Liv Eidsmo

Om mig
Publikationer
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Populärvetenskap och samverkan

Om mig

Professor i dermatologi och venereologi vid institutionen för medicin, Solna vid Karolinska Institutet samt överläkare vid Karolinska Universitetssjukhuset.

Forskningsbeskrivning

Människans hud bildar en barriär mot den yttre miljön som ständigt utsätts för koloniserande mikrobiota, invasiva patogener och allergener. Hudbarriären upprätthålls av immunceller, men dessa celler är också inblandade i vanliga inflammatoriska sjukdomar. I frisk hud har vi definierat funktionellt distinkta undergrupper av vävnadsresistenta minnes-T (Trm) celler baserat på deras uttryck av integrinet CD49a och vi har karakteriserat patogena Trm-celler i vitiligo och psoriasis.
Aktuella studier i mitt laboratorium syftar till att förstå hur mänskliga Trm-celler bildas och hur dessa celler påverkar sin omedelbara miljö.

Artiklar

Article: CLINICAL AND EXPERIMENTAL DERMATOLOGY. 2024;49(8):793-800
Investigation of plaque psoriasis relapse after secukinumab withdrawal in patients from two phase III studies
Lebwohl M; Iversen L; Eidsmo L; Krueger JG; Suarez-Farinas M; Tomalin L; Kolbinger F; You R; Milutinovic M
Article: BRITISH JOURNAL OF DERMATOLOGY. 2024;190(6):904-914
Initial steps towards developing a predictive algorithm of disease progression for hidradenitis suppurativa (HS): results from a Cox proportional hazard regression analysis on disease progression among a cohort of 335 Danish patients with HS
Kjaersgaard Andersen R; Pedersen O; Eidsmo L; Jemec G; Saunte D
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(1):e13326
Method for high-plex analysis of immune cells in human skin using the GeoMx system
Ignatov B; Sortebech D; Emmanuel T; Zhuravleva E; Eidsmo L
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(1):e2350658
The cellular microenvironment regulates CX3CR1 expression on CD8⁺ T cells and the maintenance of CX3CR1⁺ CD8⁺ T cells
Pokharel J; Shryki I; Zwijnenburg AJ; Sandu I; Krumm L; Bekiari C; Avramov V; Heinback R; Lysell J; Eidsmo L; Harris HE; Gerlach C
Article: IMMUNITY. 2023;56(8):1955-1974.e10
Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation
Zwijnenburg AJ; Pokharel J; Varnait R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrstrom M; Gredmark-Russ S; Eidsmo L; Gerlach C
Article: IMMUNITY. 2023;56(6):1285-1302
Human skin-resident CD8+T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a
Zitti B; Hoffer E; Zheng W; Pandey RV; Schlums H; Casoni GP; Fusi I; Nguyen L; Karner J; Kokkinou E; Carrasco A; Gahm J; Ehrstrom M; Happaniemi S; Keita AV; Hedin CRH; Mjosberg J; Eidsmo L; Bryceson YT
Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2023;37(5):1004-1016
Secukinumab demonstrates superiority over narrow-band ultraviolet B phototherapy in new-onset moderate to severe plaque psoriasis patients: Week 52 results from the STEPIn study
Iversen L; Conrad C; Eidsmo L; Costanzo A; Narbutt J; Pinter A; Kingo K; Rivera Diaz R; Kolbinger F; Nanna M; Frueh JA; Jagiello P
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1168684
Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor
Scheffschick A; Nenonen J; Xiang M; Winther AH; Ehrstrom M; Wahren-Herlenius M; Eidsmo L; Brauner H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):705-716
Single-Cell Analysis Reveals Major Histocompatibility Complex II-Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes
Li D; Cheng S; Pei Y; Sommar P; Karner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Landen NX
Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
Intestinal helminth infection transforms the CD4⁺ T cell composition of the skin
Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylen S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(2):333-342.e6
IL-22 Downregulates Peptidylarginine Deiminase-1 in Human Keratinocytes: Adding Another Piece to the IL-22 Puzzle in Epidermal Barrier Formation
Padhi A; Srivastava A; Ramesh A; Ehrstrom M; Simon M; Sonkoly E; Eidsmo L; Bergman P; Lysell J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: ADVANCED MATERIALS TECHNOLOGIES. 2021;6(7):2001307
Vancomycin-Loaded Microneedle Arrays against Methicillin-Resistant Staphylococcus Aureus Skin Infections
Ziesmer J; Tajpara P; Hempel N-J; Ehrstrom M; Melican K; Eidsmo L; Sotiriou GA
Article: JAMA DERMATOLOGY. 2021;157(6):1-8
Long-term Outcomes and Prognosis in New-Onset Psoriasis
Svedbom A; Mallbris L; Larsson P; Nikamo P; Wolk K; Kjellman P; Sonkoly E; Eidsmo L; Lindqvist U; Stahle M
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):13
Skin T cells maintain their diversity and functionality in the elderly
Koguchi-Yoshioka H; Hoffer E; Cheuk S; Matsumura Y; Vo S; Kjellman P; Grema L; Ishitsuka Y; Nakamura Y; Okiyama N; Fujisawa Y; Fujimoto M; Eidsmo L; Clark RA; Watanabe R
Article: CELL REPORTS. 2019;29(5):1074-1081.e5
Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization
Schulz A; Jiang L; de Vor L; Ehrstrom M; Wermeling F; Eidsmo L; Melican K
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(4):1444-1454
A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis
Serezal IG; Hoffer E; Ignatov B; Martini E; Zitti B; Ehrstrom M; Eidsmo L
Article: PARASITE IMMUNOLOGY. 2019;41(4):e12618
Intestinal nematode infection exacerbates experimental visceral leishmaniasis
Classon C; Feng X; Eidsmo L; Nylen S
Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2018;32(11):1930-1939
Secukinumab treatment in new-onset psoriasis: aiming to understand the potential for disease modification - rationale and design of the randomized, multicenter STEPIn study
Iversen L; Eidsmo L; Austad J; de Rie M; Osmancevic A; Skov L; Talme T; Bachmann I; van de Kerkhof P; Stahle M; Banerjee R; Oliver J; Fasth AER; Frueh J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(8):1754-1763
Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome
Serezal IG; Classon C; Cheuk S; Barrientos-Somarribas M; Wadman E; Martini E; Chang D; Landen NX; Ehrstrom M; Nylen S; Eidsmo L
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465
Human Immunodeficiency Virus-Infected Women Have High Numbers of CD103^-CD8⁺ T Cells Residing Close to the Basal Membrane of the Ectocervical Epithelium
Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Ball TB; Kimani J; Kaul R; Karlsson AC; Wahlby C; Broliden K; Tjernlund A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638
MicroRNA-132 with Therapeutic Potential in Chronic Wounds
Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(4):865-873
Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis
Martini E; Wiken M; Cheuk S; Serezal IG; Baharom F; Stahle M; Smed-Sorensen A; Eidsmo L
Article: SCIENTIFIC REPORTS. 2017;7:43989
Immunogenicity is preferentially induced in sparse dendritic cell cultures
Nasi A; Bollampalli VP; Sun M; Chen Y; Amu S; Nylen S; Eidsmo L; Rothfuchs AG; Rethi B
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075
Fetal CD103⁺ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid
Marquardt N; Ivarsson MA; Sundstrom E; Akesson E; Martini E; Eidsmo L; Mjosberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger A; Westgren M; Michaelsson J
Article: NATURE COMMUNICATIONS. 2016;7:12175
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Lieden A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylen S; Westerberg LS
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(9):2351-2360
Composition of Innate Lymphoid Cell Subsets in the Human Skin: Enrichment of NCR⁺ ILC3 in Lesional Skin and Blood of Psoriasis Patients
Teunissen MBM; Munneke JM; Bernink JH; Spuls PI; Res PCM; te Velde A; Cheuk S; Brouwer MWD; Menting SP; Eidsmo L; Spits H; Hazenberg MD; Mjosberg J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(6):1535-1541
Genetic Variants of the IL22 Promoter Associate to Onset of Psoriasis before Puberty and Increased IL-22 Production in T Cells
Nikamo P; Cheuk S; Lysell J; Enerback C; Bergh K; Landen NX; Eidsmo L; Stahle M
Article: JOURNAL OF IMMUNOLOGY. 2014;192(7):3111-3120
Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed Psoriasis
Cheuk S; Wiken M; Blomqvist L; Nylen S; Talme T; Stahle M; Eidsmo L
Article: JOURNAL OF PATHOLOGY. 2012;226(5):806-813
Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics
Eidsmo L; Stock AT; Heath WR; Bedoui S; Carbone FR
Article: PARASITOLOGY. 2011;138(14):1898-1909
