address: Solnavägen 9, 17165 Solna
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Katajisto, 171 77 Stockholm
Articles
- Article: CELL STEM CELL. 2025;32(4):613-626.e8Iqbal S; Andersson S; Nesta E; Pentinmikko N; Kumar A; Jha SK; Borshagovski D; Webb A; Gebert N; Viitala EW; Ritchie A; Scharaw S; Kuuluvainen E; Larsen HL; Saarinen T; Juuti A; Ristimaki A; Jeltsch M; Ori A; Varjosalo M; Pietilainen KH; Ollila S; Jensen KB; Oudhoff MJ; Katajisto P
- Article: NATURE. 2025;637(8048):1198-1206Das S; Parigi SM; Luo X; Fransson J; Kern BC; Okhovat A; Diaz OE; Sorini C; Czarnewski P; Webb AT; Morales RA; Lebon S; Monasterio G; Castillo F; Tripathi KP; He N; Pelczar P; Schaltenberg N; De la Fuente M; Lopez-Kostner F; Nylen S; Larsen HL; Kuiper R; Antonson P; Hermoso MA; Huber S; Biton M; Scharaw S; Gustafsson J-A; Katajisto P; Villablanca EJ
- Article: NATURE. 2025;637(8044):184-194Zhuang X; Wang Q; Joost S; Ferrena A; Humphreys DT; Li Z; Blum M; Krause K; Ding S; Landais Y; Zhan Y; Zhao Y; Chaligne R; Lee J-H; Carrasco SE; Bhanot UK; Koche RP; Bott MJ; Katajisto P; Soto-Feliciano YM; Pisanic T; Thomas T; Zheng D; Wong ES; Tammela T
- Article: ISCIENCE. 2024;27(12):111246Lemmetyinen TT; Viitala EW; Wartiovaara L; Paivinen P; Virtanen HT; Pentinmikko N; Katajisto P; Makela TP; Wang TC; Andressoo J-O; Ollila S
- Article: ANTIVIRAL RESEARCH. 2024;224:105837Bigotti MG; Klein K; Gan ES; Anastasina M; Andersson S; Vapalahti O; Katajisto P; Erdmann M; Davidson AD; Butcher SJ; Collinson I; Ooi EE; Balistreri G; Brancaccio A; Yamauchi Y
- Article: CELL REPORTS. 2023;42(8):112970Barsby T; Vähäkangas E; Ustinov J; Montaser H; Ibrahim H; Lithovius V; Kuuluvainen E; Chandra V; Saarimäki-Vire J; Katajisto P; Hietakangas V; Otonkoski T
- Article: JOURNAL OF CELL BIOLOGY. 2023;222(8):e202303107Hakanpaa L; Abouelezz A; Lenaerts A-S; Culfa S; Algie M; Barlund J; Katajisto P; McMahon H; Almeida-Souza L
- Article: DISEASE MODELS & MECHANISMS. 2023;16(4):dmm049692Lemmetyinen TT; Viitala EW; Wartiovaara L; Kaprio T; Hagstrom J; Haglund C; Katajisto P; Wang TC; Domenech-Moreno E; Ollila S
- Article: SCIENCE ADVANCES. 2023;9(2):eadd5163Lapatto HAK; Kuusela M; Heikkinen A; Muniandy M; van der Kolk BW; Gopalakrishnan S; Pollanen N; Sandvik M; Schmidt MS; Heinonen S; Saari S; Kuula J; Hakkarainen A; Tampio J; Saarinen T; Taskinen M-R; Lundbom N; Groop P-H; Tiirola M; Katajisto P; Lehtonen M; Brenner C; Kaprio J; Pekkala S; Ollikainen M; Pietilainen KH; Pirinen E
- Article: JOURNAL OF CELL SCIENCE. 2022;135(23):jcs260232Englund JI; Bui H; Dinc DD; Paavolainen O; McKenna T; Laitinen S; Munne P; Klefstrom J; Peuhu E; Katajisto P
- Article: SCIENCE ADVANCES. 2022;8(41):eabm1847Pentinmikko N; Lozano R; Scharaw S; Andersson S; Englund JI; Castillo-Azofeifa D; Gallagher A; Broberg M; Song K-Y; Carvajal AS; Speidel AT; Sundstrom M; Allbritton N; Stevens MM; Klein OD; Teixeira A; Katajisto P
- Article: NATURE. 2022;607(7919):548-554Azkanaz M; Corominas-Murtra B; Ellenbroek SIJ; Bruens L; Webb AT; Laskaris D; Oost KC; Lafirenze SJA; Annusver K; Messal HA; Iqbal S; Flanagan DJ; Huels DJ; Rojas-Rodriguez F; Vizoso M; Kasper M; Sansom OJ; Snippert HJ; Liberali P; Simons BD; Katajisto P; Hannezo E; van Rheenen J
