Liselotte Bäckdahl

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; McInerney G; Murrell B; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam GB; Castro Dopico X; Rorbach J
Article: ANTIOXIDANTS. 2021;11(1):12

Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis.

Aoun M; Cai X; Xu B; Lahore GF; Bonner MY; He Y; Bäckdahl L; Holmdahl R
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(3):682-693

Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively.

Vaartjes D; Klaczkowska D; Cragg MS; Nandakumar KS; Bäckdahl L; Holmdahl R
Article: NATURE COMMUNICATIONS. 2021;12(1):610

Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation.

Norin U; Rintisch C; Meng L; Forster F; Ekman D; Tuncel J; Klocke K; Bäcklund J; Yang M; Bonner MY; Lahore GF; James J; Shchetynsky K; Bergquist M; Gjertsson I; Hubner N; Bäckdahl L; Holmdahl R
Article: PLOS GENETICS. 2020;16(6):e1008788

Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.

Bäckdahl L; Aoun M; Norin U; Holmdahl R
Article: BMC GENOMICS. 2014;15(1):391

Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research.

Bäckdahl L; Ekman D; Jagodic M; Olsson T; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1239-1248

The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats.

Hoffmann MH; Bruns H; Bäckdahl L; Neregård P; Niederreiter B; Herrmann M; Catrina AI; Agerberth B; Holmdahl R
Journal article: GASTROENTEROLOGY. 2013;144(5):s-193

1032 Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study

Haesler R; Feng Z; Bäckdahl L; Spehlmann ME; Franke A; Teschendorff A; Rakyan V; Down TA; Wilson GA; Feber A; Beck S; Schreiber S; Rosenstiel PC
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(12):1385-1399

Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress.

Colaianna M; Schiavone S; Zotti M; Tucci P; Morgese MG; Bäckdahl L; Holmdahl R; Krause K-H; Cuomo V; Trabace L
Journal article: GENOME RESEARCH. 2012;22(11):2130-2137

A functional methylome map of ulcerative colitis.

Häsler R; Feng Z; Bäckdahl L; Spehlmann ME; Franke A; Teschendorff A; Rakyan VK; Down TA; Wilson GA; Feber A; Beck S; Schreiber S; Rosenstiel P
Article: TRANSLATIONAL PSYCHIATRY. 2012;2(5):e111

NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology.

Schiavone S; Jaquet V; Sorce S; Dubois-Dauphin M; Hultqvist M; Bäckdahl L; Holmdahl R; Colaianna M; Cuomo V; Trabace L; Krause K-H
Article: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(83):83ra40

Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.

Feng G; Nadig SN; Bäckdahl L; Beck S; Francis RS; Schiopu A; Whatcott A; Wood KJ; Bushell A
Journal article: PLOS ONE. 2011;6(10):e26002

Genome-wide screen for differential DNA methylation associated with neural cell differentiation in mouse.

Cortese R; Lewin J; Bäckdahl L; Krispin M; Wasserkort R; Eckhardt F; Beck S
Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(12):1925-1932

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data.

Bäckdahl L; Guo JP; Jagodic M; Becanovic K; Ding B; Olsson T; Lorentzen JC
Article: EPIGENETICS. 2009;4(4):248-254

Gene body methylation of the dimethylarginine dimethylamino-hydrolase 2 (Ddah2) gene is an epigenetic biomarker for neural stem cell differentiation.

Bäckdahl L; Herberth M; Wilson G; Tate P; Campos LS; Cortese R; Eckhardt F; Beck S
Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(12):1742-1749

Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells.

Eklöw C; Makrygiannakis D; Bäckdahl L; Padyukov L; Ulfgren A-K; Lorentzen JC; Malmström V
Article: GENOME RESEARCH. 2008;18(9):1518-1529

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).

Rakyan VK; Down TA; Thorne NP; Flicek P; Kulesha E; Gräf S; Tomazou EM; Bäckdahl L; Johnson N; Herberth M; Howe KL; Jackson DK; Miretti MM; Fiegler H; Marioni JC; Birney E; Hubbard TJP; Carter NP; Tavaré S; Beck S
Article: NATURE BIOTECHNOLOGY. 2008;26(7):779-785

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis.

Down TA; Rakyan VK; Turner DJ; Flicek P; Li H; Kulesha E; Gräf S; Johnson N; Herrero J; Tomazou EM; Thorne NP; Bäckdahl L; Herberth M; Howe KL; Jackson DK; Miretti MM; Marioni JC; Birney E; Hubbard TJP; Durbin R; Tavaré S; Beck S
Article: BMC MEDICAL GENOMICS. 2008;1:19

Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis.

Tomazou EM; Rakyan VK; Lefebvre G; Andrews R; Ellis P; Jackson DK; Langford C; Francis MD; Bäckdahl L; Miretti M; Coggill P; Ottaviani D; Sheer D; Murrell A; Beck S
Article: ARTHRITIS & RHEUMATOLOGY. 2008;58(5):1343-1353

Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex.

Guo JP; Bäckdahl L; Marta M; Mathsson L; Rönnelid J; Lorentzen JC
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(8):2620-2632

Association of arthritis with a gene complex encoding C-type lectin-like receptors.

Lorentzen JC; Flornes L; Eklöw C; Bäckdahl L; Ribbhammar U; Guo JP; Smolnikova M; Dissen E; Seddighzadeh M; Brookes AJ; Alfredsson L; Klareskog L; Padyukov L; Fossum S
Article: JOURNAL OF IMMUNOLOGY. 2004;173(2):1366-1373

An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci.

Jagodic M; Becanovic K; Sheng JR; Wu X; Bäckdahl L; Lorentzen JC; Wallström E; Olsson T
Article: HUMAN MOLECULAR GENETICS. 2003;12(17):2087-2096

High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes.

Ribbhammar U; Flornes L; Bäckdahl L; Luthman H; Fossum S; Lorentzen JC
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(7):1907-1916

Paradoxical effects of arthritis-regulating chromosome 4 regions on myelin oligodendrocyte glycoprotein-induced encephalomyelitis in congenic rats.

Becanovic K; Bäckdahl L; Wallström E; Aboul-Enein F; Lassmann H; Olsson T; Lorentzen JC
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(2):551-559

Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains.

Bäckdahl L; Ribbhammar U; Lorentzen JC
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Preprint: MEDRXIV. 2021

Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;125:72-80

Association of NOX2 subunits genetic variants with autoimmune diseases.

Zhong J; Olsson LM; Urbonaviciute V; Yang M; Bäckdahl L; Holmdahl R
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):228-247

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.

Holmdahl R; Sareila O; Olsson LM; Bäckdahl L; Wing K
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:51.14

Adoptive transfers reveal dual roles in the protection against arthritis induction in the DACP rat

Norin U; Rintisch C; Tuncel J; Backdahl L; Ekman D; Holmdahl R
Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:51.4

Defining epigenome responses in T-cell arthritogenicity: in search for effectors of autoimmunity

Backdahl L; Holmdahl R
Review: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(12):1463-1474

Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells.

Holmdahl R; Sareila O; Pizzolla A; Winter S; Hagert C; Jaakkola N; Kelkka T; Olsson LM; Wing K; Bäckdahl L
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(1):176-184

Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation.

Bäckdahl L; Bushell A; Beck S
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:293-294

The APLEC gene complex regulates multiple forms of rat polyarthritis and multiple disease phenotypes

Guo J; Backdahl L; Ribbhammar U; Lorentzen JC
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2006;54(9):S301

A gene complex encoding C-type lectin-like receptors associates with arthritis in both rats and humans.

Lorentzen JC; Flornes L; Eklöw C; Bäckdahl L; Ribbhammar U; Guo JP; Dissen E; Seddighzadeh M; Ulfgren A-K; Smolnikova M; Brookes AJ; Alfredsson L; Klareskog L; Padyukov L; Fossum S
Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):20

An advanced intercross line resolves Eae18 into two narrow QTLs syntenic to multiple sclerosis candidate loci

Jagodic M; Becanovic K; Sheng JR; Wu X; Bäckdahl L; Lorentzen JC; Wallström E; Olsson T
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S228

High resolution mapping of an arthritis-susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes

Ribbhammar U; Flornes L; Bäckdahl L; Luthman H; Fossum S; Lorentzen JC

Anställningar

Forskningssamordnare, Medicinsk biokemi och biofysik, Karolinska Institutet, 2024-

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2005

Artiklar

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Anställningar

Examina och utbildning

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