Onur Dagliyan

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Background
Dr. Onur Dagliyan is a group leader with a background in biophysics, bioengineering, neurobiology, and cancer biology. Dr. Dagliyan aims to bridge spatiotemporal scales from protein dynamics to cellular circuits in order to understand cellular plasticity in health and disease. A cornerstone of Dr. Dagliyan’s research is the development of the concept of extrinsic order and disorder in proteins, a framework that elucidates how cellular signals regulate order-to-disorder and disorder-to-order transitions in protein organization and function. Dr. Dagliyan has created platforms that leverage these extrinsic order/disorder mechanisms to control protein conformations with light or small molecules in vivo. By applying these concepts, his research group at the Karolinska Institute aims to reveal the fundamental mechanisms of neuroplasticity underlying learning and memory and cancer cell plasticity underlying drug-acquired resistance.

Education & Training
Research fellow in the laboratory of Michael Greenberg, Harvard Medical School, Boston, USA. Specialization: Molecular neurobiology
Ph.D. in Biochemistry and Biophysics, UNC School of Medicine, Chapel Hill, USA. Specialization: Protein signaling and engineering
B.S. and M.S. in Chemical and Biological Engineering, Koç University, Istanbul. Specialization: Machine learning, drug screening, molecular clock

Grants&Awards:
European Research Council (ERC) starting grant
Swedish Research Council (Vetenskapsrådet) Svenska Sällskapet för Medicinsk Forskning (SSMF) starting grant
Knut and Alice Wallenberg (KAW) Foundation Research grant with Patrik Ernfors and Håkan Olausson
The Swedish Brain Foundation (Hjärnfonden) research grant
Stiftelsen för Strategisk Forskning (SSF) research grant with Jimin Park
The Strategic Research Area Neuroscience (StratNeuro) starting grant
The Strategic Research Area Neuroscience (StratNeuro) technology grant
Karolinska Institutet Allocation Grant
Goldenson Fellow 2020, Harvard University
William Randolph Hearst Fund 2019-2020, Harvard University
Alice and Joseph Brooks Postdoctoral Fellowship 2017-2018, Harvard University
Advanced imaging certificate from Max Planck Institute of Neuroscience 2017
UNC Lineberger Graduate Fellow of the Year 2014
Howard Hughes Medical Institute Predoctoral Fellowship 2012-2015
National Science Foundation- Materials Computation Center Travel Award 2012
Director’s Award from the Biological and Biomedical Sciences Program, UNC 2010

Academic Merits:
-Chairperson of the Faculty for Department of Medical Biochemistry and Biophysics, Karolinska Institute
-Board and committee memberships: Swedish Society of Neuroscience (SSFN) board member, Karolinska MBB Prefekt (Chair) selection committee,        Karolinska MBB faculty recruitment committee member
-Leadership courses completed: Doctoral supervision course,  Pedagogy course, EMBO leadership course
-Reviewer for Journals: Nature Communications; Nucleic Acid Research; PLoS Computational Biology; and others.
-Reviewer for grants: University of Gothenburg KAW nomination candidate reviewer Swiss National Science Foundation grant reviewer, Karolinska       Institute Fonden reviewer

Current Interest: Molecular neurobiology, neuroplasticity, cancer biology, protein engineering, biosensors, molecular optogenetics, extrinsic order and disorder

Teacher, "Basic Science 2: Cell Biology, Digestion and Metabolism", Karolinska  Institutet, 2022-present
Lecturer, “Neuronal circuits for appetite, food intake and satiety“, Karolinska  Institutet, 2022-present
Lecturer, “Protein Structure and Dynamics“, Karolinska Institutet, 2022-present
Lecturer, “Nucleic Acid Structure and Dynamics“, Karolinska Institutet, 2022-present

Lecturer, "Lipid Lab", Karolinska Institute, 2025-present

Lecturer, “Introduction to biochemistry: Metabolism“, Karolinska  Institutet, 2022
Teaching assistant, Macromolecular Equilibria course, 2012
Teaching assistant, Chemical and Biological Engineering Senior Project course, 2009
Teaching assistant, Process Design course, 2008