Kirsty Spalding

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Jag är professor i professor i fettcellsbiologi vid institutionen för cell- och molekylärbiologi. Min forskning är inriktad på studier av adipocyter, en typ av fettceller, hur de bildas och omsätts.
Läs mer om min forskning på
den engelska gruppsidan.

Artiklar

Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2023;378(1888):20220202
Implication of lipid turnover for the control of energy balance
Bernard S; Spalding KL
Article: NATURE. 2023;613(7943):355-364
A DNA methylation atlas of normal human cell types
Loyfer N; Magenheim J; Peretz A; Cann G; Bredno J; Klochendler A; Fox-Fisher I; Shabi-Porat S; Hecht M; Pelet T; Moss J; Drawshy Z; Amini H; Moradi P; Nagaraju S; Bauman D; Shveiky D; Porat S; Dior U; Rivkin G; Or O; Hirshoren N; Carmon E; Pikarsky A; Khalaileh A; Zamir G; Grinbaum R; Abu Gazala M; Mizrahi I; Shussman N; Korach A; Wald O; Izhar U; Erez E; Yutkin V; Samet Y; Rotnemer Golinkin D; Spalding KL; Druid H; Arner P; Shapiro AMJ; Grompe M; Aravanis A; Venn O; Jamshidi A; Shemer R; Dor Y; Glaser B; Kaplan T
Journal article: 2022
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Q L; CE H; HS C; S L; MT H; F S; P C; I A; E T; MJ H; M K; N A; N K; M A; C K; J B; A T; KL S
Article: ELIFE. 2022;11:e76391
Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study
Lubotzky A; Pelov I; Teplitz R; Neiman D; Smadja A; Zemmour H; Piyanzin S; Ochana B-L; Spalding KL; Glaser B; Shemer R; Dor Y; Kohn Y
Article: JCI INSIGHT. 2022;7(2):e153559
Graphical abstract
Lubotzky A; Zemmour H; Neiman D; Gotkine M; Loyfer N; Piyanzin S; Ochana B-L; Lehmann-Werman R; Cohen D; Moss J; Magenheim J; Loftus MF; Brais L; Ng K; Mostoslavsky R; Wolpin BM; Zick A; Maoz M; Grinshpun A; Kustanovich A; Makranz C; Cohen JE; Peretz T; Hubert A; Temper M; Salah A; Avniel-Polak S; Grozinsky-Glasberg S; Spalding KL; Rokach A; Kaplan T; Glaser B; Shemer R; Dor Y
Article: NATURE MEDICINE. 2021;27(11):1941-1953
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvonen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ; Kutschke M; Arifen N; Kramer N; Aouadi M; Knibbe C; Boucher J; Thorell A; Spalding KL
Journal article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):62
Radiocarbon dating
Hajdas I; Ascough P; Garnett MH; Fallon SJ; Pearson CL; Ouarta G; Spalding KL; Yamaguchiw H; Yoneda M
Article: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2020;97(8):800-810
Practical Guidelines for Optimization and Characterization of the Beckman Coulter CytoFLEX™ Platform
Bhowmick D; Sheridan RTC; Bushnell TP; Spalding KL
Article: NATURE MEDICINE. 2019;25(9):1385-1389
Adipose lipid turnover and long-term changes in body weight
Arner P; Bernard S; Appelsved L; Fu K-Y; Andersson DP; Salehpour M; Thorell A; Ryden M; Spalding KL
Article: CELL REPORTS. 2019;27(1):213-225.e5
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes
Harms MJ; Li Q; Lee S; Zhang C; Kull B; Hallen S; Thorell A; Alexandersson I; Hagberg CE; Peng X-R; Mardinoglu A; Spalding KL; Boucher J
Article: NATURE COMMUNICATIONS. 2018;9(1):5068
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Moss J; Magenheim J; Neiman D; Zemmour H; Loyfer N; Korach A; Samet Y; Maoz M; Druid H; Arner P; Fu K-Y; Kiss E; Spalding KL; Landesberg G; Zick A; Grinshpun A; Shapiro AMJ; Grompe M; Wittenberg AD; Glaser B; Shemer R; Kaplan T; Dor Y
Article: CELL REPORTS. 2018;25(3):551-560.e5
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
Article: CELL REPORTS. 2018;24(10):2746-2756.e5
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
Hagberg CE; Li Q; Kutschke M; Bhowmick D; Kiss E; Shabalina IG; Harms MJ; Shilkova O; Kozina V; Nedergaard J; Boucher J; Thorell A; Spalding KL
Article: NATURE COMMUNICATIONS. 2017;8:15253
Impact of fat mass and distribution on lipid turnover in human adipose tissue
Spalding KL; Bernard S; Naslund E; Salehpour M; Possnert G; Appelsved L; Fu K-Y; Alkass K; Druid H; Thorell A; Ryden M; Arner P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(13):E1826-E1834
Identification of tissue-specific cell death using methylation patterns of circulating DNA
Lehmann-Werman R; Neiman D; Zemmour H; Moss J; Magenheim J; Vaknin-Dembinsky A; Rubertsson S; Nellgard B; Blennow K; Zetterberg H; Spalding K; Haller MJ; Wasserfall CH; Schatz DA; Greenbaum CJ; Dorrell C; Grompe M; Zick A; Hubert A; Maoz M; Fendrich V; Bartsch DK; Golan T; Ben Sasson SA; Zamir G; Razin A; Cedar H; Shapiro AMJ; Glaser B; Shemer R; Dor Y
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2016;8(3):a025981
Detection and Phenotypic Characterization of Adult Neurogenesis
Kuhn HG; Eisch AJ; Spalding K; Peterson DA
Article: CELL METABOLISM. 2015;22(3):408-417
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2015;7(7):a018994
Adult Neurogenesis in Humans
Bergmann O; Spalding KL; Frisen J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;308(9):E822-E829
Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis
Abreu-Vieira G; Hagberg CE; Spalding KL; Cannon B; Nedergaard J
Article: JOURNAL OF LIPID RESEARCH. 2013;54(10):2909-2913
Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects
Ryden M; Andersson DP; Bernard S; Spalding K; Arner P
Article: CELL. 2013;153(6):1219-1227
Dynamics of Hippocampal Neurogenesis in Adult Humans
Spalding KL; Bergmann O; Alkass K; Bernard S; Salehpour M; Huttner HB; Bostrom E; Westerlund I; Vial C; Buchholz BA; Possnert G; Mash DC; Druid H; Frisen J
Article: PLOS ONE. 2013;8(7):e69597
Analysis of Radiocarbon, Stable Isotopes and DNA in Teeth to Facilitate Identification of Unknown Decedents
Alkass K; Saitoh H; Buchholz BA; Bernard S; Holmlund G; Senn DR; Spalding KL; Druid H
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2012;1(6):e003467
Adipocyte Triglyceride Turnover Is Independently Associated With Atherogenic Dyslipidemia
Frayn K; Bernard S; Spalding K; Arner P
Article: JOURNAL OF FORENSIC SCIENCES. 2012;57(5):1354-1360
Personal Identification of Cold Case Remains Through Combined Contribution from Anthropological, mtDNA, and Bomb-Pulse Dating Analyses
Speller CF; Spalding KL; Buchholz BA; Hildebrand D; Moore J; Mathewes R; Skinner MF; Yang DY
Article: NEURON. 2012;74(4):634-639
The Age of Olfactory Bulb Neurons in Humans
Bergmann O; Liebl J; Bernard S; Alkass K; Yeung MSY; Steier P; Kutschera W; Johnson L; Landen M; Druid H; Spalding KL; Frisen J
Article: NATURE. 2011;478(7367):110-113
Dynamics of human adipose lipid turnover in health and metabolic disease
Arner P; Bernard S; Salehpour M; Possnert G; Liebl J; Steier P; Buchholz BA; Eriksson M; Arner E; Hauner H; Skurk T; Ryden M; Frayn KN; Spalding KL
Article: FORENSIC SCIENCE INTERNATIONAL. 2011;209(1-3):34-41
Analysis of ¹⁴C and ¹³C in teeth provides precise birth dating and clues to geographical origin
Alkass K; Buchholz BA; Druid H; Spalding KL
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):101-104
Fat cell turnover in humans
Arner P; Spalding KL
Article: SURFACE AND INTERFACE ANALYSIS. 2010;42(5):398-401
Year of birth determination using radiocarbon dating of dental enamel
Buchholz BA; Spalding KL
Article: DIABETES. 2010;59(1):105-109
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner E; Westermark PO; Spalding KL; Britton T; Ryden M; Frisen J; Bernard S; Arner P
Journal article: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2008;63(9):577-578
Dynamics of Fat Cell Turnover in Humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Näslund E; Britton T; Concha H; Hassan M; Rydén M; Frisén J; Arner P
Article: NATURE. 2008;453(7196):783-787
Dynamics of fat cell turnover in humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Naslund E; Britton T; Concha H; Hassan M; Ryden M; Frisen J; Arner P
Journal article: AKTUELLE NEUROLOGIE. 2007;34(S 2)
Detektion von adulter Neurogenese im Menschen mithilfe des 14C-Atombombenpeaks
Bergmann O; Spalding K; Bhardwaj R; Alkass K; Druid H; Buchholz B; Frisén J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(33):12564-12568
Neocortical neurogenesis in humans is restricted to development
Bhardwaj RD; Curtis MA; Spalding KL; Buchholz BA; Fink D; Bjork-Eriksson T; Nordborg C; Gage FH; Druid H; Eriksson PS; Frisen J
Article: CELL. 2005;122(1):133-143
Retrospective birth dating of cells in humans
Spalding KL; Bhardwaj RD; Buchholz BA; Druid H; Frisén J
Article: GENES & DEVELOPMENT. 2005;19(4):462-471
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2005;21(1):33-45
Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat.
Spalding KL; Dharmarajan AM; Harvey AR
Article: NEUROSCIENCE. 2005;131(2):387-395
Retinal ganglion cell neurotrophin receptor levels and trophic requirements following target ablation in the neonatal rat.
Spalding KL; Cui Q; Harvey AR
Article: DEVELOPMENTAL NEUROBIOLOGY. 2004;60(3):319-327
Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina.
Spalding KL; Rush RA; Harvey AR
Article: EXPERIMENTAL NEUROLOGY. 2004;186(1):6-19
Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.
Mellough CB; Cui Q; Spalding KL; Symons NA; Pollett MA; Snyder EY; Macklis JD; Harvey AR
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;19(4):485-500
Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system.
Spalding KL; Tan MML; Hendry IA; Harvey AR
Article: DEVELOPMENTAL BRAIN RESEARCH. 1998;107(1):133-142
The effects of central administration of neurotrophins or transplants of fetal tectal tissue on retinal ganglion cell survival following removal of the superior colliculus in neonatal rats.
Spalding KL; Cui Q; Harvey AR
Journal article:
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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Alla övriga publikationer

Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):270-289
White adipocyte dysfunction and obesity-associated pathologies in humans
Hagberg CE; Spalding KL
Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):333
White adipocyte dysfunction and obesity-associated pathologies in humans (vol 25, pg 270, 2023)
Hagberg CE; Spalding KL
Editorial comment: EBIOMEDICINE. 2022;81:104105
Profiling hypertrophic adipocytes in humans, from transcriptomics to diagnostics Comment
Li Q; Spalding KL
Preprint: MEDRXIV. 2022
Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study
Lubotzky A; pelov I; Teplitz R; Neiman D; Smadja A; Zemmour H; Piyanzin S; Ochana B-L; Spalding KL; Glaser B; Shemer R; Dor Y; Kohn Y
Preprint: BIORXIV. 2022
A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elements
Loyfer N; Magenheim J; Peretz A; Cann G; Bredno J; Klochendler A; Fox-Fisher I; Shabi-Porat S; Hecht M; Pelet T; Moss J; Drawshy Z; Amini H; Moradi P; Nagaraju S; Bauman D; Shveiky D; Porat S; Rivkin G; Or O; Hirshoren N; Carmon E; Pikarsky A; Khalaileh A; Zamir G; Grinboim R; Abu Gazala M; Mizrahi I; Shussman N; Korach A; Wald O; Izhar U; Erez E; Yutkin V; Samet Y; Golinkin DR; Spalding KL; Druid H; Arner P; Shapiro AMJ; Grompe M; Aravanis A; Venn O; Jamshidi A; Shemer R; Dor Y; Glaser B; Kaplan T
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1003219
The regulation of adipocyte growth in white adipose tissue
Li Q; Spalding KL
Review: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(5):934-943
Cellular senescence and its role in white adipose tissue
Smith U; Li Q; Ryden M; Spalding KL
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
Preprint: BIORXIV. 2018
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Moss J; Magenheim J; Neiman D; Zemmour H; Loyfer N; Korach A; Samet Y; Maoz M; Druid H; Arner P; Fu K-Y; Kiss E; Spalding KL; Landesberg G; Zick A; Grinshpun A; Shapiro AJ; Grompe M; Wittenberg AD; Glaser B; Shemer R; Kaplan T; Dor Y
Book chapter: NEW PERSPECTIVES IN FORENSIC HUMAN SKELETAL IDENTIFICATION. 2018;p. 185-196
Chapter 16 Bomb Pulse Radiocarbon Dating of Skeletal Tissues
Buchholz BA; Alkass K; Druid H; Spalding KL
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2017;253
Macromolecular isolation and purification in AMS
Buchholz B; Spalding K; Dreier R; Maze I; Mailloux B; Carratt S; Van WInkle L; Ognibene T; Kuhn E; Hum N; Etminan N; Loots G
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2014;56:123-132
Maintenance of white adipose tissue in man
Hyvonen MT; Spalding KL
Conference publication: JOURNAL OF MOLECULAR NEUROSCIENCE. 2013;51:S117
Radiocarbon analysis of neurogenesis in the adult human brain
Spalding K; Bergmann O; Alkass K; Buchholz B; Salehpour M; Possnert G; Liebl J; Steier P; Kutschera W; Bernard S; Druid H; Frisen J
Published conference paper: MOLECULAR & CELLULAR PROTEOMICS. 2010;9(5):1022-1030
Age Estimation in Forensic Sciences APPLICATION OF COMBINED ASPARTIC ACID RACEMIZATION AND RADIOCARBON ANALYSIS
Alkass K; Buchholz BA; Ohtani S; Yamamoto T; Druid H; Spalding KL
Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION B: BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 2010;268(7-8):1295-1298
A mathematical model for the interpretation of nuclear bomb test derived ¹⁴C incorporation in biological systems
Bernard S; Frisen J; Spalding KL
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2009;:S43
Age Determination in the Adult Human Brain and Body Using Bomb-Carbon
Spalding KL; Bergmann O; Bernard S; Druid H; Buchholz B; Arner PA; Frisen J
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2006;232
ANYL 165-Forensic dating of dental enamel with bomb-pulse radiocarbon
Buchholz BA; Spalding KL; Bergman L-E; Druid H; Frisen J
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2006;572:447-451
Injury-induced retinal ganglion cell loss in the neonatal rat retina.
Spalding KL; Cui Q; Dharmarajan AM; Harvey AR
Editorial comment: NATURE. 2005;437(7057):333-334
Age written in teeth by nuclear tests
Spalding KL; Buchholz BA; Bergman LE; Druid H; Frisén J

