Oscar Wiklander

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: ADVANCED SCIENCE. 2024;11(42):e2407619
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler AM; Liang X; Gupta D; Mamand DR; De Luca M; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy OM; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander OPB; Gorgens A; Nordin JZ; Castilla-Llorente V; EL Andaloussi S
Journal article: JOURNAL OF PROTEOME RESEARCH. 2024;23(9):4114-4127
Defining the Soluble and Extracellular Vesicle Protein Compartments of Plasma Using In-Depth Mass Spectrometry-Based Proteomics
Sharma N; Angori S; Sandberg A; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; El Andaloussi S; Eriksson H; Pernemalm M
Article: JOURNAL OF EXTRACELLULAR BIOLOGY. 2024;3(9):1-16
A protocol to differentiate the chondrogenic ATDC5 cell-line for the collection of chondrocyte-derived extracellular vesicles
Marchan-Álvarez JG; Teeuwen L; Mamand D; Gabrielsson S; Blomgren K; Wiklander O; Newton P
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471
Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting
Mamand DR; Bazaz S; Mohammad DK; Liang X; Pavlova S; Mim C; Gabrielsson S; Nordin JZ; Wiklander OPB; Abedi-Valugerdi M; EL-Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2024;:1-16
Antibody-displaying extracellular vesicles for targeted cancer therapy
Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Mager I; Alici E; Sezgin E; Nordin JZ; Gupta D; Gorgens A; EL Andaloussi S
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;129:111584
Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase
Mamand DR; Bazaz S; Mohammad DK; Saher O; Wiklander OPB; Sadeghi B; Hassan M; EL-Andaloussi S; Abedi-Valugerdi M
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(2):e12404
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh JA; Goberdhan DCI; O'Driscoll L; Buzas EI; Blenkiron C; Bussolati B; Cai H; Di Vizio D; Driedonks TAP; Erdbrugger U; Falcon-Perez JM; Fu Q-L; Hill AF; Lenassi M; Lim SK; Mahoney MG; Mohanty S; Moller A; Nieuwland R; Ochiya T; Sahoo S; Torrecilhas AC; Zheng L; Zijlstra A; Abuelreich S; Bagabas R; Bergese P; Bridges EM; Brucale M; Burger D; Carney RP; Cocucci E; Colombo F; Crescitelli R; Hanser E; Harris AL; Haughey NJ; Hendrix A; Ivanov AR; Jovanovic-Talisman T; Kruh-Garcia NA; Faustino VK-L; Kyburz D; Lasser C; Lennon KM; Lotvall J; Maddox AL; Martens-Uzunova ES; Mizenko RR; Newman LA; Ridolfi A; Rohde E; Rojalin T; Rowland A; Saftics A; Sandau US; Saugstad JA; Shekari F; Swift S; Ter-Ovanesyan D; Tosar JP; Useckaite Z; Valle F; Varga Z; van der Pol E; van Herwijnen MJC; Wauben MHM; Wehman AM; Williams S; Zendrini A; Zimmerman AJ; Thery C; Witwer KW
Article: NATURE COMMUNICATIONS. 2023;14(1):4734
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Zheng W; Raedler J; Sork H; Niu Z; Roudi S; Bost JPP; Goergens A; Zhao Y; Mamand DRR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZZ; EL Andaloussi S
Journal article: EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS. 2023;4(2):170-90
Biodistribution of therapeutic extracellular vesicles
Gupta D; Wiklander OPB; Wood MJA; El-Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248
Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models
Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(6):e12238
Identification of storage conditions stabilizing extracellular vesicles preparations
Gorgens A; Corso G; Hagey DW; Wiklander RJ; Gustafsson MO; Felldin U; Lee Y; Bostancioglu RB; Sork H; Liang X; Zheng W; Mohammad DK; van DWSI; Vader P; Zickler AM; Mamand DR; Ma L; Holme MN; Stevens MM; Wiklander OPB; El Andaloussi S
Article: PHARMACEUTICS. 2021;14(1):38
Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin
Lennaard AJ; Mamand DR; Wiklander RJ; EL Andaloussi S; Wiklander OPB
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: BIOMEDICINES. 2021;9(8):1046
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: BIOMATERIALS. 2021;266:120435
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceica M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mager I; Gorgens A; Lundin P; Musaro A; Wood MJA; Andaloussi SEL; Roberts TC
Article: ACTA ONCOLOGICA. 2020;59(11):1382-1387
Efficacy and safety of cyclin dependent kinases 4/6 inhibitors in the treatment of metastatic breast cancer: a real-world experience
Kessler LE; Wiklander O; Hamberg E; Bergh J; Foukakis T; Matikas A
Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2020;18:880-892
Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice
Berger E; Colosetti P; Jalabert A; Meugnier E; Wiklander OPB; Jouhet J; Errazurig-Cerda E; Chanon S; Gupta D; Rautureau GJP; Geloen A; El-Andaloussi S; Panthu B; Rieusset J; Rome S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging
Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: DIABETES. 2019;68(3):515-526
Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle
Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043
Systematic characterization of extracellular vesicles sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging
Corso G; Heusermann W; Trojer D; Goergens A; Steib E; Voshol J; Graff A; Genoud C; Lee Y; Hean J; Nordin JZ; Wiklander OPB; El Andaloussi S; Meisner-Kober N
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity
Saher O; Rocha CSJ; Zaghioul EM; Wiklander OPB; Zamolo S; Heitz M; Ezzat K; Gupta D; Reymond J-L; Zain R; Hollfelder F; Darbre T; Lundin KE; El Andaloussi S; Smith CIE
Article: SCIENTIFIC REPORTS. 2018;8(1):10813
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtio J; Wood MJA; Mager I; El Andaloussi S
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures
Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Bjornstedt M; Giebel B; Nordin JZ; Jones JC; EL Andaloussi S; Goergens A
Article: DIABETOLOGIA. 2016;59(5):1049-1058
Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice
Jalabert A; Vial G; Guay C; Wiklander OPB; Nordin JZ; Aswad H; Forterre A; Meugnier E; Pesenti S; Regazzi R; Danty-Berger E; Ducreux S; Vidal H; El-Andaloussi S; Rieusset J; Rome S
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2016;5(3):e290
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Sork H; Nordin JZ; Turunen JJ; Wiklander OPB; Bestas B; Zaghloul EM; Margus H; Padari K; Duru AD; Corso G; Bost J; Vader P; Pooga M; Smith CIE; Wood MJA; Schiffelers RM; Hallbrink M; Andaloussi SEL
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Haegglund H; Mattsson M; Lentio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2015;82:186-193
RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form
Rocha CSJ; Wiklander OPB; Larsson L; Moreno PMD; Parini P; Lundin KE; Smith CIE
Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin JZ; Lee Y; Vader P; Maeger I; Johansson HJ; Heusermann W; Wiklander OPB; Hallbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtio J; Smith CIE; Wood MJA; Andaloussi SEL
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles.
Li J; Lee Y; Johansson HJ; Mäger I; Vader P; Nordin JZ; Wiklander OPB; Lehtiö J; Wood MJA; Andaloussi SE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.
Wiklander OPB; Nordin JZ; O'Loughlin A; Gustafsson Y; Corso G; Mäger I; Vader P; Lee Y; Sork H; Seow Y; Heldring N; Alvarez-Erviti L; Smith CIE; Le Blanc K; Macchiarini P; Jungebluth P; Wood MJA; Andaloussi SE
Journal article: RESPIRATION. 2015;90(6):481-492
Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute Respiratory Distress Syndrome (Retracted Article)
Jungebluth P; Holzgraefe B; Lim ML; Duru AD; Lundin V; Heldring N; Wiklander OPB; Nordin JZ; Chrobok M; Roderburg C; Sjoqvist S; Anderstam B; Rodriguez AB; Haag JC; Gustafsson Y; Roddewig KG; Jones P; Wood MJA; Luedde T; Teixeira AI; Hermanson O; Winqvist O; Kalzen H; El Andaloussi S; Alici E; Macchiarini P
Article: MOVEMENT DISORDERS. 2014;29(12):1476-1485
Systemic Exosomal siRNA Delivery Reduced Alpha-Synuclein Aggregates in Brains of Transgenic Mice
Cooper JM; Wiklander PBO; Nordin JZ; Al-Shawi R; Wood MJ; Vithlani M; Schapira AHV; Simons JP; El-Andaloussi S; Alvarez-Erviti L
Article: DIABETOLOGIA. 2014;57(10):2155-2164
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice
Aswad H; Forterre A; Wiklander OPB; Vial G; Danty-Berger E; Jalabert A; Lamaziere A; Meugnier E; Pesenti S; Ott C; Chikh K; El-Andaloussi S; Vidal H; Lefai E; Rieusset J; Rome S
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(1):e140
Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression
Stenler S; Wiklander OPB; Badal-Tejedor M; Turunen J; Nordin JZ; Hallengard D; Wahren B; Andaloussi SEL; Rutland MW; Smith CIE; Lundin KE; Blomberg P
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Preprint: BIORXIV. 2024
Histones are exosome membrane proteins regulated by cell stress
Singh B; Sundbom MF; Muthukrishnan U; Natarajan B; Stransky S; Görgens A; Nordin J; Wiklander O; Sandblad L; Sidoli S; Andaloussi SEL; Haney M; Gilthorpe J
Preprint: RESEARCH SQUARE. 2023
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: BIORXIV. 2023
Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles
Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery
Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023
Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles
Zickler A; Liang X; Gupta D; Mamand D; Luca MD; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy O; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander O; Görgens A; Nordin J; Castilla-Llorente V; Andaloussi SEL
Other: RESPIRATION. 2023;102(5):402-404
Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute Respiratory Distress Syndrome (Retraction of Vol 90, Pg 481, 2015)
Jungebluth P; Holzgraefe B; Lim ML; Duru AD; Lundin V; Heldring N; Wiklander OPB; Nordin JZ; Chrobok M; Roderburg C; Sjoqvist S; Anderstam B; Rodriguez AB; C. Haag J; Gustafsson Y; Roddewig KG; Jones P; Wood MJA; Luedde T; Teixeira AI; Hermanson O; Winqvist O; Kalzen H; El Andaloussi S; Alici E; Macchiarini P
Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):s950
Improved proteome coverage for cancer plasma-derived extracellular vesicles (pEVs) using high-resolution isoelectric focusing (HiRIEF) LC-MS
Sharma N; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; Andaloussi S; Pernemalm M; Eriksson H
Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333
Antibody Displaying Extracellular Vesicles (Fc-EVs) for Delivery of Tumor Targeted Therapeutics
Wiklander OPB; Jawad R; Mamand DR; Sharma H; Liang X; Gupta D; Bost J; Zickler AM; Zheng W; Nordin JZ; Gorgens A; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):220
Albumin-Decorated Exosomes Demonstrate Extended Circulation Time In Vivo
Liang X; Gupta D; Galli V; Zheng W; Davies C; Hean J; Kyriakopoulou E; Yang X; de Andres J; Mamand DR; Amin R; Niu Z; Jawad R; Wiklander O; Zickler A; Gustafsson M; Gorgens A; Nordin JZ; EL Andaloussi S
Preprint: BIORXIV. 2020
Engineering of extracellular vesicles for display of protein biotherapeutics
Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balsu S; Felldin U; Bostancioglu B; Fiona Lee YX; Hean J; Mäger I; Roberts T; Gustafsson M; Mohammad D; Sork H; Bäcklund A; Edvard Smith CI; Wood MJA; Vandenbroucke R; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2020
Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
Conceição M; Forcina L; Wiklander O; Gupta D; Nordin J; McClorey G; Mäger I; Görgens A; Lundin P; Musarò A; Wood M; Andaloussi SEL; Roberts T
Review: AUTOIMMUNITY REVIEWS. 2019;18(6):615-620
G-CSF-induced aortitis: Two cases and review of the literature
Parodis I; Dani L; Notarnicola A; Martenhed G; Fernstrom P; Matikas A; Wiklander OPB
Review: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(492):eaav8521
Advances in therapeutic applications of extracellular vesicles
Wiklander OPB; Brennan MA; Lotval J; Breakefield XO; EL Andaloussi S
Thesis / dissertation: 2017
Therapeutic potential of extracellular vesicles
Wiklander, Oscar
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845
In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome (vol 4, pg 1199, 2015)
Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Conference publication: TRANSPLANTATION. 2016;100(7):S861
Comparison of three transplantation techniques in a mouse model of hepatocyte transplantation
Jorns C; Watanabe M; Kannisto K; Wiklander O; Zemack H; Strom S; Ericzon B-G; Ellis E
Conference publication: HUMAN GENE THERAPY. 2012;23(10):A144-A145
On small minicircles: effect on coiling and function when approaching the sterical limits
Stenler S; Wiklander O; Tejedor MB; Hallengard D; Wahren B; Rutland MW; Smith CIE; Lundin KE; Blomberg P

Forskningsbidrag

Exosome-based liquid biopsy and targeted therapy
Cancerfonden
1 January 2024 - 31 December 2026
Exosome-based Precision Medicine
Swedish Research Council
1 January 2023 - 31 December 2025

Anställningar

Biträdande Lektor, Laboratoriemedicin, Karolinska Institutet, 2024-2030
Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2023-2026

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2018
Läkarexamen, Karolinska Institutet, 2012

Artiklar

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Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI