Keira Melican

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: BIOMATERIALS ADVANCES. 2025;166:214068
Electrospun fiber patches for inflammatory skin diseases - Correlating in vitro drug release with ex vivo permeation
Gurtler A-L; Lang JC; Czyrski GS; Sirois JP; Melican K; Rades T; Heinz A
Article: BIOFILM. 2024;8:100212
The maturation of native uropathogenic Escherichia coli biofilms seen through a non-interventional lens
Zhang T; Ray S; Melican K; Richter-Dahlfors A
Journal article: RSC PHARMACEUTICS. 2024;1(3):570-580
Electrospun dressings with a dual release functionality of two anti-inflammatory active ingredients
Gürtler A-L; Sirois JP; Lang JC; Melican K; Rades T; Heinz A
Article: PLOS PATHOGENS. 2024;20(8):e1012056
Tissue resident cells differentiate S. aureus from S. epidermidis via IL-1β following barrier disruption in healthy human skin
Lang JC; Brutscher A; Ehrstrom M; Melican K
Article: NATURE NANOTECHNOLOGY. 2024;19(7):887-888
Nanoparticles subdue antibiotic-resistant bacteria's defences while enhancing innate immunity
Lang JC; Melican K
Article: FEMS MICROBES. 2023;4:xtad007
Dynamic single cell analysis in a proximal-tubule-on-chip reveals heterogeneous epithelial colonization strategies of uropathogenic Escherichia coli under shear stress
Antypas H; Zhang T; Choong FX; Melican K; Richter-Dahlfors A
Article: PATHOGENS AND DISEASE. 2022;80(1):fty087
Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147
Schulz A; Chuquimia OD; Antypas H; Steiner SE; Sandoval RM; Tanner GA; Molitoris BA; Richter-Dahlfors A; Melican K
Article: BMC INFECTIOUS DISEASES. 2022;22(1):509
Effect of anticoagulant and platelet inhibition on the risk of bacteremia among patients with acute pyelonephritis: a retrospective cohort study
Steiner SE; Edgren G; Melican K; Richter-Dahlfors A; Brauner A
Article: BIOFILM. 2021;3:100060
A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces
Choong FX; Huzell S; Rosenberg M; Eckert JA; Nagaraj M; Zhang T; Melican K; Otzen DE; Richter-Dahlfors A
Article: NATURE COMMUNICATIONS. 2021;12(1):4547
Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
Manriquez V; Nivoit P; Urbina T; Echenique-Rivera H; Melican K; Fernandez-Gerlinger M-P; Flamant P; Schmitt T; Bruneval P; Obino D; Dumenil G
Article: ADVANCED MATERIALS TECHNOLOGIES. 2021;6(7):2001307
Vancomycin-Loaded Microneedle Arrays against Methicillin-Resistant Staphylococcus Aureus Skin Infections
Ziesmer J; Tajpara P; Hempel N-J; Ehrstrom M; Melican K; Eidsmo L; Sotiriou GA
Article: PLOS PATHOGENS. 2021;17(5):e1009553
UPEC kidney infection triggers neuro-immune communication leading to modulation of local renal inflammation by splenic IFNγ
Steiner SE; Choong FX; Antypas H; Morado-Urbina CE; Schulz A; Farinotti AB; Bas DB; Svensson CI; Richter-Dahlfors A; Melican K
Article: FRONTIERS IN MICROBIOLOGY. 2020;11:26
Nitrate Metabolism Modulates Biosynthesis of Biofilm Components in Uropathogenic Escherichia coli and Acts as a Fitness Factor During Experimental Urinary Tract Infection
Martin-Rodriguez AJ; Rhen M; Melican K; Richter-Dahlfors A
Article: CELL REPORTS. 2019;29(5):1074-1081.e5
Neutrophil Recruitment to Noninvasive MRSA at the Stratum Corneum of Human Skin Mediates Transient Colonization
Schulz A; Jiang L; de Vor L; Ehrstrom M; Wermeling F; Eidsmo L; Melican K
Article: MICROBIOLOGY SPECTRUM. 2019;7(3):10.1128/microbiolspec.bai
A Cinematic View of Tissue Microbiology in the Live Infected Host
Richter-Dahlfors A; Melican K
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2744
High Resolution Intravital Imaging of the Renal Immune Response to Injury and Infection in Mice
Sedin J; Giraud A; Steinr SEE; Ahl D; Persson AEG; Melican K; Richter-Dahlfors A; Phillipson M
Article: PATHOGENS AND DISEASE. 2018;76(8):fty087
Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147
Schulz A; Chuquimia OD; Antypas H; Steiner SE; Sandoval RM; Tanner GA; Molitoris BA; Richter-Dahlfors A; Melican K
Article: NATURE COMMUNICATIONS. 2018;9(1):4450
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting
Charles-Orszag A; Tsai F-C; Bonazzi D; Manriquez V; Sachse M; Mallet A; Salles A; Melican K; Staneva R; Bertin A; Millien C; Goussard S; Lafaye P; Shorte S; Piel M; Krijnse-Locker J; Brochard-Wyart F; Bassereau P; Dumenil G
Article: SCIENTIFIC REPORTS. 2016;6:35578
Nondestructive, real-time determination and visualization of cellulose, hemicellulose and lignin by luminescent oligothiophenes
Choong FX; Back M; Steiner SE; Melican K; Nilsson KPR; Edlund U; Richter-Dahlfors A
Article: NPJ BIOFILMS AND MICROBIOMES. 2016;2:16024
Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes
Choong FX; Back M; Fahlen S; Johansson LBG; Melican K; Rhen M; Nilsson KPR; Richter-Dahlfors A
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(86):51134
Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
Melican K; Aubey F; Dumenil G
Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(86)
Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
Melican K; Aubey F; Duménil G
Article: METHODSX. 2014;1:251-253
Reducing background cytokine expression in epithelial cells without serum starvation.
Antypas H; Libberton B; Melican K
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2013;188(6):684-692
Assessment of the Interplay between Blood and Skin Vascular Abnormalities in Adult Purpura Fulminans
Lerolle N; Carlotti A; Melican K; Aubey F; Pierrot M; Diehl J-L; Caille V; Hekimian G; Gandrille S; Mandet C; Bruneval P; Dumenil G; Borgel D
Article: PLOS PATHOGENS. 2013;9(1):e1003139
Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model
Melican K; Veloso PM; Martin T; Bruneval P; Dumenil G
Article: PLOS PATHOGENS. 2011;7(2):e1001298
Uropathogenic Escherichia coli P and Type 1 Fimbriae Act in Synergy in a Living Host to Facilitate Renal Colonization Leading to Nephron Obstruction
Melican K; Sandoval RM; Kader A; Josefsson L; Tanner GA; Molitoris BA; Richter-Dahlfors A
Article: CRITICAL REVIEWS IN IMMUNOLOGY. 2010;30(2):107-117
Novel Innate Immune Functions Revealed by Dynamic, Real-Time Live Imaging of Bacterial Infections
Melican K; Boekel J; Ryden-Aulin M; Richter-Dahlfors A
Article: CELLULAR MICROBIOLOGY. 2008;10(10):1987-1998
Bacterial infection-mediated mucosal signalling induces local renal ischaemia as a defence against sepsis
Melican K; Boekel J; MaNsson LE; Sandoval RM; Tanner GA; Kaellskog O; Palm F; Molitoris BA; Richter-Dahlfors A
Article: CELLULAR MICROBIOLOGY. 2007;9(2):413-424
Real-time studies of the progression of bacterial infections and immediate tissue responses in live animals
Mansson LE; Melican K; Boekel J; Sandoval RM; Hautefort I; Tanner GA; Molitoris BA; Richter-Dahlfors A
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Alla övriga publikationer

Preprint: BIORXIV. 2024
Tissue resident cells differentiate S. aureus from S. epidermidis via IL-1ß following barrier disruption in healthy human skin
Lang JC; Brutscher A; Ehrström M; Melican K
Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(12):3680-3683
T cells in resolved allergic contact dermatitis steer tissue inflammation and MMP-12-driven tissue modulation
Gallais Serezal I; Tajpara P; Schonfeldt T; Ignatov B; Sortebech D; Hoffer E; Zhang T; Rooijackers E; Ehrstrom M; Nylen S; Matura M; Melican K; Eidsmo L
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S186
T cells in resolved allergic contact dermatitis drive inflammation and MMP-12-driven tissue modulation
Serezal IG; Tajpara P; Schonfeldt T; Ignatov B; Hoffer E; Ehrstrom M; Nylen S; Matura M; Melican K; Eidsmo L
Preprint: BIORXIV. 2021
Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils
Manriquez V; Nivoit P; Urbina T; Echenique-Rivera H; Melican K; Flamant P; Schmitt T; Bruneval P; Obino D; Duménil G
Book chapter: BACTERIA AND INTRACELLULARITY. 2019;p. 315-324
A Cinematic View of Tissue Microbiology in the Live Infected Host
Richter‐Dahlfors A; Melican K
Preprint: BIORXIV. 2018
Adhesion to nanofibers drives cell membrane remodeling through 1D wetting
Charles-Orszag A; Tsai F-C; Bonazzi D; Manriquez V; Sachse M; Mallet A; Salles A; Melican K; Staneva R; Bertin A; Millien C; Goussard S; Lafaye P; Shorte S; Piel M; Krijnse-Locker J; Brochard-Wyart F; Bassereau P; Duménil G
Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2017;282(1):24-36
Organic bioelectronics in medicine
Loffler S; Melican K; Nilsson KPR; Richter-Dahlfors A
Review: FEBS LETTERS. 2016;590(13):2014-2026
Microbial pathogenesis revealed by intravital microscopy: pros, cons and cautions
Stolp B; Melican K
Editorial comment: FUTURE MICROBIOLOGY. 2013;8(5):567-569
A humanized model of microvascular infection
Melican K; Dumenil G
Review: CURRENT OPINION IN MICROBIOLOGY. 2012;15(1):50-56
Vascular colonization by Neisseria meningitidis
Melican K; Dumenil G
Thesis / dissertation: 2010
The physiological and microbiological response to renal UPEC infection
Melican, Keira
Book chapter: BACTERIAL VIRULENCE. 2010;p. 251-277
Dynamic Imaging Technologies to Explore Infectious Processes at the Cellular, Tissue and Organ Level
Enninga J; Tournebize R; Melican K; Richter‐Dahlfors A
Review: BIOTECHNOLOGY JOURNAL. 2009;4(6):804-811
Multiphoton imaging of host-pathogen interactions.
Melican K; Richter-Dahlfors A
Review: CURRENT OPINION IN MICROBIOLOGY. 2009;12(1):31-36
Real-time live imaging to study bacterial infections in vivo
Melican K; Richter-Dahfors A
Conference publication: THE FEBS JOURNAL. 2009;276:51
Role of α-hemolysin induced Ca²⁺ signaling in the progression of uropathogenic E-coli infection within the urinary tract
Richter-Dahlfors A; Melican K; Boekel J; Mansson L; Sandoval RM; Tanner GA; Kallskog O; Palm F; Molitoris BA
Review: CELLULAR MICROBIOLOGY. 2007;9(10):2334-2343
Progression of bacterial infections studied in real time - novel perspectives provided by multiphoton microscopy
Mansson LE; Melican K; Molitoris BA; Richter-Dahlfors A

Forskningsbidrag

Preventing invasive infections by hijacking bacterial communication
Novo Nordisk Fonden
1 April 2023 - 31 December 2026
Novel probiotic and immunotherapy approaches for infection of human skin by Staphylococcus
Swedish Research Council
1 January 2021 - 31 December 2023
Fenotypiska och genetiska mekanismer som underlattar bakteriell mikrobiota kolonisering av mansklig hud in vivo.
Karolinska Institutet - KID
1 June 2020 - 1 June 2024
Uropathogenic Escherichia coli Haemolysin toxin: Beyond poking holes
Svenska Läkaresällskapet
1 June 2020 - 30 June 2022
The role of the nervous system in sensing bacterial infection and triggering an neuronal-immune reflex for inter-organ communication
Swedish Research Council
1 January 2020 - 31 December 2023
Senior Researcher position
AIMES, Center for the Advancement of Integrated Medical and Engineering Sciences
1 September 2019 - 31 March 2025
Development of Optotracing for Intravital Studies of Biofilm Infections
Swedish Research Council
1 January 2017 - 31 December 2017

Anställningar

Senior Forskare, Neurovetenskap, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Mikrobiologi, Karolinska Institutet, 2022
Medicine Doktorsexamen, Institutionen för neurovetenskap, Karolinska Institutet, 2010

Handledare

Anna-Lena Gürtler, Electrospun skin patches for the treatment of psoriasis, 2024
Mariam Shahata, 2023
Andreas Brutscher, Profiling the immune response of healthy human skin to colonization by different Staphylococcus sp., 2022
Tianqi Zhang, 2020
Julia Lang
Anette Schulz

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Handledare

Nyheter från KI

Kalenderhändelser från KI