Laura Orellana
Assistant Professor
E-mail: laura.orellana@ki.se
Visiting address: BioClinicum - J6:06, Akademiska Stråket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Orellana, 171 77 Stockholm
About me
- I am a computational and structural biophysicist with a medical background
and passionate about physics and mathematical modelling. My aim is to
understand life mechanisms and human diseases at the atomic scale: how
protein structure, motions and biological function is shaped by evolution and
perturbed in human disease.
2022: Karolinska Institute Interdisciplinary Incubator (KIRI) Grant
2021: Sagens Foundation Award
2021: Vetenskapsrådet (Swedish Research Council) Starting Grant in Medicine
2021: Petrus och Augusta Hedlunds Foundation Grant
2021: Cancerfonden (Swedish Cancer Foundation) Junior Investigator Award
2020: Jeanssons Foundation Young Leaders Starting Grant
2020: Karolinska Institute Research Foundation Special Grant
2019: Karolinska Institute Tenure-track Faculty Position with start-up grant
Award (KI Allocation of faculty funded career positions 2019)
2019: O.E. och Edla Johanssons Research Grant
2016-2018: Sven och Lily Lawski Foundation Fellow
2014-2016: KTH Physics Department Fellowship
*Academic Honors*
2006: Extraordinary Prize for Academic Excellence in Biochemistry, University
of Barcelona
*Other Awards*
Biophysical Society Travel Award, New Orleans, US (2016)
EMBO Biomolecular Simulation Bursary Award, Institute Pasteur, Paris, France
(2012)
IUBMB-FEBS Young Scientist Program Fellow Award, Seville, Spain (2012)
EMBRACE-Rigaku-EBI (European Bioinformatics Institute) Bursary Award,
Cambridge, UK (2009)
*2010–2014: PhD in Physics /summa cum laude/*/, /Faculty of Physics,
University of Barcelona
/Thesis: /“Protein Dynamics and Function studied by coarse-grained and
atomistic theoretical approaches”/ /
*2008–2011: Clinical training* (M.D. degree, 2nd cycle, up to 345 out of
500 ECTS), Hospital Clínic de Barcelona & - Hospital Universitari Sagrat Cor
*2008 –2010: MSc in Biophysics*, Faculty of Physics, University of
Barcelona
*2006 – 2007: MSc in Structure & - Function of Proteins*, Barcelona
Autonomous University
*2003–2005: BSc in Biochemistry with Extraordinary Prize & - minor in
Physics*, Faculty of Biology, University of Barcelona
*1999–2003: Medicine* (M.D. degree, 1st cycle), Faculty of Medicine,
University of Barcelona
*Academic appointments*
*Nov. 2020: Tenure-track Assistant Professor in Medical Sciences*,
Karolinska Institute
*2019-2020: Researcher (Forskare) in Structural Biology*, Stockholm
University
*2014-2018: Postdoctoral Fellow in Computational Biophysics & - Cryo-EM*,
Royal Institute of Technology (KTH) & - Stockholm University (Science for Life
Laboratory, SciLifeLab)
*2008-2014: Graduate Student in Protein Biophysics & - Molecular
Modelling*, Institute for Research in Biomedicine in Barcelona & - Barcelona
Supercomputing Center
Research
- My group develops theoretical methods and algorithms to predict
conformational changes in proteins, and apply them to the in-depth
integrative study of mutations, with the aim to generate new mechanistic
hypothesis and test them /in vitro/ and/ in vivo./
For more information check the KI website of our team:
https://ki.se/en/onkpat/research-team-laura-orellana-protein-dynamics-and-cancer-lab
A complete publication list may be found at Google scholar and
ResearchGate.
Articles
- Article: NPJ GENOMIC MEDICINE. 2023;8(1):39
- Journal article: APPLIED SCIENCES. 2023;13(11):6756
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(2):108-120
- Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:890851
- Article: NATURE COMMUNICATIONS. 2021;12(1):1728
- Article: EMBO JOURNAL. 2020;39(24):e105908-4559
- Article: NATURE. 2020;578(7794):321-325
- Journal article: CANCER CELL. 2019;36(6):690-691
- Article: BIOINFORMATICS. 2019;35(18):3505-3507
- Article: MOLECULAR & CELLULAR ONCOLOGY. 2019;6(5):e1630798
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(20):10009-10018
- Journal article: CANCER CELL. 2019;35(5):816
- Article: CANCER CELL. 2019;35(3):504-518.e7
- Article: CANCER CELL. 2018;34(1):163-177.e7
- Article: NATURE COMMUNICATIONS. 2016;7:12575
- Article: NATURE COMMUNICATIONS. 2014;5:4070
- Journal article: SCIENCE. 2013;342(6154):37
- Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2012;8(11):4707-4718
- Journal article: SCIENCE. 2012;336(6077):32-34
- Journal article: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY. 2011;85:183-215
- Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2010;6(9):2910-2923
- Article: BIOINFORMATICS. 2009;25(13):1709-1710
- Show more
All other publications
- Corrigendum: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2023;30(4):565
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S206
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S193
- Book chapter: ADVANCES IN PROTEIN MOLECULAR AND STRUCTURAL BIOLOGY METHODS. 2022;p. 199-212
- Preprint: BIORXIV. 2021
- Conference publication: BIOPHYSICAL JOURNAL. 2021;120(3):105A
- Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):584A
- Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):191A
- Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):395A-396A
- Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):245A-246A
- Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2019;6:117
- Conference publication: BIOPHYSICAL JOURNAL. 2017;112(3):485A
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):54A
- Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):454A
- Conference publication: NEURO-ONCOLOGY. 2016;18:45
Grants
- Swedish Research Council1 January 2022 - 31 December 2025