- Article: NATURE BIOTECHNOLOGY. 2022;40(7):1042-1055Balboa D; Barsby T; Lithovius V; Saarimaki-Vire J; Omar-Hmeadi M; Dyachok O; Montaser H; Lund P-E; Yang M; Ibrahim H; Naatanen A; Chandra V; Vihinen H; Jokitalo E; Kvist J; Ustinov J; Nieminen AI; Kuuluvainen E; Hietakangas V; Katajisto P; Lau J; Carlsson P-O; Barg S; Tengholm A; Otonkoski T
- Journal article: FRONTIERS IN COMPUTER SCIENCE. 2022;4:777458Ritchie A; Laitinen S; Katajisto P; Englund JI
- Article: NATURE CELL BIOLOGY. 2022;24(2):148-154Dohla J; Kuuluvainen E; Gebert N; Amaral A; Englund JI; Gopalakrishnan S; Konovalova S; Nieminen AI; Salminen ES; Munumer RT; Ahlqvist K; Yang Y; Bui H; Otonkoski T; Kakela R; Hietakangas V; Tyynismaa H; Ori A; Katajisto P
- Article: HUMAN MOLECULAR GENETICS. 2021;30(24):2429-2440Aavikko M; Kaasinen E; Andersson N; Pentinmikko N; Sulo P; Donner I; Pihlajamaa P; Kuosmanen A; Bramante S; Katainen R; Sipila LJ; Martin S; Arola J; Carpen O; Heiskanen I; Mecklin J-P; Taipale J; Ristimaki A; Lehti K; Gucciardo E; Katajisto P; Schalin-Jantti C; Vahteristo P; Aaltonen LA
- Article: NATURE COMMUNICATIONS. 2021;12(1):6741Martin-Alonso M; Iqbal S; Vornewald PM; Lindholm HT; Damen MJ; Martinez F; Hoel S; Diez-Sanchez A; Altelaar M; Katajisto P; Arroyo AG; Oudhoff MJ
- Article: CELL REPORTS: METHODS. 2021;1(5):100059Viitanen A; Gullmets J; Morikka J; Katajisto P; Mattila J; Hietakangas V
- Article: NATURE. 2021;594(7863):430-435Flanagan DJ; Pentinmikko N; Luopajarvi K; Willis NJ; Gilroy K; Raven AP; Mcgarry L; Englund JI; Webb AT; Scharaw S; Nasreddin N; Hodder MC; Ridgway RA; Minnee E; Sphyris N; Gilchrist E; Najumudeen AK; Romagnolo B; Perret C; Williams AC; Clevers H; Nummela P; Lahde M; Alitalo K; Hietakangas V; Hedley A; Clark W; Nixon C; Kirschner K; Jones EY; Ristimaki A; Leedham SJ; Fish PV; Vincent J-P; Katajisto P; Sansom OJ
- Article: DEVELOPMENT. 2021;148(12):dev199281Englund JI; Ritchie A; Blaas L; Cojoc H; Pentinmikko N; Dohla J; Iqbal S; Patarroyo M; Katajisto P
- Article: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. 2021;12(3):873-889George JJ; Oittinen M; Martin-Diaz L; Zapilko V; Iqbal S; Rintakangas T; Martins FTA; Niskanen H; Katajisto P; Kaikkonen MU; Viiri K
- Article: CANCER LETTERS. 2020;492:54-62Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
- Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2020;191:111330Pentinmikko N; Katajisto P
- Article: GASTROENTEROLOGY. 2020;158(5):1389-1401.e10Gao Y; Yan Y; Tripathi S; Pentinmikko N; Amaral A; Paivinen P; Domenech-Moreno E; Andersson S; Wong IPL; Clevers H; Katajisto P; Makela TP
- Article: AGING-US. 2019;11(22):9971-9981Bakula D; Ablasser A; Aguzzi A; Antebi A; Barzilai N; Bittner M-I; Jensen MB; Calkhoven CF; Chen D; de Grey ADNJ; Feige JN; Georgievskaya A; Gladyshev VN; Golato T; Gudkov AV; Hoppe T; Kaeberlein M; Katajisto P; Kennedy BK; Lal U; Martin-Villalba A; Moskalev AA; Ozerov I; Petr MA; Reason; Rubinsztein DC; Tyshkovskiy A; Vanhaelen Q; Zhavoronkov A; Scheibye-Knudsen M
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(11):2272-2280.e12Sola-Carvajal A; Revechon G; Helgadottir HT; Whisenant D; Hagblom R; Dohla J; Katajisto P; Brodin D; Fagerstrom-Billai F; Viceconte N; Eriksson M
- Article: NATURE. 2019;571(7765):398-402Pentinmikko N; Iqbal S; Mana M; Andersson S; Cognetta ABIII; Suciu RM; Roper J; Luopajarvi K; Markelin E; Gopalakrishnan S; Smolander O-P; Naranjo S; Saarinen T; Juuti A; Pietilainen K; Auvinen P; Ristimaki A; Gupta N; Tammela T; Jacks T; Sabatini DM; Cravatt BF; Yilmaz OH; Katajisto P
- Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2018;1859:e19Katajisto PA
- Article: CELL STEM CELL. 2018;22(5):769-778.e4Mihaylova MM; Cheng C-W; Cao AQ; Tripathi S; Mana MD; Bauer-Rowe KE; Abu-Remaileh M; Clavain L; Erdemir A; Lewis CA; Freinkman E; Dickey AS; La Spada AR; Huang Y; Bell GW; Deshpande V; Carmeliet P; Katajisto P; Sabatini DM; Yilmaz OH
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(1):402-414Ollila S; Domenech-Moreno E; Laajanen K; Wong IPL; Tripathi S; Pentinmikko N; Gao Y; Yan Y; Niemela EH; Wang TC; Viollet B; Leone G; Katajisto P; Vaahtomeri K; Makela TP
- Article: NATURE BIOTECHNOLOGY. 2017;35(6):569-576Roper J; Tammela T; Cetinbas NM; Akkad A; Roghanian A; Rickelt S; Almeqdadi M; Wu K; Oberli MA; Sanchez-Rivera F; Park YK; Liang X; Eng G; Taylor MS; Azimi R; Kedrin D; Neupane R; Beyaz S; Sicinska ET; Suarez Y; Yoo J; Chen L; Zukerberg L; Katajisto P; Deshpande V; Bass AJ; Tsichlis PN; Lees J; Langer R; Hynes RO; Chen J; Bhutkar A; Jacks T; Yilmaz OH
- Article: NATURE. 2017;545(7654):355-359Tammela T; Sanchez-Rivera FJ; Cetinbas NM; Wu K; Joshi NS; Helenius K; Park Y; Azimi R; Kerper NR; Wesselhoeft RAL; Gu X; Schmidt L; Cornwall-Brady M; Yilmaz OH; Xue W; Katajisto P; Bhutkar A; Jacks T
- Article: SCIENCE. 2015;348(6232):340-343Katajisto P; Doehla J; Chaffer CL; Pentinmikko N; Marjanovic N; Iqbal S; Zoncu R; Chen W; Weinberg RA; Sabatini DM
- Article: AGING CELL. 2014;13(5):911-917Lamming DW; Mihaylova MM; Katajisto P; Baar EL; Yilmaz OH; Hutchins A; Gultekin Y; Gaither R; Sabatini DM
- Article: NATURE. 2012;486(7404):490-495Yilmaz OH; Katajisto P; Lamming DW; Gueltekin Y; Bauer-Rowe KE; Sengupta S; Birsoy K; Dursun A; Yilmaz VO; Selig M; Nielsen GP; Mino-Kenudson M; Zukerberg LR; Bhan AK; Deshpande V; Sabatini DM
- Article: SCIENCE. 2012;335(6076):1638-1643Lamming DW; Ye L; Katajisto P; Goncalves MD; Saitoh M; Stevens DM; Davis JG; Salmon AB; Richardson A; Ahima RS; Guertin DA; Sabatini DM; Baur JA
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(7):E388-E397Partanen JI; Tervonen TA; Myllynen M; Lind E; Imai M; Katajisto P; Dijkgraaf GJP; Kovanen PE; Makela TP; Werb Z; Klefstrom J
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(5):2467-2476Udd L; Katajisto P; Kyyronen M; Ristimaki AP; Makela TP
- Article: DEVELOPMENT. 2008;135(13):2331-2338Londesborough A; Vaahtomeri K; Tiainen M; Katajisto P; Ekman N; Vallenius T; Makela TP
- Article: NATURE GENETICS. 2008;40(4):455-459Katajisto P; Vaahtomeri K; Ekman N; Ventela E; Ristimaki A; Bardeesy N; Feil R; DePinho RA; Makela TP
- Article: BRITISH JOURNAL OF CANCER. 2005;92(6):1126-1129Alhopuro P; Katajisto P; Lehtonen R; Ylisaukko-oja SK; Näätsaari L; Karhu A; Westerman AM; Wilson JHP; de Rooij FWM; Vogel T; Moeslein G; Tomlinson IP; Aaltonen LA; Mäkelä TP; Launonen V
- Article: GASTROENTEROLOGY. 2004;127(4):1030-1037Udd L; Katajisto P; Rossi DJ; Lepistö A; Lahesmaa AM; Ylikorkala A; Järvinen HJ; Ristimäki AP; Mäkelä TP
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All other publications
- Preprint: BIORXIV. 2023;BIORXIVScharaw S; Sola-Carvajal A; Belevich I; Webb AT; Das S; Andersson S; Pentinmikko N; Villablanca EJ; Goldenring JR; Jokitalo E; Coffey RJ; Katajisto P
- Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2023;34(2):258-259Scharaw S; Cavajal AS; Webb A; Belevich I; Pentinmikko N; Das S; Jokitalo E; Coffey R; Katajisto P
- Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2023;34(2):802-803Scharaw S; Cavajal AS; Webb A; Belevich I; Pentinmikko N; Das S; Jokitalo E; Coffey R; Katajisto P
- Preprint: BIORXIV. 2022Sur I; Zhao W; Zhang J; Pilström MK; Rozell B; Webb A; Cheng H; Ristimäki A; Katajisto P; Enge M; Rannikmae H; de la Roche M; Taipale J
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52:107Borsa M; Youdale T; Cantrell D; Katajisto P; Simon AK
- Preprint: BIORXIV. 2022Hakanpää L; Abouelezz A; Lenaerts A-S; Culfa S; Algie M; Bärlund J; Katajisto P; McMahon H; Almeida-Souza L
- Preprint: MEDRXIV. 2022Lapatto H; Kuusela M; Heikkinen A; Muniandy M; van der Kolk BW; Gopalakrishnan S; Sandvik M; Schmidt MS; Heinonen S; Saari S; Pöllänen N; Kuula J; Hakkarainen A; Tampio J; Saarinen T; Taskinen M-R; Lundbom N; Groop P-H; Tiirola M; Katajisto P; Lehtonen M; Brenner C; Kaprio J; Pekkala S; Ollikainen M; Pietiläinen KH; Pirinen E
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:89Das S; Parigi SM; Scharaw S; Luo X; Diaz OE; Webb A; Zagami C; Pelczar P; De La Fuente M; Czarnewski P; Lopez Kostner F; Nylen S; Antonson P; Hermoso MA; Huber S; Gustafsson JA; Katajisto P; Villablanca EJ
- Preprint: BIORXIV. 2021Iqbal S; Andersson S; Nestaite E; Pentinmikko N; Kumar A; Borshagovski D; Webb A; Saarinen T; Juuti A; Ori A; Varjosalo M; Pietiläinen KH; Jensen KB; Oudhoff M; Katajisto P
- Preprint: BIORXIV. 2021Balboa D; Barsby T; Lithovius V; Saarimäki-Vire J; Omar-Hmeadi M; Dyachok O; Montaser H; Lund P-E; Yang M; Ibrahim H; Näätänen A; Chandra V; Vihinen H; Jokitalo E; Kvist J; Ustinov J; Nieminen AI; Kuuluvainen E; Hietakangas V; Katajisto P; Lau J; Carlsson P-O; Barg S; Tengholm A; Otonkoski T
- Preprint: BIORXIV. 2021Viitanen A; Gullmets J; Morikka J; Katajisto P; Mattila J; Hietakangas V
- Preprint: SSRN ELECTRONIC JOURNAL. 2021Kumar A; Iqbal S; Pentinmikko N; Broberg M; Morikka J; Hietakangas V; Katajisto P
- Preprint: BIORXIV. 2020George JJ; Oittinen M; Martin-Diaz L; Zapilko V; Iqbal S; Rintakangas T; Martins FTA; Niskanen H; Katajisto P; Kaikkonen M; Viiri K
- Conference publication: CANCER RESEARCH. 2020;80(16):2081Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
- Preprint: BIORXIV. 2020Martín-Alonso M; Lindholm HT; Iqbal S; Vornewald P; Hoel S; Damen MJ; Altelaar AFM; Katajisto P; Arroyo AG; Oudhoff MJ
- Preprint: BIORXIV. 2019Englund JI; Cojoc H; Blaas L; Ritchie A; Pentinmikko N; Döhla J; Munne P; Patarroyo M; Klefström J; Ivaska J; Katajisto P
- Conference publication: CANCER RESEARCH. 2018;78(10):73Roper J; Tammela T; Cetinbas NM; Akkad A; Roghanian A; Rickelt S; Almeqdadi M; Wu K; Oberli M; Sanchez-Rivera F; Park Y; Liang X; Eng G; Taylor MS; Azimi R; Kedrin D; Neupane R; Beyaz S; Sicinska ET; Suarez Y; Yoo J; Chen L; Zukerberg L; Katajisto P; Deshpande V; Bass A; Tsichlis PN; Lees J; Langer R; Hynes RO; Chen J; Bhutkar AJ; Jacks T; Yilmaz OH
- Other: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(5)
- Meeting abstract: CANCER RESEARCH. 2014;74(19):99Tammela T; Kerper N; Xue W; Joshi N; Katajisto P; Jacks T
- Review: JOURNAL OF CELL SCIENCE. 2008;121(21):3531-3540Vaahtomeri K; Ventelae E; Laajanen K; Katajisto P; Wipff P-J; Hinz B; Vallenius T; Tiainen M; Makela TP
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1775(1):63-75Katajisto P; Vallenius T; Vaahtomeri K; Ekman N; Udd L; Tiainen M; Makela TP
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Grants
- Swedish Research Council1 January 2023 - 31 December 2027Tissue renewal by adult stem cells is regulated by a multitude of cell intrinsic and extrinsic mechanism, which jointly guide decisions between two cell fates - stem cell self-renewal and differentiation. Interestingly, the microenvironment of stem cells, also called the niche, has often a distinct shape.Recent findings by us and others demonstrate that metabolism can influence cell fate. As metabolites can be exchanged between cells, we hypothesize that fate of tissue stem cells is controlled by metabolism running jointly within the surrounding cellular community, and the geometry of the niche facilitates this communal metabolism. Moreover, age-induced changes in tissue architecture may deregulate metabolite sharing and thereby tissue renewal by stem cells.We will first establish the order of metabolic and transcriptional events during fate change. Second, we assess the extent and impact of metabolite sharing by developing methods capable of detecting exchange of metabolites between two cell types. To study the impact of niche geometry, we will develop artificial scaffolds instructing custom niche topology. Finally, we will characterize the tissue geometry alterations during aging, and probe the possibility to promote tissue regeneration by supporting a youthful geometry via apical constriction of cells.Our work challenges the fundamental concept of cell fate, and has the potential to uncover metabolic tools advancing protocols for future cellular therapies.
- Academy of Finland13 December 2022 - 31 December 2025The rapid advancement of stem cell research creates a foundation for future therapeutic strategies spanning from organ replacements to treatment of diabetes and neurodegenerative disease, and to aging-related frailty and disease. To fully realize the potential of stem cell based strategies, we must first understand the cellular processes critical for stem cell function. We have discovered that metabolism is a potent driver of stem cell fate and that metabolic interventions can guide stem cell function. Subsequently, we have for example succeeded in producing near-mature stem cell derived pancreatic islets, that produce insulin in response to elevated glucose. During the second term, we will focus on illuminating how metabolism controls differentiation of stem cells in a tissue environment, and whether metabolic tools can be used to enhance the maturation of lab-grown pancreatic islets for stem cell based diabetes therapy.
- Center of Excellence in Stem Cell MetabolismAcademy of Finland5 January 2020 - 31 December 2022
- Levels of cell fate regulationAcademy of Finland1 January 2020 - 31 December 2023
- Cancer Foundation Finland12 November 2019
- Swedish Research Council1 January 2019 - 31 December 2022
- Center of Excellence in Stem Cell MetabolismAcademy of Finland1 January 2018 - 31 December 2020
- Stem cell niche and asymmetric division in agingAcademy of Finland9 January 2016 - 31 August 2018
- Stem cell niche and asymmetric division in agingAcademy of Finland9 January 2013 - 31 August 2016
Employments
- Principal Researcher, Department of Cell and Molecular Biology, Karolinska Institutet, 2024-