Oscar Wiklander
Affiliated to Research | Assistant Professor
E-mail: oscar.wiklander@ki.se
Visiting address: Alfred Nobels Allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 BCM Wiklander, 171 77 Stockholm
About me
- Dr. Wiklander received his PhD in 2017 at KI shortly after receiving his certificate as a medical doctor (leg. läk) following funding as a MD/PhD-student (forskar-AT). He then continued as a resident in oncology (ST-läk) in parallel with conducting his post-doctoral studies until 2023 and 2022, respectively. He divides his time between clinical work and is currently a specialist physician in oncology at Karolinska University Hospital, Theme Cancer, and a team leader with focus on extracellular vesicles in cancer settings, at the department of Laboratory Medicine, KI.
Research
- Research area/interest: Extracellular vesicle-based precision medicine in cancer. Extracellular vesicles (EVs) are a heterogenous group of lipid-bilayer nanovesicles that are secreted by all cells and can be found in all body fluids. These natural nanovesicles range in size from 30-2, 000 nm in diameter and can impact both neighbouring cells or cells at distance. EVs contain lipids, proteins, and nucleic acid species from the source cell, and have the unique ability to convey these macromolecules via an advanced system of intercellular communication. EVs can be seen as a fingerprint of its source cell, reflecting its status and content, and are thus studied as potential biomarkers of various diseases, with particular focus on cancer. The main focus of Dr. Wiklander's research team is to utilize EVs as 1) therapeutic vehicles for advance cancer therapeutics and 2) investigate tumor-derived EVs as potential liquid biopsies for improved diagnostics in cancer settings.
Articles
- Journal article: ADVANCED SCIENCE. 2024;11(42):e2407619
- Journal article: JOURNAL OF PROTEOME RESEARCH. 2024;23(9):4114-4127
- Article: JOURNAL OF EXTRACELLULAR BIOLOGY. 2024;3(9):1-16
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(7):e12471
- Article: NATURE BIOMEDICAL ENGINEERING. 2024;:1-16
- Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;129:111584
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2024;13(2):e12404
- Article: NATURE COMMUNICATIONS. 2023;14(1):4734
- Journal article: EXTRACELLULAR VESICLES AND CIRCULATING NUCLEIC ACIDS. 2023;4(2):170-90
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(7):e12248
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2022;11(6):e12238
- Article: PHARMACEUTICS. 2021;14(1):38
- Article: NATURE BIOMEDICAL ENGINEERING. 2021;5(9):1084-1098
- Article: BIOMATERIALS. 2021;266:120435
- Article: ACTA ONCOLOGICA. 2020;59(11):1382-1387
- Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2020;18:880-892
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222
- Article: DIABETES. 2019;68(3):515-526
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2019;8(1):1663043
- Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40
- Article: SCIENTIFIC REPORTS. 2018;8(1):10813
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1326
- Article: DIABETOLOGIA. 2016;59(5):1049-1058
- Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2016;5(3):e290
- Article: STEM CELLS TRANSLATIONAL MEDICINE. 2015;4(10):1199-1213
- Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2015;82:186-193
- Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26883
- Article: JOURNAL OF EXTRACELLULAR VESICLES. 2015;4:26316
- Journal article: RESPIRATION. 2015;90(6):481-492
- Article: MOVEMENT DISORDERS. 2014;29(12):1476-1485
- Article: DIABETOLOGIA. 2014;57(10):2155-2164
- Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2014;3(1):e140
- Show more
All other publications
- Preprint: BIORXIV. 2024
- Preprint: RESEARCH SQUARE. 2023
- Preprint: BIORXIV. 2023
- Other: RESPIRATION. 2023;102(5):402-404
- Conference publication: ANNALS OF ONCOLOGY. 2022;33(7):s950
- Conference publication: MOLECULAR THERAPY. 2021;29(4):332-333
- Conference publication: MOLECULAR THERAPY. 2021;29(4):220
- Preprint: BIORXIV. 2020
- Review: AUTOIMMUNITY REVIEWS. 2019;18(6):615-620
- Review: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(492):eaav8521
- Thesis / dissertation: 2017
- Corrigendum: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(6):845
- Conference publication: TRANSPLANTATION. 2016;100(7):S861
- Conference publication: HUMAN GENE THERAPY. 2012;23(10):A144-A145
Grants
- The Swedish Cancer Society1 January 2024 - 31 December 2026
Employments
- Assistant Professor, Department of Laboratory Medicine, Karolinska Institutet, 2024-2030
- Affiliated to Research, Department of Laboratory Medicine, Karolinska Institutet, 2023-2026
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2018
- University Medical Degree, Karolinska Institutet, 2012