Nicole Marquardt
Senior Forskningsspecialist | Docent
E-postadress: nicole.marquardt@ki.se
Besöksadress: Blickagången 16, 14152 HUDDINGE
Postadress: H7 Medicin, Huddinge, H7 HERM Höglund Marquardt, 171 77 Stockholm
Artiklar
- Article: SCIENCE IMMUNOLOGY. 2025;10(109):eadq4881Niessl J; Mueller TR; Constantz C; Cai C; Nilsen V; Ballesteros OR; Adamo S; Kammann T; Mouchtaridi E; Gao Y; Akhirunnesa M; Raineri EJM; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Stellaccio T; Brownlie D; Ringqvist E; Flodstrom-Tullberg M; Llewellyn-Lacey S; Tibbitt C; Hammer Q; Michaelsson J; Price DA; Mjosberg J; Marquardt N; Sandberg JK; Sekine T; Jorns C; Buggert M
- Article: MICROORGANISMS. 2025;13(5):1077Danes NM; Brownlie D; Folkman R; Nordlander A; Blom K; Varnaite R; Niessl J; Lindsjo OK; Soderholm S; Akber M; Chen P; Buggert M; Brave A; Klingstrom J; Nowak P; Marquardt N; Sonden K; Blennow O; Gredmark-Russ S
- Article: GENES AND IMMUNITY. 2025;26(1):70-74Strunz B; Momayyezi P; Bilev E; Muvva JR; Chen P; Bister J; Schaffer M; Akber M; Cornillet M; Horowitz A; Malmberg K-J; Rooyackers O; Aleman S; Ljunggren H-G; Bjorkstrom NK; Stralin K; Hammer Q
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2025;55(2):e202451150Rodahl IE; Ivarsson MA; Loh L; Mold JE; Westgren M; Friberg D; Mjosberg J; Bjorkstrom NK; Marquardt N; Nixon DF; Michaelsson J
- Article: PLOS PATHOGENS. 2024;20(12):e1012755Bilev E; Wild N; Momayyezi P; Sala BM; Sun R; Sandalova T; Marquardt N; Ljunggren H-G; Achour A; Hammer Q
- Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326Strunz B; Maucourant C; Mehta A; Wan H; Du L; Sun D; Chen P; Nordlander A; Gao Y; Cornillet M; Bister J; Kvedaraite E; Christ W; Klingstrom J; Geanon D; Parke A; Ekwall-Larson A; Rivino L; MacAry PA; Aleman S; Buggert M; Ljunggren H-G; Pan-Hammarstrom Q; Lund-Johansen F; Stralin K; Bjorkstrom NK
- Article: NATURE IMMUNOLOGY. 2024;25(8):1445-1459Netskar H; Pfefferle A; Goodridge JP; Sohlberg E; Dufva O; Teichmann SA; Brownlie D; Michaelsson J; Marquardt N; Clancy T; Horowitz A; Malmberg K-J
- Article: ONCOIMMUNOLOGY. 2023;12(1):2233402Brownlie D; von Kries A; Valenzano G; Wild N; Yilmaz E; Safholm J; Al-Ameri M; Alici E; Ljunggren H-G; Schliemann I; Aricak O; de Flon FH; Michaelsson J; Marquardt N
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862Brownlie D; Rodahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaelsson J; Gredmark-Russ S; Smed-Sorensen A; Marquardt N
- Article: CELL REPORTS MEDICINE. 2022;3(2):100508Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myelomaNahi H; Chrobok M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Blomberg P; Holmqvist P-H; Walther-Jallow L; Mellstrom K; Liwing J; Gustafsson C; Mansson R; Klimkowska M; Gahrton G; Lund J; Ljungman P; Ljunggren H-G; Alici E
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaelsson J; Willinger T
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118Brownlie D; Scharenberg M; Mold JE; Hard J; Kekalainen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaelsson J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Myrberg IH; Lourda M; Dzidic M; Akber M; Klingstrom J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Ginhoux F; Bjorkstrom NK; Henter J-I; Svensson M
- Article: IMMUNITY. 2021;54(2):259-275.e7Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306Sandberg JT; Varnaite R; Christ W; Chen P; Muvva JR; Maleki KT; Garcia M; Dzidic M; Folkesson E; Skagerberg M; Ahlen G; Frelin L; Sallberg M; Eriksson LI; Rooyackers O; Sonnerborg A; Buggert M; Bjorkstrom NK; Aleman S; Stralin K; Klingstrom J; Ljunggren H-G; Blom K; Gredmark-Russ S
