Lena Backlund

Lena Backlund

Anknuten till Forskning
E-postadress: lena.backlund@ki.se
Besöksadress: CMM, Karolinska universitetssjukhuset L8:00, 17176 Stockholm
Postadress: K1 Molekylär medicin och kirurgi, K1 MMK Translationell psykiatri, 171 76 Stockholm
Del av:

Forskningsbeskrivning

  • Litiumprofylax vid bipolär sjukdom leder i mer än hälften av fallen till
    symtomreduktion, ibland helt tillfrisknande, s.k. litiumrespons. Behandlingen
    av bipolär sjukdom skulle förbättras avsevärt om det här fanns
    biologiska markörer för farmakaeffekter, vilket idag inte är fallet.
    Olika genvarianter kan vara en typ av markör för behandlingsrespons. Vi
    har skattat cirka 700 patienter för graden av litiumrespons, vilka utgör en
    stor del av materialet i det internationella projektet ConLiGen, men det
    finns flera molekylärgenetiska alternativ.
    Telomerer som skyddar DNA-proteinkomplex på DNA-strängarna i
    kromosomändarna förkortas med ökad ålder, stress och svår fysisk eller
    psykisk sjukdom, såsom depression, men de kan också repareras av enzymet
    telomeras. En ökad telomerasaktivitet tidigt efter insättning av
    antidepressiva, har i studier associerats till bättre behandlingssvar vid
    depression. I ett projekt som jag leder har vi visat att en fungerande
    litiumbehandling vid bipolär depression ger telomerförlängning men också
    att patienter men god litiumrespons generellt sett har längre telomerer än
    de som har sämre behandlingseffekt. Hypotesen är därför att en ökad
    telomerasaktivitet tidigt efter påbörjad litiumbehandling är kopplad till
    god behandlingsrespons.
    Epigenetiska, reversibla förändringar av genexpression utan förändringar
    i DNA sekvensen, är fundamentala för de fysiologiska processer som styr
    genernas aktivitet. De kan uppkomma genom omgivningens påverkan eller
    sjukdom. Vi undersöker om dessa förändringar förekommer i olika hög
    grad, kopplat till en senare effekt av litiumbehandling.
    I en prospektiv studie följer vi nu sjukdomsförloppet hos personer med
    bipolär sjukdom, före inledd litiumbehandling och regelbundet en tid
    därefter. Symtom, livskvalitet och funktionsförmåga skattas för att se
    hur dessa faktorer samvarierar med olika möjliga biomarkörer såsom
    genvarianter, telomeras-aktivitet och epigenetik.
    Positiva resultat kan bidra till utveckling av diagnostiska metoder och ge
    bipolära patienter en mer individualiserad behandling. Det skulle innebära
    ett minskat lidande för dessa svårt sjuka patienter och deras anhöriga och
    därmed vara av mycket stort kliniskt värde.

