Markus Dagnell

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: ELIFE. 2022;11:e74549
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; astrand A; Malhotra R; Malissen B; Zubarev RA; Arner ESJ; Holmdahl R
Article: ANTIOXIDANTS. 2021;10(1):111
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H₂O₂ Together with Bicarbonate
Dagnell M; Cheng Q; Arner ESJ
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
Article: SCIENCE ADVANCES. 2020;6(1):eaax8358
Control of protein function through oxidation and reduction of persulfidated states
Doka E; Ida T; Dagnell M; Abiko Y; Luong NC; Balog N; Takata T; Espinosa B; Nishimura A; Cheng Q; Funato Y; Miki H; Fukuto JM; Prigge JR; Schmidt EE; Arner ESJ; Kumagai Y; Akaike T; Nagy P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(33):12330-12338
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
Dagnell M; Cheng Q; Rizvi SHM; Pace PE; Boivin B; Winterbourn CC; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure
Dagnell M; Pace PE; Cheng Q; Frijhoff J; Ostman A; Arner ESJ; Hampton MB; Winterbourn CC
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2015;22(11):938-950
Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
Hellfritsch J; Kirsch J; Schneider M; Fluege T; Wortmann M; Frijhoff J; Dagnell M; Fey T; Esposito I; Koelle P; Pogoda K; Angeli JPF; Ingold I; Kuhlencordt P; Ostman A; Pohl U; Conrad M; Beck H
Article: JOURNAL OF MOLECULAR MEDICINE. 2014;92(9):983-994
Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats
Buschmann I; Hackbusch D; Gatzke N; Duelsner A; Trappiel M; Dagnell M; Ostman A; van Huijsduijnen RH; Kappert K
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277
The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation
Frijhoff J; Dagnell M; Augsten M; Beltrami E; Giorgio M; Ostman A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
Krueger J; Trappiel M; Dagnell M; Stawowy P; Meyborg H; Boehm C; Bhanot S; Ostman A; Kintscher U; Kappert K
Article: BLOOD. 2012;119(19):4499-4511
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ
Godfrey R; Arora D; Bauer R; Stopp S; Mueller JP; Heinrich T; Boehmer S-A; Dagnell M; Schnetzke U; Scholl S; Ostman A; Boehmer F-D
Article: CELLULAR SIGNALLING. 2011;23(5):820-826
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases
Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenstrom P; Kappert K; Ostman A
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102
Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases
ten Freyhaus H; Dagnell M; Leuchs M; Vantler M; Berghausen EM; Caglayan E; Weissmann N; Dahal BK; Schermuly RT; Oestman A; Kappert K; Rosenkranz S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
Conrad M; Sandin A; Foerster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Radmark O; van Huijsduijnen RH; Aspenstrom P; Boehmer F; Ostman A
Article: CANCER RESEARCH. 2007;67(19):9006-9012
FBXW7/hCDC4 is a general tumor suppressor in human cancer
Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Cepeda D; Fiegl H; Dofou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2
Weibrecht I; Boehmer S-A; Dagnell M; Kappert K; Ostman A; Boehmer F-D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K

Alla övriga publikationer

Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;115:484-496
The A to Z of modulated cell patterning by mammalian thioredoxin reductases
Dagnell M; Schmidt EE; Arner ESJ
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2014;20(13):1994-2010
Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration
Frijhoff J; Dagnell M; Godfrey R; Ostman A
Thesis / dissertation: 2013
Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
Dagnell, Markus
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S123
FLT3-ITD Mediated Transformation in Acute Myeloid Leukemia Involves Oxidation of the FLT3 Antagonist PTP, DEP-1: a Novel Redox Circuit in Cancer Cells
Godfrey R; Arora D; Bauer R; Stopp S; Heinrich T; Mueller JP; Dagnell M; Scholl S; Oestman A; Boehmer F-D
Corrigendum: CANCER RESEARCH. 2008;68(4):1245
The FBXW7 gene is mutated in a variety of human tumors (vol 67, pg 9006, 2007)
Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Capeda D; Fiegl H; Dafou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C

Forskningsbidrag

MOLECULAR MECHANISMS OF REDOX SIGNALING THROUGH PROTEIN TYROSINE PHOSPHATASES
Swedish Research Council
1 July 2014 - 30 June 2017

Anställningar

Forskare, Medicinsk biokemi och biofysik, Karolinska Institutet, 2019-

Examina och utbildning

Medicine Doktorsexamen, Institutionen för onkologi-patologi, Karolinska Institutet, 2013
Medicine Magisterexamen, Karolinska Institutet, 2008

Artiklar

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Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI