Lars Holmgren

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i tumörbiologi vid Karolinska Institutet 2008-
Ordförande tema cancer, U2/Bioclinicum planering 2012-
Ordförande hörandeförsamling, 2013
Ordförande nomineringsförsamling, 2011-2013
Koordinator EU-consortium EUCAAD, 2008-2012
Medlem av advisory board Paoli Calmette Cancer Center, Marseille
Utvärderare av forskning, Vetenskapsrådet, Cancerfonden, Fernströms stiftelse, Internationella anslag
Studierektor doktorandutbildning, OnkPat, 2004-2014

Forskningsbeskrivning

Min forskning ligger inom ämnet tumörbiologi med inriktning på hur individuella celler bildar funktionella organ och hur dessa processer reverteras under canceromvandling. Våra projekt innefattar cell och molekylärbiologiska studier av pre-klinisk karaktär samt studier av patient material.

Utvalda publikationer

Article: NATURE COMMUNICATIONS. 2014;5:4557
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Mojallal M; Zheng Y; Hultin S; Audebert S; van Harn T; Johnsson P; Lenander C; Fritz N; Mieth C; Corcoran M; Lembo F; Hallstroem M; Hartman J; Mazure NM; Weide T; Grander D; Borg J-P; Uhlen P; Holmgren L
Article: NATURE COMMUNICATIONS. 2014;5:3743
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion
Hultin S; Zheng Y; Mojallal M; Vertuani S; Gentili C; Balland M; Milloud R; Belting H-G; Affolter M; Helker CSM; Adams RH; Herzog W; Uhlen P; Majumdar A; Holmgren L
Article: SCIENCE SIGNALING. 2013;6(291):ra77
The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis
Yi C; Shen Z; Stemmer-Rachamimov A; Dawany N; Troutman S; Showe LC; Liu Q; Shimono A; Sudol M; Holmgren L; Stanger BZ; Kissil JL
Article: NATURE COMMUNICATIONS. 2013;4:1672
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation
Hayashi M; Majumdar A; Li X; Adler J; Sun Z; Vertuani S; Hellberg C; Mellberg S; Koch S; Dimberg A; Koh GY; Dejana E; Belting H-G; Affolter M; Thurston G; Holmgren L; Vestweber D; Claesson-Welsh L
Article: CANCER CELL. 2011;19(4):527-540
A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
Yi C; Troutman S; Fera D; Stemmer-Rachamimov A; Avila JL; Christian N; Persson NL; Shimono A; Speicher DW; Marmorstein R; Holmgren L; Kissil JL

Artiklar

Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2024;44(3):666-689
Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction
Mannion AJ; Zhao H; Zhang Y; von Wright Y; Bergman O; Roy J; Saharinen P; Holmgren L
Article: CELLS. 2023;12(17):2158
Deciphering the Role of p60AmotL2 in Epithelial Extrusion and Cell Detachment
Cui W; Subramani A; Fonseca P; Zhang Y; Tong L; Zhang Y; Egevad L; Lundqvist A; Holmgren L
Article: NATURE CARDIOVASCULAR RESEARCH. 2023;2(7):629-644
The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms
Zhang Y; Zhang Y; Hutterer E; Hultin S; Bergman O; Kolbeinsdottir S; Jin H; Forteza MJ; Ketelhuth DFJ; Roy J; Hedin U; Enge M; Matic L; Eriksson P; Holmgren L
Article: CELLS. 2023;12(13):1682
Modulation of E-Cadherin Function through the AmotL2 Isoforms Promotes Ameboid Cell Invasion
Subramani A; Cui W; Zhang Y; Friman T; Zhao Z; Huang W; Fonseca P; Lui W-O; Narayanan V; Bobrowska J; Lekka M; Yan J; Conway DEE; Holmgren L
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(10):535
p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin
Maeso-Alonso L; Alonso-Olivares H; Martinez-Garcia N; Lopez-Ferreras L; Villoch-Fernandez J; Puente-Santamaria L; Colas-Algora N; Fernandez-Corona A; Lorenzo-Marcos ME; Jimenez B; Holmgren L; Wilhelm M; Millan J; del Peso L; Claesson-Welsh L; Marques MM; Marin MC
Article: CELL REPORTS. 2021;36(8):109616
The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
Zhang Y; Zhang Y; Kameishi S; Barutello G; Zheng Y; Tobin NP; Nicosia J; Hennig K; Chiu DK-C; Balland M; Barker TH; Cavallo F; Holmgren L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(10):5508-5522
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells
Yang Y; Neo SY; Chen Z; Cui W; Chen Y; Guo M; Wang Y; Xu H; Kurzay A; Alici E; Holmgren L; Haglund F; Wang K; Lundqvist A
Article: PLOS BIOLOGY. 2019;17(5):e3000253
Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice
Rojek KO; Krzemien J; Dolezyczek H; Boguszewski PM; Kaczmarek L; Konopka W; Rylski M; Jaworski J; Holmgren L; Proszynski TJ
Article: SCIENTIFIC REPORTS. 2017;7(1):9540
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching
Hildebrand S; Hultin S; Subramani A; Petropoulos S; Zhang Y; Cao X; Mpindi J; Kalloniemi O; Johansson S; Majumdar A; Lanner F; Holmgren L
Article: SCIENTIFIC REPORTS. 2017;7(1):7548
AmotL2 integrates polarity and junctional cues to modulate cell shape
Hultin S; Subramani A; Hildebrand S; Zheng Y; Majumdar A; Holmgren L
Article: ACS NANO. 2017;11(7):7110-7117
Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis
Cao L; Nicosia J; Larouche J; Zhang Y; Bachman H; Brown AC; Holmgren L; Barker TH
Article: SCIENTIFIC REPORTS. 2016;6:30622
Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis
Zheng Y; Zhang Y; Barutello G; Chiu K; Arigoni M; Giampietro C; Cavallo F; Holmgren L
Article: ONCOIMMUNOLOGY. 2015;4(5):e1005500
Antitumor immunization of mothers delays tumor development in cancer-prone offspring
Barutello G; Curcio C; Spadaro M; Arigoni M; Trovato R; Bolli E; Zheng Y; Ria F; Quaglino E; Iezzi M; Riccardo F; Holmgren L; Forni G; Cavallo F
Article: EJNMMI RESEARCH. 2014;4(1):17
Visualization of angiogenesis during cancer development in the polyoma middle T breast cancer model: molecular imaging with (R)-[¹¹C]PAQ
Samen E; Lu L; Mulder J; Thorell J-O; Damberg P; Tegnebratt T; Holmgren L; Rundqvist H; Stone-Elander S
Article: CIRCULATION. 2014;129(12):1295-1302
Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever With Renal Syndrome A Self-Controlled Case Series Study
Connolly-Andersen A-M; Hammargren E; Whitaker H; Eliasson M; Holmgren L; Klingstrom J; Ahlm C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(13):8991-9000
Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin
Stalin J; Harhouri K; Hubert L; Subrini C; Lafitte D; Lissitzky J-C; Elganfoud N; Robert S; Foucault-Bertaud A; Kaspi E; Sabatier F; Aurrand-Lions M; Bardin N; Holmgren L; Dignat-George F; Blot-Chabaud M