The interplay between Leishmania promastigotes and human Natural Killer cells in vitro leads to direct lysis of Leishmania by NK cells and modulation of NK cell activity by Leishmania promastigotes
Lieke T; Nylen S; Eidsmo L; Schmetz C; Berg L; Akuffo H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529
MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2
Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Stahle M; Sonkoly E; Pivarcsi A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2010;4(10):e844
Systemic FasL and TRAIL Neutralisation Reduce Leishmaniasis Induced Skin Ulceration
Tasew G; Nylen S; Lieke T; Lemu B; Meless H; Ruffin N; Wolday D; Asseffa A; Yagita H; Britton S; Akuffo H; Chiodi F; Eidsmo L
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4
Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Stahle M; Pivarcsi A
Article: GLOBAL HEALTH ACTION. 2009;2:2046
Low-cost liquid medium for in vitro cultivation of Leishmania parasites in low-income countries
Tasew G; Kebede A; Wolday D; Gadisa E; Britton S; Eidsmo L; Akuffo H
Article: JOURNAL OF IMMUNOLOGY. 2009;182(12):7587-7594
The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses
Lahoud MH; Proietto AI; Ahmet F; Kitsoulis S; Eidsmo L; Wu L; Sathe P; Pietersz S; Chang H-W; Walker ID; Maraskovsky E; Braley H; Lew AM; Wright MD; Heath WR; Shortman K; Caminschi I
Article: NATURE IMMUNOLOGY. 2009;10(5):524-530
Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Gebhardt T; Wakim LM; Eidsmo L; Reading PC; Heath WR; Carbone FR
Article: NATURE IMMUNOLOGY. 2009;10(5):488-495
Cross-presentation of viral and self antigens by skin-derived CD103⁺ dendritic cells
Bedoui S; Whitney PG; Waithman J; Eidsmo L; Wakim L; Caminschi I; Allan RS; Wojtasiak M; Shortman K; Carbone FR; Brooks AG; Heath WR
Article: JOURNAL OF IMMUNOLOGY. 2009;182(5):3165-3172
Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection
Eidsmo L; Allan R; Caminschi I; van Rooijen N; Heath WR; Carbone FR
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;153(2):221-230
Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation
Lieke T; Nylen S; Eidsmo L; McMaster WR; Mohammadi AM; Khamesipour A; Berg L; Akuffo H
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(4):805-817
Splenic accumulation of IL-10 mRNA in T cells distinct from CD4⁺ CD25⁺ (Foxp3) regulatory T cells in human visceral leishmaniasis
Nylen S; Maurya R; Eidsmo L; Das Manandhar K; Sundar S; Sacks D
Article: JOURNAL OF IMMUNOLOGY. 2007;178(8):5340-5350
Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
Fluur C; De Milito A; Fry TJ; Vivar N; Eidsmo L; Atlas A; Federici C; Matarrese P; Logozzi M; Rajnavolgyi E; Mackall CL; Fais S; Chiodi F; Rethi B
Article: AMERICAN JOURNAL OF PATHOLOGY. 2007;170(1):227-239
FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
Eidsmo L; Fluur C; Rethi B; Ygberg SE; Ruffin N; De Milito A; Akuffo H; Chiodi F
Article: VACCINE. 2006;24(47-48):6944-6954
Surrogate markers of immunity to Leishmania major in leishmanin skin test negative individuals from an endemic area re-visited
Nylen S; Khamesipour A; Mohammadi A; Jafari-Shakib R; Eidsmo L; Noazin S; Modabber F; Akuffo H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2005;166(4):1099-1108
The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania major-induced cutaneous leishmaniasis
Eidsmo L; Nylen S; Khamesipour A; Hedblad MA; Chiodi F; Akuffo H
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2002;130(2):307-313
Alteration of Fas and Fas ligand expression during human visceral leishmaniasis
Eidsmo L; Wolday D; Berhe N; Sabri F; Satti I; El Hassan AM; Sundar S; Chiodi F; Akuffo H
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;117(3):529-534
Natural killer cells in cross-regulation of IL-12 by IL-10 in Leishmania antigen-stimulated blood donor cells
Akuffo H; Alexis A; Eidsmo L; Saed A; Nylén S; Maasho K
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1995;52(2):181-186
STEROID 21-HYDROXYLASE IN THE KIDNEY - DEMONSTRATION OF LEVELS OF MESSENGER-RNA WHICH CORRELATE WITH THE LEVEL OF ACTIVITY
LAJIC S; EIDSMO L; HOLST M
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Alla övriga publikationer

Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(12):3680-3683
T cells in resolved allergic contact dermatitis steer tissue inflammation and MMP-12-driven tissue modulation
Gallais Serezal I; Tajpara P; Schonfeldt T; Ignatov B; Sortebech D; Hoffer E; Zhang T; Rooijackers E; Ehrstrom M; Nylen S; Matura M; Melican K; Eidsmo L
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2022;387(16):1515-1516
New Hope for Patients with Vitiligo
Eidsmo L
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(5):e12953
Cellular scars and local crosstalk in relapsing psoriasis: an example of a skin sticking disease
Gallais Serezal I; Cheuk S; Martini E; Eidsmo L
Editorial comment: TRENDS IN IMMUNOLOGY. 2018;39(3):170-172
Heavy Water Shedding Light on Antigen-Specific T Cell Responses
Eidsmo L; Gerlach C
Review: FRONTIERS IN IMMUNOLOGY. 2018;9:300
Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions
Eidsmo L; Martini E
Editorial comment: IMMUNITY. 2017;47(6):1012-1014
The Skinny on Fat Trm Cells
Cheuk S; Eidsmo L
Letter: EXPERIMENTAL DERMATOLOGY. 2017;26(9):824-827
Granzyme A potentiates chemokine production in IL-17-stimulated keratinocytes
Cheuk S; Martini E; Bergh K; Chang D; Rethi B; Stahle M; Eidsmo L
Letter: EXPERIMENTAL DERMATOLOGY. 2017;26(5):444-446
IL-22 binding protein regulates murine skin inflammation
Lindahl H; Martini E; Brauner S; Nikamo P; Serezal IG; Guerreiro-Cacais AO; Jagodic M; Eidsmo L; Stahle M; Olsson T
Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(8):1033-1043
Update on innate lymphoid cells in atopic and non-atopic inflammation in the airways and skin
Mjosberg J; Eidsmo L
Review: PARASITE IMMUNOLOGY. 2012;34(12):551-561
Tissue damage and immunity in cutaneous leishmaniasis
Nylen S; Eidsmo L
Review: FRONTIERS IN IMMUNOLOGY. 2012;3:163
FasL and TRAIL signaling in the skin during cutaneous leishmaniasis - implications for tissue immunopathology and infectious control
Rethi B; Eidsmo L
Thesis / dissertation: 2006
Dysregulation of receptor induced apoptosis during human leishmaniasis : a possible mechanism of skin ulceration
Eidsmo, Liv

Anställningar

Professor/Överläkare, Medicin, Solna, Karolinska Institutet, 2024-

Examina och utbildning

Docent, Dermatologi och venereologi, Karolinska Institutet, 2014
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2006
Läkarexamen, Karolinska Institutet, 1999

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI