Markus Dagnell

About me
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Research

Redox reactions play a vital role in growth factor cell signaling. It has
been shown in numerous studies that the phosphorylation cascades initiated by
receptor binding involve inactivation of oxidant-sensitive enzymes in the
pathway, the most prominent of these being protein tyrosine phosphatases
(PTPs). However, it is not at all clear how these proteins become oxidized.
The broad aim of my projects is to advance our understanding of how PTPs are
oxidized and regulated, and how this impacts on physiological and
pathological growth factor signaling.

Articles

Article: ELIFE. 2022;11:e74549
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; astrand A; Malhotra R; Malissen B; Zubarev RA; Arner ESJ; Holmdahl R
Article: ANTIOXIDANTS. 2021;10(1):111
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H₂O₂ Together with Bicarbonate
Dagnell M; Cheng Q; Arner ESJ
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
Article: SCIENCE ADVANCES. 2020;6(1):eaax8358
Control of protein function through oxidation and reduction of persulfidated states
Doka E; Ida T; Dagnell M; Abiko Y; Luong NC; Balog N; Takata T; Espinosa B; Nishimura A; Cheng Q; Funato Y; Miki H; Fukuto JM; Prigge JR; Schmidt EE; Arner ESJ; Kumagai Y; Akaike T; Nagy P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(33):12330-12338
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
Dagnell M; Cheng Q; Rizvi SHM; Pace PE; Boivin B; Winterbourn CC; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure
Dagnell M; Pace PE; Cheng Q; Frijhoff J; Ostman A; Arner ESJ; Hampton MB; Winterbourn CC
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2015;22(11):938-950
Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
Hellfritsch J; Kirsch J; Schneider M; Fluege T; Wortmann M; Frijhoff J; Dagnell M; Fey T; Esposito I; Koelle P; Pogoda K; Angeli JPF; Ingold I; Kuhlencordt P; Ostman A; Pohl U; Conrad M; Beck H
Article: JOURNAL OF MOLECULAR MEDICINE. 2014;92(9):983-994
Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats
Buschmann I; Hackbusch D; Gatzke N; Duelsner A; Trappiel M; Dagnell M; Ostman A; van Huijsduijnen RH; Kappert K
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277
The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation
Frijhoff J; Dagnell M; Augsten M; Beltrami E; Giorgio M; Ostman A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
Krueger J; Trappiel M; Dagnell M; Stawowy P; Meyborg H; Boehm C; Bhanot S; Ostman A; Kintscher U; Kappert K
Article: BLOOD. 2012;119(19):4499-4511
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ
Godfrey R; Arora D; Bauer R; Stopp S; Mueller JP; Heinrich T; Boehmer S-A; Dagnell M; Schnetzke U; Scholl S; Ostman A; Boehmer F-D
Article: CELLULAR SIGNALLING. 2011;23(5):820-826
Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases
Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenstrom P; Kappert K; Ostman A
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102
Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases
ten Freyhaus H; Dagnell M; Leuchs M; Vantler M; Berghausen EM; Caglayan E; Weissmann N; Dahal BK; Schermuly RT; Oestman A; Kappert K; Rosenkranz S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
Conrad M; Sandin A; Foerster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Radmark O; van Huijsduijnen RH; Aspenstrom P; Boehmer F; Ostman A
Article: CANCER RESEARCH. 2007;67(19):9006-9012
FBXW7/hCDC4 is a general tumor suppressor in human cancer
Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Cepeda D; Fiegl H; Dofou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110
Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2
Weibrecht I; Boehmer S-A; Dagnell M; Kappert K; Ostman A; Boehmer F-D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K

All other publications

Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;115:484-496
The A to Z of modulated cell patterning by mammalian thioredoxin reductases
Dagnell M; Schmidt EE; Arner ESJ
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2014;20(13):1994-2010
Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration
Frijhoff J; Dagnell M; Godfrey R; Ostman A
Thesis / dissertation: 2013
Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling
Dagnell, Markus
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S123
FLT3-ITD Mediated Transformation in Acute Myeloid Leukemia Involves Oxidation of the FLT3 Antagonist PTP, DEP-1: a Novel Redox Circuit in Cancer Cells
Godfrey R; Arora D; Bauer R; Stopp S; Heinrich T; Mueller JP; Dagnell M; Scholl S; Oestman A; Boehmer F-D
Corrigendum: CANCER RESEARCH. 2008;68(4):1245
The FBXW7 gene is mutated in a variety of human tumors (vol 67, pg 9006, 2007)
Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Capeda D; Fiegl H; Dafou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C

Grants

MOLECULAR MECHANISMS OF REDOX SIGNALING THROUGH PROTEIN TYROSINE PHOSPHATASES
Swedish Research Council
1 July 2014 - 30 June 2017

Employments

Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2019-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2013
Master Of Medical Science, Karolinska Institutet, 2008

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