Margaret Sällberg Chen
Om mig
Professor i klinisk oral immunologi. Studierektor för forskarutbildning och forskargruppledare vid Institutionen för laboratoriemedicin. Lärarrepresentant vid Kommittén för utbildning på forskarnivå (KFU) på KI.
Jag är legitimerad tandläkare och har genomgått både min forskarutbildning och grundutbildning vid Karolinska Institutet. Efter min postdoc vid The Scripps Research Institute i La Jolla, San Diego, fortsatte jag min forskning vid Folkhälsomyndigheten (tidigare Smittskyddsinstitutet) med fokus på att utveckla nya RNA-vacciner och immunoterapi för infektionssjukdomar och cancer.
Jag är aktiv inom forskarutbildningen genom mitt uppdrag som lärarrepresentant vid KFU, och är ordförande för styrgruppen för KID. Jag är studierektor för forskarutbildningen vid Labmed, och har tidigare varit studierektor för forskarutbildningen vid både DentMed (2010–2023) och MTC (2004). Som professor i ett kliniskt ämne har jag även omfattande pedagogisk och klinisk erfarenhet från grundutbildningen. Jag handleder doktorander och postdocs, och vår forskning stöds av flera externa forskningsanslag.
Jag har publicerat vetenskapliga artiklar som har citerats i över 4000 andra studier. Jag har även aktiva uppdrag inom nationella och internationella styrelser och är associate editor för flera internationella vetenskapliga tidskrifter.
Forskningsbeskrivning
Group members
Dr. Michal Sobkowiak, Research specialist, Dr Sobkowiak holds a PhD in mucosal immunology
Dr. Pooja Tajpara, Postdoc, Dr. Tajpara holds a Master in Biotechnology and a PhD in human tissue immunology.
Dr. Mahin Ghorbani, Postdoc, Dr Ghorbani has a PhD in metatranscriptome analysis of gut microbiome and biomarker discovery.
Dr. Zara Ahmad Khan, Postdoc, Dr Khan holds a PhD in human microbiota and microbial proteomics.
PhD students: Rahul Harshad Nagadia (DDS, MD, Specialist in Oral and Maxillofacial Surgery), Khaled Al-Manei (DDS, MSc Specialist in Endodontics), Agne Kvedaraite (DDS, FTV Region Stockholm). Affiliated research student Choon Boon Too (Singapore NTU).
Co-supervisor to PhD student: Ira Sotirova (Umeå University, Region Västerbotten)
Alumni
Tanja Näslund PhD 2009, Anna Pasetto PhD 2012, Haleh Davanian PhD 2014, Michal Sobkowiak PhD 2019. Hassan Alkharaan PhD 2021. Katie Healy PhD 2022, Zeeshan Ateeb PhD 2023, Asif Halimi PhD 2024, Liyan Lu PhD 2024.
Dr. Anila Yasmeen, Postdoc. Dr. Balasiddaiah Anangi, Postdoc. Dr Rogier Gaiser, Dr Haleh Davanian, Dr Giorgio Garbarini, Dr Sabrina Naud.
