Marcus Buggert
Forskarassistent | Docent
E-postadress: marcus.buggert@ki.se
Besöksadress: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postadress: H7 Medicin, Huddinge, H7 CIM Buggert, 171 77 Stockholm
Om mig
- Docent och gruppledare vid Institutionen för medicin. Min forskning
fokuserar på cellmedierad immunitet mot virusinfektioner och cancer.
Master i biomedicin vid KI, 2004-2009. Doktorandstudier vid KI, 2010-2014.
Post doc vid University of Pennsylvania, USA, 2014-2017. Docent vid KI,
2018-. Gruppledare på KI, 2019-. Docent vid KI, 2021-
Forskningsbeskrivning
- Forskningen i min grupp T-cellsimmunitet mot virusinfektioner och cancer, [1]
bedrivs vid Centrum för infektionsmedicin (CIM) i Huddinge.
[2]Vår grupp forskar på cellmedierad immunitet. Mer specifikt är vi
intresserade av att förstå hur minnes T-celler känner igen och eliminerar
virusinfektioner och tumörer. T-celler är kritiska för immunkontroll av de
flesta virusinfektioner och utgör också en central komponent för
immunterapier som helt har revolutionerat behandlingsalternativen inom
cancervården.
Mycket av vår nuvarande förståelse av minnes T-cellfunktioner härrör
dock från studier av perifert blod hos människor. Med ny data från oss och
andra som visar att de flesta minnes T-celler i vävnader är
icke-cirkulerande residenta celler, är det nödvändigt att bättre förstå
hur, var och vilken typ av T-celler som genererar immunitet i kroppen. Min
grupp fokuserar vårt arbete kring dessa frågeställningar med det
övergripande syftet att i) studera diversitet av minnes T-celler i
mänskliga organdonatorer, ii) identifiera alternativa funktioner för minnes
T-celler i mänskliga vävnader, och iii) förstå hur minnes T-celler
upprätthåller kontrollen över tumörer och virusinfektioner, såsom HIV
och SARS-CoV-2.
[1] https://ki.se/medh/marcus-buggerts-grupp-t-cellsimmunitet-mot-virusinfektioner-och-cancer
[2] https://ki.se/en/medh/marcus-buggert-group-human-memory-cd8-t-cells
Artiklar
- Journal article: IMMUNITY. 2024;57(9):2007-2009
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2024;44(5):116
- Article: GENES AND IMMUNITY. 2024;25(2):168-169
- Article: NATURE COMMUNICATIONS. 2024;15(1):1752
- Article: CELL HOST AND MICROBE. 2024;32(2):156-161.e3
- Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
- Article: NPJ BIOFILMS AND MICROBIOMES. 2023;9(1):104
- Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687
- Article: NATURE COMMUNICATIONS. 2023;14(1):6527
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2023;43(6):1075-1082
- Article: JOURNAL OF HEMATOLOGY. 2023;12(4):170-175
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452
- Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2023;80(7):189
- Article: CELL HOST AND MICROBE. 2023;31(6):928-936.e4
- Article: NATURE COMMUNICATIONS. 2023;14(1):2952
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):223.13
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1):63.22
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):226.09
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.20
- Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.16
- Journal article: CYTOTHERAPY. 2023;25(6):s237-s238
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120
- Article: NATURE COMMUNICATIONS. 2023;14(1):1438
- Article: RESPIRATORY RESEARCH. 2023;24(1):62
- Journal article: JOURNAL OF VIRUS ERADICATION. 2022;8:100274
- Article: NATURE COMMUNICATIONS. 2022;13(1):6436
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
- Article: CELLS. 2022;11(19):3142
- Article: IMMUNITY. 2022;55(9):1732-1746.e5
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(6):1130-1136
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
- Article: MOLECULAR MEDICINE. 2022;28(1):54
- Journal article: JOURNAL OF IMMUNOLOGY. 2022;208(1):169.16
- Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(4):716-727
- Article: NATURE MEDICINE. 2022;28(3):472-476
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
