Lu Yi

Lu Yi

Principal Researcher
E-mail: lu.yi@ki.se
Telephone: +46852487772
Visiting address: Nobelsvägen 12a, 17165 SOLNA
Postal address: C8 Medicinsk epidemiologi och biostatistik, C8 MEB I Lu, 171 77 Stockholm
Part of:

About me

  • I am a Principal Researcher at Karolinska Institutet (KI), Sweden. I lead a research group conducting psychiatric genetics research, especially in major depressive disorder (MDD). I am directing the KI Psychiatric Genomics Institute and co-leading the Nordic Tryggve consortium.

    My research involves integrating large-scale genomic data and nationwide electronic healthcare records to investigate depression subtypes, as a way to reduce the substantial heterogeneity in this disorder. My long-term research vision is to promote targeted drug development and treatment optimization for MDD patient subgroups to achieve precision psychiatry.

    My research excellence has been recognised nationally and internationally, for which I have been awarded many prestigious grants including a recent award of €1.5 million from European Research Council. I am also the Sweden PI on major funding from US-NIH and EU-Horizon2020.

Research

  • 1. Genetics of major depressive disorder and its subtypes
    MDD is heterogeneous: however, the extent to which genetic factors distinguish patient subgroups (genetic heterogeneity) remains uncertain. We
    therefore seek evidence for genetic heterogeneity in MDD by studying patient subgroups. In particular, we focus on patients who are most severely ill ("extreme MDD"). I am also a key analyst in the Psychiatric Genomics Consortium MDD working group.

    2. Trans-Nordic collaboration of “register genomics” in psychiatry
    I have co-led the Nordic Tryggve consortium since 2018 (Tryggve: trans-Nordic collaboration on register and genomics research in psychiatry). The Tryggve consortium has enabled integration of genetics in population-based psychiatric studies in Sweden, Denmark, and Norway. We have achieved comprehensive harmonization of software, data processing pipelines, and register phenotype and genomic data using singularity containers. Altogether, these allow us to analyze Nordic register and genomic data in a unified scheme where we ask empirical questions and get rapid, secure, and reproducible answers.

    3. Genetic risk factors of other complex disorders
    I led and contributed to many genome-wide association studies on complex traits and diseases of medical importance, including cancers, eye diseases, and allergic diseases. These work have been published in leading genetic journals, including three in Nature Genetics.

    *My research are proudly supported by:*
    KI Consolidator Grant 2023, *PI.* 2024-2028
    SfoEpi Consolidator Grant 2023, *PI.* 2023-2026 (withdrawn upon the recipient of the KI consolidator grant)
    European Research Council Starting Grant 2021, *PI.* 2022-2027.
    KI Faculty-funded career position as *Senior Researcher.* 2022-2024.
    Swedish Research Council. *PI.* 2022-2026.
    European Union's Horizon 2020. Grant No 964874. *Sub-award PI*. 2021-2025.
    NIH/NIMH R01 MH123724. *Co-PI/Sub-award PI*. 2020-2025.
    KI Faculty-funded career position as *Assistant Professor.* 2018-2022.
    StratNeuro Start Up Award, KI Neuroscience, 2019-2020.
    2018 NARSAD Young Investigator Award, Brain &

  • Behavior Research Foundation, USA. 2019-2021.
    KI Research Foundation. 2018-2019.
    Assistant professor, funded by the Department of Medical Epidemiology and Biostatistics (rank #1). 2018-2022
    NHMRC Early Career Fellowship (CJ Martin - Overseas Biomedical Fellowship). Australian Government. 2015-2018
    Australian delegate of early career researcher at the 64th Nobel Laureates Meeting (Physiology or Medicine). Australian Academy of Science 2014

Teaching

  • SUPERVISION:
    Research specialist Tong Gong
    Postdoc: Shengxin Liu, Thi Thuy Dung Nguyen, Joelle Pasman.
    PhD student Ying Xiong. "Genetic epidemiology of treatment-resistant depression", since 2021. As main supervisor.
    PhD student Arvid Harder. "Genomics and treatment outcomes of major depressive disorder subtypes", since 2023. As main supervisor.
    *Former students*
    PhD student Thi Thuy Dung Nguyen. “Aetiology and outcomes in psychiatric disorders”, As main supervisor. (Defended thesis 2023.12.15)
    PhD student Jet Termorshuizen. “Genetic and environmental factors influencing the course and outcome of eating disorder”, As co-supervisor. (Defended thesis 2023.12.08)
    PhD student Ashley Thompson. “Prediction of negative life outcomes in children with ADHD”. As co-supervisor. (Defended thesis 2022.02.18)
    Bachelor student Alison Baxley, Bachelor Thesis in Medical Science with a Major in Biomedicine, Karolinska Institutet. “Polygenic risk scores for
    schizophrenia and childhood accidents, injury and self-harm”. Spring 2017.

    TEACHING:
    Lecturer: "Psychiatric Genetics" within the Research School of Psychiatry (Forskarskolan inom klinisk psykiatri), Karolinska Institutet and Region
    Stockholm. Feb 6-10, 2023.
    Course: “Molecular genetic psychiatry”. Clinical Psychology program, Karolinska Institutet. 2017, 2018, 2019.
    Course: “Molecular epidemiology”. Epidemiology program, Karolinska Institutet. 2018, 2020.
    Summer school: “GWAS and imputation”, Brain Imaging Genetics Summer School, Nijmegen, the Netherlands. 2018.

Articles

  • Article: JAMA PSYCHIATRY. 2024
    Song J; Pasman JA; Johansson V; Kuja-Halkola R; Harder A; Karlsson R; Lu Y; Kowalec K; Pedersen NL; Cannon TD; Hultman CM; Sullivan PF
  • Article: JAMA PSYCHIATRY. 2024;81(8):807-816
    Grimes PZ; Adams MJ; Thng G; Edmonson-Stait AJ; Lu Y; Mcintosh A; Cullen B; Larsson H; Whalley HC; Kwong ASF
  • Article: NATURE COMMUNICATIONS. 2024;15(1):5064
    Meijsen J; Hu K; Krebs MD; Athanasiadis G; Washbrook S; Zetterberg R; Silva RNAE; Shorter JR; Gadin JR; Bergstedt J; Howard DM; Ye W; Lu Y; Valdimarsdottir UA; Ingason A; Helenius D; Plana-Ripoll O; Mcgrath JJ; Micali N; Andreassen OA; Werge TM; Fang F; Buil A
  • Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2024;11(6):1393-1404
    Kowalec K; Harder A; Dolovich C; Fitzgerald KC; Salter A; Lu Y; Bernstein CN; Bolton JM; Cutter G; Fisk JD; Gelernter J; Graff LA; Haegg S; Hitchon CA; Levey DF; Lublin FD; Mckay KA; Patten S; Patki A; Stein MB; Tiwari HK; Wolinsky JS; Marrie RA
  • Article: JAMA PSYCHIATRY. 2024;81(6):579-585
    Simonsson O; Mosing MA; Osika W; Ullen F; Larsson H; Lu Y; Wesseldijk LW
  • Article: NATURE GENETICS. 2024;56(5):792-808
    Nievergelt CM; Maihofer AX; Atkinson EG; Chen C-Y; Choi KW; Coleman JRI; Daskalakis NP; Duncan LE; Polimanti R; Aaronson C; Amstadter AB; Andersen SB; Andreassen OA; Arbisi PA; Ashley-Koch AE; Austin SB; Avdibegovic E; Babic D; Bacanu S-A; Baker DG; Batzler A; Beckham JC; Belangero S; Benjet C; Bergner C; Bierer LM; Biernacka JM; Bierut LJ; Bisson JI; Boks MP; Bolger EA; Brandolino A; Breen G; Bressan RA; Bryant RA; Bustamante AC; Bybjerg-Grauholm J; Baekvad-Hansen M; Borglum AD; Borte S; Cahn L; Calabrese JR; Caldas-de-Almeida JM; Chatzinakos C; Cheema S; Clouston SAP; Colodro-Conde L; Coombes BJ; Cruz-Fuentes CS; Dale AM; Dalvie S; Davis LK; Deckert J; Delahanty DL; Dennis MF; Desarnaud F; DiPietro CP; Disner SG; Docherty AR; Domschke K; Dyb G; Kulenovic AD; Edenberg HJ; Evans A; Fabbri C; Fani N; Farrer LA; Feder A; Feeny NC; Flory JD; Forbes D; Franz CE; Galea S; Garrett ME; Gelaye B; Gelernter J; Geuze E; Gillespie CF; Goleva SB; Gordon SD; Goci A; Grasser LR; Guindalini C; Haas M; Hagenaars S; Hauser MA; Heath AC; Hemmings SMJ; Hesselbrock V; Hickie IB; Hogan K; Hougaard DM; Huang H; Huckins LM; Hveem K; Jakovljevic M; Javanbakht A; Jenkins GD; Johnson J; Jones I; Jovanovic T; Karstoft K-I; Kaufman ML; Kennedy JL; Kessler RC; Khan A; Kimbrel NA; King AP; Koen N; Kotov R; Kranzler HR; Krebs K; Kremen WS; Kuan P-F; Lawford BR; Lebois LAM; Lehto K; Levey DF; Lewis C; Liberzon I; Linnstaedt SD; Logue MW; Lori A; Lu Y; Luft BJ; Lupton MK; Luykx JJ; Makotkine I; Maples-Keller JL; Marchese S; Marmar C; Martin NG; Martinez-Levy GA; McAloney K; McFarlane A; McLaughlin KA; McLean SA; Medland SE; Mehta D; Meyers J; Michopoulos V; Mikita EA; Milani L; Milberg W; Miller MW; Morey RA; Morris CP; Mors O; Mortensen PB; Mufford MS; Nelson EC; Nordentoft M; Norman SB; Nugent NR; O'Donnell M; Orcutt HK; Pan PM; Panizzon MS; Pathak GA; Peters ES; Peterson AL; Peverill M; Pietrzak RH; Polusny MA; Porjesz B; Powers A; Qin X-J; Ratanatharathorn A; Risbrough VB; Roberts AL; Rothbaum AO; Rothbaum BO; Roy-Byrne P; Ruggiero KJ; Rung A; Runz H; Rutten BPF; de Viteri SS; Salum GA; Sampson L; Sanchez SE; Santoro M; Seah C; Seedat S; Seng JS; Shabalin A; Sheerin CM; Silove D; Smith AK; Smoller JW; Sponheim SR; Stein DJ; Stensland S; Stevens JS; Sumner JA; Teicher MH; Thompson WK; Tiwari AK; Trapido E; Uddin M; Ursano RJ; Valdimarsdottir U; Van Hooff M; Vermetten E; Vinkers CH; Voisey J; Wang Y; Wang Z; Waszczuk M; Weber H; Wendt FR; Werge T; Williams MA; Williamson DE; Winsvold BS; Winternitz S; Wolf C; Wolf EJ; Xia Y; Xiong Y; Yehuda R; Young KA; Young RM; Zai CC; Zai GC; Zervas M; Zhao H; Zoellner LA; Zwart J-A; DeRoon-Cassini T; Van Rooij SJH; van den Heuvel LL; Stein MB; Ressler KJ; Koenen KC
