Magnus Nilsson

Magnus Nilsson

Professor/Överläkare
E-postadress: magnus.nilsson@ki.se
Besöksadress: Hälsovägen, Enheten för kirurgi C1:77, 14186 Stockholm
Postadress: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Kirurgi och onkologi, 141 52 Huddinge
Del av:

Om mig

  • Professor i kirurgi vid institutionen för klinisk vetenskap, intervention och teknik, CLINTEC

    Magnus Nilsson är född i Lund 1968. och läste medicin vid KI med examen 1992. Han blev specialist i kirurgi 2000 och har framför allt verkat vid Karolinska universitetssjukhuset där han idag är överläkare vid ME Övre buk. 2007–2014 var han sektionschef vid sektionen för övre abdominal kirurgi.

    Magnus Nilsson disputerade vid KI 2004 och blev docent 2011. Sedan 2014 är han chef för enheten för kirurgi, som sedan 2022 bytt namn till enheten för kirurgi och onkologi, vid CLINTEC. Han är sedan juli 2017 också stf prefekt vid CLINTEC. Han har också bland annat varit ordförande för SFOAK, Svensk förening för övre abdominell kirurgi och han är för närvarande chefredaktör för den internationella vetenskapliga tidskriften Diseases of the Esophagus. Magnus Nilsson utnämndes den 1 juli 2017 till professor i kirurgi vid Karolinska Institutet.

Forskningsbeskrivning

  • Huvudsakligen klinisk och translationell forskning inom fälten magsäcks och matstrupscancer. Han har lett, och leder fortsatt, flera kliniska prövningar avseende perioperativ behandling med cytostatika och strålning vid matstrupscancer och cancer i gastroesofageala övergången. På senare år har han påbörjat nya forskningsprojekt med syfte att hitta nya behandlingar mot bukhinnemetastaser vid magsäckscancer.

Undervisning

  • Magnus Nilsson har extensiv erfarenhet av undervisning på alla universitetsnivåer. Han är sedan 2017 ämnesansvarig i kirurgi vid läkarprogrammet vid Karolinska Institutet.

