Oscar Wiklander

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471

Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting.

Mamand DR; Bazaz S; Mohammad DK; Liang X; Pavlova S; Mim C; Gabrielsson S; Nordin JZ; Wiklander OPB; Abedi-Valugerdi M; El-Andaloussi S
Article: NATURE BIOMEDICAL ENGINEERING. 2024;:1-16

Antibody-displaying extracellular vesicles for targeted cancer therapy.

Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaárd AJ; Abedi-Valugerdi M; Mäger I; Alici E; Sezgin E; Nordin JZ; Gupta D; Görgens A; El Andaloussi S
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;129:111584

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase.

Mamand DR; Bazaz S; Mohammad DK; Saher O; Wiklander OPB; Sadeghi B; Hassan M; El-Andaloussi S; Abedi-Valugerdi M
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(2):e12404

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

Welsh JA; Goberdhan DCI; O'Driscoll L; Buzas EI; Blenkiron C; Bussolati B; Cai H; Di Vizio D; Driedonks TAP; Erdbrügger U; Falcon-Perez JM; Fu Q-L; Hill AF; Lenassi M; Lim SK; Mahoney MG; Mohanty S; Möller A; Nieuwland R; Ochiya T; Sahoo S; Torrecilhas AC; Zheng L; Zijlstra A; Abuelreich S; Bagabas R; Bergese P; Bridges EM; Brucale M; Burger D; Carney RP; Cocucci E; Crescitelli R; Hanser E; Harris AL; Haughey NJ; Hendrix A; Ivanov AR; Jovanovic-Talisman T; Kruh-Garcia NA; Ku'ulei-Lyn Faustino V; Kyburz D; Lässer C; Lennon KM; Lötvall J; Maddox AL; Martens-Uzunova ES; Mizenko RR; Newman LA; Ridolfi A; Rohde E; Rojalin T; Rowland A; Saftics A; Sandau US; Saugstad JA; Shekari F; Swift S; Ter-Ovanesyan D; Tosar JP; Useckaite Z; Valle F; Varga Z; van der Pol E; van Herwijnen MJC; Wauben MHM; Wehman AM; Williams S; Zendrini A; Zimmerman AJ; MISEV Consortium; Théry C; Witwer KW
Article: NATURE COMMUNICATIONS. 2023;14(1):4734

Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles.

Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost JP; Görgens A; Zhao Y; Mamand DR; Liang X; Wiklander OPB; Lehto T; Gupta D; Nordin JZ; El Andaloussi S
Journal article: EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS. 2023;4(2):170-190

Biodistribution of therapeutic extracellular vesicles

Gupta D; Wiklander OPB; Wood MJA; El-Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models.

Liang X; Niu Z; Galli V; Howe N; Zhao Y; Wiklander OPB; Zheng W; Wiklander RJ; Corso G; Davies C; Hean J; Kyriakopoulou E; Mamand DR; Amin R; Nordin JZ; Gupta D; Andaloussi SE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(6):e12238

Identification of storage conditions stabilizing extracellular vesicles preparations.

Görgens A; Corso G; Hagey DW; Jawad Wiklander R; Gustafsson MO; Felldin U; Lee Y; Bostancioglu RB; Sork H; Liang X; Zheng W; Mohammad DK; van de Wakker SI; Vader P; Zickler AM; Mamand DR; Ma L; Holme MN; Stevens MM; Wiklander OPB; El Andaloussi S
Article: PHARMACEUTICS. 2021;14(1):38

Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin.

Lennaárd AJ; Mamand DR; Wiklander RJ; El Andaloussi S; Wiklander OPB
Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles.

Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balusu S; Feldin U; Bostancioglu B; Jawad R; Mamand DR; Lee YXF; Hean J; Mäger I; Roberts TC; Gustafsson M; Mohammad DK; Sork H; Backlund A; Lundin P; de Fougerolles A; Smith CIE; Wood MJA; Vandenbroucke RE; Nordin JZ; El-Andaloussi S
Article: BIOMEDICINES. 2021;9(8):1046

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo.

Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hällbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; Andaloussi SE; Lehto T
Article: BIOMATERIALS. 2021;266:120435

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle.

Conceição M; Forcina L; Wiklander OPB; Gupta D; Nordin JZ; Vrellaku B; McClorey G; Mäger I; Gӧrgens A; Lundin P; Musarò A; Wood MJA; Andaloussi SE; Roberts TC
Article: ACTA ONCOLOGICA. 2020;59(11):1382-1387

Efficacy and safety of cyclin dependent kinases 4/6 inhibitors in the treatment of metastatic breast cancer: a real-world experience.

Edman Kessler L; Wiklander O; Hamberg E; Bergh J; Foukakis T; Matikas A
Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2020;18:880-892

Use of Nanovesicles from Orange Juice to Reverse Diet-Induced Gut Modifications in Diet-Induced Obese Mice.

Berger E; Colosetti P; Jalabert A; Meugnier E; Wiklander OPB; Jouhet J; Errazurig-Cerda E; Chanon S; Gupta D; Rautureau GJP; Geloen A; El-Andaloussi S; Panthu B; Rieusset J; Rome S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging.

Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Görgens A; Nordin JZ; El Andaloussi S
Article: DIABETES. 2019;68(3):515-526

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.

Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging.

Corso G; Heusermann W; Trojer D; Görgens A; Steib E; Voshol J; Graff A; Genoud C; Lee Y; Hean J; Nordin JZ; Wiklander OPB; El Andaloussi S; Meisner-Kober N
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.

Saher O; Rocha CSJ; Zaghloul EM; Wiklander OPB; Zamolo S; Heitz M; Ezzat K; Gupta D; Reymond J-L; Zain R; Hollfelder F; Darbre T; Lundin KE; El Andaloussi S; Smith CIE
Article: SCIENTIFIC REPORTS. 2018;8(1):10813

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome.

Sork H; Corso G; Krjutskov K; Johansson HJ; Nordin JZ; Wiklander OPB; Lee YXF; Westholm JO; Lehtiö J; Wood MJA; Mäger I; El Andaloussi S
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures.

Wiklander OPB; Bostancioglu RB; Welsh JA; Zickler AM; Murke F; Corso G; Felldin U; Hagey DW; Evertsson B; Liang X-M; Gustafsson MO; Mohammad DK; Wiek C; Hanenberg H; Bremer M; Gupta D; Björnstedt M; Giebel B; Nordin JZ; Jones JC; El Andaloussi S; Görgens A
Article: DIABETOLOGIA. 2016;59(5):1049-1058

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice.

Jalabert A; Vial G; Guay C; Wiklander OPB; Nordin JZ; Aswad H; Forterre A; Meugnier E; Pesenti S; Regazzi R; Danty-Berger E; Ducreux S; Vidal H; El-Andaloussi S; Rieusset J; Rome S
Article: MOLECULAR THERAPY-NUCLEIC ACIDS. 2016;5(3):e290

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.

Sork H; Nordin JZ; Turunen JJ; Wiklander OP; Bestas B; Zaghloul EM; Margus H; Padari K; Duru AD; Corso G; Bost J; Vader P; Pooga M; Smith CE; Wood MJ; Schiffelers RM; Hällbrink M; Andaloussi SE
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalén M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hägglund H; Mattsson M; Lehtiö J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2015;82:186-193

RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form.

Rocha CSJ; Wiklander OPB; Larsson L; Moreno PMD; Parini P; Lundin KE; Smith CIE
Article: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE. 2015;11(4):879-883

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties.

Nordin JZ; Lee Y; Vader P; Mäger I; Johansson HJ; Heusermann W; Wiklander OPB; Hällbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtiö J; Smith CIE; Wood MJA; El Andaloussi S
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883

Serum-free culture alters the quantity and protein composition of neuroblastoma-derived extracellular vesicles.

Li J; Lee Y; Johansson HJ; Mäger I; Vader P; Nordin JZ; Wiklander OPB; Lehtiö J; Wood MJA; Andaloussi SE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.

Wiklander OPB; Nordin JZ; O'Loughlin A; Gustafsson Y; Corso G; Mäger I; Vader P; Lee Y; Sork H; Seow Y; Heldring N; Alvarez-Erviti L; Smith CIE; Le Blanc K; Macchiarini P; Jungebluth P; Wood MJA; Andaloussi SE
Journal article: RESPIRATION. 2015;90(6):481-492

Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute Respiratory Distress Syndrome.

Jungebluth P; Holzgraefe B; Lim ML; Duru AD; Lundin V; Heldring N; Wiklander OPB; Nordin JZ; Chrobok M; Roderburg C; Sjöqvist S; Anderstam B; Beltrán Rodríguez A; Haag JC; Gustafsson Y; Roddewig KG; Jones P; Wood MJA; Luedde T; Teixeira AI; Hermanson O; Winqvist O; Kalzén H; El Andaloussi S; Alici E; Macchiarini P
Article: MOVEMENT DISORDERS. 2014;29(12):1476-1485

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.

Cooper JM; Wiklander PBO; Nordin JZ; Al-Shawi R; Wood MJ; Vithlani M; Schapira AHV; Simons JP; El-Andaloussi S; Alvarez-Erviti L
Article: DIABETOLOGIA. 2014;57(10):2155-2164

Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.

Aswad H; Forterre A; Wiklander OPB; Vial G; Danty-Berger E; Jalabert A; Lamazière A; Meugnier E; Pesenti S; Ott C; Chikh K; El-Andaloussi S; Vidal H; Lefai E; Rieusset J; Rome S
Article: MOLECULAR THERAPY-NUCLEIC ACIDS. 2014;2(1):e140

Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression.

Stenler S; Wiklander OP; Badal-Tejedor M; Turunen J; Nordin JZ; Hallengärd D; Wahren B; Andaloussi SE; Rutland MW; Smith CIE; Lundin KE; Blomberg P
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2024

Exosomes are vehicles for the stress-regulated secretion of histones

Singh B; Sundbom MF; Muthukrishnan U; Natarajan B; Stransky S; Görgens A; Nordin J; Wiklander O; Sandblad L; Sidoli S; EL Andaloussi S; Haney M; Gilthorpe J
Preprint: RESEARCH SQUARE. 2023

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Liang X; Gupta D; Xie J; Wonterghem E; Hoecke L; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander R; He R; Mammad D; Bost J; Zhou G; Zhou H; Roudi S; Zickler A; Gorgens A; Hagey D; de Jong O; Uy A; Zong Y; Mager I; Perez C; Roberts T; Vader P; Fougerolles A; Wood M; Vandenbroucke R; Nordin J; El-Andaloussi S
Preprint: BIORXIV. 2023

Identification of Novel Scaffold Proteins for Improved Endogenous Engineering of Extracellular Vesicles

Zheng W; Rädler J; Sork H; Niu Z; Roudi S; Bost J; Görgens A; Zhao Y; Mamand D; Liang X; Wiklander O; Lehto T; Gupta D; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023

Multimodal engineering of extracellular vesicles for efficient intracellular protein delivery

Liang X; Gupta D; Xie J; Wonterghem EV; Hoecke LV; Hean J; Niu Z; Wiklander O; Zheng W; Wiklander RJ; He R; Mamand D; Bost J; Zhou G; Zhou H; Roudi S; Zickler AM; Gorgens A; Hagey D; de Jong O; Uy AG; Zong Y; Mager I; Perez CM; Roberts T; Vader P; Fougerolles AD; Wood M; Vandenbroucke R; Nordin J; EL Andaloussi S
Preprint: BIORXIV. 2023

Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles

Zickler A; Liang X; Gupta D; Mamand D; Luca MD; Corso G; Errichelli L; Hean J; Sen T; Elsharkasy O; Kamei N; Niu Z; Zhou G; Zhou H; Roudi S; Wiklander O; Görgens A; Nordin J; Castilla-Llorente V; Andaloussi SEL
Other: RESPIRATION. 2023;102(5):402-404

Retraction Statement.
Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):s950

Improved proteome coverage for cancer plasma-derived extracellular vesicles (pEVs) using high-resolution isoelectric focusing (HiRIEF) LC-MS

Sharma N; Mermelekas G; Lehtio J; Wiklander OPB; Gorgens A; Andaloussi S; Pernemalm M; Eriksson H
Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333

Antibody Displaying Extracellular Vesicles (Fc-EVs) for Delivery of Tumor Targeted Therapeutics

Wiklander OPB; Jawad R; Mamand DR; Sharma H; Liang X; Gupta D; Bost J; Zickler AM; Zheng W; Nordin JZ; Gorgens A; Andaloussi SEL
Conference publication: MOLECULAR THERAPY. 2021;29(4):220

Albumin-Decorated Exosomes Demonstrate Extended Circulation Time In Vivo

Liang X; Gupta D; Galli V; Zheng W; Davies C; Hean J; Kyriakopoulou E; Yang X; de Andres J; Mamand DR; Amin R; Niu Z; Jawad R; Wiklander O; Zickler A; Gustafsson M; Gorgens A; Nordin JZ; EL Andaloussi S
Preprint: BIORXIV. 2020

Engineering of extracellular vesicles for display of protein biotherapeutics

Gupta D; Wiklander OPB; Görgens A; Conceição M; Corso G; Liang X; Seow Y; Balsu S; Felldin U; Bostancioglu B; Fiona Lee YX; Hean J; Mäger I; Roberts T; Gustafsson M; Mohammad D; Sork H; Bäcklund A; Edvard Smith CI; Wood MJA; Vandenbroucke R; Nordin J; Andaloussi SEL
Preprint: BIORXIV. 2020

Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle

Conceição M; Forcina L; Wiklander O; Gupta D; Nordin J; McClorey G; Mäger I; Görgens A; Lundin P; Musarò A; Wood M; Andaloussi SEL; Roberts T
Review: AUTOIMMUNITY REVIEWS. 2019;18(6):615-620

G-CSF-induced aortitis: Two cases and review of the literature.

Parodis I; Dani L; Notarnicola A; Martenhed G; Fernström P; Matikas A; Wiklander OPB
Review: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(492):eaav8521

Advances in therapeutic applications of extracellular vesicles.

Wiklander OPB; Brennan MÁ; Lötvall J; Breakefield XO; El Andaloussi S
Thesis / dissertation: 2017

Therapeutic potential of extracellular vesicles

Wiklander, Oscar
Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845

In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome.

Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalén M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hägglund H; Mattsson M; Lehtiö J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K
Conference publication: TRANSPLANTATION. 2016;100(7):S861

Comparison of three transplantation techniques in a mouse model of hepatocyte transplantation

Jorns C; Watanabe M; Kannisto K; Wiklander O; Zemack H; Strom S; Ericzon B-G; Ellis E
Conference publication: HUMAN GENE THERAPY. 2012;23(10):A144-A145

On small minicircles: effect on coiling and function when approaching the sterical limits

Stenler S; Wiklander O; Tejedor MB; Hallengard D; Wahren B; Rutland MW; Smith CIE; Lundin KE; Blomberg P

Forskningsbidrag

Exosome-based liquid biopsy and targeted therapy

Cancerfonden

1 January 2024 - 31 December 2026
Exosome-based Precision Medicine

Swedish Research Council

1 January 2023 - 31 December 2025

Anställningar

Biträdande Lektor, Laboratoriemedicin, Karolinska Institutet, 2024-2030
Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2023-2026

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2018
Läkarexamen, Karolinska Institutet, 2012

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI