Mattias Carlsten

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Se sidan på engelska [1]
Tema: Att delta i forskning [2]
[1] http://ki.se/en/people/mattca
[2] http://ki.se/forskning/tema-att-delta-i-forskning

Artiklar

Article: BJS-BRITISH JOURNAL OF SURGERY. 2025;112:znaf149.082-XI23
A First-in-Human, phase I/IIa trial of the novel T cell immunotherapy pTTL in patients with advanced colorectal cancer
Tarfy A; Chabok A; Nikberg M; Nilsson P; Kordes M; Carlsten M; Joly A-L; Berglund S; Nilsson O; Salmen A; Svensson S; Norlen P; Gafvelin G; Gronlund H
Article: GUT. 2025;74(7):1125-1136
Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation
Maravelia P; Yao H; Cai C; Silva DN; Fransson J; Nilsson OB; Lu Y-CW; Micke P; Botling J; Gatto F; Rovesti G; Carlsten M; Sallberg M; Stal P; Jorns C; Buggert M; Pasetto A
Journal article: HEMASPHERE. 2025;9(6):e70160
Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?
Carlsten M; Lindfors Rossi EL; Jädersten M; Tesi B; Abd Own S; Sander B; Deneberg S; Ivinskiy A; Sonnevi K; Sjölund H; Enblad G; Wahlin B; Mielke S
Article: CURRENT PROTOCOLS. 2024;4(11):e70040
Optimizing CAR-NK Cell Transduction and Expansion: Leveraging Cytokine Modulation for Enhanced Performance
Ingegnere T; Segain B; Cozzani A; Carlsten M; Mitra S; Gaggero S
Article: MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT. 2024;32(2):101225
Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart
Al-Saadi J; Walden M; Sandell M; Sohlmer J; Grankvist R; Friberger I; Andersson A; Carlsten M; Chien K; Lundberg J; Witman N; Holmin S
Journal article: CYTOTHERAPY. 2024;26(6):s206
DIRECT PARENCHYMAL DELIVERY TO ANY ORGAN OR TUMOR VIA NEXT GENERATION ENDOVASCULAR TECHNIQUE MINIMALLY INVASIVE AND EFFICIENT METHOD FOR TARGETED CELL AND GENE THERAPY
Al-Saadi J; Walden M; Sohlmer J; Grankvist R; Friberger I; Andersson A; Lovljung V; Settergren M; Carlsten M; Chien K; Lundberg J; Witman N; Holmin S
Article: NPJ PRECISION ONCOLOGY. 2024;8(1):108
Redirecting NK cells to the lymph nodes to augment their lymphoma-targeting capacity
Sanz-Ortega L; Leijonhufvud C; Schoutens L; Lambert M; Levy E; Andersson A; Wahlin BE; Carlsten M
Article: LEUKEMIA. 2024;38(3):579-589
Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow
Sanz-Ortega L; Andersson A; Carlsten M
Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880
KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity
Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Journal article: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:108673
P-208 In vivo evaluation and optimization of [89Zr]Zr-DFO-NCS and [89Zr] Zr-(oxinate)4 for cell tracking
Friberger I; Tran T; Lu L; Milton S; Samen E; Goos J; Carlsten M; Holmin S
Article: EJNMMI RESEARCH. 2023;13(1):73
Comparative in vivo biodistribution of cells labelled with [⁸⁹Zr]Zr-(oxinate)₄ or [⁸⁹Zr]Zr-DFO-NCS using PET
Friberger I; Nilsson JNN; Lu L; Siikanen J; Ardenfors O; Milton S; Samen E; Goos JACM; Carlsten M; Holmin S; Tran TAA
Article: LEUKEMIA. 2023;37(9):1830-1841
Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells
Palau A; Segerberg F; Lidschreiber M; Lidschreiber K; Naughton AJ; Needhamsen M; Jung LA; Jagodic M; Cramer P; Lehmann S; Carlsten M; Lennartsson A
Article: HAEMATOLOGICA. 2022;107(8):1786-1795
A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo
Arruda LCM; Stikvoort A; Lambert M; Jin L; Rivera LS; Alves RMP; de Moura TR; Mim C; Lehmann S; Axelsson-Robertson R; Dick JE; Mattsson J; Onfelt B; Carlsten M; Uhlin M
Article: BLOOD ADVANCES. 2022;6(11):3352-3366
Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses
Daly J; Sarkar S; Natoni A; Stark JC; Riley NM; Bertozzi CR; Carlsten M; O'Dwyer ME
Article: VIRCHOWS ARCHIV. 2022;480(3):655-666
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
Merrien M; Wasik AM; Ljung E; Morsy MHA; Rodrigues JDM; Carlsten M; Rassidakis GZ; Christensson B; Kolstad A; Jerkeman M; Ek S; Herold N; Wahlin BE; Sander B
Article: MOLECULAR IMAGING AND BIOLOGY. 2021;23(6):952-962
Optimisation of the Synthesis and Cell Labelling Conditions for [⁸⁹Zr]Zr-oxine and [⁸⁹Zr]Zr-DFO-NCS: a Direct In Vitro Comparison in Cell Types with Distinct Therapeutic Applications
Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
Journal article: BRITISH JOURNAL OF HAEMATOLOGY. 2021;193(5):951-960
Combined haploidentical and cord blood transplantation for refractory severe aplastic anaemia and hypoplastic myelodysplastic syndrome.
Childs RW; Tian X; Vo P; Purev E; Kotecha RR; Carlsten M; Clara J; Flegel WA; Adams SD; Khuu HM; Stroncek DF; Cook L; Worthy T; Geller NL; Wells B; Wilder J; Reger R; Aue G
Article: BMC CANCER. 2021;21(1):500
The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome
Noring K; Carlsten M; Sonnevi K; Wahlin BE
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(10):e1346
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity
Leijonhufvud C; Reger R; Segerberg F; Theorell J; Schlums H; Bryceson YT; Childs RW; Carlsten M
Journal article: METHODS IN MOLECULAR BIOLOGY. 2020;2121:213-239
CRISPR/Cas9-Based Gene Engineering of Human Natural Killer Cells: Protocols for Knockout and Readouts to Evaluate Their Efficacy.
Lambert M; Leijonhufvud C; Segerberg F; Melenhorst JJ; Carlsten M
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Alla övriga publikationer