Forskningsbidrag

Investigating DNA damage as a driver of adipocyte senescence and inflammation in obese, hyperinsulinemic individuals
Novo Nordisk Foundation
1 August 2023 - 31 July 2026
Targeting senescent adipocytes to treat tumour progression and metastasis in humans
Swedish Research Council
1 January 2023 - 31 December 2026
ADIPOSE TISSUE SENESCENCE IN HUMANS
Novo Nordisk Foundation
11 January 2021 - 31 July 2023
Senescens i fettvävnad och metabola sjukdomar hos människa
Knut and Alice Wallenberg Foundation
1 January 2020 - 1 January 2025
Cell regeneration in the human kidney in health and disease
Swedish Research Council
1 January 2019 - 31 December 2022
Adipose tissue and metabolic disease in man
Swedish Research Council
1 January 2013 - 31 December 2018
Adipose tissue and metabolic disease in man
Novo Nordisk Foundation
19 March 2012 - 31 March 2019
Adipose tissue mass regulation in lean and obese individuals
European Research Council
1 April 2011 - 31 March 2017
The contribution of failing neurogenesis to psychiatric disorders
Swedish Research Council
1 January 2011 - 31 December 2013
VINNMER Marie Curie international qualification, Kirsty Spalding
VINNOVA
1 September 2009 - 31 December 2015
Equipment for research aimed at assessing neurogenesis in the adult human brain by measuring nuclear bomb test-derived carbon-14 in DNA
Swedish Research Council
1 July 2009 - 31 March 2014
Planning Grant Kirsty Spalding
VINNOVA
21 March 2009 - 10 October 2009

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