Karl Tryggvason

About me
Publications
Public outreach and news

About me

Karl Tryggvason, MD, PhD, a citizen of Iceland and Sweden, got his MD training at the Univerisity of Oulu in Finland. He is a specialist in clinical chemistry (clinical pathology). He has spent 4 years as postdoc and visiting professor in the USA, and was professor of biochemistry at the University of Oulu prior to his move to Karolinska Institutet in 1995. He is currently professor of medical chemistry at the Department of Medical Chemistry and Biophysics (MBB) and a member of the Nobel Assembly for physiology or medicine.

Karl Tryggvason has made broad contributions to the characterization of the structure and biology of basement membranes and has identified the molecular basis of five genetic diseases, two of which are kidney diseases. He has a research staff of about 30 persons from numerous countries.Tryggvason is cofounder of BioStratum Inc. and NephroGenex Inc.

Articles

Article: CELL REPORTS. 2019;26(12):3231-3245.e9
In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors
Yap L; Wang J-W; Moreno-Moral A; Chong LY; Sun Y; Harmston N; Wang X; Chong SY; Ohman MK; Wei H; Bunte R; Gosh S; Cook S; Hovatta O; de KDPV; Petretto E; Tryggvason K
Article: NATURE COMMUNICATIONS. 2018;9(1):4432
Biologically relevant laminin as chemically defined and fully human platform for human epidermal keratinocyte culture
Tjin MS; Chua AWC; Moreno-Moral A; Chong LY; Tang PY; Harmston NP; Cai Z; Petretto E; Tan BK; Tryggvason K
Article: MATRIX BIOLOGY. 2018;70:5-19
Culturing functional pancreatic islets on α5-Iaminins and curative transplantation , to diabetic mice
Sigmundsson K; Ojala JRM; Ohman MK; Osterholm A-M; Moreno-Moral A; Domogatskaya A; Chong LY; Sun Y; Chai X; Steele JAM; George B; Patarroyo M; Nilsson A-S; Rodin S; Ghosh S; Stevens MM; Petretto E; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2018;29(5):1426-1436
Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome
Lin M-H; Miller JB; Kikkawa Y; Suleiman HY; Tryggvason K; Hodges BL; Miner JH
Article: NATURE COMMUNICATIONS. 2018;9(1):1031
A systematic approach to the development of a safe live attenuated Zika vaccine
Sen Kwek S; Watanabe S; Chan KR; Ong EZ; Tan HC; Ng WC; Nguyen MTX; Gan ES; Zhang SL; Chan KWK; Tan JH; Sessions OM; Manuel M; Pompon J; Chua C; Hazirah S; Tryggvason K; Vasudevan SG; Ooi EE
Article: PLOS ONE. 2018;13(8):e0202400
Association of crumbs homolog-2 with mTORC1 in developing podocyte
Hamano S; Nishibori Y; Hada I; Mikami N; Ito-Nitta N; Fukuhara D; Kudo A; Xiao Z; Nukui M; Patrakka J; Tryggvason K; Yan K
Article: NATURE COMMUNICATIONS. 2017;8:15509
Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
Horejs C-M; St-Pierre J-P; Ojala JRM; Steele JAM; da Silva PB; Rynne-Vidal A; Maynard SA; Hansel CS; Rodriguez-Fernandez C; Mazo MM; You AYF; Wang AJ; von Erlach T; Tryggvason K; Lopez-Cabrera M; Stevens MM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2017;312(6):F1184-F1199
Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression
Ito Y; Katayama K; Nishibori Y; Akimoto Y; Kudo A; Kurayama R; Hada I; Takahashi S; Kimura T; Fukutomi T; Katada T; Suehiro J; Beltcheva O; Tryggvason K; Yan K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(14):3637-3641
Ab initio solution of macromolecular crystal structures without direct methods
McCoy AJ; Oeffner RD; Wrobel AG; Ojala JRM; Tryggvason K; Lohkamp B; Read RJ
Article: STEM CELL REPORTS. 2016;7(4):802-816
Differentiation of Human Embryonic Stem Cells to Endothelial Progenitor Cells on Laminins in Defined and Xeno-free Systems
Nguyen MTX; Okina E; Chai X; Tan KH; Hovatta O; Ghosh S; Tryggvason K
Article: SCIENTIFIC REPORTS. 2016;6:29450
COL4A6 is dispensable for autosomal recessive Alport syndrome
Murata T; Katayama K; Oohashi T; Jahnukainen T; Yonezawa T; Sado Y; Ishikawa E; Nomura S; Tryggvason K; Ito M
Article: SCIENTIFIC REPORTS. 2016;6:25955
A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.
Ishibashi R; Takemoto M; Akimoto Y; Ishikawa T; He P; Maezawa Y; Sakamoto K; Tsurutani Y; Ide S; Ide K; Kawamura H; Kobayashi K; Tokuyama H; Tryggvason K; Betsholtz C; Yokote K
Article: STEM CELL REPORTS. 2016;6(4):607-617
Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Mansson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Lofling M; Genead R; Wardell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salasova A; Westgren M; Sundstrom E; Uhlen P; Arenas E; Sylven C; Tryggvason K; Corbascio M; Simonson OE; Osterholm C; Grinnemo K-H
Article: BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY. 2016;31:2-12
Human embryonic stem cells
Damdimopoulou P; Rodin S; Stenfelt S; Antonsson L; Tryggvason K; Hovatta O
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2015;309(11):F955-F966
Knockdown of Tmem234 in zebrafish results in proteinuria
Rodriguez PQ; Oddsson A; Ebarasi L; He B; Hultenby K; Wernerson A; Betsholtz C; Tryggvason K; Patrakka J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2015;185(8):2143-2157
Dendrin Ablation Prolongs Life Span by Delaying Kidney Failure
Weins A; Wong JS; Basgen JM; Gupta R; Daehn I; Casagrande L; Lessman D; Schwartzman M; Meliambro K; Patrakka J; Shaw A; Tryggvason K; He JC; Nicholas SB; Mundel P; Campbell KN
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2015;26(3):647-662
Rhophilin-1 Is a Key Regulator of the Podocyte Cytoskeleton and Is Essential for Glomerular Filtration
Lal MA; Andersson A-C; Katayama K; Xiao Z; Nukui M; Hultenby K; Wernerson A; Tryggvason K
Article: PLOS ONE. 2015;10(3):e0122067
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(12):2764-2777
Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes
He B; Ebarasi L; Zhao Z; Guo J; Ojala JRM; Hultenby K; De Val S; Betsholtz C; Tryggvason K
Article: CANADIAN JOURNAL OF CARDIOLOGY. 2014;30(11):1444-1451
Perlecan Heparan Sulfate Proteoglycan Is a Critical Determinant of Angiogenesis in Response to Mouse Hind-Limb Ischemia
Qiang B; Lim SY; Lekas M; Kuliszewski MA; Wolff R; Osherov AB; Rudenko D; Leong-Poi H; Noyan H; Husain M; Tran K; Tryggvason K; Hedin U; Tran-Lundmark K; Strauss BH
Article: NATURE PROTOCOLS. 2014;9(10):2354-2368
Monolayer culturing and cloning of human pluripotent stem cells on laminin-521-based matrices under xeno-free and chemically defined conditions
Rodin S; Antonsson L; Hovatta O; Tryggvason K
Article: NEPHRON EXTRA. 2014;4(3):146-154
Neph1 is reduced in primary focal segmental glomerulosclerosis, minimal change nephrotic syndrome, and corresponding experimental animal models of adriamycin-induced nephropathy and puromycin aminonucleoside nephrosis.