- Article: MED. 2022;3(2):137-153.e3
- Article: MOLECULAR MEDICINE. 2022;28(1):20
- Article: LEUKEMIA. 2022;36(2):476-481
- Journal article: NATURE MEDICINE. 2022
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2574:209-219
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:896242
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1079995
- Article: SCIENCE IMMUNOLOGY. 2021;6(64):eabk0894
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:744530
- Article: PLOS ONE. 2021;16(9):e0258041
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
- Article: CELL. 2020;183(7):1946-1961.e15
- Article: SCIENCE IMMUNOLOGY. 2020;5(53):eabe8063
- Article: CELL. 2020;183(1):158-168.e14
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
- Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s630-s631
- Journal article: JOURNAL OF HEPATOLOGY. 2020;73:s576
- Article: SCIENCE IMMUNOLOGY. 2020;5(49):eaba7918
- Article: JOURNAL OF VIROLOGY. 2020;94(14):e02128-e02119
- Journal article: JOURNAL OF IMMUNOLOGY. 2020;204(1_Supplement):86.46
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2019;11(523):eaax4077
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(8):3185-3200
- Article: JOURNAL OF INFECTIOUS DISEASES. 2019;219(11):1749-1754
- Journal article: JOURNAL OF IMMUNOLOGY. 2019;202(1_Supplement):51.5
- Journal article: JOURNAL OF IMMUNOLOGY. 2019;202(1_Supplement):189.7
- Journal article: JOURNAL OF IMMUNOLOGY. 2019;202(1_Supplement):121.16
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(49):E11513-E11522
- Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(137)
- Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(137)
- Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(6):1531-1542
- Article: SCIENCE IMMUNOLOGY. 2018;3(24):eaar4526
- Journal article: JOURNAL OF IMMUNOLOGY. 2018;200(1_Supplement):120.12
- Article: JCI INSIGHT. 2018;3(7):98487
- Article: PLOS PATHOGENS. 2018;14(4):e1006973
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:19
- Article: CELL REPORTS. 2017;21(12):3458-3470
- Journal article: JOURNAL OF VIRUS ERADICATION. 2017;3:32
- Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):78.25
- Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):152.7
- Article: JCI INSIGHT. 2017;2(8):92943
- Article: TRANSLATIONAL CANCER RESEARCH. 2017;6:S65-S67
- Article: SCIENTIFIC REPORTS. 2017;7:40354
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2017;214(1):91-106
- Article: AIDS. 2016;30(16):2415-2426
- Article: PLOS PATHOGENS. 2016;12(8):e1005805
- Article: CLINICAL IMMUNOLOGY. 2015;161(2):180-189
- Article: PLOS PATHOGENS. 2015;11(8):e1005072
- Article: FRONTIERS IN IMMUNOLOGY. 2015;6:196
- Article: PLOS ONE. 2015;10(9):e0137635
- Article: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2014;85A(11):969-977
- Article: PLOS PATHOGENS. 2014;10(7):e1004251
- Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4685-4696
- Article: JOURNAL OF IMMUNOLOGY. 2014;192(5):2099-2108
- Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2013;29(3):602-612
- Article: JOURNAL OF VIROLOGY. 2012;86(18):9802-9816
- Article: PLOS ONE. 2012;7(7):e39874
- Article: JOURNAL OF IMMUNOLOGY. 2010;184(9):5383-5391
- Journal article:Reinvigoration of Progenitor-Exhausted CD8 T Cells by anti-CTLA-4 Contributes to the Sustained Activity of Combination Checkpoint Blockade
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Alla övriga publikationer
- Letter: HAEMATOLOGICA. 2024;109(2):646-651
- Preprint: BIORXIV. 2024
- Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2023;98(6):e13340
- Corrigendum: NATURE IMMUNOLOGY. 2023;24(10):1778
- Review: NATURE IMMUNOLOGY. 2023;24(10):1616-1627
- Corrigendum: NATURE IMMUNOLOGY. 2023;24(9):1591
- Editorial comment: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2023;220(7):e20230550
- Review: NATURE IMMUNOLOGY. 2023;24(7):1076-1086
- Meeting abstract: JOURNAL OF IMMUNOLOGY. 2023;210(1):59.47
- Preprint: RESEARCH SQUARE. 2023
- Preprint: RESEARCH SQUARE. 2023
- Preprint: RESEARCH SQUARE. 2023
- Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
- Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2023;29:241-242
- Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
- Editorial comment: FRONTIERS IN IMMUNOLOGY. 2023;14:1159452
- Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S169
- Conference publication: CYTOTHERAPY. 2023;25(6):S237-S238
- Letter: BLOOD. 2022;140(22):2403-2407
- Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2022;22(9):533
- Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;95(4):e13153
- Review: MUCOSAL IMMUNOLOGY. 2022;15(3):389-397
- Preprint: BIORXIV. 2022
- Preprint: RESEARCH SQUARE. 2022
- Review: SEMINARS IN IMMUNOLOGY. 2021;55:101505
- Conference publication: JOURNAL OF IMMUNOLOGY. 2021;206:26.12
- Conference publication: CYTOTHERAPY. 2021;23(5):S90
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Editorial comment: NATURE IMMUNOLOGY. 2021;22(1):8-9
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:95
- Conference publication: ANNALS OF ONCOLOGY. 2020;31:S1426
- Preprint: MEDRXIV. 2020
- Preprint: BIORXIV. 2020
- Editorial comment: SCIENCE IMMUNOLOGY. 2020;5(50):eabd3638
- Preprint: MEDRXIV. 2020
- Preprint: BIORXIV. 2020
- Conference publication: ZEITSCHRIFT FUR GASTROENTEROLOGIE. 2020;58(01):e38
- Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S630-S631
- Conference publication: JOURNAL OF IMMUNOLOGY. 2020;204(1)
- Conference publication: JOURNAL OF HEPATOLOGY. 2020;73:S576
- Preprint: BIORXIV. 2019
- Review: CURRENT OPINION IN HIV AND AIDS. 2019;14(2):93-99
- Conference publication: JOURNAL OF IMMUNOLOGY. 2019;202(1)
- Conference publication: JOURNAL OF IMMUNOLOGY. 2018;200(1)
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:1602
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):318
- Conference publication: JOURNAL OF IMMUNOLOGY. 2017;198(1)
- Conference publication: JOURNAL OF IMMUNOLOGY. 2017;198(1)
- Conference publication: JOURNAL OF CLINICAL IMMUNOLOGY. 2017;37(2):230
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):288-289
- Conference publication: JOURNAL OF IMMUNOLOGY. 2016;196:146.4
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:307
- Review: CELLULAR IMMUNOLOGY. 2015;298(1-2):126-133
- Thesis / dissertation: 2014
- Conference publication: IMMUNOLOGY. 2014;143:108
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(4):325
- Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A88
- Conference publication: 2010;:658-659
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Forskningsbidrag
- Swedish Research Council1 December 2023 - 30 November 2026
- Swedish Research Council1 January 2023 - 31 December 2027
- Swedish Research Council1 January 2023 - 31 December 2027
- Swedish Research Council1 January 2023 - 31 December 2025
- Swedish Research Council1 December 2022 - 31 December 2026
- Swedish Research Council1 December 2022 - 30 November 2025
- Deutsche Forschungsgemeinschaft1 January 2022 - 31 December 2024
- Swedish Research Council1 December 2021 - 30 November 2024
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council1 June 2021 - 31 May 2025
- Swedish Heart-Lung Foundation1 January 2021 - 31 December 2021
- Swedish Research Council1 January 2021 - 31 December 2023
- Swedish Research Council1 January 2019 - 31 December 2022
- Define the origin and subset of PD-1+ CD8+ T cells responding to cancer immunotherapySwedish Cancer Society1 January 2019
- Swedish Research Council1 January 2015 - 31 December 2017
Anställningar
- Forskarassistent, Medicin, Huddinge, Karolinska Institutet, 2018-2026
Examina och utbildning
- Docent, Immunologi, Karolinska Institutet, 2021
- Medicine Doktorsexamen, Institutionen för laboratoriemedicin, Karolinska Institutet, 2014
Nyheter från KI
Kalenderhändelser från KI
Nyheter från externa medier
- KNUT AND ALICE WALLENBERG FOUNDATION. 2023
- KNUT OCH ALICE WALLENBERGS STIFTELSE. 2023