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Cancer Society
    1 January 2021
    There are two types of esophageal cancer, adenocarcinoma and squamous cell carcinoma. Curative treatment for adenocarcinoma is based on surgery to remove the esophagus after chemotherapy or combined treatment with chemotherapy and radiation, so-called chemoradiotherapy (CRT). In the case of squamous cell carcinoma, the most established treatment is surgery after pre-treatment with CRT, but in this type of esophageal cancer there is also an option to treat with CRT for curative purposes, then given in a higher dose and with careful follow-up afterwards, with the possibility of surgery in cases where the tumor does not disappear completely or return locally. In the randomized study NeoRes 2, we investigate for adenocarcinoma of the esophagus whether an extended wait of 10-12 weeks between completed CRT and surgery, compared to the usual wait of 4-6 weeks, results in better tumor response, less risk of residual tumor tissue and better recovery before surgery . In the randomized study NEEDS, we investigate for squamous cell carcinoma of the esophagus whether CRT followed by careful controls, and surgery only when needed, provides similar survival but with a better quality of life, compared to today's standard treatment with CRT followed by mandatory surgery. For esophageal adenocardinomas, a randomized trial demonstrating oncologic benefits and better quality of life after delayed surgery would be of great value as many patients are not recovered and ready for major surgery within the conventional time frame of 4-6 weeks. In the case of squamous cell carcinoma, the vast majority of patients today routinely undergo surgery after CRT. However, the operation causes a lifelong reduction in the quality of life. If CRT with surgery only when really needed for local tumor control were to be shown to provide as good a survival rate as routine surgery, then it is likely to become the new standard treatment worldwide.
  • Swedish Research Council
    1 January 2019 - 31 December 2022
  • Two studies carried out in a Nordic research network on cancers of the esophagus or upper stomach where the type of treatment given for curative purposes is determined by lottery.
    Swedish Cancer Society
    1 January 2018
    Cancer of the esophagus has poor prognosis. The best chance of being cured has patients who are first treated with chemotherapy, or a combination of chemotherapy and radiotherapy, and then operated. However, it is not entirely clear which pretreatment is better, chemotherapy alone or combination of chemotherapy and radiation. It is also not clear how long you should wait with surgery after pretreatment with chemotherapy and radiation. Previous preliminary data suggest that you can get better treatment effect if you wait much longer with the surgery than is normal today. This research project consists of two studies in which we each draw two different treatment options. In study 1, we draw between giving pretreatment with chemotherapy alone and giving pretreatment with combination of chemotherapy and radiation. In study 2, all patients receive combination therapy with chemotherapy and radiation, but instead we draw between waiting 4-6 weeks with the operation, which is common today, and waiting 10-12 weeks, which in preliminary, unlisted studies, shown promising results with better shrinkage effect on the tumor. I hope with this research can contribute with well-founded knowledge about how to pre-treat with chemotherapy and radiation before surgery of esophageal cancer in as efficient and safe manner as possible. In the first study, we hope to answer the question whether radiation has a place in the pretreatment or not, which most previous data suggests, but this study could ultimately determine. In the second study, we hope to get an answer to the question of how long one should wait for surgery of esophageal cancer after pretreatment with chemotherapy and radiation.
  • Two studies carried out in a Nordic research network on cancers of the esophagus or upper stomach where the type of treatment given for curative purposes is determined by lottery.
    Swedish Cancer Society
    1 January 2017
    Cancer of the esophagus has poor prognosis. The best chance of being cured has patients who are first treated with chemotherapy, or a combination of chemotherapy and radiotherapy, and then operated. However, it is not entirely clear which pretreatment is better, chemotherapy alone or combination of chemotherapy and radiation. It is also not clear how long you should wait with surgery after pretreatment with chemotherapy and radiation. Previous preliminary data suggest that you can get better treatment effect if you wait much longer with the surgery than is normal today. This research project consists of two studies in which we each draw two different treatment options. In study 1, we draw between giving pretreatment with chemotherapy alone and giving pretreatment with combination of chemotherapy and radiation. In study 2, all patients receive combination therapy with chemotherapy and radiation, but instead we draw between waiting 4-6 weeks with the operation, which is common today, and waiting 10-12 weeks, which in preliminary, unlisted studies, shown promising results with better shrinkage effect on the tumor. I hope with this research can contribute with well-founded knowledge about how to pre-treat with chemotherapy and radiation before surgery of esophageal cancer in as efficient and safe manner as possible. In the first study, we hope to answer the question whether radiation has a place in the pretreatment or not, which most previous data suggests, but this study could ultimately determine. In the second study, we hope to get an answer to the question of how long one should wait for surgery of esophageal cancer after pretreatment with chemotherapy and radiation.
  • Two studies with a draw between different treatment concepts for potentially curable cancers in the esophagus or upper stomach
    Swedish Cancer Society
    1 January 2016
    Cancer of the esophagus has poor prognosis. The best chance of being cured has patients who are first treated with chemotherapy, or a combination of chemotherapy and radiotherapy, and then operated. However, it is not entirely clear which pretreatment is better, chemotherapy alone or combination of chemotherapy and radiation. It is also not clear how long you should wait with surgery after pretreatment with chemotherapy and radiation. Previous preliminary data suggest that you can get better treatment effect if you wait much longer with the surgery than is normal today. This research project consists of two studies in which we each draw two different treatment options. In study 1, we draw between giving pretreatment with chemotherapy alone and giving pretreatment with combination of chemotherapy and radiation. In study 2, all patients receive combination therapy with chemotherapy and radiation, but instead we draw between waiting 4-6 weeks with the operation, which is common today, and waiting 10-12 weeks, which in preliminary, unlisted studies, shown promising results with better shrinkage effect on the tumor. I hope with this research can contribute with well-founded knowledge about how to pre-treat with chemotherapy and radiation before surgery of esophageal cancer in the most effective and safe way possible. In the first study, we hope to answer the question whether radiation has a place in the pretreatment or not, which most previous data suggests, but this study could ultimately determine. In the second study, we hope to get an answer to the question of how long one should wait for surgery of esophageal cancer after pretreatment with chemotherapy and radiation.
  • Two studies with a draw between different treatment concepts for potentially curable cancers in the esophagus or upper stomach
    Swedish Cancer Society
    1 January 2015
    Cancer of the esophagus has poor prognosis. The best chance of being cured has patients who are first treated with chemotherapy, or a combination of chemotherapy and radiotherapy, and then operated. However, it is not entirely clear which pretreatment is better, chemotherapy alone or combination of chemotherapy and radiation. It is also not clear how long you should wait with surgery after pretreatment with chemotherapy and radiation. Previous preliminary data suggest that you can get better treatment effect if you wait much longer with the surgery than is normal today. This research project consists of two studies in which we each draw two different treatment options. In study 1, we draw between giving pretreatment with chemotherapy alone and giving pretreatment with combination of chemotherapy and radiation. In study 2, all patients receive combination therapy with chemotherapy and radiation, but instead we draw between waiting 4-6 weeks with the operation, which is common today, and waiting 10-12 weeks, which in preliminary, unlisted studies, shown promising results with better shrinkage effect on the tumor. I hope with this research can contribute with well-founded knowledge about how to pre-treat with chemotherapy and radiation before surgery of esophageal cancer in the most effective and safe way possible. In the first study, we hope to answer the question whether radiation has a place in the pretreatment or not, which most previous data suggests, but this study could ultimately determine. In the second study, we hope to get an answer to the question of how long one should wait for surgery of esophageal cancer after pretreatment with chemotherapy and radiation.
  • Two studies with a draw between different treatment concepts for potentially curable cancers in the esophagus or upper stomach
    Swedish Cancer Society
    1 January 2014
    Cancer of the esophagus has poor prognosis. The best chance of being cured has patients who are first treated with chemotherapy, or a combination of chemotherapy and radiotherapy, and then operated. However, it is not entirely clear which pretreatment is better, chemotherapy alone or combination of chemotherapy and radiation. It is also not clear how long you should wait with surgery after pretreatment with chemotherapy and radiation. Previous preliminary data suggest that you can get better treatment effect if you wait much longer with the surgery than is normal today. This research project consists of two studies in which we each draw two different treatment options. In study 1, we draw between giving pretreatment with chemotherapy alone and giving pretreatment with combination of chemotherapy and radiation. In study 2, all patients receive combination therapy with chemotherapy and radiation, but instead we draw between waiting 4-6 weeks with the operation, which is common today, and waiting 10-12 weeks, which in preliminary, unlisted studies, shown promising results with better shrinkage effect on the tumor. I hope with this research can contribute with well-founded knowledge about how to pre-treat with chemotherapy and radiation before surgery of esophageal cancer in the most effective and safe way possible. In the first study, we hope to answer the question whether radiation has a place in the pretreatment or not, which most previous data suggests, but this study could ultimately determine. In the second study, we hope to get an answer to the question of how long one should wait for surgery of esophageal cancer after pretreatment with chemotherapy and radiation.

Anställningar

  • Professor/Överläkare, Klinisk vetenskap, intervention och teknik, Karolinska Institutet, 2017-

Examina och utbildning

  • Docent, Kirurgi, Karolinska Institutet, 2011
  • MEDICINE DOKTORSEXAMEN, INST F KIRURGISK VETENSKAP (K3), Karolinska Institutet, 2004
  • Läkarexamen, Karolinska Institutet, 1992

Handledning

  • Handledning till doktorsexamen

    • Yun Du, Ph.D., Karolinska Institute, Sweden, 2023

Nyheter från KI

Kalenderhändelser från KI