Niklas Björkström
Professor/Specialistläkare | Docent
E-postadress: niklas.bjorkstrom@ki.se
Telefon: +46852482912
Besöksadress: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postadress: H7 Medicin, Huddinge, H7 CIM Björkström, 171 77 Stockholm
Om mig
- 2010, MD, Karolinska Institutet, Sweden
2011, PhD, Karolinska Institutet, Sweden
2011-2012, Postdoctoral Fellow, VRC, NIH, USA
2013, Swedish Medical License, Karolinska University Hospital, Sweden
2016, Associate Professor in Immunology, Karolinska Institutet, Sweden
Forskningsbeskrivning
- Jag leder en forskargrupp inom Institutionen för medicin i Huddinge, i vilken vi bedriver translationella immunologiska studier på naturliga mördarceller (NK-celler) och andra lymfocyter i livmoder och lever. Fokus för vår forskning är att förstå biologin och funktionen hos dessa celler.
Vi karakteriserar proteiner som är viktiga för cellernas funktion, bland annat KIR-receptorer på NK-cellernas yta i livmoderns slemhinna, och försöker förstå hur dessa är involverade i att styra utgången av graviditet.
Vår forskning på lever syftar till att studera NK-celler och vävnadspermanenta lymfocyters reglering och funktion, dels under normala förhållanden då deras uppgift är att bekämpa virus och cancer, dels under olika sjukdomstillstånd så som hepatitinfektioner, primär skleroserande kolangit (PSC), och icke-alkoholrelaterad fettlever (NASH). Dessa sjukdomar har inflammatoriska förlopp som medför en ökad risk för tumörutveckling. Vi använder den senaste teknologin inom flödescytometri och bildanalys för att studera cellernas fenotyp och funktion, samt hur de påverkas av tumörmikromiljöer.
Vi samarbetar bland annat med forskargrupper vid Centrum för Infektionsmedicin (CIM) vid KI, och har genom unika samarbeten med många av klinikerna inom Karolinska Universitetssjukhuset, kontinuerlig tillgång till patientmaterial att bedriva forskning på.
Utbildning
- 2010, MD, Karolinska Institutet, Sweden
- 2011, PhD, Karolinska Institutet, Sweden
- 2011-2012, Postdoctoral Fellow, VRC, NIH, USA
- 2013, Swedish Medical License, Karolinska University Hospital, Sweden
- 2016, Associate Professor in Immunology, Karolinska Institutet, Sweden
Artiklar
- Article: NATURE COMMUNICATIONS. 2024;15(1):7957
- Journal article: HEPATOLOGY. 2024
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
- Journal article: NATURE IMMUNOLOGY. 2024;25(8):1474-1488
- Journal article: NATURE IMMUNOLOGY. 2024;25(7):1126-1128
- Article: HEPATOLOGY. 2024;80(1):202-222
- Journal article: JHEP REPORTS. 2024;6(6):101074
- Article: SCIENCE IMMUNOLOGY. 2024;9(94):eadj7168
- Article: GASTROENTEROLOGY. 2024;166(4):667-679
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(2):e13336
- Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
- Article: PLOS ONE. 2024;19(5):e0294695
- Article: SCIENTIFIC REPORTS. 2023;13(1):22590
- Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2023;114(5):507-512
- Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;90(2):e13738
- Article: NATURE METABOLISM. 2023;5(7):1188-1203
- Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s229
- Article: RESPIRATORY RESEARCH. 2023;24(1):62
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2023;53(2):e2249990
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1130370
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1186097
- Article: FRONTIERS IN ONCOLOGY. 2023;13:1169537
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(3):441-452
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
- Article: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. 2022;10(5):465-476
- Article: HEPATOLOGY. 2022;75(5):1154-1168
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2022;192(4):629-641
- Article: CELL REPORTS. 2022;38(10):110503
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):472-483
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
- Article: MOLECULAR MEDICINE. 2022;28(1):20
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:856530
- Journal article: HPB. 2022;24:s455-s456
- Article: LAKARTIDNINGEN. 2021;118:21163
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
- Article: LIVER INTERNATIONAL. 2021;41(9):2046-2058
- Article: CURRENT OPINION IN VIROLOGY. 2021;49:176-182
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
- Article: CELLS. 2021;10(6):1369
- Article: CELL REPORTS MEDICINE. 2021;2(3):100220
- Article: MUCOSAL IMMUNOLOGY. 2021;14(2):357-365
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(582):eabb0036
- Article: SCIENCE IMMUNOLOGY. 2021;6(56):eabb7800
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2021;100(2):339-346
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
- Article: BMC GASTROENTEROLOGY. 2020;20(1):428
- Article: CELL. 2020;183(7):1946-1961.e15
- Article: GUT. 2020;69(12):2203-2213
- Article: HEPATOLOGY. 2020;72(4):1378-1393
- Article: CELL. 2020;183(1):158-168.e14
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
- Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2020;46(5):804-810
- Article: NATURE COMMUNICATIONS. 2020;11(1):2049
- Article: SCIENTIFIC REPORTS. 2020;10(1):2081
- Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:71-82
- Article: METHODS IN MOLECULAR BIOLOGY. 2020;2164:55-63
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224
- Article: JOURNAL OF IMMUNOLOGY. 2019;203(8):2210-2221
- Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9
- Article: NATURE COMMUNICATIONS. 2019;10(1):3897
- Article: CELL REPORTS. 2019;28(8):2124-2139.e6
- Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312
- Article: LIVER INTERNATIONAL. 2019;39(6):1098-1108
- Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):510-523
- Article: NATURE METABOLISM. 2019;1(4):445-459
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1255
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2692
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(12):1997-2004
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(9):1456-1469
- Article: JOURNAL OF HEPATOLOGY. 2018;69(3):584-593
- Article: GUT. 2018;67(8):1517-1524
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(8):1329-1335
- Article: NATURE COMMUNICATIONS. 2018;9(1):2275
- Article: JOURNAL OF INFECTIOUS DISEASES. 2018;217(10):1656-1666
- Article: JOURNAL OF HEPATOLOGY. 2018;68(3):421-430
- Article: PLOS GENETICS. 2018;14(1):e1007163
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
- Article: PLOS PATHOGENS. 2017;13(6):e1006462
- Article: MUCOSAL IMMUNOLOGY. 2017;10(2):322-331
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:765
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:525
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(9):2204-2210
- Article: ENDOSCOPY INTERNATIONAL OPEN. 2016;4(8):E901-E911
- Article: NATURE MEDICINE. 2016;22(6):614-623
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(7):E864-E873
- Article: HEPATOLOGY. 2015;62(4):1249-1259
- Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
- Article: PLOS PATHOGENS. 2014;10(11):e1004521
- Article: CLINICAL INFECTIOUS DISEASES. 2014;59(8):1130-1132
- Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(9):1362-1373
- Article: VACCINE. 2014;32(6):717-724
- Article: PLOS ONE. 2014;9(8):e105375
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901
- Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2013;48(6):719-728
- Article: PLOS PATHOGENS. 2013;9(3):e1003272
- Article: BLOOD. 2012;120(17):3455-3465
- Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205(9):1351-1362
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(2):447-457
- Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554
- Article: JOURNAL OF VIROLOGY. 2011;85(19):10252-10260
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2011;208(1):13-21
- Article: PLOS ONE. 2011;6(11):e27664
- Article: BLOOD. 2010;116(19):3853-3864
- Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500
- Article: GASTROENTEROLOGY. 2010;138(5):1885-1U68
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(2):378-387
- Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
- Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:335-352
- Article: JOURNAL OF IMMUNOLOGY. 2009;183(10):6612-6618
- Article: IMMUNOTHERAPY. 2009;1(5):753-764
- Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
- Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
- Article: CANCER RESEARCH. 2007;67(3):1317-1325
- Article: ARTHRITIS RESEARCH & THERAPY. 2007;9(5):r87
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Alla övriga publikationer
- Conference publication: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2023;102:65
- Review: JOURNAL OF HEPATOLOGY. 2022;77(6):1657-1669
- Letter: THE LANCET INFECTIOUS DISEASES. 2022;22(11):1538-1540
- Letter: THE LANCET INFECTIOUS DISEASES. 2022;22(10):1421-1422
- Review: NATURE REVIEWS IMMUNOLOGY. 2022;22(2):112-123
- Corrigendum: NATURE METABOLISM. 2021;3(2):287
- Review: FRONTIERS IN IMMUNOLOGY. 2020;11:571166
- Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2020;31(1):3-12
- Review: LIVER INTERNATIONAL. 2019;39(Suppl 1):63-78
- Corrigendum: NATURE METABOLISM. 2019;1(4):497
- Letter: JOURNAL OF INFECTIOUS DISEASES. 2018;218(11):1853-1854
- Other: CELL STRESS. 2018;2(8):216-218
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
- Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320
- Review: CLINICAL IMMUNOLOGY. 2016;163:52-59
- Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(7):2154-2157
- Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
- Review: IMMUNOLOGY. 2013;139(4):416-427
- Thesis / dissertation: 2011
- Review: TRENDS IN IMMUNOLOGY. 2010;31(11):401-406
- Published conference paper: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2008;57(10):1541-1552
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Anställningar
- Professor/Specialistläkare, Medicin, Huddinge, Karolinska Institutet, 2023-
Examina och utbildning
- Docent, Immunologi, Karolinska Institutet, 2016
- Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2011
- Läkarexamen, Karolinska Institutet, 2010
Handledare
- Christine Zimmer
- Lena Berglin