Artiklar

  • Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):109
    Ou AH; Rosenthal SB; Adli M; Akiyama K; Akula N; Alda M; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Del Zompo M; Degenhardt F; DePaulo JR; Etain B; Falkai P; Fellendorf FT; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Gruber O; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kato T; Kittel-Schneider S; Koenig B; Kuo P-H; Kusumi I; Lackner N; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Lopez Jaramillo CA; MacQueen G; Maj M; Manchia M; Marie-Claire C; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; McMahon FJ; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; Oesby U; Ozaki N; Papiol S; Perlis RH; Pisanu C; Potash JB; Pfennig A; Reich-Erkelenz D; Reif A; Reininghaus EZ; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schulze TG; Schweizer BW; Seemueller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Vieta E; Volkert J; Witt S; Wray NR; Wright A; Young LT; Zandi PP; Kelsoe JR
  • Article: MOLECULAR PSYCHIATRY. 2023;28(12):5251-5261
    Amare AT; Thalamuthu A; Schubert KO; Fullerton JM; Ahmed M; Hartmann S; Papiol S; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hou L; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Hasler R; Richard-Lepouriel H; Perroud N; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Marie-Claire C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Fallgatter AJ; Stegmaier S; Ethofer T; Biere S; Petrova K; Schuster C; Adorjan K; Budde M; Heilbronner M; Kalman JL; Kohshour MO; Reich-Erkelenz D; Schaupp SK; Schulte EC; Senner F; Vogl T; Anghelescu I-G; Arolt V; Dannlowski U; Dietrich D; Figge C; Jaeger M; Lang FU; Juckel G; Konrad C; Reimer J; Schmauss M; Schmitt A; Spitzer C; von Hagen M; Wiltfang J; Zimmermann J; Andlauer TFM; Fischer A; Bermpohl F; Ritter P; Matura S; Gryaznova A; Falkenberg I; Yildiz C; Kircher T; Schmidt J; Koch M; Gade K; Trost S; Haussleiter IS; Lambert M; Rohenkohl AC; Kraft V; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Ferensztajn-Rochowiak E; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Clark SR; Baune BT
  • Article: BIPOLAR DISORDERS. 2023;25(5):391-401
    Ponzer K; Millischer V; Schalling M; Gissler M; Lavebratt C; Backlund L
  • Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2023;227:115269
    Wikstrom F; Olsson C; Palm B; Roxhed N; Backlund L; Schalling M; Beck O
  • Article: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. 2023;58(4):537-545
    Wikstrom F; Zeberg H; Mayston R; Backlund L; Fekadu A
  • Article: LANCET PSYCHIATRY. 2022;9(6):447-457
    Millischer V; Matheson GJ; Bergen SE; Coombes BJ; Ponzer K; Wikstrom F; Jagiello K; Lundberg M; Stenvinkel P; Biernacka JM; Breuer O; Martinsson L; Landen M; Backlund L; Lavebratt C; Schalling M
  • Article: BRITISH JOURNAL OF PSYCHIATRY. 2022;220(4):1-10
    Cearns M; Amare AT; Schubert KO; Thalamuthu A; Frank J; Streit F; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Del Zompo M; De Paulo JR; Etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Hsu YH; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; Konig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; O'Donovan C; Ozaki N; Millischer V; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tekola-Ayele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Clark SR; Baune BT
  • Article: COMPLEX PSYCHIATRY. 2021;7(3-4):80-89
    Coombes BJ; Millischer V; Batzler A; Larrabee B; Hou L; Papiol S; Heilbronner U; Adli M; Akiyama K; Akula N; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cruceanu C; Czerski PM; Dalkner N; Degenhardt F; Del Zompo M; DePaulo JR; Étain B; Falkai P; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Jamain S; Jiménez E; Kahn J-P; Kassem L; Kato T; Kelsoe JR; Kittel-Schneider S; König B; Kuo P-H; Kusumi I; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Novák T; O'Donovan C; Osby U; Ozaki N; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tortorella A; Turecki G; Vieta E; Witt SH; Zandi PP; Fullerton JM; Alda M; Frye MA; Schulze TG; McMahon FJ; Biernacka JM
  • Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):606
    Schubert KO; Thalamuthu A; Amare AT; Frank J; Streit F; Adl M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Marie-Claire C; Cearns M; Cervantes P; Chen H-C; Chillotti C; Cichon S; Clark SR; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Del Zompo M; DePaulo JR; Etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hou L; Hsu Y-H; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Ferensztajn-Rochowiak E; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Oesby U; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tekola-Ayele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Baune BT
  • Article: SCIENTIFIC REPORTS. 2021;11(1):17823
    Le Clerc S; Lombardi L; Baune BT; Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Cearns M; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hofmann P; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe JR; Kittel-Schneider S; Ferensztajn-Rochowiak E; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leckband S; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Colom F; Millischer V; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofeld PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Pisanu C; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Boukouaci W; Richard J-R; Le Corvoisier P; Barrau C; Zagury J-F; Leboyer M; Tamouza R
  • Article: NATURE GENETICS. 2021;53(6):817-829
    Mullins N; Forstner AJ; O'Connell KS; Coombes B; Coleman JRI; Qiao Z; Als TD; Bigdeli TB; Borte S; Bryois J; Charney AW; Drange OK; Gandal MJ; Hagenaars SP; Ikeda M; Kamitaki N; Kim M; Krebs K; Panagiotaropoulou G; Schilder BM; Sloofman LG; Steinberg S; Trubetskoy V; Winsvold BS; Won H-H; Abramova L; Adorjan K; Agerbo E; Al Eissa M; Albani D; Alliey-Rodriguez N; Anjorin A; Antilla V; Antoniou A; Awasthi S; Baek JH; Baekvad-Hansen M; Bass N; Bauer M; Beins EC; Bergen SE; Birner A; Pedersen CB; Boen E; Boks MP; Bosch R; Brum M; Brumpton BM; Brunkhorst-Kanaan N; Budde M; Bybjerg-Grauholm J; Byerley W; Cairns M; Casas M; Cervantes P; Clarke T-K; Cruceanu C; Cuellar-Barboza A; Cunningham J; Curtis D; Czerski PM; Dale AM; Dalkner N; David FS; Degenhardt F; Djurovic S; Dobbyn AL; Douzenis A; Elvsashagen T; Escott-Price V; Ferrier IN; Fiorentino A; Foroud TM; Forty L; Frank J; Frei O; Freimer NB; Frisen L; Gade K; Garnham J; Gelernter J; Pedersen MG; Gizer IR; Gordon SD; Gordon-Smith K; Greenwood TA; Grove J; Guzman-Parra J; Ha K; Haraldsson M; Hautzinger M; Heilbronner U; Hellgren D; Herms S; Hoffmann P; Holmans PA; Huckins L; Jamain S; Johnson JS; Kalman JL; Kamatani Y; Kennedy JL; Kittel-Schneider S; Knowles JA; Kogevinas M; Koromina M; Kranz TM; Kranzler HR; Kubo M; Kupka R; Kushner SA; Lavebratt C; Lawrence J; Leber M; Lee H-J; Lee PH; Levy SE; Lewis C; Liao C; Lucae S; Lundberg M; MacIntyre DJ; Maier W; Maihofer A; Malaspina D; Maratou E; Martinsson L; Mattheisen M; McCarroll SA; McGregor NW; McGuffin P; McKay JD; Medeiros H; Medland SE; Millischer V; Montgomery GW; Moran JL; Morris DW; Muhleisen TW; O'Brien N; O'Donovan C; Loohuis LMO; Oruc L; Papiol S; Pardinas AF; Perry A; Pfennig A; Porichi E; Potash JB; Quested D; Raj T; Rapaport MH; DePaulo JR; Regeer EJ; Rice JP; Rivas F; Rivera M; Roth J; Roussos P; Ruderfer DM; Sanchez-Mora C; Schulte EC; Senner F; Sharp S; Shilling PD; Sigurdsson E; Sirignano L; Slaney C; Smeland OB; Sobell JL; Hansen CS; Artigas MS; Spijker AT; Stein DJ; Strauss JS; Swiatkowska B; Terao C; Thorgeirsson TE; Toma C; Tooney P; Tsermpini E-E; Vawter MP; Vedder H; Walters JTR; Witt SH; Xi S; Xu W; Yang JMK; Young AH; Young H; Zandi PP; Zhou H; Zillich L; Adolfsson R; Agartz I; Alda M; Alfredsson L; Babadjanova G; Backlund L; Baune BT; Bellivier F; Bengesser S; Berrettini WH; Blackwood DHR; Boehnke M; Borglum AD; Breen G; Carr VJ; Catts S; Corvin A; Craddock N; Dannlowski U; Dikeos D; Esko T; Etain B; Ferentinos P; Frye M; Fullerton JM; Gawlik M; Gershon ES; Goes F; Green MJ; Grigoroiu-Serbanescu M; Hauser J; Henskens F; Hillert J; Hong KS; Hougaard DM; Hultman CM; Hveem K; Iwata N; Jablensky AV; Jones I; Jones LA; Kahn RS; Kelsoe JR; Kirov G; Landen M; Leboyer M; Lewis CM; Li QS; Lissowska J; Lochner C; Loughland C; Martin NG; Mathews CA; Mayoral F; McElroy SL; McIntosh AM; McMahon FJ; Melle I; Michie P; Milani L; Mitchell PB; Morken G; Mors O; Mortensen PB; Mowry B; Muller-Myhsok B; Myers RM; Neale BM; Nievergelt CM; Nordentoft M; Nothen MM; ODonovan MC; Oedegaard KJ; Olsson T; Owen MJ; Paciga SA; Pantelis C; Pato C; Pato MT; Patrinos GP; Perlis RH; Posthuma D; Ramos-Quiroga JA; Reif A; Reininghaus EZ; Ribases M; Rietschel M; Ripke S; Rouleau GA; Saito T; Schall U; Schalling M; Schofield PR; Schulze TG; Scott LJ; Scott RJ; Serretti A; Weickert CS; Smoller JW; Stefansson H; Stefansson K; Stordal E; Streit F; Sullivan PF; Turecki G; Vaaler AE; Vieta E; Vincent JB; Waldman ID; Weickert TW; Werge T; Wray NR; Zwart J; Biernacka JM; Nurnberger JI; Cichon S; Edenberg HJ; Stahl EA; McQuillin A; Di Florio A; Ophoff RA; Andreassen OA
  • Article: MOLECULAR PSYCHIATRY. 2021;26(6):2457-2470
    Amare AT; Schubert KO; Hou L; Clark SR; Papiol S; Cearns M; Heilbronner U; Degenhardt F; Tekola-Ayele F; Hsu Y-H; Shekhtman T; AdIi M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J-M; Backlund L; Bhattacharjee K; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H-C; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Del Zompo M; DePaulo JR; Etain B; Jamain S; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe JR; Kittel-Schneider S; Kliwicki S; Koenig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Tortorella A; Manchia M; Martinsson L; McCarthy MJ; McElroy SL; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Noethen MM; Novak T; O'Donovan C; Ozaki N; Osby U; Pfennig A; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Maj M; Turecki G; Vieta E; Veeh J; Witt SH; Wright A; Zandi PP; Mitchell PB; Bauer M; Alda M; Rietschel M; McMahon FJ; Schulze TG; Baune BT
  • Article: SCIENTIFIC REPORTS. 2021;11(1):1155
    Stone W; Nunes A; Akiyama K; Akula N; Ardau R; Aubry J-M; Backlund L; Bauer M; Bellivier F; Cervantes P; Chen H-C; Chillotti C; Cruceanu C; Dayer A; Degenhardt F; Del Zompo M; Forstner AJ; Frye M; Fullerton JM; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hou L; Jimenez E; Kato T; Kelsoe J; Kittel-Schneider S; Kuo P-H; Kusumi I; Lavebratt C; Manchia M; Martinsson L; Mattheisen M; McMahon FJ; Millischer V; Mitchell PB; Noethen MM; O'Donovan C; Ozaki N; Pisanu C; Reif A; Rietschel M; Rouleau G; Rybakowski J; Schalling M; Schofield PR; Schulze TG; Severino G; Squassina A; Veeh J; Vieta E; Trappenberg T; Alda M
  • Article: BIPOLAR DISORDERS. 2020;22(3):255-265
    Scott J; Etain B; Manchia M; Brichant-Petitjean C; Geoffroy PA; Schulze T; Alda M; Bellivier F; Amare A; Ardau R; Backlund L; Baune B; Barboza A; Benabarre A; Chaumette B; Chen H; Chillotti C; Clark S; Colom F; Del Zompo M; Dalkner N; Dantas C; Ferentinos P; Garnham J; Jamain S; Jimenez E; Khan J-P; Kuo P; Lavebratt C; Maj M; Millischer V; Monteleone P; Pisanu C; Potash J; Reif A; Reininghaus E; Schalling M; Schofield P; Schubert K; Severino G; Slaney C; Smith D; Squassina A; Tondo L; Vieta E; Witt S
  • Article: PSYCHIATRY RESEARCH. 2020;284:112677
    Millischer V; Matheson GJ; Martinsson L; Ek IR; Schalling M; Lavebratt C; Backlund L
  • Article: CELL. 2019;179(7):1469-1482.e11
    Lee PH; Anttila V; Won H; Feng Y-CA; Rosenthal J; Zhu Z; Tucker-Drob EM; Nivard MG; Grotzinger AD; Posthuma D; Wang MM-J; Yu D; Stahl EA; Walters R-MK; Anney RJL; Duncan LE; Ge T; Adolfsson R; Banaschewski T; Belangero S; Cook EH; Coppola G; Derks EM; Hoekstra PJ; Kaprio J; Keski-Rahkonen A; Kirov G; Kranzler HR; Luykx JJ; Rohde LA; Zai CC; Agerbo E; Arranz MJ; Asherson P; Baekvad-Hansen M; Baldursson G; Bellgrove M; Belliveau RAJ; Buitelaar J; Burton CL; Bybjerg-Grauholm J; Casas M; Cerrato F; Chambert K; Churchhouse C; Gormand B; Crosbie J; Dalsgaard S; Demontis D; Doyle AE; Dumont A; Elia J; Grove J; Gudmundsson OO; Haavik J; Hakonarson H; Hansen CS; Hartman CA; Hawi Z; Hervas A; Hougaard DM; Howrigan DP; Huang H; Kuntsi J; Langley K; Lesch K-P; Leung PWL; Loo SK; Martin J; Martin AR; McGough JJ; Medland SE; Moran JL; Mors O; Mortensen PB; Oades RD; Palmer DS; Pedersen CB; Pedersen MG; Peters T; Poterba T; Poulsen JB; Ramos-Quiroga JA; Reif A; Ribases M; Rothenberger A; Rovira P; Sanchez-Mora C; Satterstrom FK; Schachar R; Artigas MS; Steinberg S; Stefansson H; Turley P; Walters GB; Werge T; Zayats T; Arking DE; Bettella F; Buxbaum JD; Christensen JH; Collins RL; Coon H; De Rubeis S; Delorme R; Grice DE; Hansen TF; Holmans PA; Hope S; Hultman CM; Klei L; Ladd-Acosta C; Magnusson P; NrIand T; Nyegaard M; Pinto D; Qvist P; Rehnstrom K; Reichenberg A; Reichert J; Roeder K; Rouleau GA; Saemundsen E; Sanders SJ; Sandin S; St Pourcain B; Stefansson K; Sutcliffe JS; Talkowski ME; Weiss LA; Willsey AJ; Agartz I; Akil H; Albani D; Alda M; Als TD; Anjorin A; Backlund L; Bass N; Bauer M; Baune BT; Bellivier F; Bergen SE; Berrettini WH; Biernacka JM; Blackwood DHR; Boen E; Budde M; Bunney W; Burmeister M; Byerley W; Byrne EM; Cichon S; Clarke T-K; Coleman