- Article: CELL. 2020;183(1):158-168.e14Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
- Article: NATURE COMMUNICATIONS. 2019;10(1):3897Zimmer CL; Cornillet M; Sola-Riera C; Cheung K-W; Ivarsson MA; Lim MQ; Marquardt N; Leo Y-S; Lye DC; Klingstrom J; MacAry PA; Ljunggren H-G; Rivino L; Bjorkstrom NK
- Article: NATURE COMMUNICATIONS. 2019;10(1):3841Marquardt N; Kekalainen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hard J; Mold JE; Ljunggren H-G; Michaelsson J
- Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312Chronic hepatitis delta virus infection leads to functional impairment and severe loss of MAIT cellsDias J; Hengst J; Parrot T; Leeansyah E; Lunemann S; Malone DFG; Hardtke S; Strauss O; Zimmer CL; Berglin L; Schirdewahn T; Ciesek S; Marquardt N; von Hahn T; Manns MP; Cornberg M; Ljunggren H-G; Wedemeyer H; Sandberg JK; Bjorkstrom NK
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116Scharenberg M; Vangeti S; Kekalainen E; Bergman P; Al-Ameri M; Johansson N; Sonden K; Falck-Jones S; Farnert A; Ljunggren H-G; Michaelsson J; Smed-Sorensen A; Marquardt N
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4Marquardt N; Kekalainen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjosberg J; Berglin L; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
- Article: MUCOSAL IMMUNOLOGY. 2017;10(2):322-331Ivarsson MA; Stiglund N; Marquardt N; Westgren M; Gidlof S; Bjorkstrom NK
- Article: IMMUNITY. 2017;46(2):287-300Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075Marquardt N; Ivarsson MA; Sundstrom E; Akesson E; Martini E; Eidsmo L; Mjosberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger A; Westgren M; Michaelsson J
- Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaelsson J
- Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471Marquardt N; Beziat V; Nystrom S; Hengst J; Ivarsson MA; Kekalainen E; Johansson H; Mjosberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaelsson J; Bjorkstrom NK
- Article: FRONTIERS IN IMMUNOLOGY. 2014;5:662Chatterjee D; Marquardt N; Tufa DM; Hatlapatka T; Hass R; Kasper C; von Kaisenberg C; Schmidt RE; Jacobs R
- Article: CELL COMMUNICATION AND SIGNALING. 2014;12:63Chatterjee D; Marquardt N; Tufa DM; Beauclair G; Low HZ; Hatlapatka T; Hass R; Kasper C; von Kaisenberg C; Schmidt RE; Jacobs R
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901Ivarsson MA; Loh L; Marquardt N; Kekalainen E; Berglin L; Bjorkstrom NK; Westgren M; Nixon DF; Michaelsson J
- Article: BRAIN BEHAVIOR AND IMMUNITY. 2011;25(6):1233-1241Steiner J; Marquardt N; Pauls I; Schiltz K; Rahmoune H; Bahn S; Bogerts B; Schmidt RE; Jacobs R
- Article: TISSUE ENGINEERING PART C-METHODS. 2011;17(4):485-493Hatlapatka T; Moretti P; Lavrentieva A; Hass R; Marquardt N; Jacobs R; Kasper C
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1428-1439Marquardt N; Wilk E; Pokoyski C; Schmidt RE; Jacobs R
- Article: JOURNAL OF STEM CELLS AND REGENERATIVE MEDICINE. 2010;6(2):101-102Hatlapatka T; Lavrentieva A; Moretti P; Hass R; Marquardt N; Jacobs R; Kasper C
- Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(12):3563-3571Wilk E; Witte T; Marquardt N; Horvath T; Kalippke K; Scholz K; Wilke N; Schmidt RE; Jacobs R
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Alla övriga publikationer
- Book chapter: NATURAL KILLER CELLS. 2025;p. 1-23Marquardt N; Ljunggren H-G; Michaëlsson J
- Preprint: BIORXIV. 2024Rødahl IE; Ivarsson MA; Loh L; Mold JE; Westgren M; Friberg D; Mjösberg J; Björkström NK; Marquardt N; Nixon DF; Michaëlsson J
- Preprint: BIORXIV. 2024Strunz B; Ivarsson MA; Sun D; Ziegenhain C; Crona-Guterstam Y; Solders M; Björklund A; Marquardt N; Kaipe H; Flöter-Rådestad A; Gidlöf S; Brännström M; Björkström NK
- Conference publication: EXPERIMENTAL DERMATOLOGY. 2024;33(3)Zimmer CL; Schierhofer LI; Clavero P; Schlueter K; Marschall J; Santos AM; Hinterseher J; Polakova A; Didona D; Hertl M; Marquardt N
- Meeting abstract: BLOOD. 2021;138:4796Nahi H; Chrobook M; Meinke S; Gran C; Marquardt N; Afram G; Sutlu T; Gilljam M; Stellan B; Wagner AK; Walther-Jallow L; Liwing J; Klimkowska M; Gahrton G; Ljungman P; Ljunggren H-G; Alici E
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:170Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; Von Kries A; Jorns C; Michaelsson J; Marquardt N; Willinger T
- Preprint: BIORXIV. 2021Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
- Preprint: MEDRXIV. 2020Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Gomez AC; Ask EH; Hull R; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg J; Eriksson L; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström N; Karolinska COVID-19 Study Group
- Preprint: BIORXIV. 2019Marquardt N; Scharenberg M; Mold JE; Hård J; Kekäläinen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Michaëlsson J
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318Marquardt N; Ljunggren H-G; Michaelsson J
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:67-68Marquardt N; Kekalainen E; Wilson JN; Ivarsson MA; Mjosberg J; Safholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Dahlen B; Dahlen S-E; Ljunggren H-G; Michaelsson J
- Other: ALLERGY. 2015;70(11):1353-1355Protudjer JLP; Binnmyr J; Grundstrom J; Manson ML; Marquardt N; Safholm J; Ullemar V
- Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:173.17Marquardt N; Ivarsson M; Blom K; Braun M; Gonzalez V; Falconer K; Sandberg J; Michaelsson J
- Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:52.46Ivarsson M; Loh L; Marquardt N; Bjorkstrom N; Westgren M; Nixon D; Michaelsson J
- Conference publication: IMMUNOLOGY. 2012;137:92Chatterjee D; Hass R; Marquardt N; Kasper C; Schmidt RE; Jacobs R
- Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:180Steiner J; Marquardt N; Pauls I; Schiltz K; Bogerts B; Schmidt R-E; Jacobs R
- Conference publication: TISSUE ENGINEERING PART A. 2011;17(3-4):575Hatlapatka T; Kasper C; Lavrentieva A; Hass R; Marquardt N; Jacobs R
- Letter: ARTHRITIS & RHEUMATOLOGY. 2010;62(8):2563-2565Wilk E; Witte T; Marquardt N; Hennig C; Hansen G; Schmidt RE; Jacobs R
- Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:107Marquardt N; Wilk E; Schmidt RE; Jacobs R
Forskningsbidrag
- Induction of cytotoxic NK cells with a tissue-resident phenotype for treatment against human lung tumorsMagnus Bergvalls Stiftelse1 January 2024 - 31 December 2024
- Harnessing human adaptive-like tissue-resident Natural Killer cells for treatment of lung cancerCancerfonden1 January 2023 - 31 December 2025
- Swedish Cancer Society1 January 2023Lung cancer is one of the leading causes of death in the world and curative treatments are still lacking for most patients. Immunotherapeutic approaches in lung cancer patients focus on immune checkpoint receptors, but usually do not cure the patient per se, and combinatorial approaches are required to increase survival. Natural Killer (NK) cells, part of the innate immune response, are well known for their ability to kill tumor cells. We propose that so-called "adaptive tissue-resident NK cells" are particularly suitable for infiltrating lung tumors and could be exploited to treat lung tumors in future therapeutic strategies. To study the potential of adaptive tissue-resident NK cells in cancer therapies, we will collect lung tumors from lung cancer patients and perform a spatial analysis of the different regions of the tumors (distal, marginal, central) with multiparameter flow cytometry and spatial transcriptomics, providing us with data of high-dimensional quality (goal 1). In vitro-expanded NK cells (aim 2a) will be co-cultured with lung tumor target cells and 3D lung tumor models, and cytotoxicity and infiltration in these artificial tumors will be analyzed by microscopy where one can follow living cells over time (aim 2b). Here, we aim to map adaptive tissue-resident NK cells in human lung tumors, isolate and expand this NK cell population, and analyze their cytotoxicity and tumor infiltration capacity. We expect that the results will help to evaluate the applicability of adaptive tissue-resident NK cells in therapeutic approaches for lung cancer patients. My overall vision is to define new treatment strategies to complement immunotherapeutic applications in lung cancer patients and ultimately increase overall patient survival.
- Swedish Research Council1 January 2022 - 31 December 2024
- Mapping NK cell heterogeneity and functions in human lung tissues in health and diseaseKID1 January 2022 - 31 December 2025
- Modifiera lunginfiltration av NK-celler i luftvägsinfektioner för att förhindra lungvävnadsskadaKI Research Foundation1 January 2022 - 31 December 2023
- Swedish Research Council1 December 2021 - 30 November 2024
- Prevention of NK cell-induced lung tissue-damage upon severe respiratory viral infections (SARS-CoV-2, Influenza A virus)Centrum för innovativ medicin (CIMED)1 January 2021 - 31 December 2023
- Stiftelsen Tornspiran1 January 2021 - 31 December 2021
- Harnessing intratumoral tissue-resident NK cells for treatment of lung cancer with inhibitory checkpoint blockadeCentrum för innovativ medicin1 January 2021 - 31 December 2023
- Metabolic regulation of tumor-infiltrating NK cells in human sarcomaMagnus Bergvalls Stiftelse1 January 2020 - 31 December 2020
- Human lung NK cells in severe respiratory viral infectionsStiftelsen Clas Groschinskys Minnesfond1 January 2020 - 31 December 2021
- Humana NK cellers funktion och reglering vid infekction med influensavirusKI Research Foundation1 January 2019 - 31 December 2020
- Funktion och manipulering av naturliga killer celler i virusinfektion i human lungaStiftelsen Tornspiran1 January 2019 - 31 December 2019
- Role and manipulation of human lung NK cells in influenza infectionÅke Wibergs Stiftelse1 January 2019 - 31 December 2019
- Deutsche Forschungsgemeinschaft1 January 2011 - 31 December 2013
Anställningar
- Senior Forskningsspecialist, Medicin, Huddinge, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Immunologi, Karolinska Institutet, 2025
- PhD, Immunology, Characterization of immunoregulatory NK cells, non-Treg T cells and mesenchymal stem cells, Department of Clinical Immunology and Rheumatology, Hannover Medical School, 2011