Kirsty Spalding

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About me

I am a Professor of Adipocyte Biology at the Department of Cell and Molecular Biology. My lab is primarily interested in investigating the origin and turnover of adipocytes, their progenitor cells and lipid stores in lean and obese individuals.
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Articles

Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2023;378(1888):20220202
Implication of lipid turnover for the control of energy balance
Bernard S; Spalding KL
Article: NATURE. 2023;613(7943):355-364
A DNA methylation atlas of normal human cell types
Loyfer N; Magenheim J; Peretz A; Cann G; Bredno J; Klochendler A; Fox-Fisher I; Shabi-Porat S; Hecht M; Pelet T; Moss J; Drawshy Z; Amini H; Moradi P; Nagaraju S; Bauman D; Shveiky D; Porat S; Dior U; Rivkin G; Or O; Hirshoren N; Carmon E; Pikarsky A; Khalaileh A; Zamir G; Grinbaum R; Abu Gazala M; Mizrahi I; Shussman N; Korach A; Wald O; Izhar U; Erez E; Yutkin V; Samet Y; Rotnemer Golinkin D; Spalding KL; Druid H; Arner P; Shapiro AMJ; Grompe M; Aravanis A; Venn O; Jamshidi A; Shemer R; Dor Y; Glaser B; Kaplan T
Journal article: 2022
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Q L; CE H; HS C; S L; MT H; F S; P C; I A; E T; MJ H; M K; N A; N K; M A; C K; J B; A T; KL S
Article: ELIFE. 2022;11:e76391
Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study
Lubotzky A; Pelov I; Teplitz R; Neiman D; Smadja A; Zemmour H; Piyanzin S; Ochana B-L; Spalding KL; Glaser B; Shemer R; Dor Y; Kohn Y
Article: JCI INSIGHT. 2022;7(2):e153559
Graphical abstract
Lubotzky A; Zemmour H; Neiman D; Gotkine M; Loyfer N; Piyanzin S; Ochana B-L; Lehmann-Werman R; Cohen D; Moss J; Magenheim J; Loftus MF; Brais L; Ng K; Mostoslavsky R; Wolpin BM; Zick A; Maoz M; Grinshpun A; Kustanovich A; Makranz C; Cohen JE; Peretz T; Hubert A; Temper M; Salah A; Avniel-Polak S; Grozinsky-Glasberg S; Spalding KL; Rokach A; Kaplan T; Glaser B; Shemer R; Dor Y
Article: NATURE MEDICINE. 2021;27(11):1941-1953
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvonen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ; Kutschke M; Arifen N; Kramer N; Aouadi M; Knibbe C; Boucher J; Thorell A; Spalding KL
Journal article: NATURE REVIEWS METHODS PRIMERS. 2021;1(1):62
Radiocarbon dating
Hajdas I; Ascough P; Garnett MH; Fallon SJ; Pearson CL; Ouarta G; Spalding KL; Yamaguchiw H; Yoneda M
Article: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2020;97(8):800-810
Practical Guidelines for Optimization and Characterization of the Beckman Coulter CytoFLEX™ Platform
Bhowmick D; Sheridan RTC; Bushnell TP; Spalding KL
Article: NATURE MEDICINE. 2019;25(9):1385-1389
Adipose lipid turnover and long-term changes in body weight
Arner P; Bernard S; Appelsved L; Fu K-Y; Andersson DP; Salehpour M; Thorell A; Ryden M; Spalding KL
Article: CELL REPORTS. 2019;27(1):213-225.e5
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes
Harms MJ; Li Q; Lee S; Zhang C; Kull B; Hallen S; Thorell A; Alexandersson I; Hagberg CE; Peng X-R; Mardinoglu A; Spalding KL; Boucher J
Article: NATURE COMMUNICATIONS. 2018;9(1):5068
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Moss J; Magenheim J; Neiman D; Zemmour H; Loyfer N; Korach A; Samet Y; Maoz M; Druid H; Arner P; Fu K-Y; Kiss E; Spalding KL; Landesberg G; Zick A; Grinshpun A; Shapiro AMJ; Grompe M; Wittenberg AD; Glaser B; Shemer R; Kaplan T; Dor Y
Article: CELL REPORTS. 2018;25(3):551-560.e5
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
Article: CELL REPORTS. 2018;24(10):2746-2756.e5
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
Hagberg CE; Li Q; Kutschke M; Bhowmick D; Kiss E; Shabalina IG; Harms MJ; Shilkova O; Kozina V; Nedergaard J; Boucher J; Thorell A; Spalding KL
Article: NATURE COMMUNICATIONS. 2017;8:15253
Impact of fat mass and distribution on lipid turnover in human adipose tissue
Spalding KL; Bernard S; Naslund E; Salehpour M; Possnert G; Appelsved L; Fu K-Y; Alkass K; Druid H; Thorell A; Ryden M; Arner P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(13):E1826-E1834
Identification of tissue-specific cell death using methylation patterns of circulating DNA
Lehmann-Werman R; Neiman D; Zemmour H; Moss J; Magenheim J; Vaknin-Dembinsky A; Rubertsson S; Nellgard B; Blennow K; Zetterberg H; Spalding K; Haller MJ; Wasserfall CH; Schatz DA; Greenbaum CJ; Dorrell C; Grompe M; Zick A; Hubert A; Maoz M; Fendrich V; Bartsch DK; Golan T; Ben Sasson SA; Zamir G; Razin A; Cedar H; Shapiro AMJ; Glaser B; Shemer R; Dor Y
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2016;8(3):a025981
Detection and Phenotypic Characterization of Adult Neurogenesis
Kuhn HG; Eisch AJ; Spalding K; Peterson DA
Article: CELL METABOLISM. 2015;22(3):408-417
Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis
Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2015;7(7):a018994
Adult Neurogenesis in Humans
Bergmann O; Spalding KL; Frisen J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;308(9):E822-E829
Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis
Abreu-Vieira G; Hagberg CE; Spalding KL; Cannon B; Nedergaard J
Article: JOURNAL OF LIPID RESEARCH. 2013;54(10):2909-2913
Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects
Ryden M; Andersson DP; Bernard S; Spalding K; Arner P
Article: CELL. 2013;153(6):1219-1227
Dynamics of Hippocampal Neurogenesis in Adult Humans
Spalding KL; Bergmann O; Alkass K; Bernard S; Salehpour M; Huttner HB; Bostrom E; Westerlund I; Vial C; Buchholz BA; Possnert G; Mash DC; Druid H; Frisen J
Article: PLOS ONE. 2013;8(7):e69597
Analysis of Radiocarbon, Stable Isotopes and DNA in Teeth to Facilitate Identification of Unknown Decedents
Alkass K; Saitoh H; Buchholz BA; Bernard S; Holmlund G; Senn DR; Spalding KL; Druid H
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2012;1(6):e003467
Adipocyte Triglyceride Turnover Is Independently Associated With Atherogenic Dyslipidemia
Frayn K; Bernard S; Spalding K; Arner P
Article: JOURNAL OF FORENSIC SCIENCES. 2012;57(5):1354-1360
Personal Identification of Cold Case Remains Through Combined Contribution from Anthropological, mtDNA, and Bomb-Pulse Dating Analyses
Speller CF; Spalding KL; Buchholz BA; Hildebrand D; Moore J; Mathewes R; Skinner MF; Yang DY
Article: NEURON. 2012;74(4):634-639
The Age of Olfactory Bulb Neurons in Humans
Bergmann O; Liebl J; Bernard S; Alkass K; Yeung MSY; Steier P; Kutschera W; Johnson L; Landen M; Druid H; Spalding KL; Frisen J
Article: NATURE. 2011;478(7367):110-113
Dynamics of human adipose lipid turnover in health and metabolic disease
Arner P; Bernard S; Salehpour M; Possnert G; Liebl J; Steier P; Buchholz BA; Eriksson M; Arner E; Hauner H; Skurk T; Ryden M; Frayn KN; Spalding KL
Article: FORENSIC SCIENCE INTERNATIONAL. 2011;209(1-3):34-41
Analysis of ¹⁴C and ¹³C in teeth provides precise birth dating and clues to geographical origin
Alkass K; Buchholz BA; Druid H; Spalding KL
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):101-104
Fat cell turnover in humans
Arner P; Spalding KL
Article: SURFACE AND INTERFACE ANALYSIS. 2010;42(5):398-401
Year of birth determination using radiocarbon dating of dental enamel
Buchholz BA; Spalding KL
Article: DIABETES. 2010;59(1):105-109
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner E; Westermark PO; Spalding KL; Britton T; Ryden M; Frisen J; Bernard S; Arner P
Journal article: OBSTETRICAL AND GYNECOLOGICAL SURVEY. 2008;63(9):577-578
Dynamics of Fat Cell Turnover in Humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Näslund E; Britton T; Concha H; Hassan M; Rydén M; Frisén J; Arner P
Article: NATURE. 2008;453(7196):783-787
Dynamics of fat cell turnover in humans
Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Naslund E; Britton T; Concha H; Hassan M; Ryden M; Frisen J; Arner P
Journal article: AKTUELLE NEUROLOGIE. 2007;34(S 2)
Detektion von adulter Neurogenese im Menschen mithilfe des 14C-Atombombenpeaks
Bergmann O; Spalding K; Bhardwaj R; Alkass K; Druid H; Buchholz B; Frisén J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(33):12564-12568
Neocortical neurogenesis in humans is restricted to development
Bhardwaj RD; Curtis MA; Spalding KL; Buchholz BA; Fink D; Bjork-Eriksson T; Nordborg C; Gage FH; Druid H; Eriksson PS; Frisen J
Article: CELL. 2005;122(1):133-143
Retrospective birth dating of cells in humans
Spalding KL; Bhardwaj RD; Buchholz BA; Druid H; Frisén J
Article: GENES & DEVELOPMENT. 2005;19(4):462-471
Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis
Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2005;21(1):33-45
Caspase-independent retinal ganglion cell death after target ablation in the neonatal rat.
Spalding KL; Dharmarajan AM; Harvey AR
Article: NEUROSCIENCE. 2005;131(2):387-395
Retinal ganglion cell neurotrophin receptor levels and trophic requirements following target ablation in the neonatal rat.
Spalding KL; Cui Q; Harvey AR
Article: DEVELOPMENTAL NEUROBIOLOGY. 2004;60(3):319-327
Target-derived and locally derived neurotrophins support retinal ganglion cell survival in the neonatal rat retina.
Spalding KL; Rush RA; Harvey AR
Article: EXPERIMENTAL NEUROLOGY. 2004;186(1):6-19
Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.
Mellough CB; Cui Q; Spalding KL; Symons NA; Pollett MA; Snyder EY; Macklis JD; Harvey AR
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2002;19(4):485-500
Anterograde transport and trophic actions of BDNF and NT-4/5 in the developing rat visual system.
Spalding KL; Tan MML; Hendry IA; Harvey AR
Article: DEVELOPMENTAL BRAIN RESEARCH. 1998;107(1):133-142
The effects of central administration of neurotrophins or transplants of fetal tectal tissue on retinal ganglion cell survival following removal of the superior colliculus in neonatal rats.
Spalding KL; Cui Q; Harvey AR
Journal article:
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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All other publications

Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):333
White adipocyte dysfunction and obesity-associated pathologies in humans (vol 25, pg 270, 2023)
Hagberg CE; Spalding KL
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):270-289
White adipocyte dysfunction and obesity-associated pathologies in humans
Hagberg CE; Spalding KL
Editorial comment: EBIOMEDICINE. 2022;81:104105
Profiling hypertrophic adipocytes in humans, from transcriptomics to diagnostics Comment
Li Q; Spalding KL
Preprint: MEDRXIV. 2022
Elevated brain-derived cell-free DNA among patients with first psychotic episode - a proof-of-concept study
Lubotzky A; pelov I; Teplitz R; Neiman D; Smadja A; Zemmour H; Piyanzin S; Ochana B-L; Spalding KL; Glaser B; Shemer R; Dor Y; Kohn Y
Preprint: BIORXIV. 2022
A human DNA methylation atlas reveals principles of cell type-specific methylation and identifies thousands of cell type-specific regulatory elements
Loyfer N; Magenheim J; Peretz A; Cann G; Bredno J; Klochendler A; Fox-Fisher I; Shabi-Porat S; Hecht M; Pelet T; Moss J; Drawshy Z; Amini H; Moradi P; Nagaraju S; Bauman D; Shveiky D; Porat S; Rivkin G; Or O; Hirshoren N; Carmon E; Pikarsky A; Khalaileh A; Zamir G; Grinboim R; Abu Gazala M; Mizrahi I; Shussman N; Korach A; Wald O; Izhar U; Erez E; Yutkin V; Samet Y; Golinkin DR; Spalding KL; Druid H; Arner P; Shapiro AMJ; Grompe M; Aravanis A; Venn O; Jamshidi A; Shemer R; Dor Y; Glaser B; Kaplan T
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1003219
The regulation of adipocyte growth in white adipose tissue
Li Q; Spalding KL
Review: INTERNATIONAL JOURNAL OF OBESITY. 2021;45(5):934-943
Cellular senescence and its role in white adipose tissue
Smith U; Li Q; Ryden M; Spalding KL
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
Preprint: BIORXIV. 2018
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Moss J; Magenheim J; Neiman D; Zemmour H; Loyfer N; Korach A; Samet Y; Maoz M; Druid H; Arner P; Fu K-Y; Kiss E; Spalding KL; Landesberg G; Zick A; Grinshpun A; Shapiro AJ; Grompe M; Wittenberg AD; Glaser B; Shemer R; Kaplan T; Dor Y
Book chapter: NEW PERSPECTIVES IN FORENSIC HUMAN SKELETAL IDENTIFICATION. 2018;p. 185-196
Chapter 16 Bomb Pulse Radiocarbon Dating of Skeletal Tissues
Buchholz BA; Alkass K; Druid H; Spalding KL
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2017;253
Macromolecular isolation and purification in AMS
Buchholz B; Spalding K; Dreier R; Maze I; Mailloux B; Carratt S; Van WInkle L; Ognibene T; Kuhn E; Hum N; Etminan N; Loots G
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2014;56:123-132
Maintenance of white adipose tissue in man
Hyvonen MT; Spalding KL
Conference publication: JOURNAL OF MOLECULAR NEUROSCIENCE. 2013;51:S117
Radiocarbon analysis of neurogenesis in the adult human brain
Spalding K; Bergmann O; Alkass K; Buchholz B; Salehpour M; Possnert G; Liebl J; Steier P; Kutschera W; Bernard S; Druid H; Frisen J
Published conference paper: MOLECULAR & CELLULAR PROTEOMICS. 2010;9(5):1022-1030
Age Estimation in Forensic Sciences APPLICATION OF COMBINED ASPARTIC ACID RACEMIZATION AND RADIOCARBON ANALYSIS
Alkass K; Buchholz BA; Ohtani S; Yamamoto T; Druid H; Spalding KL
Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION B: BEAM INTERACTIONS WITH MATERIALS AND ATOMS. 2010;268(7-8):1295-1298
A mathematical model for the interpretation of nuclear bomb test derived ¹⁴C incorporation in biological systems
Bernard S; Frisen J; Spalding KL
Conference publication: MOLECULAR & CELLULAR PROTEOMICS. 2009;:S43
Age Determination in the Adult Human Brain and Body Using Bomb-Carbon
Spalding KL; Bergmann O; Bernard S; Druid H; Buchholz B; Arner PA; Frisen J
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2006;232
ANYL 165-Forensic dating of dental enamel with bomb-pulse radiocarbon
Buchholz BA; Spalding KL; Bergman L-E; Druid H; Frisen J
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2006;572:447-451
Injury-induced retinal ganglion cell loss in the neonatal rat retina.
Spalding KL; Cui Q; Dharmarajan AM; Harvey AR
Editorial comment: NATURE. 2005;437(7057):333-334
Age written in teeth by nuclear tests
Spalding KL; Buchholz BA; Bergman LE; Druid H; Frisén J

Grants

Investigating DNA damage as a driver of adipocyte senescence and inflammation in obese, hyperinsulinemic individuals
Novo Nordisk Foundation
1 August 2023 - 31 July 2026
Targeting senescent adipocytes to treat tumour progression and metastasis in humans
Swedish Research Council
1 January 2023 - 31 December 2026
ADIPOSE TISSUE SENESCENCE IN HUMANS
Novo Nordisk Foundation
11 January 2021 - 31 July 2023
Senescens i fettvävnad och metabola sjukdomar hos människa
Knut and Alice Wallenberg Foundation
1 January 2020 - 1 January 2025
Cell regeneration in the human kidney in health and disease
Swedish Research Council
1 January 2019 - 31 December 2022
Adipose tissue and metabolic disease in man
Swedish Research Council
1 January 2013 - 31 December 2018
Adipose tissue and metabolic disease in man
Novo Nordisk Foundation
19 March 2012 - 31 March 2019
Adipose tissue mass regulation in lean and obese individuals
European Research Council
1 April 2011 - 31 March 2017
The contribution of failing neurogenesis to psychiatric disorders
Swedish Research Council
1 January 2011 - 31 December 2013
VINNMER Marie Curie international qualification, Kirsty Spalding
VINNOVA
1 September 2009 - 31 December 2015
Equipment for research aimed at assessing neurogenesis in the adult human brain by measuring nuclear bomb test-derived carbon-14 in DNA
Swedish Research Council
1 July 2009 - 31 March 2014
Planning Grant Kirsty Spalding
VINNOVA
21 March 2009 - 10 October 2009

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