Hulkko J; Patrakka J; Lal M; Tryggvason K; Hultenby K; Wernerson A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2014;307(3):H337-H345
Heparan sulfate side chains have a critical role in the inhibitory effects of perlecan on vascular smooth muscle cell response to arterial injury
Gotha L; Lim SY; Osherov AB; Wolff R; Qiang B; Erlich I; Nili N; Pillarisetti S; Chang Y-T; Tran P-K; Tryggvason K; Hedin U; Tran-Lundmark K; Advani SL; Gilbert RE; Strauss BH
Article: DIABETOLOGIA. 2014;57(8):1611-1622
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
Sambo F; Malovini A; Sandholm N; Stavarachi M; Forsblom C; Maekinen V-P; Harjutsalo V; Lithovius R; Gordin D; Parkkonen M; Saraheimo M; Thorn LM; Tolonen N; Waden J; He B; Osterholm A-M; Tuomilehto J; Lajer M; Salem RM; McKnight AJ; Tarnow L; Panduru NM; Barbarini N; Di Camillo B; Toffolo GM; Tryggvason K; Bellazzi R; Cobelli C; Groop P-H
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2014;3(7):e172
Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression
Oprea II; Viola JR; Moreno PMD; Simonson OE; Rodin S; Teller N; Tryggvason K; Lundin KE; Girnita L; Smith CIE
Article: DIABETOLOGIA. 2014;57(6):1143-1153
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
Sandholm N; Forsblom C; Makinen V-P; McKnight AJ; Osterholm A-M; He B; Harjutsalo V; Lithovius R; Gordin D; Parkkonen M; Saraheimo M; Thorn LM; Tolonen N; Waden J; Tuomilehto J; Lajer M; Ahlqvist E; Mollsten A; Marcovecchio ML; Cooper J; Dunger D; Paterson AD; Zerbini G; Groop L; Tarnow L; Maxwell AP; Tryggvason K; Groop P-H
Article: PLOS ONE. 2014;9(10):e109854
Laminin α4 Deficient Mice Exhibit Decreased Capacity for Adipose Tissue Expansion and Weight Gain
Vaicik MK; Kortesmaa JT; Moverare-Skrtic S; Kortesmaa J; Soininen R; Bergstrom G; Ohlsson C; Chong LY; Rozell B; Emont M; Cohen RN; Brey EM; Tryggvason K
Article: NATURE COMMUNICATIONS. 2014;5:3195
Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
Rodin S; Antonsson L; Niaudet C; Simonson OE; Salmela E; Hansson EM; Domogatskaya A; Xiao Z; Damdimopoulou P; Sheikhi M; Inzunza J; Nilsson A-S; Baker D; Kuiper R; Sun Y; Blennow E; Nordenskjold M; Grinnemo K-H; Kere J; Betsholtz C; Hovatta O; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2013;24(10):1537-1543
Chromosome 2q31.1 Associates with ESRD in Women with Type 1 Diabetes
Sandholm N; McKnight AJ; Salem RM; Brennan EP; Forsblom C; Harjutsalo V; Makinen V-P; McKay GJ; Sadlier DM; Williams WW; Martin F; Panduru NM; Tarnow L; Tuomilehto J; Tryggvason K; Zerbini G; Comeau ME; Langefeld CD; Godson C; Hirschhorn JN; Maxwell AP; Florez JC; Groop P-H
Article: KIDNEY INTERNATIONAL. 2013;84(3):591-599
A meta-analysis of expression signatures in glomerular disease
Tryggvason SH; Guo J; Nukui M; Norlin J; Haraldsson B; Jornvall H; Tryggvason K; He L
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(5):1681-1695
Progressive Reactive Lymphoid Connective Tissue Disease and Development of Autoantibodies in Scavenger Receptor A5-Deficient Mice
Ojala JRM; Pikkarainen T; Elmberger G; Tryggvason K
Article: PEDIATRIC NEPHROLOGY. 2013;28(2):339-343
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy
Rodriguez PQ; Lohkamp B; Celsi G; Mache CJ; Auer-Grumbach M; Wernerson A; Hamajima N; Tryggvason K; Patrakka J
Article: PLOS ONE. 2013;8(8):e72750
Myo1e Impairment Results in Actin Reorganization, Podocyte Dysfunction, and Proteinuria in Zebrafish and Cultured Podocytes
Mao J; Wang D; Mataleena P; He B; Niu D; Katayama K; Xu X; Ojala JRM; Wang W; Shu Q; Du L; Liu A; Pikkarainen T; Patrakka J; Tryggvason K
Article: PLOS ONE. 2013;8(2):e56414
A Remote Cis-Acting Variant at 3q Links Glomerular NCK1 to Diabetic Nephropathy
He B; Osterholm A-M; Ojala JRM; Andersson A-C; Tryggvason K
Article: PLOS ONE. 2013;8(12):e83133
Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
Xiao Z; Rodriguez PQ; He L; Betsholtz C; Tryggvason K; Patrakka J
Article: KIDNEY INTERNATIONAL. 2013;83(1):63-71
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation
Sistani L; Rodriguez PQ; Hultenby K; Uhlen M; Betsholtz C; Jalanko H; Tryggvason K; Wernerson A; Patrakka J
Article: CELL METABOLISM. 2012;16(6):738-750
Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
Liu B; Ghosh S; Yang X; Zheng H; Liu X; Wang Z; Jin G; Zheng B; Kennedy BK; Suh Y; Kaeberlein M; Tryggvason K; Zhou Z
Article: KIDNEY INTERNATIONAL. 2012;82(10):1071-1083
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
Perisic L; Lal M; Hulkko J; Hultenby K; Onfelt B; Sun Y; Duner F; Patrakka J; Betsholtz C; Uhlen M; Brismar H; Tryggvason K; Wernerson A; Pikkarainen T
Article: BIOTECHNIQUES. 2012;53(4):221-230
A novel scavenger receptor 5-based antibiotic-independent selection method for generation of stable recombinant protein-producing mammalian cell lines especially suitable for proteins affecting cell adhesion
Ojala JRM; Pikkarainen T; Domogatskaya A; Tryggvason K; Rodin S
Article: PLOS GENETICS. 2012;8(9):e1002921
New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes
Sandholm N; Salem RM; McKnight AJ; Brennan EP; Forsblom C; Isakova T; McKay GJ; Williams WW; Sadlier DM; Makinen V-P; Swan EJ; Palmer C; Boright AP; Ahlqvist E; Deshmukh HA; Keller BJ; Huang H; Ahola AJ; Fagerholm E; Gordin D; Harjutsalo V; He B; Heikkila O; Hietala K; Kyto J; Lahermo P; Lehto M; Lithovius R; Osterholm A-M; Parkkonen M; Pitkaniemi J; Rosengard-Barlund M; Saraheimo M; Sarti C; Soderlund J; Soro-Paavonen A; Syreeni A; Thorn LM; Tikkanen H; Tolonen N; Tryggvason K; Tuomilehto J; Waden J; Gill GV; Prior S; Guiducci C; Mirel DB; Taylor A; Hosseini SM; Parving H-H; Rossing P; Tarnow L; Ladenvall C; Alhenc-Gelas F; Lefebvre P; Rigalleau V; Roussel R; Tregouet D-A; Maestroni A; Maestroni S; Falhammar H; Gu T; Mollsten A; Cimponeriu D; Ioana M; Mota M; Mota E; Serafinceanu C; Stavarachi M; Hanson RL; Nelson RG; Kretzler M; Colhoun HM; Panduru NM; Gu HF; Brismar K; Zerbini G; Hadjadj S; Marre M; Groop L; Lajer M; Bull SB; Waggott D; Paterson AD; Savage DA; Bain SC; Martin F; Hirschhorn JN; Godson C; Florez JC; Groop P-H; Maxwell AP
Article: DIABETES. 2012;61(8):2187-2194
Association Testing of Previously Reported Variants in a Large Case-Control Meta-analysis of Diabetic Nephropathy
Williams WW; Salem RM; McKnight AJ; Sandholm N; Forsblom C; Taylor A; Guiducci C; McAteer JB; McKay GJ; Isakova T; Brennan EP; Sadlier DM; Palmer C; Soederlund J; Fagerholm E; Harjutsalo V; Lithovius R; Gordin D; Hietala K; Kyto J; Parkkonen M; Rosengard-Barlund M; Thorn L; Syreeni A; Tolonen N; Saraheimo M; Waden J; Pitkaniemi J; Sarti C; Tuomilehto J; Tryggvason K; Osterholm A-M; He B; Bain S; Martin F; Godson C; Hirschhorn JN; Maxwel AP; Groop P-H; Florez JC
Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190
MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20479-20484
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
Haas U; Raschperger E; Hamberg M; Samuelsson B; Tryggvason K; Haeggstrom JZ
Article: DEVELOPMENTAL DYNAMICS. 2011;240(12):2646-2656
Deficiency in Crumbs Homolog 2 (Crb2) Affects Gastrulation and Results in Embryonic Lethality in Mice
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainan T; Vainio S; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(11):2037-2046
Glcci1 Deficiency Leads to Proteinuria
Nishibori Y; Katayama K; Parikka M; Oddsson A; Nukui M; Hultenby K; Wernerson A; He B; Ebarasi L; Raschperger E; Norlin J; Uhlen M; Patrakka J; Betsholtz C; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2011;80(10):1045-1054
Pdlim2 is a novel actin-regulating protein of podocyte foot processes
Sistani L; Duner F; Udumala S; Hultenby K; Uhlen M; Betsholtz C; Tryggvason K; Wernerson A; Patrakka J
Article: EMBO REPORTS. 2011;12(11):1135-1143
Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo
Stenzel D; Franco CA; Estrach S; Mettouchi A; Sauvaget D; Rosewell I; Schertel A; Armer H; Domogatskaya A; Rodin S; Tryggvason K; Collinson L; Sorokin L; Gerhardt H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):3965-3980
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival
Yaddanapudi S; Altintas MM; Kistler AD; Fernandez I; Moeller CC; Wei C; Peev V; Flesche JB; Forst A-L; Li J; Patrakka J; Xiao Z; Grahammer F; Schiffer M; Lohmueller T; Reinheckel T; Gu C; Huber TB; Ju W; Bitzer M; Rastaldi MP; Ruiz P; Tryggvason K; Shaw AS; Faul C; Sever S; Reiser J
Article: HUMAN MOLECULAR GENETICS. 2011;20(11):2182-2194
The podocyte protein nephrin is required for cardiac vessel formation
Wagner N; Morrison H; Pagnotta S; Michiels J-F; Schwab Y; Tryggvason K; Schedl A; Wagner K-D
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(6):1019-1023
Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes
He B; Ebarasi L; Hultenby K; Tryggvason K; Betsholtz C
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(8):1119-1133
Melanoma cells produce multiple laminin isoforms and strongly migrate on α5 laminin(s) via several integrin receptors
Oikawa Y; Hansson J; Sasaki T; Rousselle P; Domogatskaya A; Rodin S; Tryggvason K; Patarroyo M
Article: BLOOD. 2011;117(4):1319-1328
SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens
Mukhopadhyay S; Varin A; Chen Y; Liu B; Tryggvason K; Gordon S
Article: NEPHRON. 2011;118(3):e39-e48
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria
Xiao Z; He L; Takemoto M; Jalanko H; Chan GC; Storm DR; Betsholtz C; Tryggvason K; Patrakka J
Article: NEPHRON. 2011;117(2):e39-e46
Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25
Xu X; Patrakka J; Sistani L; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(53):42023-42032
Deficiency of a Transmembrane Prolyl 4-Hydroxylase in the Zebrafish Leads to Basement Membrane Defects and Compromised Kidney Function
Hyvarinen J; Parikka M; Sormunen R; Ramet M; Tryggvason K; Kivirikko KI; Myllyharju J; Koivunen P
Article: NATURE BIOTECHNOLOGY. 2010;28(6):611-615
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
Rodin S; Domogatskaya A; Strom S; Hansson EM; Chien KR; Inzunza J; Hovatta O; Tryggvason K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):164-169
Molecular make-up of the glomerular filtration barrier
Patrakka J; Tryggvason K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses
Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
Article: DIABETES. 2010;59(1):190-199
Nephrin Is Expressed on the Surface of Insulin Vesicles and Facilitates Glucose-Stimulated Insulin Release
Fornoni A; Jeon J; Santos JV; Cobianchi L; Jauregui A; Inverardi L; Mandic SA; Bark C; Johnson K; McNamara G; Pileggi A; Molano RD; Reiser J; Tryggvason K; Kerjaschki D; Berggren P-O; Mundel P; Ricordi C
Article: NEPHRON. 2010;114(1):e15-e22
Sp1 Specifically Binds to an Evolutionarily Conserved DNA Segment within a Region Necessary for Podocyte-Specific Expression of Nephrin
Beltcheva O; Hjorleifsdottir EE; Kontusaari S; Tryggvason K
Article: NEPHRON. 2010;116(2):e42-e52
Permeability, Ultrastructural Changes, and Distribution of Novel Proteins in the Glomerular Barrier in Early Puromycin Aminonucleoside Nephrosis
Duner F; Lindstrom K; Hultenby K; Hulkko J; Patrakka J; Tryggvason K; Haraldsson B; Wernerson A; Pettersson E
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(8):1814-1825
Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo
Salo S; Boutaud A; Hansen AJ; He L; Sun Y; Morales S; Venturini A; Martin P; Nokelainen P; Betsholtz C; Mathiasen IS; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2009;183(7):4657-4665
Human Mast Cells Adhere to and Migrate on Epithelial and Vascular Basement Membrane Laminins LM-332 and LM-511 via α₃β₁ Integrin
Sime W; Lunderius-Andersson C; Enoksson M; Rousselle P; Tryggvason K; Nilsson G; Harvima I; Patarroyo M
Article: DEVELOPMENTAL BIOLOGY. 2009;334(1):1-9
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier
Ebarasi L; He L; Hultenby K; Takemoto M; Betsholtz C; Tryggvason K; Majumdar A
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(7):2044-2051
Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane
Goldberg S; Harvey SJ; Cunningham J; Tryggvason K; Miner JH
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2009;20(7):1586-1596
Amino Acid Transporter LAT3 Is Required for Podocyte Development and Function
Sekine Y; Nishibori Y; Akimoto Y; Kudo A; Ito N; Fukuhara D; Kurayama R; Higashihara E; Babu E; Kanai Y; Asanuma K; Nagata M; Majumdar A; Tryggvason K; Yan K
Article: PLOS PATHOGENS. 2009;5(6):e1000474
MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis
Bowdish DME; Sakamoto K; Kim M-J; Kroos M; Mukhopadhyay S; Leifer CA; Tryggvason K; Gordon S; Russell DG
Article: NATURE MEDICINE. 2009;15(5):519-527
Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain
Wu C; Ivars F; Anderson P; Hallmann R; Vestweber D; Nilsson P; Robenek H; Tryggvason K; Song J; Korpos E; Loser K; Beissert S; Georges-Labouesse E; Sorokin LM
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(3):731-734
Stem cell therapy for Alport syndrome: the hope beyond the hype
Gross O; Borza D-B; Anders H-J; Licht C; Weber M; Segerer S; Torra R; Gubler M-C; Heidet L; Harvey S; Cosgrove D; Lees G; Kashtan C; Gregory M; Savige J; Ding J; Thorner P; Abrahamson DR; Antignac C; Tryggvason K; Hudson B; Miner JH
Article: LABORATORY INVESTIGATION. 2009;89(2):178-195
Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome
Shimizu M; Khoshnoodi J; Akimoto Y; Kawakami H; Hirano H; Higashihara E; Hosoyamada M; Sekine Y; Kurayama R; Kurayama H; Joh K; Hirabayashi J; Kasai K; Tryggvason K; Ito N; Yan K
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2009;84(1):5-13
Association of Genetic Variants at 3q22 with Nephropathy in Patients with Type 1 Diabetes Mellitus
He B; Osterholm A-M; Hoverfalt A; Forsblom C; Hjorleifsdottir EE; Nilsson A-S; Parkkonen M; Pitkaniemi J; Hreidarsson A; Sarti C; McKnight AJ; Maxwell AP; Tuomilehto J; Groop P-H; Tryggvason K
Article: JOURNAL OF INNATE IMMUNITY. 2009;1(2):153-163
SR-A, MARCO and TLRs Differentially Recognise Selected Surface Proteins from Neisseria meningitidis: an Example of Fine Specificity in Microbial Ligand Recognition by Innate Immune Receptors
Plueddemann A; Mukhopadhyay S; Sankala M; Savino S; Pizza M; Rappuoli R; Tryggvason K; Gordon S
Article: AMERICAN JOURNAL OF NEPHROLOGY. 2009;29(6):558-570
Glomerular Transcriptome Changes Associated with Lipopolysaccharide-Induced Proteinuria
Sun Y; He L; Takemoto M; Patrakka J; Pikkarainen T; Genove G; Norlin J; Truve K; Tryggvason K; Betsholtz C
Article: STEM CELLS. 2008;26(11):2800-2809
Laminin-511 but Not-332,-111, or-411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro
Domogatskaya A; Rodin S; Boutaud A; Tryggvason K
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;39(1):50-62
Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
Plantman S; Patarroyo M; Fried K; Domogatskaya A; Tryggvason K; Hammarberg H; Cullheim S
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;84(3):701-712
Laminin isoforms of lymph nodes and predominant role of α5-laminin(s) in adhesion and migration of blood lymphocytes
Gorfu G; Virtanen I; Hukkanen M; Lehto V-P; Rousselle P; Kenne E; Lindbom L; Kramer R; Tryggvason K; Patarroyo M
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2008;23(8):2504-2511
Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome
Duner F; Patrakka J; Xiao Z; Larsson J; Vlamis-Gardikas A; Pettersson E; Tryggvason K; Hultenby K; Wernerson A
Article: CIRCULATION RESEARCH. 2008;103(1):43-52
Heparan sulfate in perlecan promotes mouse atherosclerosis -: Roles in lipid permeability, lipid retention, and smooth muscle cell proliferation
Tran-Lundmark K; Tran P-K; Paulsson-Berne G; Friden V; Soininen R; Tryggvason K; Wight TN; Kinsella MG; Boren J; Hedin U
Article: FASEB JOURNAL. 2008;22(5):1530-1539
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
Jakobsson L; Domogatskaya A; Tryggvason K; Edgar D; Claesson-Welsh L
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(8):1734-1743
Effects of conformational activation of integrin α1I and α2I domains on selective recognition of laminin and collagen subtypes
Tulla M; Lahti M; Puranen JS; Brandt A-M; Kaepylae J; Domogatskaya A; Salminen TA; Tryggvason K; Johnson MS; Heino J
Article: JOURNAL OF CELL BIOLOGY. 2008;181(1):27-35
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Espada J; Varela I; Flores I; Ugalde AP; Cadinanos J; Pendas AM; Stewart CL; Tryggvason K; Blasco MA; Freije JMP; Lopez-Otin C
Article: KIDNEY INTERNATIONAL. 2008;73(6):697-704
Nephrin is involved in podocyte maturation but not survival during glomerular development
Done SC; Takemoto M; He L; Sun Y; Hultenby K; Betsholtz C; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):260-268
The glomerular transcriptome and a predicted protein-protein interaction network
He L; Sun Y; Takemoto M; Norlin J; Tryggvason K; Samuelsson T; Betsholtz C
Article: BMC GENETICS. 2007;8:84
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland
Qiao Q; Oesterholm A-M; He B; Pitkaeniemi J; Cordell HJ; Sarti C; Kinnunen L; Tuomilehto-Wolf E; Tryggvason K; Tuomilehto J
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(24):3317-3335
Glomerulus proteome analysis with two-dimensional gel electrophoresis and mass spectrometry
Tryggvason S; Nukui M; Oddsson A; Tryggvason K; Jornvall H
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(18):3819-3831
Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness:: Evidence for a role of α5-laminin(s) and α3β1 integrin
