Kaarina Kowalec

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: EBIOMEDICINE. 2025;112:105576
Genetic insights into psychotic major depressive disorder: bridging the mood-psychotic disorder spectrum
Nguyen T-D; Meijsen JJ; Sigstroem R; Kuja-Halkola R; Xiong Y; Harder A; Kowalec K; Pasman JA; Scarpa C; Horbeck E; Jonsson L; Hagg S; Mullins N; O'Connell KS; Dalman C; Helenius D; Zetterberg R; Larsson H; Lichtenstein P; Andreassen OA; Werge T; Buil A; Landen M; Sullivan PF; Lu Y
Article: JAMA PSYCHIATRY. 2024;81(12):1246-1252
Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J; Pasman JA; Johansson V; Kuja-Halkola R; Harder A; Karlsson R; Lu Y; Kowalec K; Pedersen NL; Cannon TD; Hultman CM; Sullivan PF
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2024;91:105866
Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study
Hu C; Vasileiou ES; Salter A; Marrie RA; Kowalec K; Fitzgerald KC
Article: SCHIZOPHRENIA RESEARCH. 2024;272:69-76
The impact of COVID-19 public health measures on the utilization of antipsychotics in schizophrenia in Manitoba - A population-based study
Shirinbakhshmasoleh M; Aboulatta L; Leong C; Riel H; Liu K; Delaney JC; Bolton JM; Falk J; Alessi-Severini S; Eltonsy S; Kowalec K
Article: JAMA NEUROLOGY. 2024;81(11):1170-1177
Comorbidity and Disease Activity in Multiple Sclerosis
Salter A; Lancia S; Kowalec K; Fitzgerald KC; Marrie RA
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2024;11(6):1393-1404
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis
Kowalec K; Harder A; Dolovich C; Fitzgerald KC; Salter A; Lu Y; Bernstein CN; Bolton JM; Cutter G; Fisk JD; Gelernter J; Graff LA; Haegg S; Hitchon CA; Levey DF; Lublin FD; Mckay KA; Patten S; Patki A; Stein MB; Tiwari HK; Wolinsky JS; Marrie RA
Article: BMJ GLOBAL HEALTH. 2024;9(5):e015098
The state of mental health among Ebola virus disease survivors through a cross-sectional study in Sierra Leone
Schindell BG; Fredborg B; Kowalec K; Shaw S; Kangbai JB; Kindrachuk J
Article: NEUROLOGY. 2024;102(5):e209135
Investigating the Prevalence of Comorbidity in Multiple Sclerosis Clinical Trial Populations
Salter A; Lancia S; Kowalec K; Fitzgerald KC; Marrie RA
Article: PHARMACOGENOMICS. 2024;25(4):175-186
Knowledge and perceptions of pharmacogenomics among pharmacists in Manitoba, Canada
Al Maruf A; Shields M; Fryza A; Wondrasek A; Leong C; Kowalec K; Bousman C
Article: HEALTH SCIENCE REPORTS. 2024;7(1):e1844
Knowledge, perceptions, and attitudes toward pharmacogenomics among pharmacists and pharmacy students: A systematic review
Wondrasek A; Fryza A; Aziz MA; Leong C; Kowalec K; Al Maruf A
Article: FRONTIERS IN PHARMACOLOGY. 2024;15:1469552
Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO)
Peymani P; Berard A; Winquist B; Kaul P; Sheehy O; Lavu A; Leong C; Falk J; Delaney JA; Kowalec K; Ng M; Ruth C; Aboulatta L; Alessi-Severini S; Dragan R; Derksen S; Barrett O; Shams G; Eltonsy S
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2023;180(10):714-722
Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers
Thuy-Dung N; Kowalec K; Pasman J; Larsson H; Lichtenstein P; Dalman C; Sullivan PF; Kuja-Halkola R; Lu Y
Article: TRANSLATIONAL PSYCHIATRY. 2023;13(1):301
Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Xiong Y; Karlsson R; Song J; Kowalec K; Rueck C; Sigstroem R; Jonsson L; Clements CC; Andersson E; Boberg J; Lewis CM; Sullivan PF; Landen M; Lu Y
Article: JOURNAL OF PSYCHOSOMATIC RESEARCH. 2023;172:111415
Assessment of differential item functioning of the PHQ-9, HADS-D and PROMIS-depression scales in persons with and without multiple sclerosis
Marrie RA; Lix LM; Bolton JM; Fisk JD; Fitzgerald KC; Graff LA; Hitchon CA; Kowalec K; Marriott JJ; Patten SB; Salter A; Bernstein CN
Article: NEUROLOGY. 2023;101(5):e522-e532
Polygenicity of Comorbid Depression in Multiple Sclerosis
Kowalec K; Fitzgerald KC; Salter A; Dolovich C; Harder A; Bernstein CN; Bolton J; Cutter GR; Graff LA; Hagg S; Hitchon CA; Lu Y; Lublin F; McKay KA; Patten SB; Patki A; Tiwari HK; Wolinsky JS; Marrie RA
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2023;43(4):313-319
Adherence to Psychotropic Medication Before and During COVID-19 A Population-Wide Retrospective Observational Study
Froese B; Aquino G; Valencia E; Tan Q; Yogendran M; Katz C; Bolton JM; Falk J; Kowalec K; Chateau D; Delaney JC; Logsetty S; Spiwak R; Enns MW; Sareen J; Alessi-Severini S; Olafson K; Eltonsy S; Leong C
Journal article: BMJ OPEN. 2023;13(6):e073782
Well-being and flourishing mental health in adults with inflammatory bowel disease, multiple sclerosis and rheumatoid arthritis in Manitoba, Canada: a cross-sectional study.
Almweisheer S; Bernstein CN; Graff LA; Patten SB; Bolton J; Fisk JD; Hitchon CA; Marriott JJ; Marrie RA; CIHR Team in Defining the Burden and Managing the
Article: LANCET REGIONAL HEALTH-EUROPE. 2023;29:100621
Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers
Pasman JA; Meijsen J; Haram M; Kowalec K; Harder A; Xiong Y; Nguyen T-D; Jangmo A; Shorter JR; Bergstedt J; Das U; Zetterberg R; Tate A; Lichtenstein P; Larsson H; Odsbu I; Werge T; Reichborn-Kjennerud T; Andreassen OA; Sullivan PF; Buil A; Tesli M; Lua Y
Article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACY. 2023;45(1):233-239
Sex differences among users of NSAIDs and opioids during COVID-19 Pandemic
Offiah R; Aboulatta L; Peymani P; Aloud B; Kowalec K; Leong C; Delaney J; Falk J; Alessi-Severini S; Eltonsy S
Article: BMJ PAEDIATRICS OPEN. 2023;7(1):e001686
Preterm birth and stillbirth rates associated with socioeconomic disparities during COVID-19 pandemic: a population-based cross-sectional study
Aboulatta L; Kowalec K; Leong C; Delaney JA; Falk J; Alessi-Severini S; Chateau D; Tan Q; Kearns K; Raimondi C; Vaccaro C; Lavu A; Haidar L; Peymani P; Eltonsy S
Article: FRONTIERS IN PSYCHIATRY. 2023;14:1260420
Sex differences evident in elevated anxiety symptoms in multiple sclerosis, inflammatory bowel disease, and rheumatoid arthritis
Joyees J; Marrie RA; Bernstein CN; Bolton JM; Fisk JD; Graff LA; Hitchon C; Patten SB; Kowalec K
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200062
Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis
Vasileiou ES; Hu C; Bernstein CN; Lublin F; Wolinsky JS; Cutter GR; Sotirchos ES; Kowalec K; Salter A; Saidha S; Mowry EM; Calabresi PA; Marrie RA; Fitzgerald KC
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(11):844-852
Association Between Polygenic Risk Scores and Outcome of ECT
Sigstrom R; Kowalec K; Jonsson L; Clements CC; Karlsson R; Nordenskjold A; Palsson E; Sullivan PF; Landen M
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e198
T55. POLYGENICITY OF COMORBID DEPRESSION IN MULTIPLE SCLEROSIS
Kowalec K; Salter A; Fitzgerald KC; Harder A; Lu Y; Dolovich C; Hägg S; Hitchon C; Bernstein CN; Cutter G; Bolton JM; McKay K; Graff LA; Patten S; Marrie RA
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e31-e32
TRYGGVE2: SECURE & PRECISE GENETIC ANALYSES IN THE NORDIC COUNTRIES AND BEYOND
Lu Y; Kowalec K; Werge T; Andreassen O; Sullivan P
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e270
INVESTIGATING GENETIC OVERLAP BETWEEN ANTIDEPRESSANTS AND LITHIUM RESPONSE AND TREATMENT RESISTANCE IN MAJOR DEPRESSIVE DISORDER
Xiong Y; Karlsson R; Song J; Kowalec K; Rück C; Jonsson L; Clements C; Andersson E; Boberg J; Lewis C; Sullivan P; Landén M; Lu Y
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:e32-e33
NEXT GENERATION GENOME-WIDE ASSOCIATION STUDY OF SCHIZOPHRENIA FROM SWEDEN
Kowalec K; Karlsson R; Lu Y; Song J; Yao S; Szatkiewicz J; Kähler A; Schalling M; Österholm A-M; Hultman C; Lavebratt C; Landen M; Karlsson H; Dalman C; Sullivan P
Article: GENERAL HOSPITAL PSYCHIATRY. 2022;77:21-28
Depressive symptom trajectories and polygenic risk scores in individuals with an immune-mediated inflammatory disease
Kowalec K; Salter A; Fitzgerald KC; Patel M; Han J; Lu Y; Bolton JM; Hitchon C; Bernstein CN; Patten S; Graff LA; Marriott JJ; Marrie RA
Article: BMC RESEARCH NOTES. 2022;15(1):162
Trends of COVID-19 incidence in Manitoba and public health measures: March 2020 to February 2022
Aboulatta L; Kowalec K; Delaney J; Alessi-Severini S; Leong C; Falk J; Eltonsy S
Article: MOLECULAR PSYCHIATRY. 2022;27(5):2439-2447
The impact of educational attainment, intelligence and intellectual disability on schizophrenia: a Swedish population-based register and genetic study
Song J; Yao S; Kowalec K; Lu Y; Sariaslan A; Szatkiewicz JP; Larsson H; Lichtenstein P; Hultman CM; Sullivan PF
Article: MOLECULAR PSYCHIATRY. 2022;27(3):1667-1675
Genetic heterogeneity and subtypes of major depression
Thuy-Dung N; Harder A; Xiong Y; Kowalec K; Hagg S; Cai N; Kuja-Halkola R; Dalman C; Sullivan PF; Lu Y
Article: JAMA PSYCHIATRY. 2022;79(3):260-269
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
Pardinas AF; Smart SE; Willcocks IR; Holmans PA; Dennison CA; Lynham AJ; Legge SE; Baune BT; Bigdeli TB; Cairns MJ; Corvin A; Fanous AH; Frank J; Kelly B; McQuillin A; Melle I; Mortensen PB; Mowry BJ; Pato CN; Periyasamy S; Rietschel M; Rujescu D; Simonsen C; St Clair D; Tooney P; Wu JQ; Andreassen OA; Kowalec K; Sullivan PF; Murray RM; Owen MJ; MacCabe JH; O'Donovan MC; Walters JTR
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:886652
Psychotropic Medication Use Before and During COVID-19: A Population-Wide Study
Leong C; Kowalec K; Eltonsy S; Bolton JM; Enns MW; Tan Q; Yogendran M; Chateau D; Delaney JA; Sareen J; Falk J; Spiwak R; Logsetty S; Alessi-Severini S
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:871136
Trends of Utilization of Antiseizure Medications Among Pregnant Women in Manitoba, Canada: A 20-Year Population-Based Study
Shouman W; Delaney JA; Kowalec K; Ng M; Ruth C; Falk J; Leong C; Alessi-Severini S; Lavu A; Peymani P; Eltonsy S
Article: PLOS ONE. 2022;17(11):e0278072
Drug utilization patterns before and during COVID-19 pandemic in Manitoba, Canada: A population-based study
Aboulatta L; Peymani P; Vaccaro C; Leong C; Kowalec K; Delaney J; Falk J; Alessi-Severini S; Aloud B; Eltonsy S
Article: ACR OPEN RHEUMATOLOGY. 2021;3(12):889-896
Prevalence and Risk Factors of Substance Use Disorder in Rheumatoid Arthritis
Kowalec K; Carney H; Patel M; Hitchon C; Bolton JM; Patten SB; Graff LA; Bernstein CN; Peschken C; Marrie RA
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(13):2077-2084
Mendelian randomization provides no evidence for a causal role in the bidirectional relationship between depression and multiple sclerosis
Harroud A; Marrie RA; Fitzgerald KC; Salter A; Lu Y; Patel M; Kowalec K
Article: MOLECULAR PSYCHIATRY. 2021;26(8):4487-4495
Increased schizophrenia family history burden and reduced premorbid IQ in treatment-resistant schizophrenia: a Swedish National Register and Genomic Study
Kowalec K; Lu Y; Sariaslan A; Song J; Ploner A; Dalman C; Hultman CM; Larsson H; Lichtenstein P; Sullivan PF
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):163
The association between family history and genomic burden with schizophrenia mortality: a Swedish population-based register and genetic sample study
Kowalec K; Lu Y; Song J; Dalman C; Hultman CM; Larsson H; Lichtenstein P; Sullivan PF
Article: ELIFE. 2021;10:e58430
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
Hannon E; Dempster EL; Mansell G; Burrage J; Bass N; Bohlken MM; Corvin A; Curtis CJ; Dempster D; Di Forti M; Dinan TG; Donohoe G; Gaughran F; Gill M; Gillespie A; Gunasinghe C; Hulshoff HE; Hultman CM; Johansson V; Kahn RS; Kaprio J; Kenis G; Kowalec K; MacCabe J; McDonald C; McQuillin A; Morris DW; Murphy KC; Mustard CJ; Nenadic I; O'Donovan MC; Quattrone D; Richards AL; Rutten BP; St Clair D; Therman S; Toulopoulou T; Van Os J; Waddington JL; Sullivan P; Vassos E; Breen G; Collier DA; Murray RM; Schalkwyk LS; Mill J
Article: INFLAMMATORY BOWEL DISEASES. 2021;27(1):58-64
Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
Carney H; Marrie RA; Bolton JM; Patten SB; Graff LA; Bernstein CN; Kowalec K
Article: NEUROLOGY. 2020;95(5):e446-e456
Comorbidity is associated with disease activity in MS Findings from the CombiRx trial
Salter A; Kowalec K; Fitzgerald KC; Cutter G; Marrie RA
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:s236
T36UNDERSTANDING PSYCHIATRIC COMORBIDITY IN CHRONIC IMMUNOINFLAMMATORY DISEASES USING GENOMICS
Kowalec K; Bernstein CN; Hitchon C; Bolton J; Marrie RA
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):157
Methylation age acceleration does not predict mortality in schizophrenia
Kowalec K; Hannon H; Mansell G; Burrage J; Ori APS; Ophoff RA; Mill J; Sullivan PF
Article: NATURE GENETICS. 2018;50(8):1081-1085
Common variation near IRF6 is associated with IFN-β-induced liver injury in multiple sclerosis
Kowalec K; Wright GEB; Drogemoller BI; Aminkeng F; Bhavsar AP; Kingwell E; Yoshida EM; Traboulsee A; Marrie RA; Kremenchutzky M; Campbell TL; Duquette P; Chalasani N; Wadelius M; Hallberg P; Xia Z; De Jager PL; Denny JC; Davis MF; Ross CJD; Tremlett H; Carleton BC
Article: NEUROLOGY. 2018;90(4):e332-e341
Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients
McCormack M; Gui H; Ingason A; Speed D; Wright GEB; Zhang EJ; Secolin R; Yasuda C; Kwok M; Wolking S; Becker F; Rau S; Avbersek A; Heggeli K; Leu C; Depondt C; Sills GJ; Marson AG; Auce P; Brodie MJ; Francis B; Johnson MR; Koeleman BPC; Striano P; Coppola A; Zara F; Kunz WS; Sander JW; Lerche H; Klein KM; Weckhuysen S; Krenn M; Gudmundsson LJ; Stefansson K; Krause R; Shear N; Ross CJD; Delanty N; Pirmohamed M; Carleton BC; Cendes F; Lopes-Cendes I; Liao W-P; O'Brien TJ; Sisodiya SM; Cherny S; Kwan P; Baum L; Cavalleri GL
Article: NEUROLOGY. 2017;89(24):2455-2461
Comorbidity increases the risk of relapse in multiple sclerosis A prospective study
Kowalec K; McKay KA; Patten SB; Fisk JD; Evans C; Tremlett H; Marrie RA
Journal article: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017;88:173
Genome-wide Scan Identifies Association Between an Interferon Regulatory Factor Variant and Interferon-beta Induced Liver Injury in Multiple Sclerosis Patients
Kowalec K; Wright GEB; Drögemöller BI; Aminkeng F; Bhavsar AP; Kingwell E; Yoshida EM; Traboulsee A; Marrie RA; Kremenchutzky M; Campbell TL; Duquette P; Chalasani N; Wadelius M; Hallberg P; Xia Z; De Jager P; Ross C; Tremlett H; Carleton B
Journal article: JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017;88:167
Pharmacogenomic Prediction of Ribavirin-Induced Hemolytic Anemia in Patients Treated for Hepatitis C Infection
Abel S; Aminkeng F; Kowalec K; Drogemoller B; Wright G; Bader R; Stortz J; Yoshida E; Lee S; Al-Judaibi B; Kim R; Tam E; Ramji A; Ross C; Carleton B
Article: BMJ OPEN. 2017;7(5):e016276
Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case-control study protocol for dimethyl fumarate-induced lymphopenia
Kowalec K; Kingwell E; Carruthers R; Marrie RA; Bernatsky S; Traboulsee A; Ross CJD; Carleton B; Tremlett H
Article: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE. 2016;85(3):328-333
Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant
Osiowy C; Kowalec K; Giles E
Article: NATURE GENETICS. 2015;47(9):1079-1084
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Aminkeng F; Bhavsar AP; Visscher H; Rassekh SR; Li Y; Lee JW; Brunham LR; Caron HN; van Dalen EC; Kremer LC; van der Pal HJ; Amstutz U; Rieder MJ; Bernstein D; Carleton BC; Hayden MR; Ross CJD
Article: JOURNAL OF VIRAL HEPATITIS. 2013;20(2):122-130
Genetic diversity of hepatitis B virus genotypes B6, D and F among circumpolar indigenous individuals
Kowalec K; Minuk GY; Borresen ML; Koch A; McMahon BJ; Simons B; Osiowy C
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2013;2(1):57-59
Suspected autoimmune hepatitis and primary biliary cirrhosis unmasked by interferon-beta in a multiple sclerosis patient
Kowalec K; Yoshida EM; Traboulsee A; Carleton B; Tremlett H
Article: JOURNAL OF MEDICAL VIROLOGY. 2012;84(9):1369-1375
The prevalence and long term outcome of occult hepatitis B virus infections in community based populations
Minuk GY; Kowalec K; Caouette S; Larke B; Osiowy C
Article: JOURNAL OF MEDICAL VIROLOGY. 2010;82(6):942-948
Molecular Characterization of Hepatitis B Virus and a 9-Year Clinical Profile in a Patient Infected With Genotype I
Osiowy C; Kaita K; Solar K; Mendoza K
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Assistant Professor, Genetics, University of Manitoba, 2019-
Anknuten till Forskning, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2025-2027

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PhD, Genetics and epidemiology, University of British Columbia, 2016
MSc, Viral genetics, University of Manitoba, 2011
BSc, Microbiology, University of Manitoba, 2008

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