Research awards
Cancerfonden, Vetenskapsrådet, KI KID faculty funds, CIMED, Johnson &- Johnson Innovation Award, KI/SLL SOF, ALF Stockholm, Radiumhemmets Forskningsfond, NBIS/SciLifeLab Bioinformatics Long-term Support
Undervisning
- Formal courses taught at university level:
- Course director “General Pathology”, Dentistry Programme KI, 2023 – present
- Course director “Exam Work in Oral Sciences”, Dentistry Programme KI, 2015 – 2023
- Course director “Medical Microbiology, Medical Programme KI, 2002
- Curriculum Director, Year 2, Dentistry Programme KI, 2014- present
- Clinical instructor for Dentistry Students (Year 3-5), Dentistry Programme KI, 2008-2017
Utvalda publikationer
- Article: CELL HOST AND MICROBE. 2024;32(2):156-161.e3
- Article: NPJ BIOFILMS AND MICROBIOMES. 2023;9(1):104
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
- Article: IMMUNITY. 2022;55(9):1732-1746.e5
- Article: MED. 2022;3(2):137-153.e3
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1079995
- Article: JCI INSIGHT. 2021;6(5):140074
- Article: GUT MICROBES. 2021;13(1):1983101
- Article: GUT. 2019;68(12):2186-2194
- Article: JOURNAL OF HEPATOLOGY. 2019;71(4):673-684
- Article: INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2019;11(2):16
- Article: GASTROENTEROLOGY. 2018;155(1):180-193.e6
Artiklar
- Journal article: JOURNAL OF DENTAL SCIENCES. 2024
- Article: SCIENTIFIC REPORTS. 2024;14(1):17820
- Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1346749
- Article: ORAL ONCOLOGY. 2023;146:106556
- Article: JOURNAL OF HEMATOLOGY. 2023;12(4):170-175
- Article: MICROBIOLOGY SPECTRUM. 2022;10(6):e0248722-e02422
- Article: BRITISH JOURNAL OF CANCER. 2022;127(12):2133-2140
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
- Article: JOURNAL OF VIRAL HEPATITIS. 2022;29(9):835-839
- Article: CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION. 2022;31(7):1418-1425
- Article: MOLECULAR MEDICINE. 2022;28(1):54
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):462-471
- Article: MOLECULAR MEDICINE. 2022;28(1):20
- Article: LEUKEMIA. 2022;36(2):476-481
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:896242
- Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(3):407-414
- Article: JHEP REPORTS. 2021;3(4):100318
- Article: JOURNAL OF PROTEOME RESEARCH. 2021;20(5):2725-2738
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
- Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s83-s84
- Article: FRONTIERS IN IMMUNOLOGY. 2020;11:2003
- Article: SCIENTIFIC REPORTS. 2019;9(1):10208
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2076
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(1):133-143
- Journal article: ANNALS OF PANCREATIC CANCER. 2018;1(4):ab100
- Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):149.8
- Article: JOURNAL OF VIROLOGY. 2017;91(9):e00010-e00017
- Article: ONCOTARGET. 2017;8(3):4530-4542
- Article: SCIENTIFIC REPORTS. 2016;6:24991
- Article: ACTA ODONTOLOGICA SCANDINAVICA. 2014;72(7):557-560
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(3):1113-1124
- Article: JOURNAL OF IMMUNOLOGY. 2012;189(9):4510-4519
- Article: CYTOKINE. 2012;57(3):406-416
- Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 2):247-258
- Article: JOURNAL OF IMMUNOLOGY. 2011;186(9):5107-5118
- Article: VIROLOGY JOURNAL. 2011;8:36
- Article: DRUG NEWS AND PERSPECTIVES. 2010;23(10):647-653
- Article: VACCINE. 2009;27(5):701-707
- Journal article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;96(3):403-409
- Article: VACCINE. 2007;25(11):1969-1992
- Article: JOURNAL OF VIROLOGY. 2005;79(5):3016-3027
- Article: JOURNAL OF VIROLOGY. 2005;79(5):2964-2972
- Article: NATURE. 2005;433(7028):887-892
- Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2005;43(2):269-276
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(41):14913-14918
- Article: JOURNAL OF IMMUNOLOGY. 2002;169(6):3208-3216
- Article: INTERNATIONAL JOURNAL OF CANCER. 2002;98(4):554-560
- Article: JOURNAL OF GENERAL VIROLOGY. 2002;83(Pt 2):369-381
- Article: FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY. 2001;31(2):105-112
- Article: JOURNAL OF GENERAL VIROLOGY. 2001;82(Pt 6):1299-1308
- Article: JOURNAL OF INFECTIOUS DISEASES. 2001;183(9):1395-1398
- Article: JOURNAL OF MEDICAL VIROLOGY. 2000;62(3):334-344
- Article: JOURNAL OF VIROLOGY. 2000;74(16):7587-7599
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2000;32(4):445-446
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 2000;7(1):58-63
- Article: JOURNAL OF CLINICAL MICROBIOLOGY. 1999;37(12):4153-4155
- Article: GASTROENTEROLOGY. 1999;116(1):135-143
- Article: HEPATOLOGY. 1998;28(1):219-224
- Journal article: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 1998;53(4):208-209.
- Article: JOURNAL OF IMMUNOLOGY. 1998;160(4):2013-2021
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(26):14648-14653
- Article: JOURNAL OF GENERAL VIROLOGY. 1997;78:2735-2746
- Article: JOURNAL OF INFECTIOUS DISEASES. 1997;176(1):281-285
- Article: JOURNAL OF VIROLOGY. 1997;71(7):5295-5303
- Article: JOURNAL OF CLINICAL MICROBIOLOGY. 1997;35(4):973-975
- Journal article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 1997;24(4):488
- Article: JOURNAL OF GENERAL VIROLOGY. 1996;77:2721-2728
- Article: JOURNAL OF MEDICAL VIROLOGY. 1995;45(2):223-226
- Article: JOURNAL OF MEDICAL VIROLOGY. 1995;45(1):50-55
- Article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1995;27(4):319-324
- Journal article: CLINICAL AND VACCINE IMMUNOLOGY. 1994;1(3):290-294
- Journal article: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1994;26(3):263-270
- Visa fler
Alla övriga publikationer
- Preprint: RESEARCH SQUARE. 2024
- Letter: HAEMATOLOGICA. 2024;109(2):646-651
- Letter: BLOOD. 2022;140(22):2403-2407
- Corrigendum: SCIENTIFIC REPORTS. 2022;12(1):5281
- Review: CELLS. 2020;9(6):E1471-1471
- Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S83-S84
- Meeting abstract: JOURNAL OF HEPATOLOGY. 2018;68:s798-s799
- Conference publication: JOURNAL OF VIRAL HEPATITIS. 2018;25:123
- Review: EXPERT REVIEW OF VACCINES. 2016;15(5):629-640
- Review: MEDICAL MICROBIOLOGY AND IMMUNOLOGY. 2015;204(1):131-135
- Review: ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. 2014;62(1):23-30
- Review: DRUG RESISTANCE UPDATES. 2013;16(3-5):60-67
- Meeting abstract: JOURNAL OF HEPATOLOGY. 2011;54:S476-S477
- Published conference paper: ANTIVIRAL RESEARCH. 2001;52(2):99-111
- Thesis / dissertation: 1998
- Other: JOURNAL OF INFECTIOUS DISEASES. 1995;171(5):1356-1359
- Other: JOURNAL OF CLINICAL MICROBIOLOGY. 1995;33(3):778-780
- Addendum: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 1995;27(5):319-324
Forskningsbidrag
- Radiumhemmets Forskningsfonder1 January 2024 - 31 December 2025
- Cancerfonden1 January 2023 - 31 December 2025
- Swedish Cancer Society1 January 2023
- CIMED1 January 2022 - 31 December 2024
- Swedish Research Council1 June 2021 - 31 May 2025
- Swedish Research Council1 January 2021 - 31 December 2023
- RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2018
- RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2017
- RNA as cell therapy and tumor marker to prevent cancerSwedish Cancer Society1 January 2016
- T cell Receptor Transfer: Translationella Studier för Förbättrad Behandling av Virushepatit and LevercancerSwedish Cancer Society1 January 2015
- T cell Receptor Transfer: Translationella Studier för Förbättrad Behandling av Virushepatit and LevercancerSwedish Cancer Society1 January 2014
- Swedish Research Council1 January 2009 - 31 December 2010
Anställningar
- Professor, Laboratoriemedicin, Karolinska Institutet, 2023-
- Professor, Odontologi, Karolinska Institutet, 2023-2026
Examina och utbildning
- DOKTORSEXAMEN I MEDICINSK VETENSKAP, Institutionen för odontologi, Karolinska Institutet, 1998
- Doctor Of Medical Science, Department of Laboratory Medicine, Karolinska Institute, 1998
Uppdrag i kommitté
- Medlem, Committee for Doctoral Education of Karolinska Instititet
- Ordförande, Steering group for KID-funding