Editorial: BLOOD. 2026;147(11):1144-1145
Maneuvering of CS toward precision medicine for AML?
Carlsten M
Letter: HEMASPHERE. 2025;9(6):e70160
Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations?
Carlsten M; Lindfors Rossi EL; Jaedersten M; Tesi B; Abd Own S; Sander B; Deneberg S; Ivinskiy A; Sonnevi K; Sjoelund H; Enblad G; Wahlin B; Mielke S
Conference publication: 2024;:a496
437 Personalized tumor-trained lymphocytes – a neoantigen targeted T cell therapy product for treatment of colorectal cancer
Gafvelin G; Joly A-L; Berglund S; Maitre EL; Urbonaviciute V; Day K; Notari L; Nilsson O; Kaiser A; Carvalho-Queiroz C; Bylund K; Woodbridge AF; Akpinar B; Jiang L; Kordes M; Carlsten M; Nikberg M; Tarfy AS; Chabok A; Salmén A; Svensson S; Xie H; Grönlund H
Letter: HEMASPHERE. 2023;7(11):e974
Improved Leukemia Clearance After Adoptive Transfer of NK Cells Expressing the Bone Marrow Homing Receptor CXCR4^R334X
Segerberg F; Lambert M; Sanz-Ortega L; Andersson A; Childs RW; Carlsten M
Conference publication: 2023;:a736
643 A first in human phase I/IIa trial of personalized tumor-trained lymphocytes, pTTL, derived from regional lymph nodes for treatment of colorectal cancer
Berglund S; Joly A-L; Maitre EL; Day K; Notari L; Carvalho-Queiroz C; Nilsson O; Kaiser A; Kordes M; Yachnin J; Carlsten M; Mielke S; Chabok A; Nikberg M; Tarfy AS; Salmén A; Svensson S; Xie H; Gafvelin G; Grönlund H
Conference publication: 2023;:a471
422 Hijacking upregulated E-selectin while boosting SDF-1α sensing rewires infused NK cells to the AML-perturbed bone marrow
Ortega LS; Andersson A; Carlsten M
Editorial: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):316
Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer
Carlsten M; Bryceson YT
Conference publication: BRITISH JOURNAL OF HAEMATOLOGY. 2023;201:114-115
Redirecting NK cells to the lymph nodes to augment their lymphoma-targeting capacity
Schoutens L; Sanz-Ortega L; Leijonhufvud C; Lambert M; Levy E; Andersson A; Wahlin B; Carlsten M
Conference publication: NUCLEAR MEDICINE AND BIOLOGY. 2023;126:S212-S213
In vivo evaluation and optimization of [⁸⁹Zr]Zr-DFO-NCS and [⁸⁹Zr] Zr-(oxinate)₄ for cell tracking
Friberger I; Thuy T; Lu L; Milton S; Samen E; Goos J; Carlsten M; Holmin S
Conference publication: BLOOD. 2022;140:8350
Comprehensive Exploration of NK Cell Education in ADCC Triggered By a Monoclonal Antibody or a Bispecific Killer Engager Molecule (BiKE)
Leijonhufvud C; Schlums H; Stikvoort A; Uhlin M; Bryceson YT; Carlsten M
Corrigendum: MOLECULAR IMAGING AND BIOLOGY. 2022;24(3):510
Optimisation of the Synthesis and Cell Labelling Conditions for [89Zr]Zr-oxine and [89Zr]Zr-DFO-NCS: a Direct In Vitro Comparison in Cell Types with Distinct Therapeutic Applications (vol 23, pg 952, 2021)
Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samen E; Carlsten M; Holmin S; Tran TA
Meeting abstract: BLOOD. 2021;138:2861
A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo
Arruda LCM; Jin L; Lambert M; Rivera LS; Alvez R; de Moura TR; Mim C; Axelsson-Robertson R; Dick JE; Mattsson J; Onfelt B; Carlsten M; Uhlin M
Review: FRONTIERS IN IMMUNOLOGY. 2021;11:621225
Cytokines Orchestrating the Natural Killer-Myeloid Cell Crosstalk in the Tumor Microenvironment: Implications for Natural Killer Cell-Based Cancer Immunotherapy
Gaggero S; Witt K; Carlsten M; Mitra S
Preprint: RESEARCH SQUARE. 2020
The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome
Noring K; Carlsten M; Sonnevi K; Wahlin B
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2357
Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells
Carlsten M; Jaras M
Conference publication: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2019;19(10):E159-E160
Hypersialylation protects Myeloma cells from NK cell mediated killing and this can be overcome by targeted desialylation using a sialyltransferase inhibitor
Daly J; Sarkar S; Natoni A; Henderson R; Swan D; Carlsten M; O'Dwyer M
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:1047
Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer
Daly J; Carlsten M; O'Dwyer M
Preprint: SSRN ELECTRONIC JOURNAL. 2018
Morbidity, Mortality and Normality after Autologous Stem-Cell Transplantation for Lymphoma: A Comprehensive, Single-Centre, Population-Based, Real-World Analysis of Patients Transplanted 1994-2016
Carlsten M; Jädersten M; Hellström A; Littmann K; Melén CM; Junlén HR; Sonnevi K; Ljungman P; Björkstrand B; Wahlin B
Conference publication: BLOOD. 2017;130
Complete Remission and Signs of Immunoediting Following Haploidentical NK Cell Therapy in Refractory High-Risk MDS and AML Ell Therapy in Refractory High-Risk MDS and AML
Bjorklund AT; Carlsten M; Sohlberg E; Clancy T; Liu L; Karimi M; Cooley S; Miller JS; Watz E; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29
Natural killer cell-mediated immunosurveillance of human cancer
Malmberg K-J; Carlsten M; Bjorklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
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Anställningar

Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2024-2027
Senior Forskare, Laboratoriemedicin, Karolinska Institutet, 2025-2025

Examina och utbildning

Docent, hematologi, Karolinska Institutet, 2022
Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2010
Läkarexamen, Karolinska Institutet, 2007

Om mig

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Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI