Karl-Johan Malmberg

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: BLOOD ADVANCES. 2024;8(11):2933-2951
A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis
Vo DN; Yuan O; Kanaya M; Telliam-Dushime G; Li H; Kotova O; Caglar E; de Lichtenberg KH; Rahman SH; Soneji S; Scheding S; Bryder D; Malmeberg K-J; Sitnicka E
Article: NEW BIOTECHNOLOGY. 2023;77:139-148
Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells
Giang KA; Boxaspen T; Diao Y; Nilvebrant J; Kosugi-Kanaya M; Kanaya M; Krokeide SZ; Lehmann F; Gelius SS; Malmberg K-J; Nygren P-A
Article: JOURNAL OF IMMUNOLOGY. 2023;211(9):1348-1358
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
Clement D; Szabo EK; Krokeide SZ; Wiiger MT; Vincenti M; Palacios D; Chang Y-T; Grimm C; Patel S; Stenmark H; Brech A; Majhi RK; Malmberg K-J
Article: EBIOMEDICINE. 2023;96:104811
Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine
Lachota M; Zielniok K; Palacios D; Kanaya M; Peena L; Hoel HJ; Wiiger MT; Kveberg L; Hautz W; Zagozdzon R; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2023;14(1):6035
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
Sandoz PA; Kuhnigk K; Szabo EK; Thunberg S; Erikson E; Sandstroem N; Verron Q; Brech A; Watzl C; Wagner AK; Alici E; Malmberg K-J; Uhlin M; Oenfelt B
Article: BLOOD ADVANCES. 2023;7(16):4492-4504
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Philippon C; Tao S; Clement D; Haroun-Izquierdo A; Kichula KM; Netskar H; Brandt L; Oei VS; Kanaya M; Lanuza PM; Schaffer M; Goodridge JP; Horowitz A; Zhu F; Hammer Q; Sohlberg E; Majhi RK; Kveberg L; Onfelt B; Norman PJ; Malmberg K-J
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(6):376.e1-376.e11
Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
Haroun-Izquierdo A; Lanuza PM; Pfefferle A; Netskar H; Ask EH; Torlen J; Bjorklund A; Sohlberg E; Malmberg K-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120
Functional SARS-CoV-2 cross-reactive CD4⁺ T cells established in early childhood decline with age
Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Bjorkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: RESPIRATORY RESEARCH. 2023;24(1):62
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
Palma Medina LM; Babacic H; Dzidic M; Parke A; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgard J; Moll K; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-JK; Sandberg J; Gredmark-Russ S; Rooyackers O; Svensson MJ; Chambers BI; Eriksson L; Pernemalm MK; Bjorkstrom N; Aleman S; Ljunggren H-G; Klingstrom J; Stralin K; Norrby-Teglund A
Article: CURRENT PROTOCOLS. 2022;2(11):e613
Small Interfering RNA Delivery Into Primary Human Natural Killer Cells for Functional Gene Analyses
Momayyezi P; Malmberg K-J; Hammer Q
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(11):e005577
Adaptive single-KIR⁺NKG2C⁺ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia
Haroun-Izquierdo A; Vincenti M; Netskar H; van Ooijen H; Zhang B; Bendzick L; Kanaya M; Momayyezi P; Li S; Wiiger MT; Hoel HJ; Krokeide SZ; Kremer V; Tjonnfjord G; Berggren S; Wikstroem K; Blomberg P; Alici E; Felices M; oenfelt B; Hoeglund P; Valamehr B; Ljunggren H-G; Bjoerklund A; Hammer Q; Kveberg L; Cichocki F; Miller JS; Malmberg K-J; Sohlberg E
Article: CANCER CELL. 2022;40(9):1027-1043.e9
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
Salome B; Sfakianos JP; Ranti D; Daza J; Bieber C; Charap A; Hammer C; Banchereau R; Farkas AM; Ruan DF; Izadmehr S; Geanon D; Kelly G; Real RMD; Lee B; Beaumont KG; Shroff S; Wang YA; Wang Y-C; Thin TH; Garcia-Barros M; Hegewisch-Solloa E; Mace EM; Wang L; O'Donnell T; Chowell D; Fernandez-Rodriguez R; Skobe M; Taylor N; Kim-Schulze S; Sebra RP; Palmer D; Clancy-Thompson E; Hammond S; Kamphorst AO; Malmberg K-J; Marcenaro E; Romero P; Brody R; Viard M; Yuki Y; Martin M; Carrington M; Mehrazin R; Wiklund P; Mellman I; Mariathasan S; Zhu J; Galsky MD; Bhardwaj N; Horowitz A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(7):1190-1193
An optimized platform for efficient siRNA delivery into human NK cells
Palacios D; Momayyezi P; Huhn O; Ask EH; Dunst J; Malmberg K-J; Hammer Q
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
The Karolinska KI/K COVID-19 immune atlas: An open resource for immunological research and educational purposes
Ljunggren H-G; Heggernes Ask E; Cornillet Jeannin M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio Gomez A; Dzidic M; Filipovic I; Flodstrom-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingstrom J; Kokkinou E; Kvedaraite E; Lourda M; Mjosberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Eriksson LI; Aleman S; Malmberg K-J; Stralin K; Bjorkstrom NK
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(11):e154334
Expansion, persistence, and efficacy of donor memory- like NK cells infused for posttransplant relapse
Shapiro RM; Birch GC; Hu G; Cadavid JV; Nikiforow S; Baginska J; Ali AK; Tarannum M; Sheffer M; Abdulhamid YZ; Rambaldi B; Arihara Y; Reynolds C; Halpern MS; Rodig SJ; Cullen N; Wolff JO; Pfaff KL; Lane AA; Lindsley RC; Cutler CS; Antin JH; Ho VT; Koreth J; Gooptu M; Kim HT; Malmberg K-J; Wu CJ; Chen J; Soiffer RJ; Ritz J; Romee R
Article: CELL REPORTS. 2022;38(10):110503
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; Garcia M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Degenhardt F; Franke A; Spallotta F; Mori M; Michaelsson J; Bjorkstrom NK; Rueckert T; Romagnani C; Horowitz A; Klingstrom J; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2022;139(5):704-716
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia
Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mortberg A; Hoglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Article: CELL STEM CELL. 2021;28(12):2062-2075.e5
Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
Woan KV; Kim H; Bjordahl R; Davis ZB; Gaidarova S; Goulding J; Hancock B; Mahmood S; Abujarour R; Wang H; Tuininga K; Zhang B; Wu C-Y; Kodal B; Khaw M; Bendzick L; Rogers P; Ge MQ; Bonello G; Meza M; Felices M; Huffman J; Dailey T; Lee TT; Walcheck B; Malmberg KJ; Blazar BR; Bryceson YT; Valamehr B; Miller JS; Cichocki F
Article: MOLECULAR THERAPY. 2021;29(12):3410-3421
Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+NK cells to target myeloid leukemia
Chiu E; Felices M; Cichocki F; Davis Z; Wang H; Tuninga K; Vallera DA; Lee T; Bjordahl R; Malmberg KJ; Valamehr B; Miller JS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19
Lourda M; Dzidic M; Hertwig L; Bergsten H; Medina LMP; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgard J; Moll K; Garcia M; Maleki KT; Klingstrom J; Michaelsson J; Flodstrom-Tullberg M; Brighenti S; Buggert M; Mjosberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sonnerborg A; Eriksson LI; Rooyackers O; Aleman S; Stralin K; Ljunggren H-G; Bjorkstrom NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY RESEARCH. 2021;2021:9920234-18
Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression
Lachota M; Lennikov A; Malmberg K-J; Zagozdzon R
Article: SCIENCE IMMUNOLOGY. 2021;6(58):eabe9057
Natural killer cell receptors regulate responses of HLA-E-restricted T cells
Sullivan LC; Nguyen THO; Harpur CM; Stankovic S; Kanagarajah AR; Koutsakos M; Saunders PM; Cai Z; Gray JA; Widjaja JML; Lin J; Pietra G; Mingari MC; Moretta L; Samir J; Luciani F; Westall GP; Malmberg KJ; Kedzierska K; Brooks AG
Article: CYTOTHERAPY. 2021;23(4):329-338
Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma
Tschan-Plessl A; Kalberer CP; Wieboldt R; Stern M; Siegler U; Wodnar-Filipowicz A; Gerull S; Halter J; Heim D; Tichelli A; Tsakiris DA; Malmberg K-J; Passweg JR; Bottos A
Article: MED. 2021;2(2):180-195.e5
A Systemic Protein Deviation Score Linked to PD-1⁺ CD8⁺ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Ask EH; Tschan-Plessl A; Gjerdingen TJ; Saetersmoen ML; Hoel HJ; Wiiger MT; Olweus J; Wahlin BE; Lingjaerde OC; Horowitz A; Cashen AF; Watkins M; Fehniger TA; Holte H; Kolstad A; Malmberg K-J
Article: CELL. 2020;183(1):158-168.e14
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter J-I; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
MAIT cell activation and dynamics associated with COVID-19 disease severity
Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
Article: CELL STEM CELL. 2020;27(2):224-237.e6
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity.
Zhu H; Blum RH; Bernareggi D; Ask EH; Wu Z; Hoel HJ; Meng Z; Wu C; Guan K-L; Malmberg K-J; Kaufman DS
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:561553
Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
Goldenson BH; Zhu H; Wang YM; Heragu N; Bernareggi D; Ruiz-Cisneros A; Bahena A; Ask EH; Hoel HJ; Malmberg K-J; Kaufman DS
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:2128
The Oncometabolite 5′-Deoxy-5′-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
Jacobs B; Schloegl S; Strobl CD; Voelkl S; Stoll A; Mougiakakos D; Malmberg K-J; Mackensen A; Aigner M
Article: CELL REPORTS. 2019;29(8):2284-2294.e4
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Pfefferle A; Jacobs B; Netskar H; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9
Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
Cornillet M; Jansson H; Schaffer M; Hertwig L; Berglin L; Zimmer CL; Johansson H; Ellis E; Isaksson B; Gonzalez-Galarza FF; Middleton D; Malmberg K-J; Sparrelid E; Bjorkstrom NK
Article: JOURNAL OF IMMUNOLOGY. 2019;202(3):736-746
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
Jacobs B; Pfefferle A; Clement D; Berg-Larsen A; Saetersmoen ML; Lorenz S; Wiiger MT; Goodridge JP; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2019;10(1):514
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Goodridge JP; Jacobs B; Saetersmoen ML; Clement D; Hammer Q; Clancy T; Skarpen E; Brech A; Landskron J; Grimm C; Pfefferle A; Meza-Zepeda L; Lorenz S; Wiiger MT; Louch WE; Ask EH; Liu LL; Oei VYS; Kjallquist U; Linnarsson S; Patel S; Tasken K; Stenmark H; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2085
Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma
Enqvist M; Jacobs B; Junlen HR; Schaffer M; Melen CM; Friberg D; Wahlin BE; Malmberg K-J
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844
Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML
Bjorklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikstrom K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellstrom-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(4):467-480
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Oei VYS; Siernicka M; Graczyk-Jarzynka A; Hoel HJ; Yang W; Palacios D; Almasbak H; Bajor M; Clement D; Brandt L; Onfelt B; Goodridge J; Winiarska M; Zagozdzon R; Olweus J; Kyte J-A; Malmberg K-J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(11):4042-4058
CD56^bright NK cells exhibit potent antitumor responses following IL-15 priming
Wagner JA; Rosario M; Romee R; Berrien-Elliott MM; Schneider SE; Leong JW; Sullivan RP; Jewell BA; Becker-Hapak M; Schappe T; Abdel-Latif S; Ireland AR; Jaishankar D; King JA; Vij R; Clement D; Goodridge J; Malmberg K-J; Wong HC; Fehniger TA
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Liu LL; Beziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellstrom-Lindberg E; Soderhall S; Heyman M; Grander D; Malmberg K-J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(10):3772-3782
Cognate HLA absence in trans diminishes human NK cell education
Landtwing V; Raykova A; Pezzino G; Beziat V; Marcenaro E; Graf C; Moretta A; Capaul R; Zbinden A; Ferlazzo G; Malmberg K-J; Chijioke O; Munz C
Article: SCIENCE IMMUNOLOGY. 2016;1(3):eaag1672
Class I HLA haplotypes form two schools that educate NK cells in different ways
Horowitz A; Djaoud Z; Nemat-Gorgani N; Blokhuis J; Hilton HG; Beziat V; Malmberg K-J; Norman PJ; Guethlein LA; Parham P
Article: ONCOIMMUNOLOGY. 2016;5(5):e1138199
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Mensali N; Ying F; Sheng VOY; Yang W; Walseng E; Kumari S; Fallang L-E; Kolstad A; Uckert W; Malmberg KJ; Walchli S; Olweus J
Article: CELL REPORTS. 2016;15(5):1088-1099
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Liu LL; Landskron J; Ask EH; Enqvist M; Sohlberg E; Traherne JA; Hammer Q; Goodridge JP; Larsson S; Jayaraman J; Oei VYS; Schaffer M; Tasken K; Ljunggren H-G; Romagnani C; Trowsdale J; Malmberg K-J; Beziat V
Article: JOURNAL OF IMMUNOLOGY. 2016;196(3):1400-1411
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
Bjorklund AT; Clancy T; Goodridge JP; Beziat V; Schaffer M; Hovig E; Ljunggren H-G; Ljungman PT; Malmberg K-J
Article: ONCOTARGET. 2015;6(33):34178-34190
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Sohlberg E; Pfefferle A; Andersson S; Baumann BC; Hellstrom-Lindberg E; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3374-3381
Microchip-Based Single-Cell Imaging Reveals That CD56^dim CD57^-KIR^-NKG2A⁺ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56^dimCD57^-KIR^-NKG2A^- NK Cells
Forslund E; Sohlberg E; Enqvist M; Olofsson PE; Malmberg K-J; Onfelt B
Article: BONE MARROW TRANSPLANTATION. 2015;50(9):1217-1223
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation
von Bahr L; Blennow O; Alm J; Bjorklund A; Malmberg K-J; Mougiakakos D; Le Blanc A; Oefner PJ; Labopin M; Ljungman P; Le Blanc K
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(9):1589-1596
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation
Sobecks RM; Wang T; Askar M; Gallagher MM; Haagenson M; Spellman S; Fernandez-Vina M; Malmberg K-J; Mueller C; Battiwalla M; Gajewski J; Verneris MR; Ringden O; Marino S; Davies S; Dehn J; Bornhaeuser M; Inamoto Y; Woolfrey A; Shaw P; Pollack M; Weisdorf D; Milller J; Hurley C; Lee SJ; Hsu K
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527
Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells
Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Beziat V; Andersson SA; Schaffer M; Spurkland A; Bryceson Y; Onfelt B; Malmberg K-J
Article: IMMUNITY. 2015;42(3):443-456
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: GUT. 2015;64(3):469-482
Effects of HDV infection and pegylated interferon a treatment on the natural killer cell compartment in chronically infected individuals
Lunemann S; Malone DFG; Grabowski J; Port K; Beziat V; Bremer B; Malmberg K-J; Manns MP; Sandberg JK; Cornberg M; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
Article: FRONTIERS IN IMMUNOLOGY. 2015;6:507
Polyclonal expansion of NKG2C⁺ NK cells in TAP-deficient patients
Beziat V; Sleiman M; Goodridge JP; Kaarbo M; Liu LL; Rollag H; Ljunggren H-G; Zimmer J; Malmberg K-J
Article: BLOOD. 2014;124(16):2533-2543
Role for early-differentiated natural killer cells in infectious mononucleosis
Azzi T; Luenemann A; Murer A; Ueda S; Beziat V; Malmberg K-J; Staubli G; Gysin C; Berger C; Muenz C; Chijioke O; Nadal D
Article: BLOOD. 2014;124(5):812-821
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease
Munneke JM; Bjorklund AT; Mjosberg JM; Garming-Legert K; Bernink JH; Blom B; Huisman C; van Oers MHJ; Spits H; Malmberg K-J; Hazenberg MD
Article: AGE. 2014;36(2):571-582
Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity
Bengner M; Beziat V; Ernerudh J; Nilsson B-O; Lofgren S; Wikby A; Malmberg KJ; Strindhall J
Article: BLOOD. 2013;121(23):4703-4707
Influence of KIR gene copy number on natural killer cell education
Beziat V; Traherne JA; Liu LL; Jayaraman J; Enqvist M; Larsson S; Trowsdale J; Malmberg K-J
Article: BLOOD. 2013;121(14):2678-2688
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Beziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Bjorklund AT; Retiere C; Sverremark-Ekstrom E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2013;121(8):1326-1334
Classification of human natural killer cells based on migration behavior and cytotoxic response
Vanherberghen B; Olofsson PE; Forslund E; Sternberg-Simon M; Khorshidi MA; Pacouret S; Guldevall K; Enqvist M; Malmberg K-J; Mehr R; Onfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Karre K; Malmberg K-J; Hoglund P; Mehr R
Article: BLOOD. 2012;120(17):3455-3465
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Bjorkstrom NK; Beziat V; Cichocki F; Liu LL; Levine J; Larsson S; Koup RA; Anderson SK; Ljunggren H-G; Malmberg K-J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(2):447-457
CMV drives clonal expansion of NKG2C⁺ NK cells expressing self-specific KIRs in chronic hepatitis patients
Beziat V; Dalgard O; Asselah T; Halfon P; Bedossa P; Boudifa A; Hervier B; Theodorou I; Martinot M; Debre P; Bjorkstrom NK; Malmberg K-J; Marcellin P; Vieillard V
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(11):1688-1697
Improved Survival after Allogeneic Hematopoietic Stem Cell Transplantation in Recent Years. A Single-Center Study
Remberger M; Ackefors M; Berglund S; Blennow O; Dahllof G; Dlugosz A; Garming-Legert K; Gertow J; Gustafsson B; Hassan M; Hassan Z; Hauzenberger D; Hagglund H; Karlsson H; Klingspor L; Kumlien G; Le Blanc K; Ljungman P; Machaczka M; Malmberg K-J; Marschall H-U; Mattsson J; Olsson R; Omazic B; Sairafi D; Schaffer M; Svahn B-M; Svenberg P; Swartling L; Szakos A; Uhlin M; Uzunel M; Watz E; Wernerson A; Wikman A; Wikstrom A-C; Winiarski J; Ringden O
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554
Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Bjoerkstroem NK; Bjornstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923
NKG2D performs two functions in invariant NKT cells: Direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Kuylenstierna C; Bjorkstrom NK; Andersson SK; Sahlstrom P; Bosnjak L; Paquin-Proulx D; Malmberg K-J; Ljunggren H-G; Moll M; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2011;208(1):13-21
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Bjorkstrom NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaelsson J; Malmberg K-J; Klingstrom J; Ahlm C; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2011;186(1):62-72
Interactions of NK Cell Receptor KIR3DL1*004 with Chaperones and Conformation-Specific Antibody Reveal a Functional Folded State As Well As Predominant Intracellular Retention
Taner SB; Pando MJ; Roberts A; Schellekens J; Marsh SGE; Malmberg K-J; Parham P; Brodsky FM
Article: PLOS ONE. 2011;6(11):e27664
Characterization of Natural Killer Cell Phenotype and Function during Recurrent Human HSV-2 Infection
Bjorkstrom NK; Svensson A; Malmberg K-J; Eriksson K; Ljunggren H-G
Article: BLOOD. 2010;116(19):3853-3864
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56^dim NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Bjorklund AT; Flodstrom-Tullberg M; Michaelsson J; Rottenberg ME; Guzman CA; Ljunggren H-G; Malmberg K-J
Article: LEUKEMIA. 2010;24(9):1607-1616
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34⁺ blasts in myelodysplastic syndrome
Carlsten M; Baumann BC; Simonsson M; Jadersten M; Forsblom A-M; Hammarstedt C; Bryceson YT; Ljunggren H-G; Hellstrom-Lindberg E; Malmberg K-J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500
Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE^-/- Mice
Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng C-N; Bjorkstrom NK; Malmberg K-J; Lindbom L; Eriksson EE
Article: BLOOD. 2010;115(13):2686-2694
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Bjorklund AT; Schaffer M; Fauriat C; Ringden O; Remberger M; Hammarstedt C; Barrett AJ; Ljungman P; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaelsson J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(2):378-387
Activating NK-cell receptors co-stimulate CD4⁺CD28^- T cells in patients with rheumatoid arthritis
Fasth AER; Bjorkstrom NK; Anthoni M; Malmberg K-J; Malmstrom V
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
Analysis of the KIR repertoire in human NK cells by flow cytometry.
Björkström NK; Fauriat C; Bryceson YT; Sandberg JK; Ljunggren H-G; Malmberg K-J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1272-1277
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Curbo S; Gaudin R; Carlsten M; Malmberg K-J; Troye-Blomberg M; Ahlborg N; Karlsson A; Johansson M; Lundberg M
Article: JOURNAL OF IMMUNOLOGY. 2009;183(8):4921-4930
Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells
Carlsten M; Norell H; Bryceson YT; Poschke I; Schedvins K; Liunggren H-G; Kiessling R; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2009;183(7):4792-4799
T Cell Infiltrates in the Muscles of Patients with Dermatomyositis and Polymyositis Are Dominated by CD28^null T Cells
Fasth AER; Dastmalchi M; Rahbar A; Salomonsson S; Pandya JM; Lindroos E; Nennesmo I; Malmberg K-J; Soderberg-Naucler C; Trollmo C; Lundberg IE; Malmstrom V
Article: BLOOD. 2009;114(1):95-104
KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Andersson S; Fauriat C; Malmberg J-A; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype
Fauriat C; Andersson S; Bjorklund AT; Carlsten M; Schaffer M; Bjorkstrom NK; Baumann BC; Michaelsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228
Elevated numbers of FcγRIIIA⁺ (CD16⁺) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
Bjorkstrom NK; Gonzalez VD; Malmberg K-J; Falconer K; Alaeus A; Nowak G; Jorns C; Ericzon B-G; Weiland O; Sandberg JK; Ljunggren H-G
Article: CELLULAR MICROBIOLOGY. 2008;10(2):426-436
IFN-γ production dominates the early human natural killer cell response to Coxsackievirus infection
Huhn MH; Hultcrantz M; Lind K; Ljunggren H-G; Malmberg K-J; Flodstrom-Tullberg M
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
Gonzalez VD; Bjorkstroem NK; Malmberg K-J; Moll M; Kuylenstierna C; Michalsson J; Ljunggren H-G; Sandberg JK
Article: JOURNAL OF IMMUNOLOGY. 2007;179(7):4513-4519
The CD16-CD56^bright NK cell subset is resistant to reactive oxygen species produced by activated Granulocytes and has higher antioxidative capacity than the CD16+CD56^dim subset
Harlin H; Hanson M; Johansson CC; Sakurai D; Poschke I; Norell H; Malmberg K-J; Kiessling R
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2007;56(7):973-984
A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
Hanson MGV; Ozenci V; Carlsten MCV; Glimelius BL; Frodin J-EA; Masucci G; Malmberg K-J; Kiessling RVR
Article: CANCER RESEARCH. 2007;67(3):1317-1325
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Carlsten M; Bjorkstrom NK; Norell H; Bryceson Y; van Hall T; Baumann BC; Hanson M; Schedvins K; Kiessling R; Ljunggren H-G; Malmberg KJ
Article: CANCER RESEARCH. 2006;66(12):6387-6394
Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity
Norell H; Carlsten M; Ohlum T; Malmberg K-J; Masucci G; Schedvins K; Altermann W; Handke D; Atkins D; Seliger B; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 2005;174(10):6080-6087
Preferential cell death of CD8⁺ effector memory (CCR7^-CD45RA^-) T cells by hydrogen peroxide-induced oxidative stress
Takahashi A; Hanson MGV; Norell HR; Havelka AM; Kono K; Malmberg KJ; Kiessling RVR
Article: TRANSPLANTATION. 2004;78(7):1081-1085
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Schaffer M; Malmberg KJ; Ringdén O; Ljunggren HG; Remberger M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;110(10):1515-1523
IFN-γ protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
Malmberg KJ; Levitsky V; Norell H; de Matos CT; Carlsten M; Schedvins K; Rabbani H; Moretta A; Söderström K; Levitskaya J; Kiessling R
Article: CLINICAL CANCER RESEARCH. 2002;8(6):1772-1778
A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer
Malmberg KJ; Lenkei R; Petersson M; Ohlum T; Ichihara F; Glimelius B; Frödin JE; Masucci G; Kiessling R
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(12):3602-3611
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Charo J; Geluk A; Sundbäck M; Mirzai B; Diehl AD; Malmberg KJ; Achour A; Huriguchi S; van Meijgaarden KE; Drijfhout JW; Beekman N; van Veelen P; Ossendorp F; Ottenhoff THM; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 2001;167(5):2595-2601
Inhibition of activated/memory (CD45RO⁺) T cells by oxidative stress associated with block of NF-κB activation
Malmberg KJ; Arulampalam V; Ichihara F; Petersson M; Seki K; Andersson T; Lenkei R; Masucci G; Pettersson S; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):1037-1044
Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas
Yang RC; Salazar-Onfray F; Charo J; Malmberg KJ; Evrin K; Maes H; Kono K; Hising C; Petersson M; Larsson O; Lan L; Appella E; Sette A; Celis E; Kiessling R
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Alla övriga publikationer

Review: NATURE REVIEWS IMMUNOLOGY. 2024;24(9):680-693
Engineering immune-evasive allogeneic cellular immunotherapies
Martin KE; Hammer Q; Perica K; Sadelain M; Malmberg K-J
Preprint: BIORXIV. 2023;BIORXIV
MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration.
Ask EH; Tschan-Plessl A; Hoel HJ; Kolstad A; Holte H; Malmberg K-J
Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):205-220
Advances in immune therapies in hematological malignancies
Mazzarella L; Enblad G; Olweus J; Malmberg K-J; Jerkeman M
Review: CANCERS. 2020;12(12):E3719-3719
Prospects for NK Cell Therapy of Sarcoma
Lachota M; Vincenti M; Winiarska M; Boye K; Zagozdzon R; Malmberg K-J
Editorial comment: CELL CALCIUM. 2020;92:102289
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Patel S; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:812
Deciphering Natural Killer Cell Homeostasis
Pfefferle A; Jacobs B; Haroun-Izquierdo A; Kveberg L; Sohlberg E; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:753
TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
Clement D; Goodridge JP; Grimm C; Patel S; Malmberg K-J
Review: SEMINARS IN IMMUNOPATHOLOGY. 2019;41(1):59-68
Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells
Saetersmoen ML; Hammer Q; Valamehr B; Kaufman DS; Malmberg K-J
Review: CYTOKINE AND GROWTH FACTOR REVIEWS. 2018;44:1-10
Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting
De Santis F; Del Vecchio M; Castagnoli L; De Braud F; Di Cosimo S; Franceschini D; Fuca G; Hiscott J; Malmberg KJ; McGranahan N; Pietrantonio F; Rivoltini L; Sangaletti S; Tagliabue E; Tripodo C; Vernieri C; Zitvogel L; Pupa SM; Di Nicola M
Review: CURRENT PHARMACEUTICAL DESIGN. 2017;23(32):4716-4725
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Clancy T; Dannenfelser R; Troyanskaya O; Malmberg KJ; Hovig E; Kristensen V
Review: IMMUNOGENETICS. 2017;69(8-9):547-556
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Malmberg K-J; Sohlberg E; Goodridge JP; Ljunggren H-G
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29
Natural killer cell-mediated immunosurveillance of human cancer
Malmberg K-J; Carlsten M; Bjorklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Review: MOLECULAR ONCOLOGY. 2015;9(10):1904-1917
Harnessing adaptive natural killer cells in cancer immunotherapy
Liu LL; Pfefferle A; Sheng VOY; Bjorklund AT; Beziat V; Goodridge JP; Malmberg KJ
Review: IMMUNOLOGICAL REVIEWS. 2015;267(1):197-213
Newtonian cell interactions shape natural killer cell education
Goodridge JP; Onfelt B; Malmberg K-J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Beziat V; Traherne J; Malmberg J-A; Ivarsson MA; Bjorkstrom NK; Retiere C; Ljunggren H-G; Michaelsson J; Trowsdale J; Malmberg K-J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(12):3141-3145
Spotlight on NKG2C and the human NK-cell response to CMV infection
Malmberg K-J; Beziat V; Ljunggren H-G
Other: IMMUNITY. 2011;35(5):653-657
Killer Cell Immunoglobulin-like Receptor Workshop: Insights into Evolution, Genetics, Function, and Translation
Malmberg K-J; Michaelsson J; Parham P; Ljunggren H-G
Editorial comment: HLA. 2010;76(1):74-75
Identification of a novel KIR3DL1*072 allele by sequence-based typing
Schellekens J; Schaffer M; Malmberg K-J; Madrigal JA; Marsh SGE
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1309-1315
Tolerant and diverse natural killer cell repertoires in the absence of selection
Andersson S; Malmberg J-A; Malmberg K-J
Review: INTERNATIONAL JOURNAL OF CANCER. 2009;124(4):757-762
Natural killer cell-mediated lysis of freshly isolated human tumor cells
Carlsten M; Malmberg K-J; Ljunggren H-G
Editorial comment: NATURE IMMUNOLOGY. 2009;10(1):11-12
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Malmberg K-J; Ljunggren H-G
Published conference paper: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2008;57(10):1541-1552
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Malmberg K-J; Bryceson YT; Carlsten M; Andersson S; Bjorklund A; Bjorkstrom NK; Baumann BC; Fauriat C; Alici E; Dilber MS; Ljunggren H-G
Review: NATURE REVIEWS IMMUNOLOGY. 2007;7(5):329-339
Prospects for the use of NK cells in immunotherapy of human cancer
Ljunggren H-G; Malmberg K-J
Meeting abstract: HUMAN IMMUNOLOGY. 2006;67(10):S129
KIR-HLA mismatch in T-cell replete HLA-identical sibling hematopoietic stem cell transplantation for acute myelogenous leukemia
Schaffer M; Remberger M; Ringden O; Ljunggren H-G; Malmberg K-J
Review: SEMINARS IN CANCER BIOLOGY. 2006;16(1):16-31
Escape from immune- and nonimmune-mediated tumor surveillance
Malmberg KJ; Ljunggren HG
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):531-534
KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Malmberg KJ; Schaffer M; Ringdén O; Remberger M; Ljunggren HG
Review: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2004;53(10):879-892
Effective immunotherapy against cancer - A question of overcoming immune suppression and immune escape?
Malmberg KJ
Thesis / dissertation: 2003
Mechanisms of immune escape : implications for immunotherapy against cancer
Malmberg, Karl-Johan
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Anställningar

Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Experimentell hematologi, Karolinska Institutet, 2009
MEDICINE DOKTORSEXAMEN, Institutionen för onkologi-patologi, Karolinska Institutet, 2003
Läkarexamen, Karolinska Institutet, 2000

Handledare

Alvaro Haroun-Izquierdo, NATURAL KILLER CELL DEVELOPMENT AND FUNCTION IN THE CONTEXT OF ALLOGENEIC STEM CELL TRANSPLANTATION AND CELL THERAPY
Aline Pfefferle, Dynamics of natural killer cell homeostasis : implications for cell-based cancer immunotherapy.

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Anställningar

Examina och utbildning

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Nyheter från KI

Kalenderhändelser från KI