JRI; Craddock N; Curtis D; Czerski PM; Dale AM; Dalkner N; Dannlowski U; Degenhardt F; Di Florio A; Elvsashagen T; Etain B; Fischer SB; Forstner AJ; Forty L; Frank J; Frye M; Fullerton JM; Gade K; Gaspar HA; Gershon ES; Gill M; 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Mir P; Morer A; Mueller-Vahl KR; Munchau A; Murphy TL; Naarden A; Nagy P; Nestadt G; Nestadt PS; Nicolini H; Nurmi EL; Okun MS; Paschou P; Piras F; Piras F; Pittenger C; Plessen KJ; Richter MA; Rizzo R; Robertson M; Roessner V; Ruhrmann S; Samuels JF; Sandor P; Schlogelhofer M; Shin E-Y; Singer H; Song D-H; Song J; Spalletta G; Stein DJ; Stewart SE; Storch EA; Stranger B; Stuhrmann M; Tarnok Z; Tischfield JA; Tubing J; Visscher F; Vulink N; Wagner M; Walitza S; Wanderer S; Woods M; Worbe Y; Zai G; Zinner SH; Sullivan PF; Franke B; Daly MJ; Bulik CM; McIntosh AM; O'Donovan MC; Zheutlin A; Andreassen OA; Borglum AD; Breen G; Edenberg HJ; Fanous AH; Faraone SV; Gelernter J; Mathews CA; Mattheisen M; Mitchell KS; Neale MC; Nurnberger JI; Ripke S; Santangelo SL; Scharf JM; Stein MB; Thornton LM; Walters JTR; Wray NR; Geschwind DH; Neale BM; Kendler KS; Smoller JW
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    Cearns M; Amare AT; Schubert KO; Thalamuthu A; Frank J; Streit F; Adli M; Akula N; Akiyama K; Ardau R; Arias B; Aubry J; Backlund L; Bhattacharjee AK; Bellivier F; Benabarre A; Bengesser S; Biernacka JM; Birner A; Brichant-Petitjean C; Cervantes P; Chen H; Chillotti C; Cichon S; Cruceanu C; Czerski PM; Dalkner N; Dayer A; Degenhardt F; Zompo MD; DePaulo JR; etain B; Falkai P; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Hsu Y-H; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kuo P-H; Kato T; Kelsoe J; Kittel-Schneider S; Kliwicki S; Konig B; Kusumi I; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Maj M; Manchia M; Martinsson L; McCarthy MJ; McElroy S; Colom F; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; O'Donovan C; Ozaki N; Millischer V; Papiol S; Pfennig A; Pisanu C; Potash JB; Reif A; Reininghaus E; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schweizer BW; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; TekolaAyele F; Tortorella A; Turecki G; Veeh J; Vieta E; Witt SH; Roberts G; Zandi PP; Alda M; Bauer M; McMahon FJ; Mitchell PB; Schulze TG; Rietschel M; Clark SR; Baune BT
  • Corrigendum: TRANSLATIONAL PSYCHIATRY. 2022;12(1):278
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  • Review: FRONTIERS IN PSYCHIATRY. 2020;11:586083
    Lundberg M; Millischer V; Backlund L; Martinsson L; Stenvinkel P; Sellgren CM; Lavebratt C; Schalling M
  • Thesis / dissertation: 2010
    Backlund, Lena
  • Letter: LAKARTIDNINGEN. 2009;106(23):1582
    Isacsson G; Backlund L; Spjut C; Andréewitch S
  • Meeting abstract: EUROPEAN PSYCHIATRY. 2008;23:S225
    Backlund L; Nikamo P; Rosvall L; Frisen L; Landen M; Ladanayi J; Traeskman-Bendz L; Agren H; Schalling M; Oesby U
  • Meeting abstract: EUROPEAN PSYCHIATRY. 2008;23:s227-s228
    Edman G; Backlund L; Adler M; Hallgren J; Sparen P; Osby U

Anställningar

  • Anknuten till Forskning, Molekylär medicin och kirurgi, Karolinska Institutet, 2023-2026

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för klinisk neurovetenskap, Karolinska Institutet, 2010

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