Article: ANGIOGENESIS. 2012;15(2):305-316
A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors
Arigoni M; Barutello G; Lanzardo S; Longo D; Aime S; Curcio C; Iezzi M; Zheng Y; Barkefors I; Holmgren L; Cavallo F
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(7):811-820
Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes
Zhang X; Zheng Y; Fried LE; Du Y; Montano SJ; Sohn A; Lefkove B; Holmgren L; Arbiser JL; Holmgren A; Lu J
Article: MOLECULAR CANCER RESEARCH. 2010;8(9):1198-1206
Regional Control of Tumor Growth
Zaslavsky A; Chen C; Grillo J; Baek K-H; Holmgren L; Yoon SS; Folkman J; Ryeom S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):147-151
Horizontal gene transfer: You are what you eat
Holmgren L
Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2009;36(8):1283-1295
Synthesis and preclinical evaluation of [¹¹C]PAQ as a PET imaging tracer for VEGFR-2
Samen E; Thorell J-O; Lu L; Tegnebratt T; Holmgren L; Stone-Elander S
Article: CIRCULATION RESEARCH. 2009;105(3):260-270
Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis
Zheng Y; Vertuani S; Nystrom S; Audebert S; Meijer I; Tegnebratt T; Borg J-P; Uhlen P; Majumdar A; Holmgren L
Article: CELL DEATH AND DIFFERENTIATION. 2009;16(5):749-757
Horizontal transfer of tumor DNA to endothelial cells in vivo
Ehnfors J; Kost-Alimova M; Persson NL; Bergsmedh A; Castro J; Levchenko-Tegnebratt T; Yang L; Panaretakis T; Holmgren L
Article: BLOOD. 2009;113(1):244-253
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells
Ernkvist M; Persson NL; Audebert S; Lecine P; Sinha I; Liu M; Schlueter M; Horowitz A; Aase K; Weide T; Borg J-P; Majumdar A; Holmgren L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2008;1783(3):429-437
Differential roles of p80-and p130-angiomotin in the switch between migration and stabilization of endothelial cells
Ernkvist M; Birot O; Sinha I; Veitonmaki N; Nystrom S; Aase K; Holmgren L
Article: THE FASEB JOURNAL. 2008;22(3):880-889
Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo
Levchenko T; Veitonmaeki N; Lundkvist A; Gerhardt H; Ming Y; Berggren K; Kvanta A; Carlsson R; Holmgren L
Article: GENES & DEVELOPMENT. 2007;21(16):2055-2068
Angiomotin regulates endothelial cell migration during embryonic angiogenesis
Aase K; Ernkvist M; Ebarasi L; Jakobsson L; Majumdar A; Yi C; Birot O; Ming Y; Kvanta A; Edholm D; Aspenstrom P; Kissil J; Claesson-Welsh L; Shimono A; Holmgren L
Article: FEBS LETTERS. 2007;581(16):2943-2946
A Cre-loxP based system for studying horizontal gene transfer
Bergsmedh A; Ehnfors J; Spetz A-L; Holmgren L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(24):9208-9213
A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth
Holmgren L; Ambrosino E; Birot O; Tullus C; Veitonmaki N; Levchenko T; Carlson L-M; Musiari P; Iezzi M; Curcio C; Forni G; Cavallo F; Kiessling R
Article: THE FEBS JOURNAL. 2006;273(9):2000-2011
p130-Angiomotin associates to actin and controls endothelial cell shape
Ernkvist M; Aase K; Ukomadu C; Wohlschlegel J; Blackman R; Veitonmäki N; Bratt A; Dutta A; Holmgren L
Article: MOLECULAR CANCER RESEARCH. 2006;4(3):187-195
DNase II and the Chk2 DNA damage pathway form a genetic barrier blocking replication of horizontally transferred DNA
Bergsmedh A; Ehnfors J; Kawane K; Motoyama N; Nagata S; Holmgren L
Article: BMC CANCER. 2006;6:16
Angiomotin and angiomotin like proteins, their expression and correlation with angiogenesis and clinical outcome in human breast cancer
Jiang WG; Watkins G; Douglas-Jones A; Holmgren L; Mansel RE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(41):34859-34869
Angiomotin regulates endothelial cell-cell junctions and cell motility
Bratt A; Birot O; Sinha I; Veitonmäki N; Aase K; Ernkvist M; Holmgren L
Article: ONCOGENE. 2004;23(7):1469-1473
Angiomotin expression promotes hemangioendothelioma invasion
Levchenko T; Bratt A; Arbiser JL; Holmgren L
Article: JOURNAL OF CELL SCIENCE. 2003;116(18):3803-3810
Loss of responsiveness to chemotactic factors by deletion of the C-terminal protein interaction site of angiomotin
Levchenko T; Aase K; Troyanovsky B; Bratt A; Holmgren L
Article: ANNALS OF SURGERY. 2003;237(4):530-535
Endothelial-directed hepatic regeneration after partial hepatectomy
Greene AK; Wiener S; Puder M; Yoshida A; Shi B; Perez-Atayde AR; Efstathiou JA; Holmgren L; Adamis AP; Rupnick M; Folkman J; O'Reilly MS
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(4):1260-1268
Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction
Antonson P; Schuster GU; Wang L; Rozell B; Holter E; Flodby P; Treuter E; Holmgren L; Gustafsson J
Article: JOURNAL OF IMMUNOLOGY. 2002;169(10):5771-5779
Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells
Spetz AL; Sörensen AS; Walther-Jallow L; Wahren B; Andersson J; Holmgren L; Hinkula J
Article: GENE. 2002;298(1):69-77
Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains
Bratt A; Wilson WJ; Troyanovsky B; Aase K; Kessler R; Van Meir EG; Holmgren L
Article: CANCER RESEARCH. 2002;62(2):575-579
Loss of the p21^Cip1/Waf1 cyclin kinase inhibitor results in propagation of horizontally transferred DNA
Bergsmedh A; Szeles A; Spetz AL; Holmgren L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6407-6411
Horizontal transfer of oncogenes by uptake of apoptotic bodies
Bergsmedh A; Szeles A; Henriksson M; Bratt A; Folkman MJ; Spetz AL; Holmgren L
Article: JOURNAL OF CELL BIOLOGY. 2001;152(6):1247-1254
Angiomotin:: An angiostatin binding protein that regulates endothelial cell migration and tube formation
Troyanovsky B; Levchenko T; Månsson G; Matvijenko O; Holmgren L
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):736-742
Functional gene transfer of HIV DNA by an HIV receptor-independent mechanism
Spetz AL; Patterson BK; Lore K; Andersson J; Holmgren L
Article: BLOOD. 1999;93(11):3956-3963
Horizontal transfer of DNA by the uptake of apoptotic bodies
Holmgren L; Szeles A; Rajnavölgyi E; Folkman J; Klein G; Ernberg I; Falk KI
Article: ANGIOGENESIS. 1999;3(4):291-293
A novel method of visualizing vessels in human tumor biopsies.
Lenander C; Holmgren L
Article: BLOOD. 1998;92(12):4730-4741
Multiple forms of angiostatin induce apoptosis in endothelial cells
Lucas R; Holmgren L; Garcia I; Jimenez B; Mandriota SJ; Borlat F; Sim BKL; Wu Z; Grau GE; Shing Y; Soff GA; Bouck N; Pepper MS
Article: ONCOGENE. 1998;17(7):819-824
P53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma
Holmgren L; Jackson G; Arbiser J
Article: NATURE MEDICINE. 1996;2(6):689-692
Angiostatin induces and sustains dormancy of human primary tumors in mice
OReilly MS; Holmgren L; Chen C; Folkman J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(5):2002-2007
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
Parangi S; O'Reilly M; Christofori G; Holmgren L; Grosfeld J; Folkman J; Hanahan D
Article: NATURE MEDICINE. 1995;1(2):149-153
Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression.
Holmgren L; O'Reilly MS; Folkman J
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Alla övriga publikationer

Review: DISEASE MODELS & MECHANISMS. 2023;16(10):dmm050361
Nuclear mechanosensing of the aortic endothelium in health and disease
Mannion AJ; Holmgren L
Corrigendum: GENE. 2003;310:221
Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains (vol 298, pg 69, 2002)
Bratt A; Wilson WJ; Troyanovsky B; Aase K; Kessler R; Van Meir EG; Holmgren L
Published conference paper: VOX SANGUINIS. 2002;83:305-306
Horizontal transfer of DNA by the uptake of apoptotic bodies
Holmgren L; Bergsmedh A; Spetz AL
Review: CANCER AND METASTASIS REVIEWS. 1996;15(2):241-245
Antiangiogenesis restricted tumor dormancy
Holmgren L

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