Kawataki T; Yamane T; Naganuma H; Rousselle P; Anduren I; Tryggvason K; Patarroyo M
Article: BLOOD. 2007;110(8):2916-2923
Functional interplay between endothelial nitric oxide synthase and membrane type 1-matrix metalloproteinase in migrating endothelial cells
Genis L; Gonzalo P; Tutor AS; Galvez BG; Martinez-Ruiz A; Zaragoza C; Lamas S; Tryggvason K; Apte SS; Arroyo AG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
Article: BLOOD. 2007;110(7):2399-2407
Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(9):2554-2564
Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance
Nakajo A; Khoshnoodi J; Takenaka H; Hagiwara E; Watanabe T; Kawakami H; Kurayama R; Sekine Y; Bessho F; Takahashi S; Swiatecka-Urban A; Tryggvason K; Yan K
Article: LABORATORY INVESTIGATION. 2007;87(8):780-791
Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function
Vainionpaa N; Lehto V-P; Tryggvason K; Virtanen I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(22):16654-16666
Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition
Ojala JRM; Pikkarainen T; Tuuttila A; Sandalova T; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2007;178(9):5912-5920
Scavenger receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation
Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L
Article: KIDNEY INTERNATIONAL. 2007;71(9):889-900
Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis
He L; Sun Y; Patrakka J; Mostad P; Norlin J; Xiao Z; Andrae J; Tryggvason K; Samuelsson T; Betsholtz C; Takemoto M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(3):757-764
Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II
Dahl M; Bauer AK; Arredouani M; Soininen R; Tryggvason K; Kleeberger SR; Kobzik L
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(3):689-697
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
Patrakka J; Xiao Z; Nukui M; Takemoto M; He L; Oddsson A; Perisic L; Kaukinen A; Szigyarto CA-K; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: JOURNAL OF MASS SPECTROMETRY. 2007;42(3):370-379
Identification of N-linked glycosylation sites in human nephrin using mass spectrometry
Khoshnoodi J; Hill S; Tryggvason K; Hudson B; Friedman DB
Article: NEPHRON. 2007;106(2):e32-e36
The glomerular transcriptome and Proteome
Betsholtz C; He L; Takemoto M; Norlin J; Sun Y; Patrakka J; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2007;71(2):140-145
Genome-wide scan for type 1 diabetic nephropathy in the Finnish population reveals suggestive linkage to a single locus on chromosome 3q
Osterholm A-M; He B; Pitkaniemi J; Albinsson L; Berg T; Sarti C; Tuomilehto J; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(18):12767-12775
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO
Chen YY; Sankala M; Ojala JRM; Sun Y; Tuuttila A; Isenman DE; Tryggvason K; Pikkarainen T
Article: PEDIATRIC NEPHROLOGY. 2006;21(5):711-718
Recurrence of proteinuria following renal transplantation in congenital nephrotic syndrome of the Finnish type
Srivastava T; Garola RE; Kestila M; Tryggvason K; Ruotsalainen V; Sharma M; Savin VJ; Jalanko H; Warady BA
Article: BLOOD. 2006;107(9):3503-3510
Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins
Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: KIDNEY INTERNATIONAL. 2006;69(8):1350-1359
The effect of dexamethasone on defective nephrin transport caused by ER stress: A potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases
Fujii Y; Khoshnoodi J; Takenaka H; Hosoyamada M; Nakajo A; Bessho F; Kudo A; Takahashi S; Arimura Y; Yamada A; Nagasawa T; Ruotsalainen V; Tryggvason K; Lee AS; Yan K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2006;36(4):940-949
MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis
Mukhopadhyay S; Chen YY; Sankala M; Peiser L; Pikkarainen T; Kraal G; Tryggvason K; Gordon S
Article: EMBO JOURNAL. 2006;25(5):1160-1174
Large-scale identification of genes implicated in kidney glomerulus development and function
Takemoto M; He LQ; Norlin J; Patrakka J; Xiao ZJ; Petrova T; Bondjers C; Asp J; Wallgard E; Sun Y; Samuelsson T; Mostad P; Lundin S; Miura N; Sado Y; Alitalo K; Quaggin SE; Tryggvason K; Betsholtz C
Article: DEVELOPMENTAL CELL. 2006;10(3):397-405
The vascular basement membrane:: A niche for insulin gene expression and β cell proliferation
Nikolova G; Jabs N; Konstantinova I; Domogatskaya A; Tryggvason K; Sorokin L; Fässler R; Gu GQ; Gerber HP; Ferrara N; Melton DA; Lammert E
Article: JOURNAL OF PATHOLOGY. 2006;208(4):574-589
Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis
Martens JH; Kzhyshkowska J; Falkowski-Hansen M; Schledzewski K; Gratchev A; Mansmann U; Schmuttermaier C; Dippel E; Koenen W; Riedel F; Sankala M; Tryggvason K; Kobzik L; Moldenhauer G; Arnold B; Goerdt S
Article: MATRIX BIOLOGY. 2006;25(2):89-93
Characterization of commercial laminin preparations from human placenta in comparison to recombinant laminins 2 (α2β1γ1),8 (α4β1γ1),10 (α5β1γ1)
Wondimu Z; Gorfu G; Kawataki T; Smirnov S; Yurchenco P; Tryggvason K; Patarroyo M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(1):213-220
Cardiomyopathy associated with microcirculation dysfunction in laminin α 4 chain-deficient mice
Wang JM; Hoshijima M; Lam J; Zhou ZJ; Jokiel A; Dalton ND; Hultenby K; Ruiz-Lozano P; Ross J; Tryggvason K; Chien KR
Article: THROMBOSIS AND HAEMOSTASIS. 2006;95(1):85-93
Megakaryocytic cells synthesize and platelets secrete α5-laminins, and the endothelial laminin isoform laminin 10 (α5β1γ1) strongly promotes adhesion but not activation of platelets
Nigatu A; Sime W; Gorfu G; Geberhiwot T; Andurén I; Ingerpuu S; Doi M; Tryggvason K; Hjemdahl P; Patarroyo M
Article: JOURNAL OF IMMUNOLOGY. 2005;175(12):8173-8180
Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A
Chen YY; Pikkarainen T; Elomaa O; Soininen R; Kodama T; Kraal G; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2005;175(9):6058-6064
MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages
Arredouani MS; Palecanda A; Koziel H; Huang YC; Imrich A; Sulahian TH; Ning YY; Yang ZP; Pikkarainen T; Sankala M; Vargas SO; Takeya M; Tryggvason K; Kobzik L
Article: NATURE. 2005;437(7058):564-568
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela I; Cadiñanos J; Pendás AM; Gutiérrez-Fernández A; Folgueras AR; Sánchez LM; Zhou ZJ; Rodríguez FJ; Stewart CL; Vega JA; Tryggvason K; Freije JMP; López-Otín C
Article: EXPERIMENTAL CELL RESEARCH. 2005;307(2):329-341
Laminins 2(α2β1γ1, Lm-211) and 8(α4β1γ1, Lm-411) are synthesized and secreted by tooth pulp fibroblasts and differentially promote neurite outgrowth from trigeminal ganglion sensory neurons
Fried K; Sime W; Lillesaar C; Virtanen I; Tryggvasson K; Patarroyo M
Article: NATURE MEDICINE. 2005;11(7):780-785
Genomic instability in laminopathy-based premature aging
Liu BH; Wang JM; Chan KM; Tjia WM; Deng W; Guan XY; Huang JD; Li KM; Chau PY; Chen DJ; Pei DQ; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen JJ; Cao YH; Cheah KSE; Tryggvason K; Zhou ZJ
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2005;16(6):1703-1710
Heparan sulfate of perlecan is involved in glomerular filtration
Morita H; Yoshimura A; Inui K; Lodeura T; Watanabe H; Wang L; Soininen R; Tryggvason K
Article: JOURNAL OF NEUROSCIENCE. 2005;25(14):3692-3700
Impeded interaction between Schwann cells and axons in the absence of laminin α4
Wallquist W; Plantman S; Thams S; Thyboll J; Kortesmaa J; Lännergren J; Domogatskaya A; Ögren SO; Risling M; Hammarberg H; Tryggvason K; Cullheim S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(2):1292-1298
Membrane type 1-matrix metalloproteinase is regulated by chemokines monocyte-chemoattractant protein-1/CCL2 and Interleukin-8/CXCL8 in endothelial cells during angiogenesis
Gálvez BG; Genís L; Matías-Román S; Oblander SA; Tryggvason K; Apte SS; Arroyo AG
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2005;15(1):120-126
Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva
Stoltzfus P; Heselmeyer-Haddad K; Castro J; White N; Silfversward C; Sjovall K; Einhorn N; Tryggvason K; Auer G; Ried T; Nordstrom B
Article: FEBS JOURNAL. 2005;272(1):228-243
Characterization of the interactions of the nephrin intracellular domain -: Evidence that the scaffolding protein IQGAP1 associates with nephrin
Liu XL; Kilpeläinen P; Hellman U; Sun Y; Wartiovaara J; Morgunova E; Pikkarainen T; Yan K; Jonsson AP; Tryggvason K
Article: DEVELOPMENTAL BIOLOGY. 2005;277(1):255-269
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
Oblander SA; Zhou ZJ; Gálvez BG; Starcher B; Shannon JM; Durbeej M; Arroyo AG; Tryggvason K; Apte SS
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(23):2979-2982
Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity
Melles E; Jörnvall H; Tryggvason S; Danielsson KG; Ekberg K; Tryggvason K; Wahren J; Bergman T
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(10):1475-1483
Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography
Wartiovaara J; Öfverstedt LG; Khoshnoodi J; Zhang JJ; Mäkelä E; Sandin S; Ruotsalainen V; Cheng RH; Jalanko H; Skoglund U; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2004;66(5):1755-1765
Disease-causing missense mutations in NPHS2 gene alter normal nephrin trafficking to the plasma membrane
Nishibori Y; Liu L; Hosoyamada M; Endou H; Kudo A; Takenaka H; Higashihara E; Bessho F; Takahashi S; Kershaw D; Ruotsalainen V; Tryggvason K; Khoshnoodi J; Yan K
Article: BLOOD. 2004;104(6):1859-1866
An endothelial laminin isoform, laminin 8 (α4β1γ1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis
Wondimu Z; Geberhiwot T; Ingerpuu S; Juronen E; Xie X; Lindbom L; Doi M; Kortesmaa J; Thyboll J; Tryggvason K; Fadeel B; Patarroyo M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2004;200(2):267-272
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles
Arredouani M; Yang ZP; Ning YY; Qin GZ; Soininen R; Tryggvason K; Kobzik L
Article: CANCER RESEARCH. 2004;64(14):4699-4702
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
Zhou ZJ; Wang JM; Cao RH; Morita H; Soininen R; Chan KM; Liu B; Cao YH; Tryggvason K
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY. 2004;23(3):215-222
Laminin-5 γ2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix
Stoltzfus P; Salo S; Eriksson E; Aspenblad U; Tryggvason K; Auer G; Avall-Lundqvist E
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2004;15(7):1731-1738
Defective trafficking of nephrin missense mutants rescued by a chemical chaperone
Liu XL; Doné SC; Yan K; Kilpeläinen P; Pikkarainen T; Tryggvason K
Article: CANCER RESEARCH. 2004;64(12):4059-4063
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
Zhou ZJ; Doi M; Wang JM; Cao RH; Liu BH; Chan KM; Kortesmaa J; Sorokin L; Cao YH; Tryggvason K
Article: PEDIATRIC RESEARCH. 2004;55(5):774-781
Tissue expression of nephrin in human and pig
Kuusniemi AM; Kestilä M; Patrakka J; Lahdenkari AT; Ruotsalainen V; Holmberg C; Karikoski R; Salonen R; Tryggvason K; Jalanko H
Article: CIRCULATION RESEARCH. 2004;94(4):550-558
Increased intimal hyperplasia and smooth muscle cell proliferation in transgenic mice with heparan sulfate-deficient perlecan
Tran PK; Tran-Lundmark K; Soininen R; Tryggvason K; Thyberg J; Hedin U
Article: NEUROREPORT. 2004;15(3):569-574
Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice
Byrne LC; Zhou ZG; Tryggvason K; Hökfelt T; Fetissov SO
Article: HYBRIDOMA. 2004;23(1):55-63
Monoclonal antibodies to human nephrin
Ruotsalainen V; Reponen P; Khoshnoodi J; Kilpeläinen P; Tryggvason K
Article: CELL AND TISSUE RESEARCH. 2004;315(1):27-37
Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic mice
Salonurmi T; Parikka M; Kontusaari S; Pirilä E; Munaut C; Salo T; Tryggvason K
Article: JOURNAL OF CLINICAL PATHOLOGY. 2003;56(6):342-346
Laminin 5 γ2 chain expression:: a marker of early invasiveness in colorectal adenomas
Lenander C; Roblick UJ; Habermann JK; Öst Å; Tryggvason K; Auer G
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;163(6):2337-2346
Nephrin promotes cell-cell adhesion through homophilic interactions
Khoshnoodi J; Sigmundsson K; Öfverstedt LG; Skoglund U; Öbrink B; Wartiovaara J; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(10):2603-2610
X-linked Alport syndrome:: Natural history and genotype-phenotype correlations in girls and women belonging to 195 families:: A "European community Alport syndrome concerted action" study
Jais JP; Knebelmann B; Giatras I; De Marchi M; Rizzoni G; Renieri A; Weber M; Gross O; Netzer KO; Flinter F; Pirson Y; Dahan K; Wieslander J; Persson U; Tryggvason K; Martin P; Hertz JM; Schröder C; Sanak M; Carvalho MF; Saus J; Antignac C; Smeets H; Gubler MC
Article: KIDNEY INTERNATIONAL. 2003;64(2):404-413
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases
Lahdenperä J; Kilpeläinen P; Liu XL; Pikkarainen T; Reponen P; Ruotsalainen V; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 2003;171(1):398-406
A site on laminin α5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis
Adair-Kirk TL; Atkinson JJ; Broekelmann TJ; Doi M; Tryggvason K; Miner JH; Mecham RP; Senior RM
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14(2):352-358
Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin
Beltcheva O; Kontusaari S; Fetissov S; Putaala H; Kilpeläinen P; Hökfelt T; Tryggvason K
Article: BLOOD. 2003;101(3):877-885
Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells
Gu YC; Kortesmaa J; Tryggvason K; Persson J; Ekblom P; Jacobsen SE; Ekblom M
Article: EMBO JOURNAL. 2003;22(2):236-245
Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney
Rossi M; Morita H; Sormunen R; Airenne S; Kreivi M; Wang L; Fukai N; Olsen BR; Tryggvason K; Soininen R
Article: MEDICAL ONCOLOGY. 2003;20(2):147-156
Laminin-5 γ2-chain expression and DNA ploidy as predictors of prognosis in endometrial carcinoma
Lundgren C; Frankendal B; Silfverswärd C; Nilsson B; Tryggvason K; Auer G; Nordström B
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2003;18(1):70-76
Altered ultrastructural distribution of nephrin in minimal change nephrotic syndrome
Wernerson A; Dunér F; Pettersson E; Widholm SM; Berg U; Ruotsalainen V; Tryggvason K; Hultenby K; Söderberg M
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;161(4):1459-1466
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.
Saleem MA; Ni L; Witherden I; Tryggvason K; Ruotsalainen V; Mundel P; Mathieson PW
Article: MATRIX BIOLOGY. 2002;21(6):483-486
Chondroitin sulphate modification in the α4 chain of human recombinant laminin-8 (α4β1γ1)
Kortesmaa J; Doi M; Patarroyo M; Tryggvason K
Article: EMBO JOURNAL. 2002;21(19):5026-5035
Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs
Franzke CW; Tasanen K; Schäcke H; Zhou ZJ; Tryggvason K; Mauch C; Zigrino P; Sunnarborg S; Lee DC; Fahrenholz F; Bruckner-Tuderman L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(36):33378-33385
Characterization of recombinant soluble macrophage scavenger receptor MARCO
Sankala M; Brännström A; Schulthess T; Bergmann U; Morgunova E; Engel J; Tryggvason K; Pikkarainen T
Article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 2002;50(8):1113-1130
Localization of laminin α4-chain in developing and adult human tissues
Petäjäniemi N; Korhonen M; Kortesmaa J; Tryggvason K; Sekiguchi K; Fujiwara H; Sorokin L; Thornell LE; Wondimu Z; Assefa D; Patarroyo M; Virtanen I
Article: SEMINARS IN CANCER BIOLOGY. 2002;12(3):197-207
Laminin isoforms in tumor invasion, angiogenesis and metastasis
Patarroyo M; Tryggvason K; Virtanen I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(11):7414-7419
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
Morgunova E; Tuuttila A; Bergmann U; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(21):18928-18937
Contributions of the LG modules and furin processing to laminin-2 functions
Smirnov SP; McDearmon EL; Li SH; Ervasti JM; Tryggvason K; Yurchenco PD
Article: LANCET. 2002;359(9317):1575-1577
Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations
Patrakka J; Martin P; Salonen R; Kestilä M; Ruotsalainen V; Männikkö M; Ryynänen M; Rapola J; Holmberg C; Tryggvason K; Jalanko H
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2002;13(5):1385-1389
N-linked glycosylation is critical for the plasma membrane localization of nephrin
Yan K; Khoshnoodi J; Ruotsalainen V; Tryggvason K
Article: NATURE GENETICS. 2002;31(1):94-99
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
Pendás AM; Zhou ZJ; Cadiñanos J; Freije JMP; Wang JM; Hultenby K; Astudillo A; Wernerson A; Rodríguez F; Tryggvason K; López-Otín C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(15):12741-12748
Recombinant human laminin-10 (α5,β1,γ1) -: Production, purification, and migration-promoting activity on vascular endothelial cells
Doi M; Thyboll J; Kortesmaa J; Jansson K; Iivanainen A; Parvardeh M; Timpl R; Hedin U; Swedenborg J; Tryggvason K
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2002;17(3):478-484
Expression of nephrin in acquired human glomerular disease
Huh W; Kim DJ; Kim MK; Kim YG; Oh HY; Ruotsalainen V; Tryggvason K
Article: TRANSPLANTATION. 2002;73(3):394-403
Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type - Role of nephrin
Patrakka J; Ruotsalainen V; Reponen P; Qvist E; Laine J; Holmberg C; Tryggvason K; Jalanko H
Article: HUMAN MOLECULAR GENETICS. 2002;11(4):379-388
Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration
Koziell A; Grech V; Hussain S; Lee G; Lenkkeri U; Tryggvason K; Scambler P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(5):1462-1469
Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO
Brännström A; Sankala M; Tryggvason K; Pikkarainen T
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202
Deletion of the laminin α4 chain leads to impaired microvessel maturation
Thyboll J; Kortesmaa J; Cao RH; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao YH; Tryggvason K
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2002;12(1):105-109
Laminin-5 γ 2 chain as an invasivity marker for uni- and multifocal lesions in the lower anogenital tract
Nordström B; Einhorn N; Silfverswärd C; Sjövall K; Tryggvason K; Auer G
Article: PEDIATRIC NEPHROLOGY. 2001;16(12):1022-1029
Podocyte proteins in Galloway-Mowat syndrome
Srivastava T; Whiting JM; Garola RE; Dasouki MJ; Ruotsalainen V; Tryggvason K; Hamed R; Alon US
Article: ANNALS OF MEDICINE. 2001;33(8):526-533
Genetic kidney diseases disclose the pathogenesis of proteinuria
Jalanko H; Patrakka J; Tryggvason K; Holmberg C
Article: HUMAN MOLECULAR GENETICS. 2001;10(23):2637-2644
Defective nephrin trafficking caused by missense mutations in the NPHS1 gene:: insight into the mechanisms of congenital nephrotic syndrome
Liu L; Doné SC; Khoshnoodi J; Bertorello A; Wartiovaara J; Berggren PO; Tryggvason K
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2001;36(7):751-758
Ulcerative colitis and colorectal carcinoma -: DNA-profile, laminin-5 γ2 chain and cyclin A expression as early markers for risk assessment
Habermann J; Lenander C; Roblick UJ; Krüger S; Ludwig D; Alaiya A; Freitag S; Dümbgen L; Bruch HP; Stange E; Salo S; Tryggvason K; Auer G; Schimmelpenning H
Article: GENE THERAPY. 2001;8(11):882-890
Adenovirus-mediated transfer of type IV collagen α5 chain cDNA into swine kidney in vivo:: deposition of the protein into the glomerular basement membrane
Heikkilä P; Tibell A; Morita T; Chen Y; Wu G; Sado Y; Ninomiya Y; Pettersson E; Tryggvason K
Article: NATURE NEUROSCIENCE. 2001;4(6):597-604
Properly formed but improperly localized synaptic specializations in the absence of laminin α4
Patton BL; Cunningham JM; Thyboll J; Kortesmaa J; Westerblad H; Edström L; Tryggvason K; Sanes JR
Article: AMERICAN JOURNAL OF PATHOLOGY. 2001;158(5):1723-1731
Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome
Doublier S; Ruotsalainen V; Salvidio G; Lupia E; Biancone L; Conaldi PG; Reponen P; Tryggvason K; Camussi G
Article: HUMAN MUTATION. 2001;17(5):368-373
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome
Beltcheva O; Martin P; Lenkkeri U; Tryggvason K
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2001;31(3):264-271
Closed-circuit organ perfusion technique for gene transfer into the lungs.: An experimental trial on farm pigs
Parpala-Spårman T; Pääkkö P; Kortteinen P; Salonurmi T; Lukkarinen O; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2001;12(2):289-296
Expression of nephrin in pediatric kidney diseases
Patrakka J; Ruotsalainen V; Ketola I; Holmberg C; Heikinheimo M; Tryggvason K; Jalanko H
Article: JOURNAL OF CELL SCIENCE. 2001;114(2):423-433
Laminin-8 (α4β1γ1) is synthesized by lymphoid cells, promotes lymphocyte migration and costimulates T cell proliferation
Geberhiwot T; Assefa D; Kortesmaa J; Ingerpuu S; Pedraza C; Wondimu Z; Charo J; Kiessling R; Virtanen I; Tryggvason K; Patarroyo M
Article: CELLULAR ONCOLOGY. 2001;22(4):201-209
Laminin-5 γ2 chain expression correlates with unfavorable prognosis in colon carcinomas
Lenander C; Habermann J; Öst Å; Nilsson B; Schimmelpenning H; Tryggvason K; Auer G
Article: ANTICANCER RESEARCH. 2001;21(1B):509-512
Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx
Nordemar S; Kronenwett U; Auer G; Högmo A; Lindholm J; Edström S; Tryggvasson K; Linder S; Munck-Wikland E
Article: PEDIATRIC NEPHROLOGY. 2001;16(1):41-44
Two novel alternatively spliced 9-bp exons in the COL4A5 gene
Martin PH; Tryggvason K
Article: HUMAN MOLECULAR GENETICS. 2001;10(1):1-8
The murine nephrin gene is specifically expressed in kidney, brain and pancreas:: inactivation of the gene leads to massive proteinuria and neonatal death
Putaala H; Soininen R; Kilpeläinen P; Wartiovaara J; Tryggvason K
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(6):1905-1916
Role of nephrin in cell junction formation in human nephrogenesis
Ruotsalainen V; Patrakka J; Tissari P; Reponen P; Hess M; Kestilä M; Holmberg C; Salonen R; Heikinheimo M; Wartiovaara J; Tryggvason K; Jalanko H
Article: JOURNAL OF IMMUNOLOGY. 2000;165(10):5831-5838
Monocytic cells synthesize, adhere to, and migrate on laminin-8 (α₄β₁γ₁)
Pedraza C; Geberhiwot T; Ingerpuu S; Assefa D; Wondimu Z; Kortesmaa J; Tryggvason K; Virtanen I; Patarroyo M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2000;279(4):F785-F792
CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.
Li C; Ruotsalainen V; Tryggvason K; Shaw AS; Miner JH
Article: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2000;10(5):391-396
Cancer of the vagina:: Laminin-5γ2 chain expression and prognosis
Hellman K; Hellström AC; Silfverswärd C; Salo S; Aspenblad U; Nilsson B; Frankendal B; Tryggvasson K; Auer G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2000;11(6):991-1001
Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene
Putaala H; Sainio K; Sariola H; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(20):14853-14859
Recombinant laminin-8 (α₄β₁γ₁) -: Production, purification, and interactions with integrins
Kortesmaa J; Yurchenco P; Tryggvason K
Article: MATRIX BIOLOGY. 2000;19(2):163-167
Chain specificity assignment of monoclonal antibodies to human laminins by using recombinant laminin β1 and γ1 chains
Geberhiwot T; Wondimu Z; Salo S; Pikkarainen T; Kortesmaa J; Tryggvason K; Virtanen I; Patarroyo M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Zhou ZJ; Apte SS; Soininen R; Cao RH; Baaklini GY; Rauser RW; Wang JM; Cao YH; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2000;11(4):649-657
X-linked Alport syndrome:: Natural history in 195 families and genotype-phenotype correlations in males
Jais JP; Knebelmann B; Giatras I; De Marchi M; Rizzoni G; Renieri A; Weber M; Gross O; Netzer KO; Flinter F; Pirson Y; Verellen C; Wieslander J; Persson U; Tryggvason K; Martin P; Hertz JM; Schröder C; Sanak M; Krejcova S; Carvalho MF; Saus J; Antignac C; Smeets H; Gubler MC
Article: CELL AND TISSUE RESEARCH. 2000;300(1):129-137
Differential expression of mouse laminin γ2 and γ2*chain transcripts
Airenne T; Lin YF; Olsson M; Ekblom P; Vainio S; Tryggvason K
Article: MICROBES AND INFECTION. 2000;2(3):313-316
The macrophage receptor MARCO
Kraal G; van der Laan LJW; Elomaa O; Tryggvason K
Article: EXPERIMENTAL CELL RESEARCH. 2000;254(1):189-195
Erythromegakaryocytic cells synthesize laminin-8 (α4β1γ1)
Geberhiwot T; Ingerpuu S; Pedraza C; Neira M; Virtanen I; Tryggvason K; Patarroyo M
Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):723-732
Blood platelets contain and secrete laminin-8 (α4β1γ1) and adhere to laminin-8 via α6β1 integrin
Geberhiwot T; Ingerpuu S; Pedraza C; Neira M; Lehto U; Virtanen I; Kortesmaa J; Tryggvason K; Engvall E; Patarroyo M
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 1999;91(21):1882-1887
Laminin-5 as a marker of invasiveness in cervical lesions
Skyldberg B; Salo S; Eriksson E; Aspenblad U; Moberger B; Tryggvason K; Auer G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1999;10(11):2440-2445
Unraveling the mechanisms of glomerular ultrafiltration: Nephrin, a key component of the slit diaphragm
Tryggvason K
Article: JOURNAL OF PATHOLOGY. 1999;188(4):361-368
Expression of the laminin γ2 chain in different histological types of lung carcinoma.: A study by immunohistochemistry and in situ hybridization
Määttä M; Soini Y; Pääkkö P; Salo S; Tryggvason K; Autio-Harmainen H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(14):7962-7967
Nephrin is specifically located at the slit diaphragm of glomerular podocytes
Ruotsalainen V; Ljungberg P; Wartiovaara J; Lenkkeri U; Kestilä M; Jalanko H; Holmberg C; Tryggvason K
Article: SCIENCE. 1999;284(5420):1667-1670
Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
Morgunova E; Tuuttila A; Bergmann U; Isupov M; Lindqvist Y; Schneider G; Tryggvason K
Article: GENOMICS. 1999;58(1):82-89
Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor
Kangas M; Brännström A; Elomaa O; Matsuda Y; Eddy R; Shows TB; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(20):14107-14111
Molecular cloning and tissue-specific expression of a novel murine laminin γ3 chain
Iivanainen A; Morita T; Tryggvason K
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(9):1497-1506
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles
Palecanda A; Paulauskis J; Al-Mutairi E; Imrich A; Qin GZ; Suzuki H; Kodama T; Tryggvason K; Koziel H; Kobzik L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(16):10975-10982
Expression of macrophage MARCO receptor induces formation of dendritic plasma membrane processes
Pikkarainen T; Brännström A; Tryggvason K
Article: UROLOGICAL RESEARCH. 1999;27(2):97-102
A novel surgical organ perfusion method for effective ex vivo and in vivo gene transfer into renal glomerular cells
Parpala-Spårman T; Lukkarinen O; Heikkilä P; Tryggvason K
Article: MATRIX BIOLOGY. 1999;18(2):197-210
Laminin-5 promotes adhesion and migration of epithelial cells:: identification of a migration-related element in the γ2 chain gene (LAMC2) with activity in transgenic mice
Salo S; Haakana H; Kontusaari S; Hujanen E; Kallunki T; Tryggvason K
Article: EUROPEAN JOURNAL OF ORAL SCIENCES. 1999;107(2):121-130
Timp-1, -2 and -3 show coexpression with gelatinases A and B during mouse tooth morphogenesis
Sahlberg C; Reponen P; Tryggvason K; Thesleff I
Article: ARCHIVES OF HISTOLOGY AND CYTOLOGY. 1999;62(1):83-95
Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages
Ito S; Naito M; Kobayashi Y; Takatsuka H; Jiang S; Usuda H; Umezu H; Hasegawa G; Arakawa M; Shultz LD; Elomaa O; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(9):5588-5596
Murine matrix metalloproteinase 9 gene -: 5′-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice
Munaut C; Salonurmi T; Kontusaari S; Reponen P; Morita T; Foidart JM; Tryggvason K
Article: JOURNAL OF IMMUNOLOGY. 1999;162(2):939-947
Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo
van der Laan LJW; Döpp EA; Haworth R; Pikkarainen T; Kangas M; Elomaa O; Dijkstra CD; Gordon S; Tryggvason K; Kraal G
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1999;64(1):51-61
Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations
Lenkkeri U; Männikkö M; McCready P; Lamerdin J; Gribouval O; Niaudet P; Antignac C; Kashtan CE; Holmberg C; Olsen A; Kestilä M; Tryggvason K
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1999;43(5):445-451
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney
Tryggvason K; Ruotsalainen V; Wartiovaara J
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;284(4):1133-1140
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 Å resolution
Tuuttila A; Morgunova E; Bergmann U; Lindqvist Y; Maskos K; Fernandez-Catalan C; Bode W; Tryggvason K; Schneider G
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1998;9(12):2291-2301
High mutation detection rate in the COL4A5 collagen gene in suspected Alport syndrome using PCR and direct DNA sequencing
Martin P; Heiskari N; Zhou J; Leinonen A; Tumelius T; Hertz JM; Barker D; Gregory M; Atkin C; Styrkarsdottir U; Neumann H; Springate J; Shows T; Pettersson E; Tryggvason K
Article: MOLECULAR CELL. 1998;1(4):575-582
Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome
Kestila M; Lenkkeri U; Mannikko M; Lamerdin J; McCready P; Putaala H; Ruotsalainen V; Morita T; Nissinen M; Herva R; Kashtan CE; Peltonen L; Holmberg C; Olsen A; Tryggvason K
Article: JOURNAL OF MEDICAL GENETICS. 1998;35(3):211-217
PCR based mutation screening of the laminin α2 chain gene (LAMA2):: application to prenatal diagnosis and search for founder effects in congenital muscular dystrophy
Guicheney P; Vignier N; Zhang X; He Y; Cruaud C; Frey V; Helbling-Leclerc A; Richard P; Estournet B; Merlini L; Topaloglu H; Mora M; Harpey JP; Haenggeli CA; Barois A; Hainque B; Schwartz K; Tome FMS; Fardeau M; Tryggvason K
Article: HUMAN GENETICS. 1998;102(2):192-196
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1
Lenkkeri U; Kestilä M; Lamerdin J; McCready P; Adamson A; Olsen A; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(8):4530-4538
Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region
Elomaa O; Sankala M; Pikkarainen T; Bergmann U; Tuuttila A; Raatikainen-Ahokas A; Sariola H; Tryggvason K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(44):27862-27868
Primary structure, developmental expression, and immunolocalization of the murine laminin alpha 4 chain
Iivanainen A; Kortesmaa J; Sahlberg C; Morita T; Bergmann U; Thesleff I; Tryggvason K
Article: AMERICAN JOURNAL OF PATHOLOGY. 1997;151(4):1097-1104
Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas
Dehan P; Waltregny D; Beschin A; Noel A; Castronovo V; Tryggvason K; DeLeval J; Foidart JM
Article: FEBS JOURNAL. 1997;247(1):175-182
Evidence for the existence of multiple heparan sulfate proteoglycans in the human glomerular basement membrane and mesangial matrix
Groffen AJA; Hop FWH; Tryggvason K; Dijkman H; Assmann KJM; Veerkamp JH; Monnens LAH; VandenHeuvel LPWJ
Article: HUMAN MOLECULAR GENETICS. 1997;6(5):747-752
Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha 2-chain
Allamand V; Sunada Y; Salih MAM; Straub V; Ozo CO; AlTuraiki MHS; Akbar M; Kolo T; Colognato H; Zhang X; Sorokin LM; Yurchenco PD; Tryggvason K; Campbell KP
Article: BRITISH JOURNAL OF DERMATOLOGY. 1997;136(3):331-336
Altered distribution and synthesis of laminin-5 (kalinin) in oral lichen planus, epithelial dysplasias and squamous cell carcinomas.
Kainulainen T; Autio-Harmainen H; Oikarinen A; Salo S; Tryggvason K; Salo T
Article: KIDNEY INTERNATIONAL. 1997;51(3):868-872
Improved prenatal diagnosis of the congenital nephrotic syndrome of the Finnish type based on DNA analysis
Mannikko M; Kestila M; Lenkkeri U; Alakurtti H; Holmberg C; Leisti J; Salonen R; Aula P; Mustonen A; Peltonen L; Tryggvason K
Article: MOLECULAR MEDICINE. 1997;3(2):124-135
Detection of novel LAMC2 mutations in Herlitz junctional epidermolysis bullosa
Pulkkinen L; McGrath J; Airenne T; Haakana H; Tryggvason K; Kivirikko S; Meneguzzi G; Ortonne JP; Christiano AM; Uitto J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1996;7(12):2700-2703
Haplotype analysis of congenital nephrotic syndrome of the Finnish type in non-Finnish families
Mannikko M; Lenkkeri U; Kashtan CE; Kestila M; Holmberg C; Tryggvason K
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1996;11(11):2215-2222
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.
Dehan P; Weber M; Zhang X; Reeders ST; Foidart JM; Tryggvason K
Article: FEBS JOURNAL. 1996;241(3):827-834
Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells
Groffen AJA; Buskens CAF; Tryggvason K; Veerkamp JH; Monnens LAH; vandenHeuvel LPWJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(44):27664-27669
Structure of the human laminin alpha 2-chain gene (LAMA2), which is affected in congenital muscular dystrophy
Zhang X; Vuolteenaho R; Tryggvason K
Article: JOURNAL OF PATHOLOGY. 1996;180(3):290-294
Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma
Soini Y; Maatta M; Salo S; Tryggvason K; AutioHarmainen H
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1996;11(10):1983-1988
Identification of post-transplant anti-alpha 5 (IV) collagen alloantibodies in X-linked Alport syndrome.
Dehan P; Van den Heuvel LP; Smeets HJ; Tryggvason K; Foidart JM
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1996;58(6):1192-1204
X-linked Alport syndrome: an SSCP-based mutation survey over all 51 exons of the COL4A5 gene.
Renieri A; Bruttini M; Galli L; Zanelli P; Neri T; Rossetti S; Turco A; Heiskari N; Zhou J; Gusmano R; Massella L; Banfi G; Scolari F; Sessa A; Rizzoni G; Tryggvason K; Pignatti PF; Savi M; Ballabio A; De Marchi M
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1996;58(6):1177-1184
Substitution of a conserved cysteine-996 in a cysteine-rich motif of the laminin alpha 2-chain in congenital muscular dystrophy with partial deficiency of the protein
Nissinen M; HelblingLeclerc A; Zhang X; Evangelista T; Topaloglu H; Cruaud C; Weissenbach J; Fardeau M; Tome FMS; Schwartz K; Tryggvason K; Guicheney P
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 1996;7(5):702-709
Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: A study of 250 patients with hematuria and suspected of having Alport syndrome
Heiskari N; Zhang X; Zhou J; Leinonen A; Barker D; Gregory M; Atkin CL; Netzer KO; Weber M; Reeders S; GronhagenRiska C; Neumann HPH; Trembath R; Tryggvason K
Article: GENOMICS. 1996;33(3):473-479
Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis
Zhang X; Zhou J; Reeders ST; Tryggvason K
Article: GENOMICS. 1996;32(1):54-64
Structure of the human laminin gamma 2 chain gene (LAMC2): Alternative splicing with different tissue distribution of two transcripts
Airenne T; Haakana H; Sainio K; Kallunki T; Kallunki P; Sariola H; Tryggvason K
Article: GENE THERAPY. 1996;3(1):21-27
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Heikkila P; Parpala T; Lukkarinen O; Weber M; Tryggvason K
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 1995;57(6):1377-1383
Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1.
Männikkö M; Kestailä M; Holmberg C; Norio R; Ryynänen M; Olsen A; Peltonen L; Tryggvason K
Article: CANCER RESEARCH. 1995;55(18):4132-4139
Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas.
Pyke C; Salo S; Ralfkiaer E; Rømer J; Danø K; Tryggvason K
Article: KIDNEY INTERNATIONAL, SUPPLEMENT. 1995;47:S24-S28
MOLECULAR-PROPERTIES AND DISEASES OF COLLAGENS
TRYGGVASON K
Article: FEBS LETTERS. 1995;365(2-3):183-188
Primary structure and expression of a novel human laminin alpha 4 chain.
Iivanainen A; Sainio K; Sariola H; Tryggvason K
Article: DEVELOPMENTAL DYNAMICS. 1995;202(4):388-396
92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation.
Reponen P; Leivo I; Sahlberg C; Apte SS; Olsen BR; Thesleff I; Tryggvason K
Article: BIOCHEMISTRY. 1995;34(9):2819-2825
Autolytic activation of recombinant human 72 kilodalton type IV collagenase.
Bergmann U; Tuuttila A; Stetler-Stevenson WG; Tryggvason K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995;104(3):434-437
Identification of a homozygous exon-skipping mutation in the LAMC2 gene in a patient with Herlitz's junctional epidermolysis bullosa.
Vailly J; Pulkkinen L; Christiano AM; Tryggvason K; Uitto J; Ortonne JP; Meneguzzi G
Article: CELL. 1995;80(4):603-609
Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages.
Elomaa O; Kangas M; Sahlberg C; Tuukkanen J; Sormunen R; Liakka A; Thesleff I; Kraal G; Tryggvason K
Article: MATRIX BIOLOGY. 1995;14(6):489-497
The human laminin beta 2 chain (S-laminin): structure, expression in fetal tissues and chromosomal assignment of the LAMB2 gene.
Iivanainen A; Vuolteenaho R; Sainio K; Eddy R; Shows TB; Sariola H; Tryggvason K
Article: HUMAN MUTATION. 1995;5(3):197-204
Detection of 12 novel mutations in the collagenous domain of the COL4A5 gene in Alport syndrome patients.
Boye E; Flinter F; Zhou J; Tryggvason K; Bobrow M; Harris A
Article: HUMAN MOLECULAR GENETICS. 1995;4(1):99-108
Deletions of both alpha 5(IV) and alpha 6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours.
Heidet L; Dahan K; Zhou J; Xu Z; Cochat P; Gould JD; Leppig KA; Proesmans W; Guyot C; Guillot M
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Corrigendum: PLOS ONE. 2015;10(5):e0126079
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (vol 10, e0122067, 2015)
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Review: STEM CELLS TRANSLATIONAL MEDICINE. 2014;3(11):1269-1274
Concise Review: Animal Substance-Free Human Embryonic Stem Cells Aiming at Clinical Applications
Hovatta O; Rodin S; Antonsson L; Tryggvason K
Review: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 2012;28:523-553
Functional Diversity of Laminins
Domogatskaya A; Rodin S; Tryggvason K
Editorial comment: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2012;23(7):1128-1129
Knocking Out Podocyte Rho GTPases: And the Winner Is ...
Lal MA; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2012;21(2):195-202
Towards understanding the inherited susceptibility for nephropathy in diabetes
Thomas MC; Groop P-H; Tryggvason K
Corrigendum: DEVELOPMENTAL DYNAMICS. 2012;241(2):431
Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (vol 240, pg 2646, 2011)
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainen T; Vainio S; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2011;20(4):416-424
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology
Ebarasi L; Oddsson A; Hultenby K; Betsholtz C; Tryggvason K
Review: NATURE REVIEWS NEPHROLOGY. 2009;5(8):463-468
New insights into the role of podocytes in proteinuria
Patrakka J; Tryggvason K
Review: TRENDS IN MOLECULAR MEDICINE. 2007;13(9):396-403
Nephrin - a unique structural and signaling protein of the kidney filter
Patrakka J; Tryggvason K
Meeting abstract: BLOOD. 2006;108(11):109A
Distinct roles of integrins α6 and α4 in fetal liver hematopoietic stem and progenitor cell homing.
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Eirik S; Jacobsen W; Ekblom M
Editorial comment: CELL. 2006;125(2):221-224
Nck links nephrin to actin in kidney podocytes
Tryggvason K; Pikkarainen T; Patrakka J
Review: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(13):1387-1401
Mechanisms of disease: Hereditary proteinuria syndromes and mechanisms of proteinuria
Tryggvason K; Patrakka J; Wartiovaara J
Review: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2006;17(3):813-822
Thin basement membrane nephropathy
Tryggvason K; Patrakka J
Review: MATRIX BIOLOGY. 2005;24(5):326-332
A simplified laminin nomenclature
Aumailley M; Bruckner-Tuderman L; Carter WG; Deutzmann R; Edgar D; Ekblom P; Engel J; Engvall E; Hohenester E; Jones JCR; Kleinman HK; Marinkovich MP; Martin GR; Mayer U; Meneguzzi G; Miner JH; Miyazaki K; Patarroyo M; Paulsson M; Quaranta V; Sanes JR; Sasaki T; Sekiguchi K; Sorokin LM; Talts JF; Tryggvason K; Uitto J; Virtanen I; von der Mark K; Wewer UM; Yamada Y; Yurchenco PD
Review: PHYSIOLOGY. 2005;20:96-101
How does the kidney filter plasma?
Tryggvason K; Wartiovaara J
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(3):600-602
Wound healing in membrane-type-1 matrix metalloproteinase-deficient mice
Mirastschijski U; Zhou ZJ; Rollman O; Tryggvason K; Ågren MS
Review: JOURNAL OF INTERNAL MEDICINE. 2003;254(3):216-224
Causes and consequences of proteinuria: the kidney filtration barrier and progressive renal failure
Tryggvason K; Pettersson E
Review: NEW ENGLAND JOURNAL OF MEDICINE. 2003;348(25):2543-2556
Alport's syndrome, Goodpasture's syndrome, and type IV collagen
Hudson BG; Tryggvason K; Sundaramoorthy M; Neilson EG
Published conference paper: CONNECTIVE TISSUE RESEARCH. 2003;44:300-304
Delayed tooth eruption in membrane type-1 matrix metalloproteinase deficient mice
Bartlett JD; Zhou ZJ; Skobe Z; Dobeck JM; Tryggvason K
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2001;10(4):543-549
Molecular basis of glomerular permselectivity
Tryggvason K; Wartiovaara J
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2001;11(3):322-327
Congenital nephrotic syndromes
Khoshnoodi J; Tryggvason K
Review: ADVANCES IN NEPHROLOGY FROM THE NECKER HOSPITAL. 2001;31:221-234
Nephrin: role in normal kidney and in disease.
Tryggvason K
Review: NEPHRON. 2001;9(6):355-359
Unraveling the molecular make-up of the glomerular podocyte slit diaphragm
Khoshnoodi J; Tryggvason K
Published conference paper: KIDNEY INTERNATIONAL. 2000;58(3):972-980
Congenital nephrotic syndrome (NPHS1):: Features resulting from different mutations in Finnish patients
Patrakka J; Kestilä M; Wartiovaara J; Ruotsalainen V; Tissari P; Lenkkeri U; Männikkö M; Visapää I; Holmberg C; Rapola J; Tryggvason K; Jalanko H
Review: NEPHRON. 2000;8(1):1-7
Animal models of Alport syndrome:: Advancing the prospects for effective human gene therapy
Heikkilä P; Tryggvason K; Thorner P
Published conference paper: IMMUNOLOGY LETTERS. 1997;57(1-3):203-208
Macrophage scavenger receptor MARCO: In vitro and in vivo regulation and involvement in the anti-bacterial host defense
vanderLaan LJW; Kangas M; Dopp EA; BrougHolub E; Elomaa O; Tryggvason K; Kraal G
Published conference paper: NEUROMUSCULAR DISORDERS. 1997;7(3):180-186
Genetics of laminin alpha 2 chain (or merosin) deficient congenital muscular dystrophy: From identification of mutations to prenatal diagnosis
Guicheney P; Vignier N; HelblingLeclerc A; Nissinen M; Zhang X; Cruaud C; Lambert JC; Richelme C; Topaloglu H; Merlini L; Barois A; Schwartz K; Tome FMS; Tryggvason K; Fardeau M
Published conference paper: KIDNEY INTERNATIONAL. 1997;51(5):1493-1499
Can Alport syndrome be treated by gene therapy?
Tryggvason K; Heikkila P; Pettersson E; Tibell A; Thorner P
Letter: NATURE GENETICS. 1995;11(2):216-218
Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.
Helbling-Leclerc A; Zhang X; Topaloglu H; Cruaud C; Tesson F; Weissenbach J; Tomé FM; Schwartz K; Fardeau M; Tryggvason K
Other: KIDNEY INTERNATIONAL. 1995;47(1):327-332
A nonsense mutation in the COL4A5 collagen gene in a family with X-linked juvenile Alport syndrome.
Hertz JM; Heiskari N; Zhou J; Jensen UB; Tryggvason K
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