Karl Tryggvason

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Professor i medicinsk kemi.

Forskningsbeskrivning

Min forskning handlar om basalmembranen, dess molekylära struktur, biologi och sjukdomar. Läs mer på den engelska sidan.

Artiklar

Article: CELL REPORTS. 2019;26(12):3231-3245.e9
In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors
Yap L; Wang J-W; Moreno-Moral A; Chong LY; Sun Y; Harmston N; Wang X; Chong SY; Ohman MK; Wei H; Bunte R; Gosh S; Cook S; Hovatta O; de KDPV; Petretto E; Tryggvason K
Article: NATURE COMMUNICATIONS. 2018;9(1):4432
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
Tjin MS; Chua AWC; Moreno-Moral A; Chong LY; Tang PY; Harmston NP; Cai Z; Petretto E; Tan BK; Tryggvason K
Article: MATRIX BIOLOGY. 2018;70:5-19
Culturing functional pancreatic islets on α5-Iaminins and curative transplantation , to diabetic mice
Sigmundsson K; Ojala JRM; Ohman MK; Osterholm A-M; Moreno-Moral A; Domogatskaya A; Chong LY; Sun Y; Chai X; Steele JAM; George B; Patarroyo M; Nilsson A-S; Rodin S; Ghosh S; Stevens MM; Petretto E; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2018;29(5):1426-1436
Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome
Lin M-H; Miller JB; Kikkawa Y; Suleiman HY; Tryggvason K; Hodges BL; Miner JH
Article: NATURE COMMUNICATIONS. 2018;9(1):1031
A systematic approach to the development of a safe live attenuated Zika vaccine
Sen Kwek S; Watanabe S; Chan KR; Ong EZ; Tan HC; Ng WC; Nguyen MTX; Gan ES; Zhang SL; Chan KWK; Tan JH; Sessions OM; Manuel M; Pompon J; Chua C; Hazirah S; Tryggvason K; Vasudevan SG; Ooi EE
Article: PLOS ONE. 2018;13(8):e0202400
Association of crumbs homolog-2 with mTORC1 in developing podocyte
Hamano S; Nishibori Y; Hada I; Mikami N; Ito-Nitta N; Fukuhara D; Kudo A; Xiao Z; Nukui M; Patrakka J; Tryggvason K; Yan K
Article: NATURE COMMUNICATIONS. 2017;8:15509
Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
Horejs C-M; St-Pierre J-P; Ojala JRM; Steele JAM; da Silva PB; Rynne-Vidal A; Maynard SA; Hansel CS; Rodriguez-Fernandez C; Mazo MM; You AYF; Wang AJ; von Erlach T; Tryggvason K; Lopez-Cabrera M; Stevens MM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2017;312(6):F1184-F1199
Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression
Ito Y; Katayama K; Nishibori Y; Akimoto Y; Kudo A; Kurayama R; Hada I; Takahashi S; Kimura T; Fukutomi T; Katada T; Suehiro J; Beltcheva O; Tryggvason K; Yan K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(14):3637-3641
Ab initio solution of macromolecular crystal structures without direct methods
McCoy AJ; Oeffner RD; Wrobel AG; Ojala JRM; Tryggvason K; Lohkamp B; Read RJ
Article: STEM CELL REPORTS. 2016;7(4):802-816
Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems
Nguyen MTX; Okina E; Chai X; Tan KH; Hovatta O; Ghosh S; Tryggvason K
Article: SCIENTIFIC REPORTS. 2016;6:29450
COL4A6 is dispensable for autosomal recessive Alport syndrome
Murata T; Katayama K; Oohashi T; Jahnukainen T; Yonezawa T; Sado Y; Ishikawa E; Nomura S; Tryggvason K; Ito M
Article: SCIENTIFIC REPORTS. 2016;6:25955
A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.
Ishibashi R; Takemoto M; Akimoto Y; Ishikawa T; He P; Maezawa Y; Sakamoto K; Tsurutani Y; Ide S; Ide K; Kawamura H; Kobayashi K; Tokuyama H; Tryggvason K; Betsholtz C; Yokote K
Article: STEM CELL REPORTS. 2016;6(4):607-617
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Mansson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Lofling M; Genead R; Wardell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salasova A; Westgren M; Sundstrom E; Uhlen P; Arenas E; Sylven C; Tryggvason K; Corbascio M; Simonson OE; Osterholm C; Grinnemo K-H
Article: BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY. 2016;31:2-12
Human embryonic stem cells
Damdimopoulou P; Rodin S; Stenfelt S; Antonsson L; Tryggvason K; Hovatta O
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2015;309(11):F955-F966
Knockdown of Tmem234 in zebrafish results in proteinuria
Rodriguez PQ; Oddsson A; Ebarasi L; He B; Hultenby K; Wernerson A; Betsholtz C; Tryggvason K; Patrakka J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(8):2143-2157
Dendrin Ablation Prolongs Life Span by Delaying Kidney Failure
Weins A; Wong JS; Basgen JM; Gupta R; Daehn I; Casagrande L; Lessman D; Schwartzman M; Meliambro K; Patrakka J; Shaw A; Tryggvason K; He JC; Nicholas SB; Mundel P; Campbell KN
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2015;26(3):647-662
Rhophilin-1 Is a Key Regulator of the Podocyte Cytoskeleton and Is Essential for Glomerular Filtration
Lal MA; Andersson A-C; Katayama K; Xiao Z; Nukui M; Hultenby K; Wernerson A; Tryggvason K
Article: PLOS ONE. 2015;10(3):e0122067
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(12):2764-2777
Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes
He B; Ebarasi L; Zhao Z; Guo J; Ojala JRM; Hultenby K; De Val S; Betsholtz C; Tryggvason K
Article: CANADIAN JOURNAL OF CARDIOLOGY. 2014;30(11):1444-1451
Perlecan Heparan Sulfate Proteoglycan Is a Critical Determinant of Angiogenesis in Response to Mouse Hind-Limb Ischemia
Qiang B; Lim SY; Lekas M; Kuliszewski MA; Wolff R; Osherov AB; Rudenko D; Leong-Poi H; Noyan H; Husain M; Tran K; Tryggvason K; Hedin U; Tran-Lundmark K; Strauss BH
Article: NATURE PROTOCOLS. 2014;9(10):2354-2368
Monolayer culturing and cloning of human pluripotent stem cells on laminin-521-based matrices under xeno-free and chemically defined conditions
Rodin S; Antonsson L; Hovatta O; Tryggvason K
Article: NEPHRON EXTRA. 2014;4(3):146-154
Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.
Hulkko J; Patrakka J; Lal M; Tryggvason K; Hultenby K; Wernerson A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2014;307(3):H337-H345
Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury
Gotha L; Lim SY; Osherov AB; Wolff R; Qiang B; Erlich I; Nili N; Pillarisetti S; Chang Y-T; Tran P-K; Tryggvason K; Hedin U; Tran-Lundmark K; Advani SL; Gilbert RE; Strauss BH
Article: DIABETOLOGIA. 2014;57(8):1611-1622
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
Sambo F; Malovini A; Sandholm N; Stavarachi M; Forsblom C; Maekinen V-P; Harjutsalo V; Lithovius R; Gordin D; Parkkonen M; Saraheimo M; Thorn LM; Tolonen N; Waden J; He B; Osterholm A-M; Tuomilehto J; Lajer M; Salem RM; McKnight AJ; Tarnow L; Panduru NM; Barbarini N; Di Camillo B; Toffolo GM; Tryggvason K; Bellazzi R; Cobelli C; Groop P-H
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2014;3(7):e172
Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression
Oprea II; Viola JR; Moreno PMD; Simonson OE; Rodin S; Teller N; Tryggvason K; Lundin KE; Girnita L; Smith CIE
Article: DIABETOLOGIA. 2014;57(6):1143-1153
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
Sandholm N; Forsblom C; Makinen V-P; McKnight AJ; Osterholm A-M; He B; Harjutsalo V; Lithovius R; Gordin D; Parkkonen M; Saraheimo M; Thorn LM; Tolonen N; Waden J; Tuomilehto J; Lajer M; Ahlqvist E; Mollsten A; Marcovecchio ML; Cooper J; Dunger D; Paterson AD; Zerbini G; Groop L; Tarnow L; Maxwell AP; Tryggvason K; Groop P-H
Article: PLOS ONE. 2014;9(10):e109854
Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain
Vaicik MK; Kortesmaa JT; Moverare-Skrtic S; Kortesmaa J; Soininen R; Bergstrom G; Ohlsson C; Chong LY; Rozell B; Emont M; Cohen RN; Brey EM; Tryggvason K
Article: NATURE COMMUNICATIONS. 2014;5:3195
Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
Rodin S; Antonsson L; Niaudet C; Simonson OE; Salmela E; Hansson EM; Domogatskaya A; Xiao Z; Damdimopoulou P; Sheikhi M; Inzunza J; Nilsson A-S; Baker D; Kuiper R; Sun Y; Blennow E; Nordenskjold M; Grinnemo K-H; Kere J; Betsholtz C; Hovatta O; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2013;24(10):1537-1543
Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes
Sandholm N; McKnight AJ; Salem RM; Brennan EP; Forsblom C; Harjutsalo V; Makinen V-P; McKay GJ; Sadlier DM; Williams WW; Martin F; Panduru NM; Tarnow L; Tuomilehto J; Tryggvason K; Zerbini G; Comeau ME; Langefeld CD; Godson C; Hirschhorn JN; Maxwell AP; Florez JC; Groop P-H
Article: KIDNEY INTERNATIONAL. 2013;84(3):591-599
A meta-analysis of expression signatures in glomerular disease
Tryggvason SH; Guo J; Nukui M; Norlin J; Haraldsson B; Jornvall H; Tryggvason K; He L
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(5):1681-1695
Progressive Reactive Lymphoid Connective Tissue Disease and Development of Autoantibodies in Scavenger Receptor A5-Deficient Mice
Ojala JRM; Pikkarainen T; Elmberger G; Tryggvason K
Article: PEDIATRIC NEPHROLOGY. 2013;28(2):339-343
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy
Rodriguez PQ; Lohkamp B; Celsi G; Mache CJ; Auer-Grumbach M; Wernerson A; Hamajima N; Tryggvason K; Patrakka J
Article: PLOS ONE. 2013;8(8):e72750
Myo1e Impairment Results in Actin Reorganization, Podocyte Dysfunction, and Proteinuria in Zebrafish and Cultured Podocytes
Mao J; Wang D; Mataleena P; He B; Niu D; Katayama K; Xu X; Ojala JRM; Wang W; Shu Q; Du L; Liu A; Pikkarainen T; Patrakka J; Tryggvason K
Article: PLOS ONE. 2013;8(2):e56414
A Remote Cis-Acting Variant at 3q Links Glomerular NCK1 to Diabetic Nephropathy
He B; Osterholm A-M; Ojala JRM; Andersson A-C; Tryggvason K
Article: PLOS ONE. 2013;8(12):e83133
Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
Xiao Z; Rodriguez PQ; He L; Betsholtz C; Tryggvason K; Patrakka J
Article: KIDNEY INTERNATIONAL. 2013;83(1):63-71
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation
Sistani L; Rodriguez PQ; Hultenby K; Uhlen M; Betsholtz C; Jalanko H; Tryggvason K; Wernerson A; Patrakka J
Article: CELL METABOLISM. 2012;16(6):738-750
Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
Liu B; Ghosh S; Yang X; Zheng H; Liu X; Wang Z; Jin G; Zheng B; Kennedy BK; Suh Y; Kaeberlein M; Tryggvason K; Zhou Z
Article: KIDNEY INTERNATIONAL. 2012;82(10):1071-1083
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
Perisic L; Lal M; Hulkko J; Hultenby K; Onfelt B; Sun Y; Duner F; Patrakka J; Betsholtz C; Uhlen M; Brismar H; Tryggvason K; Wernerson A; Pikkarainen T
Article: BIOTECHNIQUES. 2012;53(4):221-230
A novel scavenger receptor 5-based antibiotic-independent selection method for generation of stable recombinant protein-producing mammalian cell lines especially suitable for proteins affecting cell adhesion
Ojala JRM; Pikkarainen T; Domogatskaya A; Tryggvason K; Rodin S
Article: PLOS GENETICS. 2012;8(9):e1002921
New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
Sandholm N; Salem RM; McKnight AJ; Brennan EP; Forsblom C; Isakova T; McKay GJ; Williams WW; Sadlier DM; Makinen V-P; Swan EJ; Palmer C; Boright AP; Ahlqvist E; Deshmukh HA; Keller BJ; Huang H; Ahola AJ; Fagerholm E; Gordin D; Harjutsalo V; He B; Heikkila O; Hietala K; Kyto J; Lahermo P; Lehto M; Lithovius R; Osterholm A-M; Parkkonen M; Pitkaniemi J; Rosengard-Barlund M; Saraheimo M; Sarti C; Soderlund J; Soro-Paavonen A; Syreeni A; Thorn LM; Tikkanen H; Tolonen N; Tryggvason K; Tuomilehto J; Waden J; Gill GV; Prior S; Guiducci C; Mirel DB; Taylor A; Hosseini SM; Parving H-H; Rossing P; Tarnow L; Ladenvall C; Alhenc-Gelas F; Lefebvre P; Rigalleau V; Roussel R; Tregouet D-A; Maestroni A; Maestroni S; Falhammar H; Gu T; Mollsten A; Cimponeriu D; Ioana M; Mota M; Mota E; Serafinceanu C; Stavarachi M; Hanson RL; Nelson RG; Kretzler M; Colhoun HM; Panduru NM; Gu HF; Brismar K; Zerbini G; Hadjadj S; Marre M; Groop L; Lajer M; Bull SB; Waggott D; Paterson AD; Savage DA; Bain SC; Martin F; Hirschhorn JN; Godson C; Florez JC; Groop P-H; Maxwell AP
Article: DIABETES. 2012;61(8):2187-2194
Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
Williams WW; Salem RM; McKnight AJ; Sandholm N; Forsblom C; Taylor A; Guiducci C; McAteer JB; McKay GJ; Isakova T; Brennan EP; Sadlier DM; Palmer C; Soederlund J; Fagerholm E; Harjutsalo V; Lithovius R; Gordin D; Hietala K; Kyto J; Parkkonen M; Rosengard-Barlund M; Thorn L; Syreeni A; Tolonen N; Saraheimo M; Waden J; Pitkaniemi J; Sarti C; Tuomilehto J; Tryggvason K; Osterholm A-M; He B; Bain S; Martin F; Godson C; Hirschhorn JN; Maxwel AP; Groop P-H; Florez JC
Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190
MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20479-20484
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
Haas U; Raschperger E; Hamberg M; Samuelsson B; Tryggvason K; Haeggstrom JZ
Article: DEVELOPMENTAL DYNAMICS. 2011;240(12):2646-2656
Deficiency in Crumbs Homolog 2 (Crb2) Affects Gastrulation and Results in Embryonic Lethality in Mice
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainan T; Vainio S; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(11):2037-2046
Glcci1 Deficiency Leads to Proteinuria
Nishibori Y; Katayama K; Parikka M; Oddsson A; Nukui M; Hultenby K; Wernerson A; He B; Ebarasi L; Raschperger E; Norlin J; Uhlen M; Patrakka J; Betsholtz C; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2011;80(10):1045-1054
Pdlim2 is a novel actin-regulating protein of podocyte foot processes
Sistani L; Duner F; Udumala S; Hultenby K; Uhlen M; Betsholtz C; Tryggvason K; Wernerson A; Patrakka J
Article: EMBO REPORTS. 2011;12(11):1135-1143
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo
Stenzel D; Franco CA; Estrach S; Mettouchi A; Sauvaget D; Rosewell I; Schertel A; Armer H; Domogatskaya A; Rodin S; Tryggvason K; Collinson L; Sorokin L; Gerhardt H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):3965-3980
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
Yaddanapudi S; Altintas MM; Kistler AD; Fernandez I; Moeller CC; Wei C; Peev V; Flesche JB; Forst A-L; Li J; Patrakka J; Xiao Z; Grahammer F; Schiffer M; Lohmueller T; Reinheckel T; Gu C; Huber TB; Ju W; Bitzer M; Rastaldi MP; Ruiz P; Tryggvason K; Shaw AS; Faul C; Sever S; Reiser J
Article: HUMAN MOLECULAR GENETICS. 2011;20(11):2182-2194
The podocyte protein nephrin is required for cardiac vessel formation
Wagner N; Morrison H; Pagnotta S; Michiels J-F; Schwab Y; Tryggvason K; Schedl A; Wagner K-D
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(6):1019-1023
Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes
He B; Ebarasi L; Hultenby K; Tryggvason K; Betsholtz C
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(8):1119-1133
Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors
Oikawa Y; Hansson J; Sasaki T; Rousselle P; Domogatskaya A; Rodin S; Tryggvason K; Patarroyo M
Article: BLOOD. 2011;117(4):1319-1328
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens
Mukhopadhyay S; Varin A; Chen Y; Liu B; Tryggvason K; Gordon S
Article: NEPHRON. 2011;118(3):e39-e48
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria
Xiao Z; He L; Takemoto M; Jalanko H; Chan GC; Storm DR; Betsholtz C; Tryggvason K; Patrakka J
Article: NEPHRON. 2011;117(2):e39-e46
Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25
Xu X; Patrakka J; Sistani L; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(53):42023-42032
Deficiency of a Transmembrane Prolyl 4-Hydroxylase in the Zebrafish Leads to Basement Membrane Defects and Compromised Kidney Function
Hyvarinen J; Parikka M; Sormunen R; Ramet M; Tryggvason K; Kivirikko KI; Myllyharju J; Koivunen P
Article: NATURE BIOTECHNOLOGY. 2010;28(6):611-615
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
Rodin S; Domogatskaya A; Strom S; Hansson EM; Chien KR; Inzunza J; Hovatta O; Tryggvason K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):164-169
Molecular make-up of the glomerular filtration barrier
Patrakka J; Tryggvason K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses
Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
Article: DIABETES. 2010;59(1):190-199
Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release
Fornoni A; Jeon J; Santos JV; Cobianchi L; Jauregui A; Inverardi L; Mandic SA; Bark C; Johnson K; McNamara G; Pileggi A; Molano RD; Reiser J; Tryggvason K; Kerjaschki D; Berggren P-O; Mundel P; Ricordi C
Article: NEPHRON. 2010;114(1):e15-e22
Sp1 Specifically Binds to an Evolutionarily Conserved DNA Segment within a Region Necessary for Podocyte-Specific Expression of Nephrin
Beltcheva O; Hjorleifsdottir EE; Kontusaari S; Tryggvason K
Article: NEPHRON. 2010;116(2):e42-e52
Permeability, Ultrastructural Changes, and Distribution of Novel Proteins in the Glomerular Barrier in Early Puromycin Aminonucleoside Nephrosis
Duner F; Lindstrom K; Hultenby K; Hulkko J; Patrakka J; Tryggvason K; Haraldsson B; Wernerson A; Pettersson E
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(8):1814-1825
Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo
Salo S; Boutaud A; Hansen AJ; He L; Sun Y; Morales S; Venturini A; Martin P; Nokelainen P; Betsholtz C; Mathiasen IS; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2009;183(7):4657-4665
Human Mast Cells Adhere to and Migrate on Epithelial and Vascular Basement Membrane Laminins LM-332 and LM-511 via α₃β₁ Integrin
Sime W; Lunderius-Andersson C; Enoksson M; Rousselle P; Tryggvason K; Nilsson G; Harvima I; Patarroyo M
Article: DEVELOPMENTAL BIOLOGY. 2009;334(1):1-9
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier
Ebarasi L; He L; Hultenby K; Takemoto M; Betsholtz C; Tryggvason K; Majumdar A
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(7):2044-2051
Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane
Goldberg S; Harvey SJ; Cunningham J; Tryggvason K; Miner JH
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2009;20(7):1586-1596
Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function
Sekine Y; Nishibori Y; Akimoto Y; Kudo A; Ito N; Fukuhara D; Kurayama R; Higashihara E; Babu E; Kanai Y; Asanuma K; Nagata M; Majumdar A; Tryggvason K; Yan K
Article: PLOS PATHOGENS. 2009;5(6):e1000474
MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis
Bowdish DME; Sakamoto K; Kim M-J; Kroos M; Mukhopadhyay S; Leifer CA; Tryggvason K; Gordon S; Russell DG
Article: NATURE MEDICINE. 2009;15(5):519-527
Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain
Wu C; Ivars F; Anderson P; Hallmann R; Vestweber D; Nilsson P; Robenek H; Tryggvason K; Song J; Korpos E; Loser K; Beissert S; Georges-Labouesse E; Sorokin LM
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(3):731-734
Stem cell therapy for Alport syndrome: the hope beyond the hype
Gross O; Borza D-B; Anders H-J; Licht C; Weber M; Segerer S; Torra R; Gubler M-C; Heidet L; Harvey S; Cosgrove D; Lees G; Kashtan C; Gregory M; Savige J; Ding J; Thorner P; Abrahamson DR; Antignac C; Tryggvason K; Hudson B; Miner JH
Article: LABORATORY INVESTIGATION. 2009;89(2):178-195
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome
Shimizu M; Khoshnoodi J; Akimoto Y; Kawakami H; Hirano H; Higashihara E; Hosoyamada M; Sekine Y; Kurayama R; Kurayama H; Joh K; Hirabayashi J; Kasai K; Tryggvason K; Ito N; Yan K
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2009;84(1):5-13
Association of Genetic Variants at 3q22 with Nephropathy in Patients with Type 1 Diabetes Mellitus
He B; Osterholm A-M; Hoverfalt A; Forsblom C; Hjorleifsdottir EE; Nilsson A-S; Parkkonen M; Pitkaniemi J; Hreidarsson A; Sarti C; McKnight AJ; Maxwell AP; Tuomilehto J; Groop P-H; Tryggvason K
Article: JOURNAL OF INNATE IMMUNITY. 2009;1(2):153-163
SR-A, MARCO and TLRs Differentially Recognise Selected Surface Proteins from Neisseria meningitidis: an Example of Fine Specificity in Microbial Ligand Recognition by Innate Immune Receptors
Plueddemann A; Mukhopadhyay S; Sankala M; Savino S; Pizza M; Rappuoli R; Tryggvason K; Gordon S
Article: AMERICAN JOURNAL OF NEPHROLOGY. 2009;29(6):558-570
Glomerular Transcriptome Changes Associated with Lipopolysaccharide-Induced Proteinuria
Sun Y; He L; Takemoto M; Patrakka J; Pikkarainen T; Genove G; Norlin J; Truve K; Tryggvason K; Betsholtz C
Article: STEM CELLS. 2008;26(11):2800-2809
Laminin-511 but Not-332,-111, or-411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro
Domogatskaya A; Rodin S; Boutaud A; Tryggvason K
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;39(1):50-62
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
Plantman S; Patarroyo M; Fried K; Domogatskaya A; Tryggvason K; Hammarberg H; Cullheim S
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;84(3):701-712
Laminin isoforms of lymph nodes and predominant role of α5-laminin(s) in adhesion and migration of blood lymphocytes
Gorfu G; Virtanen I; Hukkanen M; Lehto V-P; Rousselle P; Kenne E; Lindbom L; Kramer R; Tryggvason K; Patarroyo M
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2008;23(8):2504-2511
Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome
Duner F; Patrakka J; Xiao Z; Larsson J; Vlamis-Gardikas A; Pettersson E; Tryggvason K; Hultenby K; Wernerson A
Article: CIRCULATION RESEARCH. 2008;103(1):43-52
Heparan sulfate in perlecan promotes mouse atherosclerosis -: Roles in lipid permeability, lipid retention, and smooth muscle cell proliferation
Tran-Lundmark K; Tran P-K; Paulsson-Berne G; Friden V; Soininen R; Tryggvason K; Wight TN; Kinsella MG; Boren J; Hedin U
Article: FASEB JOURNAL. 2008;22(5):1530-1539
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
Jakobsson L; Domogatskaya A; Tryggvason K; Edgar D; Claesson-Welsh L
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(8):1734-1743
Effects of conformational activation of integrin α1I and α2I domains on selective recognition of laminin and collagen subtypes
Tulla M; Lahti M; Puranen JS; Brandt A-M; Kaepylae J; Domogatskaya A; Salminen TA; Tryggvason K; Johnson MS; Heino J
Article: JOURNAL OF CELL BIOLOGY. 2008;181(1):27-35
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Espada J; Varela I; Flores I; Ugalde AP; Cadinanos J; Pendas AM; Stewart CL; Tryggvason K; Blasco MA; Freije JMP; Lopez-Otin C
Article: KIDNEY INTERNATIONAL. 2008;73(6):697-704
Nephrin is involved in podocyte maturation but not survival during glomerular development
Done SC; Takemoto M; He L; Sun Y; Hultenby K; Betsholtz C; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):260-268
The glomerular transcriptome and a predicted protein-protein interaction network
He L; Sun Y; Takemoto M; Norlin J; Tryggvason K; Samuelsson T; Betsholtz C
Article: BMC GENETICS. 2007;8:84
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
Qiao Q; Oesterholm A-M; He B; Pitkaeniemi J; Cordell HJ; Sarti C; Kinnunen L; Tuomilehto-Wolf E; Tryggvason K; Tuomilehto J
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(24):3317-3335
Glomerulus proteome analysis with two-dimensional gel electrophoresis and mass spectrometry
Tryggvason S; Nukui M; Oddsson A; Tryggvason K; Jornvall H
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(18):3819-3831
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness:: Evidence for a role of α5-laminin(s) and α3β1 integrin
Kawataki T; Yamane T; Naganuma H; Rousselle P; Anduren I; Tryggvason K; Patarroyo M
Article: BLOOD. 2007;110(8):2916-2923
Functional interplay between endothelial nitric oxide synthase and membrane type 1-matrix metalloproteinase in migrating endothelial cells
Genis L; Gonzalo P; Tutor AS; Galvez BG; Martinez-Ruiz A; Zaragoza C; Lamas S; Tryggvason K; Apte SS; Arroyo AG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
Article: BLOOD. 2007;110(7):2399-2407
Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(9):2554-2564
Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance
Nakajo A; Khoshnoodi J; Takenaka H; Hagiwara E; Watanabe T; Kawakami H; Kurayama R; Sekine Y; Bessho F; Takahashi S; Swiatecka-Urban A; Tryggvason K; Yan K
Article: LABORATORY INVESTIGATION. 2007;87(8):780-791
Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function
Vainionpaa N; Lehto V-P; Tryggvason K; Virtanen I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(22):16654-16666
Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition
Ojala JRM; Pikkarainen T; Tuuttila A; Sandalova T; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2007;178(9):5912-5920
Scavenger receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation
Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L
Article: KIDNEY INTERNATIONAL. 2007;71(9):889-900
Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis
He L; Sun Y; Patrakka J; Mostad P; Norlin J; Xiao Z; Andrae J; Tryggvason K; Samuelsson T; Betsholtz C; Takemoto M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(3):757-764
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II
Dahl M; Bauer AK; Arredouani M; Soininen R; Tryggvason K; Kleeberger SR; Kobzik L
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(3):689-697
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
Patrakka J; Xiao Z; Nukui M; Takemoto M; He L; Oddsson A; Perisic L; Kaukinen A; Szigyarto CA-K; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: JOURNAL OF MASS SPECTROMETRY. 2007;42(3):370-379
Identification of N-linked glycosylation sites in human nephrin using mass spectrometry
Khoshnoodi J; Hill S; Tryggvason K; Hudson B; Friedman DB
Article: NEPHRON. 2007;106(2):e32-e36
The glomerular transcriptome and Proteome
Betsholtz C; He L; Takemoto M; Norlin J; Sun Y; Patrakka J; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2007;71(2):140-145
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q
Osterholm A-M; He B; Pitkaniemi J; Albinsson L; Berg T; Sarti C; Tuomilehto J; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(18):12767-12775
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO
Chen YY; Sankala M; Ojala JRM; Sun Y; Tuuttila A; Isenman DE; Tryggvason K; Pikkarainen T
Article: PEDIATRIC NEPHROLOGY. 2006;21(5):711-718
Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type
Srivastava T; Garola RE; Kestila M; Tryggvason K; Ruotsalainen V; Sharma M; Savin VJ; Jalanko H; Warady BA
Article: BLOOD. 2006;107(9):3503-3510
Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins
Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: KIDNEY INTERNATIONAL. 2006;69(8):1350-1359
The effect of dexamethasone on defective nephrin transport caused by ER stress: A potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases
Fujii Y; Khoshnoodi J; Takenaka H; Hosoyamada M; Nakajo A; Bessho F; Kudo A; Takahashi S; Arimura Y; Yamada A; Nagasawa T; Ruotsalainen V; Tryggvason K; Lee AS; Yan K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2006;36(4):940-949
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis
Mukhopadhyay S; Chen YY; Sankala M; Peiser L; Pikkarainen T; Kraal G; Tryggvason K; Gordon S
Article: EMBO JOURNAL. 2006;25(5):1160-1174
Large-scale identification of genes implicated in kidney glomerulus development and function
Takemoto M; He LQ; Norlin J; Patrakka J; Xiao ZJ; Petrova T; Bondjers C; Asp J; Wallgard E; Sun Y; Samuelsson T; Mostad P; Lundin S; Miura N; Sado Y; Alitalo K; Quaggin SE; Tryggvason K; Betsholtz C
Article: DEVELOPMENTAL CELL. 2006;10(3):397-405
The vascular basement membrane:: A niche for insulin gene expression and β cell proliferation
Nikolova G; Jabs N; Konstantinova I; Domogatskaya A; Tryggvason K; Sorokin L; Fässler R; Gu GQ; Gerber HP; Ferrara N; Melton DA; Lammert E
Article: JOURNAL OF PATHOLOGY. 2006;208(4):574-589
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
Martens JH; Kzhyshkowska J; Falkowski-Hansen M; Schledzewski K; Gratchev A; Mansmann U; Schmuttermaier C; Dippel E; Koenen W; Riedel F; Sankala M; Tryggvason K; Kobzik L; Moldenhauer G; Arnold B; Goerdt S
Article: MATRIX BIOLOGY. 2006;25(2):89-93
Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (α2β1γ1),8 (α4β1γ1),10 (α5β1γ1)
Wondimu Z; Gorfu G; Kawataki T; Smirnov S; Yurchenco P; Tryggvason K; Patarroyo M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(1):213-220
Cardiomyopathy associated with microcirculation dysfunction in laminin α 4 chain-deficient mice
Wang JM; Hoshijima M; Lam J; Zhou ZJ; Jokiel A; Dalton ND; Hultenby K; Ruiz-Lozano P; Ross J; Tryggvason K; Chien KR
Article: THROMBOSIS AND HAEMOSTASIS. 2006;95(1):85-93
Megakaryocytic cells synthesize and platelets secrete α5-laminins, and the endothelial laminin isoform laminin 10 (α5β1γ1) strongly promotes adhesion but not activation of platelets
Nigatu A; Sime W; Gorfu G; Geberhiwot T; Andurén I; Ingerpuu S; Doi M; Tryggvason K; Hjemdahl P; Patarroyo M
Article: JOURNAL OF IMMUNOLOGY. 2005;175(12):8173-8180
Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A
Chen YY; Pikkarainen T; Elomaa O; Soininen R; Kodama T; Kraal G; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2005;175(9):6058-6064
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages
Arredouani MS; Palecanda A; Koziel H; Huang YC; Imrich A; Sulahian TH; Ning YY; Yang ZP; Pikkarainen T; Sankala M; Vargas SO; Takeya M; Tryggvason K; Kobzik L
Article: NATURE. 2005;437(7058):564-568
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela I; Cadiñanos J; Pendás AM; Gutiérrez-Fernández A; Folgueras AR; Sánchez LM; Zhou ZJ; Rodríguez FJ; Stewart CL; Vega JA; Tryggvason K; Freije JMP; López-Otín C
Article: EXPERIMENTAL CELL RESEARCH. 2005;307(2):329-341
Laminins 2(α2β1γ1, Lm-211) and 8(α4β1γ1, Lm-411) are synthesized and secreted by tooth pulp fibroblasts and differentially promote neurite outgrowth from trigeminal ganglion sensory neurons
Fried K; Sime W; Lillesaar C; Virtanen I; Tryggvasson K; Patarroyo M
Article: NATURE MEDICINE. 2005;11(7):780-785
Genomic instability in laminopathy-based premature aging
Liu BH; Wang JM; Chan KM; Tjia WM; Deng W; Guan XY; Huang JD; Li KM; Chau PY; Chen DJ; Pei DQ; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen JJ; Cao YH; Cheah KSE; Tryggvason K; Zhou ZJ
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2005;16(6):1703-1710
Heparan sulfate of perlecan is involved in glomerular filtration
Morita H; Yoshimura A; Inui K; Lodeura T; Watanabe H; Wang L; Soininen R; Tryggvason K
Article: JOURNAL OF NEUROSCIENCE. 2005;25(14):3692-3700
Impeded interaction between Schwann cells and axons in the absence of laminin α4
Wallquist W; Plantman S; Thams S; Thyboll J; Kortesmaa J; Lännergren J; Domogatskaya A; Ögren SO; Risling M; Hammarberg H; Tryggvason K; Cullheim S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(2):1292-1298
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/CCL2 and Interleukin-8/CXCL8 in endothelial cells during angiogenesis
Gálvez BG; Genís L; Matías-Román S; Oblander SA; Tryggvason K; Apte SS; Arroyo AG
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2005;15(1):120-126
Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva
Stoltzfus P; Heselmeyer-Haddad K; Castro J; White N; Silfversward C; Sjovall K; Einhorn N; Tryggvason K; Auer G; Ried T; Nordstrom B
Article: FEBS JOURNAL. 2005;272(1):228-243
Characterization of the interactions of the nephrin intracellular domain -: Evidence that the scaffolding protein IQGAP1 associates with nephrin
Liu XL; Kilpeläinen P; Hellman U; Sun Y; Wartiovaara J; Morgunova E; Pikkarainen T; Yan K; Jonsson AP; Tryggvason K
Article: DEVELOPMENTAL BIOLOGY. 2005;277(1):255-269
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
Oblander SA; Zhou ZJ; Gálvez BG; Starcher B; Shannon JM; Durbeej M; Arroyo AG; Tryggvason K; Apte SS
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(23):2979-2982
Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity
Melles E; Jörnvall H; Tryggvason S; Danielsson KG; Ekberg K; Tryggvason K; Wahren J; Bergman T
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(10):1475-1483
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography
Wartiovaara J; Öfverstedt LG; Khoshnoodi J; Zhang JJ; Mäkelä E; Sandin S; Ruotsalainen V; Cheng RH; Jalanko H; Skoglund U; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2004;66(5):1755-1765
Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane
Nishibori Y; Liu L; Hosoyamada M; Endou H; Kudo A; Takenaka H; Higashihara E; Bessho F; Takahashi S; Kershaw D; Ruotsalainen V; Tryggvason K; Khoshnoodi J; Yan K
Article: BLOOD. 2004;104(6):1859-1866
An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis
Wondimu Z; Geberhiwot T; Ingerpuu S; Juronen E; Xie X; Lindbom L; Doi M; Kortesmaa J; Thyboll J; Tryggvason K; Fadeel B; Patarroyo M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2004;200(2):267-272
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles
Arredouani M; Yang ZP; Ning YY; Qin GZ; Soininen R; Tryggvason K; Kobzik L
Article: CANCER RESEARCH. 2004;64(14):4699-4702
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
Zhou ZJ; Wang JM; Cao RH; Morita H; Soininen R; Chan KM; Liu B; Cao YH; Tryggvason K
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. 2004;23(3):215-222
Laminin-5 γ2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix
Stoltzfus P; Salo S; Eriksson E; Aspenblad U; Tryggvason K; Auer G; Avall-Lundqvist E
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2004;15(7):1731-1738
Defective trafficking of nephrin missense mutants rescued by a chemical chaperone
Liu XL; Doné SC; Yan K; Kilpeläinen P; Pikkarainen T; Tryggvason K
Article: CANCER RESEARCH. 2004;64(12):4059-4063
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
Zhou ZJ; Doi M; Wang JM; Cao RH; Liu BH; Chan KM; Kortesmaa J; Sorokin L; Cao YH; Tryggvason K
Article: PEDIATRIC RESEARCH. 2004;55(5):774-781
Tissue expression of nephrin in human and pig
Kuusniemi AM; Kestilä M; Patrakka J; Lahdenkari AT; Ruotsalainen V; Holmberg C; Karikoski R; Salonen R; Tryggvason K; Jalanko H
Article: CIRCULATION RESEARCH. 2004;94(4):550-558
Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan
Tran PK; Tran-Lundmark K; Soininen R; Tryggvason K; Thyberg J; Hedin U
Article: NEUROREPORT. 2004;15(3):569-574
Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice
Byrne LC; Zhou ZG; Tryggvason K; Hökfelt T; Fetissov SO
Article: HYBRIDOMA. 2004;23(1):55-63
Monoclonal antibodies to human nephrin
Ruotsalainen V; Reponen P; Khoshnoodi J; Kilpeläinen P; Tryggvason K
Article: CELL AND TISSUE RESEARCH. 2004;315(1):27-37
Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice
Salonurmi T; Parikka M; Kontusaari S; Pirilä E; Munaut C; Salo T; Tryggvason K
Article: JOURNAL OF CLINICAL PATHOLOGY. 2003;56(6):342-346
Laminin 5 γ2 chain expression:: a marker of early invasiveness in colorectal adenomas
Lenander C; Roblick UJ; Habermann JK; Öst Å; Tryggvason K; Auer G
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(6):2337-2346
Nephrin promotes cell-cell adhesion through homophilic interactions
Khoshnoodi J; Sigmundsson K; Öfverstedt LG; Skoglund U; Öbrink B; Wartiovaara J; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(10):2603-2610
X-linked Alport syndrome:: Natural history and genotype-phenotype correlations in girls and women belonging to 195 families:: A "European community Alport syndrome concerted action" study
Jais JP; Knebelmann B; Giatras I; De Marchi M; Rizzoni G; Renieri A; Weber M; Gross O; Netzer KO; Flinter F; Pirson Y; Dahan K; Wieslander J; Persson U; Tryggvason K; Martin P; Hertz JM; Schröder C; Sanak M; Carvalho MF; Saus J; Antignac C; Smeets H; Gubler MC
Article: KIDNEY INTERNATIONAL. 2003;64(2):404-413
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases
Lahdenperä J; Kilpeläinen P; Liu XL; Pikkarainen T; Reponen P; Ruotsalainen V; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2003;171(1):398-406
A site on laminin α5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis
Adair-Kirk TL; Atkinson JJ; Broekelmann TJ; Doi M; Tryggvason K; Miner JH; Mecham RP; Senior RM
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(2):352-358
Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin
Beltcheva O; Kontusaari S; Fetissov S; Putaala H; Kilpeläinen P; Hökfelt T; Tryggvason K
Article: BLOOD. 2003;101(3):877-885
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
Gu YC; Kortesmaa J; Tryggvason K; Persson J; Ekblom P; Jacobsen SE; Ekblom M
Article: EMBO JOURNAL. 2003;22(2):236-245
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney
Rossi M; Morita H; Sormunen R; Airenne S; Kreivi M; Wang L; Fukai N; Olsen BR; Tryggvason K; Soininen R
Article: MEDICAL ONCOLOGY. 2003;20(2):147-156
Laminin-5 γ2-chain expression and DNA ploidy as predictors of prognosis in endometrial carcinoma
Lundgren C; Frankendal B; Silfverswärd C; Nilsson B; Tryggvason K; Auer G; Nordström B
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2003;18(1):70-76
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome
Wernerson A; Dunér F; Pettersson E; Widholm SM; Berg U; Ruotsalainen V; Tryggvason K; Hultenby K; Söderberg M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;161(4):1459-1466
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.
Saleem MA; Ni L; Witherden I; Tryggvason K; Ruotsalainen V; Mundel P; Mathieson PW
Article: MATRIX BIOLOGY. 2002;21(6):483-486
Chondroitin sulphate modification in the α4 chain of human recombinant laminin-8 (α4β1γ1)
Kortesmaa J; Doi M; Patarroyo M; Tryggvason K
Article: EMBO JOURNAL. 2002;21(19):5026-5035
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
Franzke CW; Tasanen K; Schäcke H; Zhou ZJ; Tryggvason K; Mauch C; Zigrino P; Sunnarborg S; Lee DC; Fahrenholz F; Bruckner-Tuderman L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(36):33378-33385
Characterization of recombinant soluble macrophage scavenger receptor MARCO
Sankala M; Brännström A; Schulthess T; Bergmann U; Morgunova E; Engel J; Tryggvason K; Pikkarainen T
Article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 2002;50(8):1113-1130
Localization of laminin α4-chain in developing and adult human tissues
Petäjäniemi N; Korhonen M; Kortesmaa J; Tryggvason K; Sekiguchi K; Fujiwara H; Sorokin L; Thornell LE; Wondimu Z; Assefa D; Patarroyo M; Virtanen I
Article: SEMINARS IN CANCER BIOLOGY. 2002;12(3):197-207
Laminin isoforms in tumor invasion, angiogenesis and metastasis
Patarroyo M; Tryggvason K; Virtanen I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(11):7414-7419
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
Morgunova E; Tuuttila A; Bergmann U; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(21):18928-18937
Contributions of the LG modules and furin processing to laminin-2 functions
Smirnov SP; McDearmon EL; Li SH; Ervasti JM; Tryggvason K; Yurchenco PD
Article: LANCET. 2002;359(9317):1575-1577
Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations
Patrakka J; Martin P; Salonen R; Kestilä M; Ruotsalainen V; Männikkö M; Ryynänen M; Rapola J; Holmberg C; Tryggvason K; Jalanko H
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2002;13(5):1385-1389
N-linked glycosylation is critical for the plasma membrane localization of nephrin
Yan K; Khoshnoodi J; Ruotsalainen V; Tryggvason K
Article: NATURE GENETICS. 2002;31(1):94-99
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
Pendás AM; Zhou ZJ; Cadiñanos J; Freije JMP; Wang JM; Hultenby K; Astudillo A; Wernerson A; Rodríguez F; Tryggvason K; López-Otín C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(15):12741-12748
Recombinant human laminin-10 (α5,β1,γ1) -: Production, purification, and migration-promoting activity on vascular endothelial cells
Doi M; Thyboll J; Kortesmaa J; Jansson K; Iivanainen A; Parvardeh M; Timpl R; Hedin U; Swedenborg J; Tryggvason K
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2002;17(3):478-484
Expression of nephrin in acquired human glomerular disease
Huh W; Kim DJ; Kim MK; Kim YG; Oh HY; Ruotsalainen V; Tryggvason K
Article: TRANSPLANTATION. 2002;73(3):394-403
Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type - Role of nephrin
Patrakka J; Ruotsalainen V; Reponen P; Qvist E; Laine J; Holmberg C; Tryggvason K; Jalanko H
Article: HUMAN MOLECULAR GENETICS. 2002;11(4):379-388
Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration
Koziell A; Grech V; Hussain S; Lee G; Lenkkeri U; Tryggvason K; Scambler P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(5):1462-1469
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO
Brännström A; Sankala M; Tryggvason K; Pikkarainen T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202
Deletion of the laminin α4 chain leads to impaired microvessel maturation
Thyboll J; Kortesmaa J; Cao RH; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao YH; Tryggvason K
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2002;12(1):105-109
Laminin-5 γ 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract
Nordström B; Einhorn N; Silfverswärd C; Sjövall K; Tryggvason K; Auer G
Article: PEDIATRIC NEPHROLOGY. 2001;16(12):1022-1029
Podocyte proteins in Galloway-Mowat syndrome
Srivastava T; Whiting JM; Garola RE; Dasouki MJ; Ruotsalainen V; Tryggvason K; Hamed R; Alon US
Article: ANNALS OF MEDICINE. 2001;33(8):526-533
Genetic kidney diseases disclose the pathogenesis of proteinuria
Jalanko H; Patrakka J; Tryggvason K; Holmberg C
Article: HUMAN MOLECULAR GENETICS. 2001;10(23):2637-2644
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene:: insight into the mechanisms of congenital nephrotic syndrome
Liu L; Doné SC; Khoshnoodi J; Bertorello A; Wartiovaara J; Berggren PO; Tryggvason K
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2001;36(7):751-758
Ulcerative colitis and colorectal carcinoma -: DNA-profile, laminin-5 γ2 chain and cyclin A expression as early markers for risk assessment
Habermann J; Lenander C; Roblick UJ; Krüger S; Ludwig D; Alaiya A; Freitag S; Dümbgen L; Bruch HP; Stange E; Salo S; Tryggvason K; Auer G; Schimmelpenning H
Article: GENE THERAPY. 2001;8(11):882-890
Adenovirus-mediated transfer of type IV collagen α5 chain cDNA into swine kidney in vivo:: deposition of the protein into the glomerular basement membrane
Heikkilä P; Tibell A; Morita T; Chen Y; Wu G; Sado Y; Ninomiya Y; Pettersson E; Tryggvason K
Article: NATURE NEUROSCIENCE. 2001;4(6):597-604
Properly formed but improperly localized synaptic specializations in the absence of laminin α4
Patton BL; Cunningham JM; Thyboll J; Kortesmaa J; Westerblad H; Edström L; Tryggvason K; Sanes JR
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(5):1723-1731
Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome
Doublier S; Ruotsalainen V; Salvidio G; Lupia E; Biancone L; Conaldi PG; Reponen P; Tryggvason K; Camussi G
Article: HUMAN MUTATION. 2001;17(5):368-373
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome
Beltcheva O; Martin P; Lenkkeri U; Tryggvason K
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2001;31(3):264-271
Closed-circuit organ perfusion technique for gene transfer into the lungs.: An experimental trial on farm pigs
Parpala-Spårman T; Pääkkö P; Kortteinen P; Salonurmi T; Lukkarinen O; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2001;12(2):289-296
Expression of nephrin in pediatric kidney diseases
Patrakka J; Ruotsalainen V; Ketola I; Holmberg C; Heikinheimo M; Tryggvason K; Jalanko H
Article: JOURNAL OF CELL SCIENCE. 2001;114(2):423-433
Laminin-8 (α4β1γ1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation
Geberhiwot T; Assefa D; Kortesmaa J; Ingerpuu S; Pedraza C; Wondimu Z; Charo J; Kiessling R; Virtanen I; Tryggvason K; Patarroyo M
Article: CELLULAR ONCOLOGY. 2001;22(4):201-209
Laminin-5 γ2 chain expression correlates with unfavorable prognosis in colon carcinomas
Lenander C; Habermann J; Öst Å; Nilsson B; Schimmelpenning H; Tryggvason K; Auer G
Article: ANTICANCER RESEARCH. 2001;21(1B):509-512
Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx
Nordemar S; Kronenwett U; Auer G; Högmo A; Lindholm J; Edström S; Tryggvasson K; Linder S; Munck-Wikland E
Article: PEDIATRIC NEPHROLOGY. 2001;16(1):41-44
Two novel alternatively spliced 9-bp exons in the COL4A5 gene
Martin PH; Tryggvason K
Article: HUMAN MOLECULAR GENETICS. 2001;10(1):1-8
The murine nephrin gene is specifically expressed in kidney, brain and pancreas:: inactivation of the gene leads to massive proteinuria and neonatal death
Putaala H; Soininen R; Kilpeläinen P; Wartiovaara J; Tryggvason K
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(6):1905-1916
Role of nephrin in cell junction formation in human nephrogenesis
Ruotsalainen V; Patrakka J; Tissari P; Reponen P; Hess M; Kestilä M; Holmberg C; Salonen R; Heikinheimo M; Wartiovaara J; Tryggvason K; Jalanko H
Article: JOURNAL OF IMMUNOLOGY. 2000;165(10):5831-5838
Monocytic cells synthesize, adhere to, and migrate on laminin-8 (α₄β₁γ₁)
Pedraza C; Geberhiwot T; Ingerpuu S; Assefa D; Wondimu Z; Kortesmaa J; Tryggvason K; Virtanen I; Patarroyo M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2000;279(4):F785-F792
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.
Li C; Ruotsalainen V; Tryggvason K; Shaw AS; Miner JH
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2000;10(5):391-396
Cancer of the vagina:: Laminin-5γ2 chain expression and prognosis
Hellman K; Hellström AC; Silfverswärd C; Salo S; Aspenblad U; Nilsson B; Frankendal B; Tryggvasson K; Auer G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2000;11(6):991-1001
Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene
Putaala H; Sainio K; Sariola H; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(20):14853-14859
Recombinant laminin-8 (α₄β₁γ₁) -: Production, purification, and interactions with integrins
Kortesmaa J; Yurchenco P; Tryggvason K
Article: MATRIX BIOLOGY. 2000;19(2):163-167
Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin β1 and γ1 chains
Geberhiwot T; Wondimu Z; Salo S; Pikkarainen T; Kortesmaa J; Tryggvason K; Virtanen I; Patarroyo M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Zhou ZJ; Apte SS; Soininen R; Cao RH; Baaklini GY; Rauser RW; Wang JM; Cao YH; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2000;11(4):649-657
X-linked Alport syndrome:: Natural history in 195 families and genotype-phenotype correlations in males
Jais JP; Knebelmann B; Giatras I; De Marchi M; Rizzoni G; Renieri A; Weber M; Gross O; Netzer KO; Flinter F; Pirson Y; Verellen C; Wieslander J; Persson U; Tryggvason K; Martin P; Hertz JM; Schröder C; Sanak M; Krejcova S; Carvalho MF; Saus J; Antignac C; Smeets H; Gubler MC
Article: CELL AND TISSUE RESEARCH. 2000;300(1):129-137
Differential expression of mouse laminin γ2 and γ2*chain transcripts
Airenne T; Lin YF; Olsson M; Ekblom P; Vainio S; Tryggvason K
Article: MICROBES AND INFECTION. 2000;2(3):313-316
The macrophage receptor MARCO
Kraal G; van der Laan LJW; Elomaa O; Tryggvason K
Article: EXPERIMENTAL CELL RESEARCH. 2000;254(1):189-195
Erythromegakaryocytic cells synthesize laminin-8 (α4β1γ1)
Geberhiwot T; Ingerpuu S; Pedraza C; Neira M; Virtanen I; Tryggvason K; Patarroyo M
Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):723-732
Blood platelets contain and secrete laminin-8 (α4β1γ1) and adhere to laminin-8 via α6β1 integrin
Geberhiwot T; Ingerpuu S; Pedraza C; Neira M; Lehto U; Virtanen I; Kortesmaa J; Tryggvason K; Engvall E; Patarroyo M
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1999;91(21):1882-1887
Laminin-5 as a marker of invasiveness in cervical lesions
Skyldberg B; Salo S; Eriksson E; Aspenblad U; Moberger B; Tryggvason K; Auer G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1999;10(11):2440-2445
Unraveling the mechanisms of glomerular ultrafiltration: Nephrin, a key component of the slit diaphragm
Tryggvason K
Article: JOURNAL OF PATHOLOGY. 1999;188(4):361-368
Expression of the laminin γ2 chain in different histological types of lung carcinoma.: A study by immunohistochemistry and in situ hybridization
Määttä M; Soini Y; Pääkkö P; Salo S; Tryggvason K; Autio-Harmainen H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(14):7962-7967
Nephrin is specifically located at the slit diaphragm of glomerular podocytes
Ruotsalainen V; Ljungberg P; Wartiovaara J; Lenkkeri U; Kestilä M; Jalanko H; Holmberg C; Tryggvason K
Article: SCIENCE. 1999;284(5420):1667-1670
Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
Morgunova E; Tuuttila A; Bergmann U; Isupov M; Lindqvist Y; Schneider G; Tryggvason K
Article: GENOMICS. 1999;58(1):82-89
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor
Kangas M; Brännström A; Elomaa O; Matsuda Y; Eddy R; Shows TB; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(20):14107-14111
Molecular cloning and tissue-specific expression of a novel murine laminin γ3 chain
Iivanainen A; Morita T; Tryggvason K
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(9):1497-1506
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles
Palecanda A; Paulauskis J; Al-Mutairi E; Imrich A; Qin GZ; Suzuki H; Kodama T; Tryggvason K; Koziel H; Kobzik L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(16):10975-10982
Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes
Pikkarainen T; Brännström A; Tryggvason K
Article: UROLOGICAL RESEARCH. 1999;27(2):97-102
A novel surgical organ perfusion method for effective ex vivo and in vivo gene transfer into renal glomerular cells
Parpala-Spårman T; Lukkarinen O; Heikkilä P; Tryggvason K
Article: MATRIX BIOLOGY. 1999;18(2):197-210
Laminin-5 promotes adhesion and migration of epithelial cells:: identification of a migration-related element in the γ2 chain gene (LAMC2) with activity in transgenic mice
Salo S; Haakana H; Kontusaari S; Hujanen E; Kallunki T; Tryggvason K
Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 1999;107(2):121-130
Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis
Sahlberg C; Reponen P; Tryggvason K; Thesleff I
Article: ARCHIVES OF HISTOLOGY AND CYTOLOGY. 1999;62(1):83-95
Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages
Ito S; Naito M; Kobayashi Y; Takatsuka H; Jiang S; Usuda H; Umezu H; Hasegawa G; Arakawa M; Shultz LD; Elomaa O; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(9):5588-5596
Murine matrix metalloproteinase 9 gene -: 5′-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice
Munaut C; Salonurmi T; Kontusaari S; Reponen P; Morita T; Foidart JM; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 1999;162(2):939-947
Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo
van der Laan LJW; Döpp EA; Haworth R; Pikkarainen T; Kangas M; Elomaa O; Dijkstra CD; Gordon S; Tryggvason K; Kraal G
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1999;64(1):51-61
Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations
Lenkkeri U; Männikkö M; McCready P; Lamerdin J; Gribouval O; Niaudet P; Antignac C; Kashtan CE; Holmberg C; Olsen A; Kestilä M; Tryggvason K
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1999;43(5):445-451
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney
Tryggvason K; Ruotsalainen V; Wartiovaara J
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;284(4):1133-1140
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 Å resolution
Tuuttila A; Morgunova E; Bergmann U; Lindqvist Y; Maskos K; Fernandez-Catalan C; Bode W; Tryggvason K; Schneider G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1998;9(12):2291-2301
High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing
Martin P; Heiskari N; Zhou J; Leinonen A; Tumelius T; Hertz JM; Barker D; Gregory M; Atkin C; Styrkarsdottir U; Neumann H; Springate J; Shows T; Pettersson E; Tryggvason K
Article: MOLECULAR CELL. 1998;1(4):575-582
Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome
Kestila M; Lenkkeri U; Mannikko M; Lamerdin J; McCready P; Putaala H; Ruotsalainen V; Morita T; Nissinen M; Herva R; Kashtan CE; Peltonen L; Holmberg C; Olsen A; Tryggvason K
Article: JOURNAL OF MEDICAL GENETICS. 1998;35(3):211-217
PCR based mutation screening of the laminin α2 chain gene (LAMA2):: application to prenatal diagnosis and search for founder effects in congenital muscular dystrophy
Guicheney P; Vignier N; Zhang X; He Y; Cruaud C; Frey V; Helbling-Leclerc A; Richard P; Estournet B; Merlini L; Topaloglu H; Mora M; Harpey JP; Haenggeli CA; Barois A; Hainque B; Schwartz K; Tome FMS; Fardeau M; Tryggvason K
Article: HUMAN GENETICS. 1998;102(2):192-196
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1
Lenkkeri U; Kestilä M; Lamerdin J; McCready P; Adamson A; Olsen A; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(8):4530-4538
Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region
Elomaa O; Sankala M; Pikkarainen T; Bergmann U; Tuuttila A; Raatikainen-Ahokas A; Sariola H; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(44):27862-27868
Primary structure, developmental expression, and immunolocalization of the murine laminin alpha 4 chain
Iivanainen A; Kortesmaa J; Sahlberg C; Morita T; Bergmann U; Thesleff I; Tryggvason K
Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;151(4):1097-1104
Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas
Dehan P; Waltregny D; Beschin A; Noel A; Castronovo V; Tryggvason K; DeLeval J; Foidart JM
Article: FEBS JOURNAL. 1997;247(1):175-182
Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix
Groffen AJA; Hop FWH; Tryggvason K; Dijkman H; Assmann KJM; Veerkamp JH; Monnens LAH; VandenHeuvel LPWJ
Article: HUMAN MOLECULAR GENETICS. 1997;6(5):747-752
Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha 2-chain
Allamand V; Sunada Y; Salih MAM; Straub V; Ozo CO; AlTuraiki MHS; Akbar M; Kolo T; Colognato H; Zhang X; Sorokin LM; Yurchenco PD; Tryggvason K; Campbell KP
Article: BRITISH JOURNAL OF DERMATOLOGY. 1997;136(3):331-336
Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas.
Kainulainen T; Autio-Harmainen H; Oikarinen A; Salo S; Tryggvason K; Salo T
Article: KIDNEY INTERNATIONAL. 1997;51(3):868-872
Improved prenatal diagnosis of the congenital nephrotic syndrome of the Finnish type based on DNA analysis
Mannikko M; Kestila M; Lenkkeri U; Alakurtti H; Holmberg C; Leisti J; Salonen R; Aula P; Mustonen A; Peltonen L; Tryggvason K
Article: MOLECULAR MEDICINE. 1997;3(2):124-135
Detection of novel LAMC2 mutations in Herlitz junctional epidermolysis bullosa
Pulkkinen L; McGrath J; Airenne T; Haakana H; Tryggvason K; Kivirikko S; Meneguzzi G; Ortonne JP; Christiano AM; Uitto J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1996;7(12):2700-2703
Haplotype analysis of congenital nephrotic syndrome of the Finnish type in non-Finnish families
Mannikko M; Lenkkeri U; Kashtan CE; Kestila M; Holmberg C; Tryggvason K
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1996;11(11):2215-2222
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.
Dehan P; Weber M; Zhang X; Reeders ST; Foidart JM; Tryggvason K
Article: FEBS JOURNAL. 1996;241(3):827-834
Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells
Groffen AJA; Buskens CAF; Tryggvason K; Veerkamp JH; Monnens LAH; vandenHeuvel LPWJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(44):27664-27669
Structure of the human laminin alpha 2-chain gene (LAMA2), which is affected in congenital muscular dystrophy
Zhang X; Vuolteenaho R; Tryggvason K
Article: JOURNAL OF PATHOLOGY. 1996;180(3):290-294
Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma
Soini Y; Maatta M; Salo S; Tryggvason K; AutioHarmainen H
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1996;11(10):1983-1988
Identification of post-transplant anti-alpha 5 (IV) collagen alloantibodies in X-linked Alport syndrome.
Dehan P; Van den Heuvel LP; Smeets HJ; Tryggvason K; Foidart JM
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1996;58(6):1192-1204
X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene.
Renieri A; Bruttini M; Galli L; Zanelli P; Neri T; Rossetti S; Turco A; Heiskari N; Zhou J; Gusmano R; Massella L; Banfi G; Scolari F; Sessa A; Rizzoni G; Tryggvason K; Pignatti PF; Savi M; Ballabio A; De Marchi M
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1996;58(6):1177-1184
Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha 2-chain in congenital muscular dystrophy with partial deficiency of the protein
Nissinen M; HelblingLeclerc A; Zhang X; Evangelista T; Topaloglu H; Cruaud C; Weissenbach J; Fardeau M; Tome FMS; Schwartz K; Tryggvason K; Guicheney P
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1996;7(5):702-709
Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: A study of 250 patients with hematuria and suspected of having Alport syndrome
Heiskari N; Zhang X; Zhou J; Leinonen A; Barker D; Gregory M; Atkin CL; Netzer KO; Weber M; Reeders S; GronhagenRiska C; Neumann HPH; Trembath R; Tryggvason K
Article: GENOMICS. 1996;33(3):473-479
Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis
Zhang X; Zhou J; Reeders ST; Tryggvason K
Article: GENOMICS. 1996;32(1):54-64
Structure of the human laminin gamma 2 chain gene (LAMC2): Alternative splicing with different tissue distribution of two transcripts
Airenne T; Haakana H; Sainio K; Kallunki T; Kallunki P; Sariola H; Tryggvason K
Article: GENE THERAPY. 1996;3(1):21-27
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Heikkila P; Parpala T; Lukkarinen O; Weber M; Tryggvason K
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1995;57(6):1377-1383
Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1.
Männikkö M; Kestailä M; Holmberg C; Norio R; Ryynänen M; Olsen A; Peltonen L; Tryggvason K
Article: CANCER RESEARCH. 1995;55(18):4132-4139
Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas.
Pyke C; Salo S; Ralfkiaer E; Rømer J; Danø K; Tryggvason K
Article: KIDNEY INTERNATIONAL, SUPPLEMENT. 1995;47:S24-S28
MOLECULAR-PROPERTIES AND DISEASES OF COLLAGENS
TRYGGVASON K
Article: FEBS LETTERS. 1995;365(2-3):183-188
Primary structure and expression of a novel human laminin alpha 4 chain.
Iivanainen A; Sainio K; Sariola H; Tryggvason K
Article: DEVELOPMENTAL DYNAMICS. 1995;202(4):388-396
92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation.
Reponen P; Leivo I; Sahlberg C; Apte SS; Olsen BR; Thesleff I; Tryggvason K
Article: BIOCHEMISTRY. 1995;34(9):2819-2825
Autolytic activation of recombinant human 72 kilodalton type IV collagenase.
Bergmann U; Tuuttila A; Stetler-Stevenson WG; Tryggvason K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995;104(3):434-437
Identification of a homozygous exon-skipping mutation in the LAMC2 gene in a patient with Herlitz's junctional epidermolysis bullosa.
Vailly J; Pulkkinen L; Christiano AM; Tryggvason K; Uitto J; Ortonne JP; Meneguzzi G
Article: CELL. 1995;80(4):603-609
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.
Elomaa O; Kangas M; Sahlberg C; Tuukkanen J; Sormunen R; Liakka A; Thesleff I; Kraal G; Tryggvason K
Article: MATRIX BIOLOGY. 1995;14(6):489-497
The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.
Iivanainen A; Vuolteenaho R; Sainio K; Eddy R; Shows TB; Sariola H; Tryggvason K
Article: HUMAN MUTATION. 1995;5(3):197-204
Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients.
Boye E; Flinter F; Zhou J; Tryggvason K; Bobrow M; Harris A
Article: HUMAN MOLECULAR GENETICS. 1995;4(1):99-108
Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours.
Heidet L; Dahan K; Zhou J; Xu Z; Cochat P; Gould JD; Leppig KA; Proesmans W; Guyot C; Guillot M
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Corrigendum: PLOS ONE. 2015;10(5):e0126079
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (vol 10, e0122067, 2015)
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Review: STEM CELLS TRANSLATIONAL MEDICINE. 2014;3(11):1269-1274
Concise Review: Animal Substance-Free Human Embryonic Stem Cells Aiming at Clinical Applications
Hovatta O; Rodin S; Antonsson L; Tryggvason K
Review: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 2012;28:523-553
Functional Diversity of Laminins
Domogatskaya A; Rodin S; Tryggvason K
Editorial comment: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2012;23(7):1128-1129
Knocking Out Podocyte Rho GTPases: And the Winner Is ...
Lal MA; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2012;21(2):195-202
Towards understanding the inherited susceptibility for nephropathy in diabetes
Thomas MC; Groop P-H; Tryggvason K
Corrigendum: DEVELOPMENTAL DYNAMICS. 2012;241(2):431
Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (vol 240, pg 2646, 2011)
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainen T; Vainio S; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2011;20(4):416-424
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology
Ebarasi L; Oddsson A; Hultenby K; Betsholtz C; Tryggvason K
Review: NATURE REVIEWS NEPHROLOGY. 2009;5(8):463-468
New insights into the role of podocytes in proteinuria
Patrakka J; Tryggvason K
Review: TRENDS IN MOLECULAR MEDICINE. 2007;13(9):396-403
Nephrin - a unique structural and signaling protein of the kidney filter
Patrakka J; Tryggvason K
Meeting abstract: BLOOD. 2006;108(11):109A
Distinct roles of integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing.
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Eirik S; Jacobsen W; Ekblom M
Editorial comment: CELL. 2006;125(2):221-224
Nck links nephrin to actin in kidney podocytes
Tryggvason K; Pikkarainen T; Patrakka J
Review: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(13):1387-1401
Mechanisms of disease: Hereditary proteinuria syndromes and mechanisms of proteinuria
Tryggvason K; Patrakka J; Wartiovaara J
Review: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2006;17(3):813-822
Thin basement membrane nephropathy
Tryggvason K; Patrakka J
Review: MATRIX BIOLOGY. 2005;24(5):326-332
A simplified laminin nomenclature
Aumailley M; Bruckner-Tuderman L; Carter WG; Deutzmann R; Edgar D; Ekblom P; Engel J; Engvall E; Hohenester E; Jones JCR; Kleinman HK; Marinkovich MP; Martin GR; Mayer U; Meneguzzi G; Miner JH; Miyazaki K; Patarroyo M; Paulsson M; Quaranta V; Sanes JR; Sasaki T; Sekiguchi K; Sorokin LM; Talts JF; Tryggvason K; Uitto J; Virtanen I; von der Mark K; Wewer UM; Yamada Y; Yurchenco PD
Review: PHYSIOLOGY. 2005;20:96-101
How does the kidney filter plasma?
Tryggvason K; Wartiovaara J
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(3):600-602
Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice
Mirastschijski U; Zhou ZJ; Rollman O; Tryggvason K; Ågren MS
Review: JOURNAL OF INTERNAL MEDICINE. 2003;254(3):216-224
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure
Tryggvason K; Pettersson E
Review: NEW ENGLAND JOURNAL OF MEDICINE. 2003;348(25):2543-2556
Alport's syndrome, Goodpasture's syndrome, and type IV collagen
Hudson BG; Tryggvason K; Sundaramoorthy M; Neilson EG
Published conference paper: CONNECTIVE TISSUE RESEARCH. 2003;44:300-304
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice
Bartlett JD; Zhou ZJ; Skobe Z; Dobeck JM; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2001;10(4):543-549
Molecular basis of glomerular permselectivity
Tryggvason K; Wartiovaara J
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2001;11(3):322-327
Congenital nephrotic syndromes
Khoshnoodi J; Tryggvason K
Review: ADVANCES IN NEPHROLOGY FROM THE NECKER HOSPITAL. 2001;31:221-234
Nephrin: role in normal kidney and in disease.
Tryggvason K
Review: NEPHRON. 2001;9(6):355-359
Unraveling the molecular make-up of the glomerular podocyte slit diaphragm
Khoshnoodi J; Tryggvason K
Published conference paper: KIDNEY INTERNATIONAL. 2000;58(3):972-980
Congenital nephrotic syndrome (NPHS1):: Features resulting from different mutations in Finnish patients
Patrakka J; Kestilä M; Wartiovaara J; Ruotsalainen V; Tissari P; Lenkkeri U; Männikkö M; Visapää I; Holmberg C; Rapola J; Tryggvason K; Jalanko H
Review: NEPHRON. 2000;8(1):1-7
Animal models of Alport syndrome:: Advancing the prospects for effective human gene therapy
Heikkilä P; Tryggvason K; Thorner P
Published conference paper: IMMUNOLOGY LETTERS. 1997;57(1-3):203-208
Macrophage scavenger receptor MARCO: In vitro and in vivo regulation and involvement in the anti-bacterial host defense
vanderLaan LJW; Kangas M; Dopp EA; BrougHolub E; Elomaa O; Tryggvason K; Kraal G
Published conference paper: NEUROMUSCULAR DISORDERS. 1997;7(3):180-186
Genetics of laminin alpha 2 chain (or merosin) deficient congenital muscular dystrophy: From identification of mutations to prenatal diagnosis
Guicheney P; Vignier N; HelblingLeclerc A; Nissinen M; Zhang X; Cruaud C; Lambert JC; Richelme C; Topaloglu H; Merlini L; Barois A; Schwartz K; Tome FMS; Tryggvason K; Fardeau M
Published conference paper: KIDNEY INTERNATIONAL. 1997;51(5):1493-1499
Can Alport syndrome be treated by gene therapy?
Tryggvason K; Heikkila P; Pettersson E; Tibell A; Thorner P
Letter: NATURE GENETICS. 1995;11(2):216-218
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.
Helbling-Leclerc A; Zhang X; Topaloglu H; Cruaud C; Tesson F; Weissenbach J; Tomé FM; Schwartz K; Fardeau M; Tryggvason K
Other: KIDNEY INTERNATIONAL. 1995;47(1):327-332
A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome.
Hertz JM; Heiskari N; Zhou J; Jensen UB; Tryggvason K
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