Mattias Hällbrink

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: BIOMEDICINES. 2021;9(8):1046
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Bazaz S; Lehto T; Tops R; Gissberg O; Gupta D; Bestas B; Bost J; Wiklander OPB; Sork H; Zaghloul EM; Mamand DR; Hallbrink M; Sillard R; Saher O; Ezzat K; Smith CIE; El Andaloussi S; Lehto T
Article: PHARMACEUTICS. 2021;13(6):878
Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP
Gustafsson O; Radler J; Roudi S; Lehto T; Hallbrink M; Lehto T; Gupta D; EL Andaloussi S; Nordin JZ
Article: MICROPOROUS AND MESOPOROUS MATERIALS. 2020;300:110173
Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks
Abdelhamid HN; Dowaidar M; Hallbrink M; Langel U
Article: THE FASEB JOURNAL. 2019;33(10):11314-11325
The nuclear concentration required for antisense oligonucleotide activity in myotonic dystrophy cells.
van der Bent ML; Paulino da Silva Filho O; Willemse M; Hällbrink M; Wansink DG; Brock R
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2019;141:180-190
Peptide-mediated delivery of therapeutic mRNA in ovarian cancer.
van den Brand D; Gorris MAJ; van Asbeck AH; Palmen E; Ebisch I; Dolstra H; Hällbrink M; Massuger LFAG; Brock R
Article: JOURNAL OF BIOMATERIALS APPLICATIONS. 2018;33(3):392-401
Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles-cell-penetrating peptide.
Dowaidar M; Nasser Abdelhamid H; Hällbrink M; Langel Ü; Zou X
Article: PEPTIDES. 2018;104:62-69
Cell-penetrating peptides for siRNA delivery to glioblastomas.
Srimanee A; Arvanitidou M; Kim K; Hällbrink M; Langel Ü
Article: BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES. 2018;1860(2):491-504
Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complexes detected by fluorescence correlation spectroscopy
Vasconcelos L; Lehto T; Madani F; Radoi V; Hallbrink M; Vukojevic V; Langel U
Article: SCIENTIFIC REPORTS. 2017;7(1):12635
Role of autophagy in cell-penetrating peptide transfection model
Dowaidar M; Gestin M; Cerrato CP; Jafferali MH; Margus H; Kivistik PA; Ezzat K; Hallberg E; Pooga M; Hallbrink M; Langel U
Article: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2017;1861(9):2334-2341
Graphene oxide nanosheets in complex with cell penetrating peptides for oligonucleotides delivery.
Dowaidar M; Abdelhamid HN; Hällbrink M; Zou X; Langel Ü
Article: SCIENTIFIC REPORTS. 2017;7(1):9159
Magnetic Nanoparticle Assisted Self-assembly of Cell Penetrating Peptides-Oligonucleotides Complexes for Gene Delivery.
Dowaidar M; Abdelhamid HN; Hällbrink M; Freimann K; Kurrikoff K; Zou X; Langel Ü
Article: NUCLEIC ACIDS RESEARCH (NAR). 2017;45(9):5153-5169
CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression
Zaghloul EM; Gissberg O; Moreno PMD; Siggens L; Hallbrink M; Jorgensen AS; Ekwall K; Zain R; Wengel J; Lundin KE; Smith CIE
Article: BIOCONJUGATE CHEMISTRY. 2017;28(3):782-792
Saturated Fatty Acid Analogues of Cell-Penetrating Peptide PepFect14: Role of Fatty Acid Modification in Complexation and Delivery of Splice-Correcting Oligonucleotides.
Lehto T; Vasconcelos L; Margus H; Figueroa R; Pooga M; Hällbrink M; Langel Ü
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2017;23(1):91-100
Refinement of a Quantitative Structure-Activity Relationship Model for Prediction of Cell-Penetrating Peptide Based Transfection Systems
Dowaidar M; Regberg J; Dobchev DA; Lehto T; Hallbrink M; Karelson M; Langel U
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2016;501(1-2):32-38
pH-responsive PepFect cell-penetrating peptides
Regberg J; Vasconcelos L; Madani F; Langel U; Hallbrink M
Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2016;500(1-2):128-135
Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood-brain barrier model.
Srimanee A; Regberg J; Hällbrink M; Vajragupta O; Langel Ü
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2016;5(3):e290
Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Sork H; Nordin JZ; Turunen JJ; Wiklander OPB; Bestas B; Zaghloul EM; Margus H; Padari K; Duru AD; Corso G; Bost J; Vader P; Pooga M; Smith CIE; Wood MJA; Schiffelers RM; Hallbrink M; Andaloussi SEL
Article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2015;11(4):879-883
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Nordin JZ; Lee Y; Vader P; Maeger I; Johansson HJ; Heusermann W; Wiklander OPB; Hallbrink M; Seow Y; Bultema JJ; Gilthorpe J; Davies T; Fairchild PJ; Gabrielsson S; Meisner-Kober NC; Lehtio J; Smith CIE; Wood MJA; Andaloussi SEL
Article: NUCLEIC ACID THERAPEUTICS. 2015;25(2):65-77
Peptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
Jarver P; Zaghloul EM; Arzumanov AA; Saleh AF; McClorey G; Hammond SM; Hallbrink M; Langel U; Smith CIE; Wood MJA; Gait MJ; EL Andaloussi S
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1324:303-315
PepFects and NickFects for the Intracellular Delivery of Nucleic Acids.
Arukuusk P; Pärnaste L; Hällbrink M; Langel Ü
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2014;20(2):169-178
Peptide-Based Delivery of Oligonucleotides Across Blood-Brain Barrier Model
Srimanee A; Regberg J; Hallbrink M; Kurrikoff K; Veiman K-L; Vajragupta O; Langel U
Article: ACS NANO. 2013;7(5):3797-3807
Molecular parameters of siRNA--cell penetrating peptide nanocomplexes for efficient cellular delivery.
van Asbeck AH; Beyerle A; McNeill H; Bovee-Geurts PHM; Lindberg S; Verdurmen WPR; Hällbrink M; Langel U; Heidenreich O; Brock R
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2012;18(4):361-371
Tumour Targeting with Rationally Modified Cell-Penetrating Peptides
Mae M; Rautsi O; Enback J; Hallbrink M; Aizman KR; Lindgren M; Laakkonen P; Langel U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(20):16880-16889
Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration.
Lorents A; Kodavali PK; Oskolkov N; Langel Ü; Hällbrink M; Pooga M
Article: CHEMISTRY AND BIOLOGY. 2011;18(8):1000-1010
Preferential uptake of L- versus D-amino acid cell-penetrating peptides in a cell type-dependent manner.
Verdurmen WPR; Bovee-Geurts PH; Wadhwani P; Ulrich AS; Hällbrink M; van Kuppevelt TH; Brock R
Article: NUCLEIC ACIDS RESEARCH (NAR). 2011;39(12):5284-5298
PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation
Ezzat K; EL Andaloussi S; Zaghloul EM; Lehto T; Lindberg S; Moreno PMD; Viola JR; Magdy T; Abdo R; Guterstam P; Sillard R; Hammond SM; Wood MJA; Arzumanov AA; Gait MJ; Smith CIE; Hallbrink M; Langel U
Article: METHODS IN MOLECULAR BIOLOGY. 2011;683:157-164
Calcium and membrane repair.
Palm-Apergi C; Hällbrink M
Article: BIOCONJUGATE CHEMISTRY. 2010;21(4):774-783
S4(13)-PV cell-penetrating peptide forms nanoparticle-like structures to gain entry into cells.
Padari K; Koppel K; Lorents A; Hällbrink M; Mano M; Pedroso de Lima MC; Pooga M
Article: THE FASEB JOURNAL. 2009;23(1):214-223
The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake
Palm-Apergi C; Lorents A; Padari K; Pooga M; Hallbrink M
Article: JOURNAL OF CONTROLLED RELEASE. 2008;132(1):49-54
A new rapid cell-penetrating peptide based strategy to produce bacterial ghosts for plasmid delivery
Palm-Apergi C; Hallrink M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1768(7):1769-1776
Peptide degradation is a critical determinant for cell-penetrating peptide uptake
Palm C; Jayamanne M; Kjellander M; Hallbrink M
Article: PEPTIDES. 2006;27(7):1710-1716
Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobial effects
Palm C; Netzerea S; Hallbrink M
Article: BIOCHEMICAL PHARMACOLOGY. 2006;71(4):416-425
Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide.
Lindgren M; Rosenthal-Aizman K; Saar K; Eiríksdóttir E; Jiang Y; Sassian M; Ostlund P; Hällbrink M; Langel U
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2005;11(4):237-247
Cell-penetrating mimics of agonist-activated G-protein coupled receptors
Östlund P; Kilk K; Lindgren M; Hällbrink M; Jiang Y; Budihna M; Cerne K; Bavec A; Östenson CG; Zorko M; Langel Ü
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2005;11(4):249-259
Prediction of cell-penetrating peptides
Hällbrink M; Kilk K; Elmquist A; Lundberg P; Lindgren M; Jiang Y; Pooga M; Soomets U; Langel Ü
Article: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 2005;11(4):261-265
Metallic zinc reduction of disulfide bonds between cysteine residues in peptides and proteins
Erlandsson M; Hällbrink M
Article: FEBS LETTERS. 2005;579(23):5217-5222
Uptake of cell-penetrating peptides in yeasts.
Holm T; Netzereab S; Hansen M; Langel U; Hällbrink M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2004;1667(2):222-228
Uptake of cell-penetrating peptides is dependent on peptide-to-cell ratio rather than on peptide concentration.
Hällbrink M; Oehlke J; Papsdorf G; Bienert M
Article: THE FASEB JOURNAL. 2004;18(2):394-396
Cell entry and antimicrobial properties of eukaryotic cell- penetrating peptides
Nekhotiaeva N; Elmquist A; Rajarao GK; Hallbrink M; Langel U; Good L
Article: BIOCHEMICAL JOURNAL. 2004;377(Pt 1):69-76
Passage of cell-penetrating peptides across a human epithelial cell layer in vitro.
Lindgren ME; Hällbrink MM; Elmquist AM; Langel U
Article: REGULATORY PEPTIDES. 2003;111(1-3):137-144
Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling.
Bavec A; Hällbrink M; Langel U; Zorko M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;299(1):85-90
Cell membrane translocation of the N-terminal (1-28) part of the prion protein.
Lundberg P; Magzoub M; Lindberg M; Hällbrink M; Jarvet J; Eriksson LEG; Langel U; Gräslund A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;291(4):945-950
Overexpression of protein-tyrosine phosphatase PTPσ is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats
Östensen CG; Sandberg-Nordqvist AC; Chen J; Hällbrink M; Rotin D; Langel Ü; Efendic S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1515(2):101-109
Cargo delivery kinetics of cell-penetrating peptides.
Hällbrink M; Florén A; Elmquist A; Pooga M; Bartfai T; Langel U
Article: THE FASEB JOURNAL. 2001;15(8):1451-1453
Cellular translocation of proteins by transportan.
Pooga M; Kut C; Kihlmark M; Hällbrink M; Fernaeus S; Raid R; Land T; Hallberg E; Bartfai T; Langel U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1546(1):79-86
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Gα_s and Gα_i/Gα_o activation
Hällbrink M; Holmqvist T; Olsson M; Östenson CG; Efendic S; Langel Ü
Article: BIOCONJUGATE CHEMISTRY. 2000;11(5):619-626
Translocation properties of novel cell penetrating transportan and penetratin analogues.
Lindgren M; Gallet X; Soomets U; Hällbrink M; Bråkenhielm E; Pooga M; Brasseur R; Langel U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2000;1467(1):165-176
Deletion analogues of transportan.
Soomets U; Lindgren M; Gallet X; Hällbrink M; Elmquist A; Balaspiri L; Zorko M; Pooga M; Brasseur R; Langel U
Article: REGULATORY PEPTIDES. 1999;82(1-3):45-51
Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity
Hällbrink M; Saar K; Östenson CG; Soomets U; Efendic S; Howl J; Wheatley M; Zorko M; Langel Ü
Article: NATURE BIOTECHNOLOGY. 1998;16(9):857-861
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
Pooga M; Soomets U; Hällbrink M; Valkna A; Saar K; Rezaei K; Kahl U; Hao JX; Xu XJ; Wiesenfeld-Hallin Z; Hökfelt T; Bartfai T; Langel Ü
Article: CELL CALCIUM. 1998;24(1):27-34
Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.
Longland CL; Mezna M; Langel U; Hällbrink M; Soomets U; Wheatley M; Michelangeli F; Howl J
Article: THE FASEB JOURNAL. 1998;12(1):67-77
Cell penetration by transportan.
Pooga M; Hällbrink M; Zorko M; Langel U
Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1997;25(3):450s
Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.
Mezna M; Langel U; Hällbrink M; Wheatley M; Michelangeli F; Howl J
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Review: METHODS IN MOLECULAR BIOLOGY. 2015;1324:39-58
Prediction of Cell-Penetrating Peptides.
Hällbrink M; Karelson M
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2000;21(3):99-103
Cell-penetrating peptides.
Lindgren M; Hällbrink M; Prochiantz A; Langel U
Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 1999;4:D782-D786
Antisense properties of peptide nucleic acids.
Soomets U; Hällbrink M; Langel U
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1998;863:450-453
Galanin-based peptides, galparan and transportan, with receptor-dependent and independent activities.
Pooga M; Lindgren M; Hällbrink M; Bråkenhielm E; Langel U

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