Osama Saher

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2024;129:111584

Tumor cell derived osteopontin and prostaglandin E2 synergistically promote the expansion of myeloid derived suppressor cells during the tumor immune escape phase

Mamand DR; Bazaz S; Mohammad DK; Saher O; Wiklander OPB; Sadeghi B; Hassan M; EL-Andaloussi S; Abedi-Valugerdi M
Article: SCIENCE ADVANCES. 2023;9(35):eadh1168

The cellular response to extracellular vesicles is dependent on their cell source and dose

Hagey DW; Ojansivu M; Bostancioglu BR; Saher O; Bost JP; Gustafsson MO; Gramignoli R; Svahn M; Gupta D; Stevens MM; Goergens A; EL Andaloussi S
Article: NUCLEIC ACID THERAPEUTICS. 2023;33(2):117-131

Chemical Modifications and Design Influence the Potency of Huntingtin Antigene Oligonucleotides

Saher O; Zaghloul EMM; Umek T; Hagey DWW; Mozafari N; Danielsen MBB; Gouda ASS; Lundin KEE; Jorgensen PTT; Wengel J; Smith CIE; Zain R
Article: ADVANCED HEALTHCARE MATERIALS. 2022;11(5):e2101658

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles

Bost JP; Saher O; Hagey D; Mamand DR; Liang X; Zheng W; Corso G; Gustafsson O; Gorgens A; Smith CIE; Zain R; El Andaloussi S; Gupta D
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):185

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

Bost JP; Ojansivu M; Munson MJ; Wesen E; Gallud A; Gupta D; Gustafsson O; Saher O; Radler J; Higgins SG; Lehto T; Holme MN; Dahlen A; Engkvist O; Stromstedt P-E; Andersson S; Smith CIE; Stevens MM; Esbjorner EK; Collen A; El Andaloussi S
Article: NUCLEIC ACID THERAPEUTICS. 2021;31(6):443-456

Oligonucleotides Targeting DNA Repeats Downregulate Huntingtin Gene Expression in Huntington's Patient-Derived Neural Model System

Umek T; Olsson T; Gissberg O; Saher O; Zaghloul EM; Lundin KE; Wengel J; Hanse E; Zetterberg H; Vizlin-Hodzic D; Smith CIE; Zain R
Article: BIOMEDICINES. 2021;9(8):1046

Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo

Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: PHARMACEUTICS. 2021;13(1):116

Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

Daralnakhla H; Saher O; Zamolo S; Bazaz S; P. Bost J; Heitz M; Lundin KE; El Andaloussi S; Darbre T; Reymond J-L; Zain R; Smith CIE
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2020;9(1):1800222

Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging

Gupta D; Liang X; Pavlova S; Wiklander OPB; Corso G; Zhao Y; Saher O; Bost J; Zickler AM; Piffko A; Maire CL; Ricklefs FL; Gustafsson O; Llorente VC; Gustafsson MO; Bostancioglu RB; Mamand DR; Hagey DW; Goergens A; Nordin JZ; EL Andaloussi S
Article: BLOOD ADVANCES. 2020;4(11):2439-2450

Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects

Estupinan HY; Bouderlique T; He C; Berglof A; Gupta D; Saher O; Daza Cruz MA; Pena-Perez L; Yu L; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: PHARMACEUTICS. 2019;11(12):E666-666

Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations

Saher O; Lehto T; Gissberg O; Gupta D; Gustafsson O; EL Andaloussi S; Darbre T; Lundin KE; Smith CIE; Zain R
Article: NATURE COMMUNICATIONS. 2019;10(1):2331

The viral protein corona directs viral pathogenesis and amyloid aggregation

Ezzat K; Pernemalm M; Palsson S; Roberts TC; Jarver P; Dondalska A; Bestas B; Sobkowiak MJ; Levanen B; Skold M; Thompson EA; Saher O; Kari OK; Lajunen T; Ekstrom ES; Nilsson C; Ishchenko Y; Malm T; Wood MJA; Power UF; Masich S; Linden A; Sandberg JK; Lehtio J; Spetz A-L; EL Andaloussi S
Article: MOLECULES. 2019;24(6):E1180-1180

Oligonucleotide-Palladacycle Conjugates as Splice-Correcting Agents

Hande M; Saher O; Lundin KE; Smith CIE; Zain R; Lonnberg T
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;132:29-40

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity

Saher O; Rocha CSJ; Zaghioul EM; Wiklander OPB; Zamolo S; Heitz M; Ezzat K; Gupta D; Reymond J-L; Zain R; Hollfelder F; Darbre T; Lundin KE; El Andaloussi S; Smith CIE

Alla övriga publikationer

Thesis / dissertation: 2021

Pharmaceutical insights into improving oligonucleotide delivery and efficacy

Saher, Osama

Anställningar

Postdoktor, Laboratoriemedicin, Karolinska Institutet, 2022-2025

Examina och utbildning

Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2021

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI