Nicole Marquardt

Nicole Marquardt

Senior Forskningsspecialist | Docent
Besöksadress: Blickagången 16, 14152 HUDDINGE
Postadress: H7 Medicin, Huddinge, H7 HERM Höglund Marquardt, 171 77 Stockholm

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Induction of cytotoxic NK cells with a tissue-resident phenotype for treatment against human lung tumors
    Magnus Bergvalls Stiftelse
    1 January 2024 - 31 December 2024
  • Harnessing human adaptive-like tissue-resident Natural Killer cells for treatment of lung cancer
    Cancerfonden
    1 January 2023 - 31 December 2025
  • Swedish Cancer Society
    1 January 2023
    Lung cancer is one of the leading causes of death in the world and curative treatments are still lacking for most patients. Immunotherapeutic approaches in lung cancer patients focus on immune checkpoint receptors, but usually do not cure the patient per se, and combinatorial approaches are required to increase survival. Natural Killer (NK) cells, part of the innate immune response, are well known for their ability to kill tumor cells. We propose that so-called "adaptive tissue-resident NK cells" are particularly suitable for infiltrating lung tumors and could be exploited to treat lung tumors in future therapeutic strategies. To study the potential of adaptive tissue-resident NK cells in cancer therapies, we will collect lung tumors from lung cancer patients and perform a spatial analysis of the different regions of the tumors (distal, marginal, central) with multiparameter flow cytometry and spatial transcriptomics, providing us with data of high-dimensional quality (goal 1). In vitro-expanded NK cells (aim 2a) will be co-cultured with lung tumor target cells and 3D lung tumor models, and cytotoxicity and infiltration in these artificial tumors will be analyzed by microscopy where one can follow living cells over time (aim 2b). Here, we aim to map adaptive tissue-resident NK cells in human lung tumors, isolate and expand this NK cell population, and analyze their cytotoxicity and tumor infiltration capacity. We expect that the results will help to evaluate the applicability of adaptive tissue-resident NK cells in therapeutic approaches for lung cancer patients. My overall vision is to define new treatment strategies to complement immunotherapeutic applications in lung cancer patients and ultimately increase overall patient survival.
  • Mapping NK cell heterogeneity and functions in human lung tissues in health and disease
    KID
    1 January 2022 - 31 December 2025
  • Modifiera lunginfiltration av NK-celler i luftvägsinfektioner för att förhindra lungvävnadsskada
    KI Research Foundation
    1 January 2022 - 31 December 2023
  • Prevention of NK cell-induced lung tissue-damage upon severe respiratory viral infections (SARS-CoV-2, Influenza A virus)
    Centrum för innovativ medicin (CIMED)
    1 January 2021 - 31 December 2023
  • Stiftelsen Tornspiran
    1 January 2021 - 31 December 2021
  • Harnessing intratumoral tissue-resident NK cells for treatment of lung cancer with inhibitory checkpoint blockade
    Centrum för innovativ medicin
    1 January 2021 - 31 December 2023
  • Metabolic regulation of tumor-infiltrating NK cells in human sarcoma
    Magnus Bergvalls Stiftelse
    1 January 2020 - 31 December 2020
  • Human lung NK cells in severe respiratory viral infections
    Stiftelsen Clas Groschinskys Minnesfond
    1 January 2020 - 31 December 2021
  • Humana NK cellers funktion och reglering vid infekction med influensavirus
    KI Research Foundation
    1 January 2019 - 31 December 2020
  • Funktion och manipulering av naturliga killer celler i virusinfektion i human lunga
    Stiftelsen Tornspiran
    1 January 2019 - 31 December 2019
  • Role and manipulation of human lung NK cells in influenza infection
    Åke Wibergs Stiftelse
    1 January 2019 - 31 December 2019

Anställningar

  • Senior Forskningsspecialist, Medicin, Huddinge, Karolinska Institutet, 2022-

Examina och utbildning

  • Docent, Immunologi, Karolinska Institutet, 2025
  • PhD, Immunology, Characterization of immunoregulatory NK cells, non-Treg T cells and mesenchymal stem cells, Department of Clinical Immunology and Rheumatology, Hannover Medical School, 2011

Nyheter från KI

Kalenderhändelser från KI