Monica Hultcrantz | Karolinska Institutet

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Jag arbetar som enhetschef för HTA Region Stockholm vid Centrum för
hälsoekonomi, informatik och sjukvårdsforskning (CHIS) och är affilierad
forskare vid LIME på KI.
På HTA Region Stockholm utvärderar vi det vetenskapliga underlaget för nya
eller ifrågasatta metoder och processer inom vården. På engelska kallas
det Health Technology Assessment (HTA). En HTA-analys kan bland annat belysa
nytta, risker, samt hälsoekonomiska och etiska aspekter av utvärderade
metoder och ger därigenom stöd för prioritering och beslutsfattande om
vårdens utformning.
Större delen av mitt yrkesliv har ägnats åt att leda arbete med
HTA-analyser samt att bedriva metodutveckling och forskning inom HTA,
framför allt med fokus på
GRADE (Grading of Recommendations Assessment, Development and Evaluation)
. I nuläget är jag styrelseledamot i den internationella arbetsgruppen
GRADE Working Group samt del av ledningsgruppen för det skandinaviska
GRADE-nätverket. Vad gäller nationell samverkan är jag bland annat
ordförande för den nationella arbetsgruppen (NAG) HTA/hälsoekonomi samt
medlem av Cochrane Sveriges rådgivande kommitté.

Forskningsbeskrivning

Min pågående forskning rör utvecklingen av metoder för evidenssynteser
och HTA-analyser. Den relaterar främst till bedömning av tillförlitlighet
i evidens och utvecklingen av GRADE (The Grading of Recommendations
Assessment, Development and Evaluation).

Artiklar

Journal article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e083867
Core GRADE 7: principles for moving from evidence to recommendations and decisions.
Guyatt G; Vandvik PO; Iorio A; Agarwal A; Yao L; Eachempati P; Zeng L; Chu DK; D'Souza R; Agoritsas T; Murad MH; Schandelmaier S; Rylance J; Djulbegovic B; Montori VM; Hultcrantz M; Brignardello-Petersen R
Journal article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e083866
Core GRADE 6: presenting the evidence in summary of findings tables.
Guyatt G; Yao L; Murad MH; Hultcrantz M; Agoritsas T; De Beer H; Schandelmaier S; Iorio A; Zeng L; Prasad M; Vandvik PO; Mustafa RA; Agarwal A; Devji T; Florez ID; Djulbegovic B; Chu DK; Rochwerg B; Montori VM; Brignardello-Petersen R
Journal article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e083865
Core GRADE 5: rating certainty of evidence-assessing indirectness
Guyatt G; Iorio A; De Beer H; Owen A; Agoritsas T; Murad MH; Karthikeyan G; Cuello C; Prasad M; Kim K; Ali DS; Agarwal A; Hemkens LG; Yao L; Hultcrantz M; Rylance J; Chu DK; Vandvik PO; Djulbegovic B; Mustafa RA; Zeng L; Eachempati P; Rochwerg B; Prasad K; Montori VM; Brignardello-Petersen R
Article: BMJ EVIDENCE-BASED MEDICINE. 2025;30(3):202-207
Rating certainty when the target threshold is the null and the point estimate is close to the null
Zeng L; Hultcrantz M; Tovey D; Santesso N; Dahm P; Brignardello-Petersen R; Mustafa RA; Murad MH; Izcovich A; de Beer H; Ragusa MA; Johnston B; Zhang L; Iorio A; Guyatt G
Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e083864
Core GRADE 4: rating certainty of evidence-risk of bias, publication bias, and reasons for rating up certainty
Guyatt G; Wang Y; Eachempati P; Iorio A; Murad MH; Hultcrantz M; Chu DK; Florez I; Hemkens LG; Agoritsas T; Yao L; Vandvik PO; Montori VM; Brignardello-Petersen R
Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e081904
Core GRADE 2: choosing the target of certainty rating and assessing imprecision
Guyatt G; Zeng L; Brignardello-Petersen R; Prasad M; De Beer H; Murad MH; Iorio A; Agarwal A; Yao L; Agoritsas T; Rylance J; Mustafa RA; Vandvik PO; Eachempati P; Zhai C; Zhang L; Montori VM; Hultcrantz M
Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e081903
Core GRADE 1: overview of the Core GRADE approach
Guyatt G; Agoritsas T; Brignardello-Petersen R; Mustafa RA; Rylance J; Foroutan F; Prasad M; Agarwal A; De Beer H; Murad MH; Schandelmaier S; Iorio A; Yao L; Jaeschke R; Vandvik PO; Zeng L; Parpia S; D'Souza R; Rind D; Chu DK; Eachempati P; Prasad K; Hultcrantz M; Montori VM
Article: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e081905
Core GRADE 3: rating certainty of evidence-assessing inconsistency
Guyatt G; Schandelmaier S; Brignardello-Petersen R; De Beer H; Prasad M; Murad MH; Eachempati P; Chu DK; D'Souza R; Iorio A; Agoritsas T; Yao L; Mustafa RA; Parpia S; Santaguida P; Vandvik PO; Hultcrantz M; Montori VM
Article: ACTA OPHTHALMOLOGICA. 2024;:371-379
Effectiveness and safety of intense pulsed light therapy for dry eye symptoms due to meibomian gland dysfunction-A systematic review and meta-analysis.
Peira N; Ali EM; Modén NK; Fjellgren E; Lennmarken C; Hultcrantz M
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2024;103(3):423-436
Identification of depression and anxiety during pregnancy: A systematic review and meta-analysis of test accuracy.
Rondung E; Massoudi P; Nieminen K; Wickberg B; Peira N; Silverstein R; Moberg K; Lundqvist M; Grundberg Å; Hultcrantz M
Article: WOMEN AND BIRTH. 2024;37(2):296-302
Support interventions to reduce psychological distress in families experiencing stillbirth in high income countries: A systematic review.
Hildingsson I; Berterö C; Hultcrantz M; Kärrman Fredriksson M; Peira N; Silverstein RA; Persson M; Sveen J
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2024;165:111189
GRADE guidance 37: rating imprecision in a body of evidence on test accuracy
Mustafa RA; El Mikati IK; Murad MH; Hultcrantz M; Steingart KR; Yang B; Leeflang MMG; Akl EA; Dahm P; Schuenemann HJ
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2023;158:70-83
GRADE guidance 36: updates to GRADE's approach to addressing inconsistency
Guyatt G; Zhao Y; Mayer M; Briel M; Mustafa R; Izcovich A; Hultcrantz M; Iorio A; Alba AC; Foroutan F; Sun X; Schunemann H; DeBeer H; Akl EA; Christensen R; Schandelmaier S
Article: JOURNAL OF AFFECTIVE DISORDERS. 2023;322:221-234
Internet-delivered psychological treatment as an add-on to treatment as usual for common mental disorders: A systematic review with meta-analysis of randomized trials.
Jonsson U; Linton SJ; Ybrandt H; Ringborg A; Leander L; Moberg K; Hultcrantz M; Arnberg FK
Article: PLOS ONE. 2023;18(8):e0289617
Care and support when a baby is stillborn: A systematic review and an interpretive meta-synthesis of qualitative studies in high-income countries.
Persson M; Hildingsson I; Hultcrantz M; Kärrman Fredriksson M; Peira N; Silverstein RA; Sveen J; Berterö C
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2022;150:225-242
GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions
Schunemann HJ; Neumann I; Hultcrantz M; Brignardello-Petersen R; Zeng L; Murad MH; Izcovich A; Morgano GP; Baldeh T; Santesso N; Cuello CG; Mbuagbaw L; Guyatt G; Wiercioch W; Piggott T; De Beer H; Vinceti M; Mathioudakis AG; Mayer MG; Mustafa R; Filippini T; Iorio A; Nieuwlaat R; Marcucci M; Coello PA; Bonovas S; Piovani D; Tomlinson G; Akl EA
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2022;150:216-224
GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach
Zeng L; Brignardello-Petersen R; Hultcrantz M; Mustafa RA; Murad MH; Iorio A; Traversy G; Akl EA; Mayer M; Schunemann HJ; Guyatt GH
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2021;139:49-56
GRADE guidelines 33: Addressing imprecision in a network meta-analysis
Brignardello-Petersen R; Guyatt GH; Mustafa RA; Chu DK; Hultcrantz M; Schuenemann HJ; Tomlinson G
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2021;137:163-175
GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings
Zeng L; Brignardello-Petersen R; Hultcrantz M; Siemieniuk RAC; Santesso N; Traversy G; Izcovich A; Sadeghirad B; Alexander PE; Devji T; Rochwerg B; Murad MH; Morgan R; Christensen R; Schunemann HJ; Guyatt GH
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2021;136:146-156
GRADE Guidance: 31. Assessing the certainty across a body of evidence for comparative test accuracy
Yang B; Mustafa RA; Bossuyt PM; Brozek J; Hultcrantz M; Leeflang MMG; Schunemann HJ; Langendam MW
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2020;122:129-141
GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy
Schunemann HJ; Mustafa RA; Brozek J; Steingart KR; Leeflang M; Murad MH; Bossuyt P; Glasziou P; Jaeschke R; Lange S; Meerpohl J; Langendam M; Hultcrantz M; Vist GE; Akl EA; Helfand M; Santesso N; Hooft L; Scholten R; Rosen M; Rutjes A; Crowther M; Muti P; Raatz H; Ansari MT; Williams J; Kunz R; Harris J; Arevalo Rodriguez I; Kohli M; Guyatt GH
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2020;122:142-152
GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tables
Schunemann HJ; Mustafa RA; Brozek J; Steingart KR; Leeflang M; Murad MH; Bossuyt P; Glasziou P; Jaeschke R; Lange S; Meerpohl J; Langendam M; Hultcrantz M; Vist GE; Akl EA; Helfand M; Santesso N; Hooft L; Scholten R; Rosen M; Rutjes A; Crowther M; Muti P; Raatz H; Ansari MT; Williams J; Kunz R; Harris J; Rodriguez IA; Kohli M; Guyatt GH
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2020;117:138-148
Defining ranges for certainty ratings of diagnostic accuracy: a GRADE concept paper
Hultcrantz M; Mustafa RA; Leeflang MMG; Lavergne V; raEstda-Orozco K; Ansari MT; Izcovich A; Singh J; Chong LY; Rutjes A; Steingart K; Stein A; Sekercioglu N; Arevalo-Rodriguez I; Morgan RL; Guyatt G; Bossuyt P; Langendam MW; Schunemann HJ
Article: BMJ OPEN. 2019;9(6):e027445
Defining certainty of net benefit: a GRADE concept paper
Alper BS; Oettgen P; Kunnamo I; Iorio A; Ansari MT; Murad MH; Meerpohl JJ; Qaseem A; Hultcrantz M; Schunemann HJ; Guyatt G
Article: FRONTIERS IN PSYCHIATRY. 2019;10:963
Pharmacological Treatment in Forensic Psychiatry-A Systematic Review.
Howner K; Andiné P; Engberg G; Ekström EH; Lindström E; Nilsson M; Radovic S; Hultcrantz M
Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2018;60(8):741-752
Experiences of living with fetal alcohol spectrum disorders: a systematic review and synthesis of qualitative data.
Domeij H; Fahlström G; Bertilsson G; Hultcrantz M; Munthe-Kaas H; Gordh CN; Helgesson G
Article: BMC MEDICAL ETHICS. 2018;19(1):1
Ethical aspects of diagnosis and interventions for children with fetal alcohol Spectrum disorder (FASD) and their families
Helgesson G; Bertilsson G; Domeij H; Fahlstrom G; Heintz E; Hjern A; Gordh CN; Nordin V; Rangmar J; Rydell A-M; Wahlsten VS; Hultcrantz M
Article: FRONTIERS IN PSYCHIATRY. 2018;9:452
Mapping Systematic Reviews on Forensic Psychiatric Care: A Systematic Review Identifying Knowledge Gaps.
Howner K; Andiné P; Bertilsson G; Hultcrantz M; Lindström E; Mowafi F; Snellman A; Hofvander B
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2017;90:59-67
GRADE equity guidelines 1: considering health equity in GRADE guideline development: introduction and rationale
Welch VA; Akl EA; Guyatt G; Pottie K; Eslava-Schmalbach J; Ansari MT; de Beer H; Briel M; Dans T; Dans I; Hultcrantz M; Jull J; Katikireddi SV; Meerpohl J; Morton R; Mosdol A; Petkovic J; Schunemann HJ; Sharaf RN; Singh JA; Stanev R; Tonia T; Tristan M; Vitols S; Watine J; Tugwell P
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2017;90:76-83
GRADE equity guidelines 3: considering health equity in GRADE guideline development: rating the certainty of synthesized evidence
Welch VA; Ald EA; Pottie K; Ansari MT; Briel M; Christensen R; Dans A; Dans L; Eslava-Schmalbach J; Guyatt G; Hultcrantz M; Jull J; Katildreddi SV; Lang E; Matovinovic E; Meerpohl JJ; Morton RL; Mosdol A; Murad MH; Petkovic J; Schunemann H; Sharaf R; Shea B; Singh JA; Sola I; Stanev R; Stein A; Thabaneii L; Tonia T; Tristan M; Vitols S; Watine J; Tugwell P
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2017;87:4-13
The GRADE Working Group clarifies the construct of certainty of evidence
Hultcrantz M; Rind D; Akl EA; Treweek S; Mustafa RA; Iorio A; Alper BS; Meerpohl JJ; Murad MH; Ansari MT; Katikireddi SV; Ostlund P; Tranaeus S; Christensen R; Gartlehner G; Brozek J; Izcovich A; Schunemann H; Guyatt G
Article: EUROPEAN JOURNAL OF RADIOLOGY. 2017;89:249-269
Diagnostic accuracy of postmortem imaging vs autopsy-A systematic review.
Eriksson A; Gustafsson T; Höistad M; Hultcrantz M; Jacobson S; Mejare I; Persson A
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2016;76:89-98
GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public health
Schunemann HJ; Mustafa R; Brozek J; Santesso N; Alonso-Coello P; Guyatt G; Scholten R; Langendam M; Leeflang MM; Akl EA; Singh JA; Meerpohl J; Hultcrantz M; Bossuyt P; Oxman AD
Article: INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE. 2015;31(3):124-130
FRAMEWORK FOR SYSTEMATIC IDENTIFICATION OF ETHICAL ASPECTS OF HEALTHCARE TECHNOLOGIES: THE SBU APPROACH
Heintz E; Lintamo L; Hultcrantz M; Jacobson S; Levi R; Munthe C; Tranaeus S; Ostlund P; Sandman L
Article: EUROPEAN JOURNAL OF RADIOLOGY. 2014;83(9):1601-1606
Limited evidence for the use of imaging to detect prostate cancer: a systematic review.
Blomqvist L; Carlsson S; Gjertsson P; Heintz E; Hultcrantz M; Mejare I; Andrén O
Article: PLOS ONE. 2014;9(5):e98118
Internet-delivered psychological treatments for mood and anxiety disorders: a systematic review of their efficacy, safety, and cost-effectiveness.
Arnberg FK; Linton SJ; Hultcrantz M; Heintz E; Jonsson U
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;71(2):83-90
Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2^-/-gc^-/- Mice
Jacobson S; Heuts F; Juarez J; Hultcrantz M; Korsgren O; Svensson M; Rottenberg M; Flodstrom-Tullberg M
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(23):3787-3795
Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death
Zaitseva II; Hultcrantz M; Sharoyko V; Flodstrom-Tullberg M; Zaitsev SV; Berggren P-O
Article: CELLULAR MICROBIOLOGY. 2008;10(2):426-436
IFN-γ production dominates the early human natural killer cell response to Coxsackievirus infection
Huhn MH; Hultcrantz M; Lind K; Ljunggren H-G; Malmberg K-J; Flodstrom-Tullberg M
Article: VIROLOGY. 2007;367(1):92-101
Interferons induce an antiviral state in human pancreatic islet cells
Hultcrantz M; Huhn MH; Wolf M; Olsson A; Jacobson S; Williams BR; Korsgren O; Flodstrom-Tullberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(34):30384-30391
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs
Bykov VJN; Issaeva N; Zache N; Shilov A; Hultcrantz M; Bergman J; Selivanova G; Wiman KG
Article: JOURNAL OF IMMUNOLOGY. 2005;174(3):1171-1177
RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection
Flodström-Tullberg M; Hultcrantz M; Stotland A; Maday A; Tsai D; Fine C; Williams B; Silverman R; Sarvetnick N
Article: NATURE MEDICINE. 2002;8(3):282-288
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
Bykov VJN; Issaeva N; Shilov A; Hultcrantz M; Pugacheva E; Chumakov P; Bergman J; Wiman KG; Selivanova G
Visa fler

Alla övriga publikationer

Editorial comment: BMJ-BRITISH MEDICAL JOURNAL. 2025;389:e081902
Why Core GRADE is needed: introduction to a new series in The BMJ
Guyatt G; Hultcrantz M; Agoritsas T; Iorio A; Vandvik PO; Montori VM
Editorial comment: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2023;159:79-84
The development methods of official GRADE articles and requirements for claiming the use of GRADE - A statement by the GRADE guidance group
Schunemann HJ; Brennan S; Akl EA; Hultcrantz M; Alonso-Coello P; Xia J; Davoli M; Rojas MX; Meerpohl JJ; Flottorp S; Guyatt G; Mustafa RA; Langendam M; Dahm P
Review: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2020;119:126-135
GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions
Santesso N; Glenton C; Dahm P; Garner P; Akl EA; Alper B; Brignardello-Petersen R; Carrasco-Labra A; De Beer H; Hultcrantz M; Kuijpers T; Meerpohl J; Morgan R; Mustafa R; Skoetz N; Sultan S; Wiysonge C; Guyatt G; Schunemann HJ
Published conference paper: DIABETOLOGIA. 2009;52(2):299-305
The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice
Hultcrantz M; Jacobson S; Hill NJ; Santamaria P; Flodstrom-Tullberg M
Doctoral thesis: 2008
Interferons in antiviral defense and autoimmunity : focus on type 1 diabetes
Hultcrantz M
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(3):589-597
Mini-review:: The target tissue in autoimmunity -: an influential niche
Hill NJ; Hultcrantz M; Sarvetnick N; Flodstrom-Tullberg M

Anställningar

Adjungerad Adjunkt, Lärande, Informatik, Management och Etik, Karolinska Institutet, 2024-2026

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Huddinge, Karolinska Institutet, 2008

Nyheter från KI

Kalenderhändelser från KI

Nyheter från externa medier

DAGENS MEDICIN. 2025
Vanligt system för gradering av evidens får en återställare
LÄKARTIDNINGEN. 2024
Diskriminera inte forskare som arbetar med systematiska översikter
Bruschettini M; Johansson M; Persad E; Hultcrantz M; Juhl Jørgensen K; Färnqvist K
SJUKHUSLÄKAREN. 2024
Bristande resurser bakbinder HTA-enheterna
DAGENS MEDICIN. 2020
Stärk strukturer för en god hälso- och sjukvård
Hellberg L; Hall U; Hultcrantz M; Lagerstedt K; Larsson L-T; Sundberg LR; Bojestig M; Hejdenberg Ronsten B; Salomonsson C
DAGENS NYHETER. 2019
Allvarliga sjukdomar ska bara få behandlas av vården
Hultcrantz M