  • Article: INFLAMMATORY BOWEL DISEASES. 2024;:izae027
    Gong T; Brew BK; Lundholm C; Smew AI; Harder A; Kuja-Halkola R; Ludvigsson JF; Lu Y; Almqvist C
  • Article: MOLECULAR PSYCHIATRY. 2024;:1-10
    Song J; Jonsson L; Lu Y; Bergen SE; Karlsson R; Smedler E; Gordon-Smith K; Jones I; Jones L; Craddock N; Sullivan PF; Lichtenstein P; Di Florio A; Landen M
  • Article: BIOINFORMATICS ADVANCES. 2024;4(1):vbae067
    Akdeniz BC; Frei O; Hagen E; Filiz TT; Karthikeyan S; Pasman J; Jangmo A; Bergstedt J; Shorter JR; Zetterberg R; Meijsen J; Sonderby IE; Buil A; Tesli M; Lu Y; Sullivan P; Andreassen OA; Hovig E
  • Article: NAT CARDIOVASC RES. 2024;3(6):754-769
    Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin AA; Meijsen JJ; Shen Q; Hagg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Borglum AD; Lewis CM; Mcintosh AM; Valdimarsdottir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
  • Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
    Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhava J; Hagg S
  • Article: AMERICAN JOURNAL OF PSYCHIATRY. 2023;180(12):884-895
    Guintivano J; Byrne EM; Kiewa J; Yao S; Bauer AE; Aberg KA; Adams MJ; Campbell A; Campbell ML; Choi KW; Corfield EC; Havdahl A; Hucks D; Koen N; Lu Y; Maegbaek ML; Mullaer J; Peterson RE; Raffield LM; Sallis HM; Sealock JM; Walker A; Watson HJ; Xiong Y; Yang JMK; Anney RJL; Gordon-Smith K; Hubbard L; Jones LA; Mihaescu R; Nyegaard M; Pardinas AF; Perry A; Saquib N; Shadyab AH; Viktorin A; Andreassen OA; Bigdeli TB; Davis LK; Dennis C-L; Di Florio A; Dubertret C; Feng Y-CA; Frey BN; Grigoriadis S; Gloaguen E; Jones I; Kennedy JL; Krohn H; Kallak TK; Li Y; Martin NG; Mcintosh AM; Milgrom J; Munk-Olsen T; Oberlander T; Olsen CM; Ramoz N; Reichborn-Kjennerud T; Blackmore ER; Rubinow D; Skalkidou A; Smoller JW; Stein DJ; Stowe ZN; Taylor V; Tebeka S; Tesli M; Van Lieshout RJ; van den Oord EJCG; Vigod SN; Werge T; Westlye LT; Whiteman DC; Zar HJ; Wray N; Meltzer-Brody S; Sullivan P
  • Article: AMERICAN JOURNAL OF PSYCHIATRY. 2023;180(10):714-722
    Thuy-Dung N; Kowalec K; Pasman J; Larsson H; Lichtenstein P; Dalman C; Sullivan PF; Kuja-Halkola R; Lu Y
  • Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):301
    Xiong Y; Karlsson R; Song J; Kowalec K; Rueck C; Sigstroem R; Jonsson L; Clements CC; Andersson E; Boberg J; Lewis CM; Sullivan PF; Landen M; Lu Y
  • Article: NEUROLOGY. 2023;101(5):e522-e532
    Kowalec K; Fitzgerald KC; Salter A; Dolovich C; Harder A; Bernstein CN; Bolton J; Cutter GR; Graff LA; Hagg S; Hitchon CA; Lu Y; Lublin F; McKay KA; Patten SB; Patki A; Tiwari HK; Wolinsky JS; Marrie RA
  • Article: AGING CELL. 2023;22(8):e13868
    Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jaaskelainen T; Koskinen S; Lu Y; Magnusson PKE; Hagg S; Jylhava J
  • Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2023;38(7):809-819
    Qin C; Diaz-Gallo L-M; Tang B; Wang Y; Nguyen T-D; Harder A; Lu Y; Padyukov L; Askling J; Hagg S
  • Article: ECLINICALMEDICINE. 2023;61:102063
    Shen Q; Mikkelsen DH; Luitva LB; Song H; Kasela S; Aspelund T; Bergstedt J; Lu Y; Sullivan PF; Ye W; Fall K; Tornvall P; Pawitan Y; Andreassen OA; Buil A; Milani L; Fang F; Valdimarsdottir U
  • Article: LANCET REGIONAL HEALTH-EUROPE. 2023;29:100621
    Pasman JA; Meijsen J; Haram M; Kowalec K; Harder A; Xiong Y; Nguyen T-D; Jangmo A; Shorter JR; Bergstedt J; Das U; Zetterberg R; Tate A; Lichtenstein P; Larsson H; Odsbu I; Werge T; Reichborn-Kjennerud T; Andreassen OA; Sullivan PF; Buil A; Tesli M; Lua Y
  • Article: ARCHIVES OF SEXUAL BEHAVIOR. 2023;52(3):1213-1228
    Oginni OA; Lim KX; Purves KL; Lu Y; Johansson A; Jern P; Rijsdijk FV
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