Juulia Jylhävä

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

My main research interest is the aging-related frailty syndrome and
epigenetics and genetics of aging. I’m also conducting research into aging
biomarkers, such as the epigenetic clock and inflammatory markers, and
interested in studying how they operate at different stages of human aging.
• PhD in Molecular Immunology (Biology of aging), University of Tampere,
Finland 2013
• MSc in Molecular Biology, University of Jyväskylä Finland, 2006

Forskningsbeskrivning

Current projects:.
• Examining the longitudinal relationship between DNA methylation and
development of the frailty syndrome
• Analyzing the genetic determinants and heritability of frailty
• Assessing the predictive role of frailty on health span, mortality and
morbidity
For a list of my publications, please visit my ResearchGate page:
https://www.researchgate.net/profile/Juulia_Jylhaevae/publications [1]
[1] https://www.researchgate.net/profile/Juulia_Jylhaevae/publications

Artiklar

Article: AGING CELL. 2024;23(6):e14135
Epigenome-wide analysis of frailty: Results from two European twin cohorts
Mak JKL; Skovgaard AC; Nygaard M; Kananen L; Reynolds CA; Wang Y; Kuja-Halkola R; Karlsson IK; Pedersen NL; Hagg S; Soerensen M; Jylhava J
Article: AGING CELL. 2024;23(6):e14132
Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden
De Oliveira TL; Tang B; Bai G; Sjolander A; Jylhava J; Finkel D; Pedersen NL; Hassing LB; Reynolds CA; Karlsson IK; Hagg S
Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2024;:14034948241240823
Association of cancer with functional decline at old age: a longitudinal study in Danish twins
Mohammadnejad A; Ryg J; Ewertz M; Jylhaevae J; Hjelmborg JV; Galvin A
Article: AGE AND AGEING. 2024;53(4):afae066
Lifestyle-related factors in late midlife as predictors of frailty from late midlife into old age: a longitudinal birth cohort study
Haapanen MJ; Mikkola TM; Jylhava J; Wasenius NS; Kajantie E; Eriksson JG; von Bonsdorff MB
Article: GEROSCIENCE. 2024;46(2):2605-2617
Interplay of body mass index and metabolic syndrome: association with physiological age from midlife to late-life
Ler P; Ploner A; Finkel D; Reynolds CA; Zhan Y; Jylhava J; Aslan AKD; Karlsson IK
Article: GERONTOLOGY. 2024;70(8):831-841
Frailty in Midlife as a Predictor of Changes in Body Composition from Midlife into Old Age: A Longitudinal Birth Cohort Study
Haapanen MJ; Kananen L; Mikkola TM; Jylhava J; Wasenius NS; Eriksson JG; von Bonsdorff MB
Journal article: INNOVATION IN AGING. 2023;7:1045-1046
FRAILTY IN MIDLIFE AS A PREDICTOR OF CHANGES IN BODY COMPOSITION FROM MIDLIFE INTO OLD AGE
Kananen L; Haapanen M; Mikkola T; Jylhava J; Wasenius N; Eriksson J; von Bonsdorff M
Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2023;11(12):e2255
Rare functional variants in the CRP and G6PC genes modify the relationship between obesity and serum C-reactive protein in white British population
Li X; Ploner A; Wang Y; Mak JKL; Lu Y; Magnusson PKE; Jylhava J; Hagg S
Article: HEALTH SCIENCE REPORTS. 2023;6(11):e1692
Anticoagulant treatment and COVID-19 mortality among older adults living in nursing homes in Sweden
Kananen L; Molnar C; Ansker F; Kozlowska DJ; Hagg S; Jylhava J; Religa D; Raaschou P
Article: AGING CELL. 2023;22(8):e13868
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses
Mak JKL; Kananen L; Qin C; Kuja-Halkola R; Tang B; Lin J; Wang Y; Jaaskelainen T; Koskinen S; Lu Y; Magnusson PKE; Hagg S; Jylhava J
Article: BRITISH JOURNAL OF CANCER. 2023;129(1):94-103
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
Mak JKL; McMurran CE; Kuja-Halkola R; Hall P; Czene K; Jylhaevae J; Haegg S
Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2023;51(4):587-594
Comparison of two different frailty scales in the longitudinal Swedish Adoption/Twin Study of Aging (SATSA)
Wennberg AM; Yin W; Fang F; Pedersen NL; Hagg S; Jylhava J; Modig K
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(6):980-987
Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age: A Longitudinal Birth Cohort Study
Haapanen MJ; Mikkola TM; Kortelainen L; Jylhava J; Wasenius NS; Kajantie E; Eriksson JG; von Bonsdorff MB
Article: GEROSCIENCE. 2023;45(3):2065-2078
Longitudinal associations between use of antihypertensive, antidiabetic, and lipid-lowering medications and biological aging
Tang B; Li X; Wang Y; Sjolander A; Johnell K; Thambisetty M; Ferrucci L; Reynolds CA; Finkel D; Jylhava J; Pedersen NL; Hagg S
Article: GEROSCIENCE. 2023;45(3):2051-2064
Can frailty scores predict the incidence of cancer? Results from two large population-based studies
Mak JKL; Kuja-Halkola R; Wang Y; Haegg S; Jylhaevae J
Article: ECLINICALMEDICINE. 2023;58:101943
Genetically and environmentally predicted obesity in relation to cardiovascular disease: a nationwide cohort study
Ojalehto E; Zhan Y; Jylhava J; Reynolds CA; Aslan AKD; Karlsson IK
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2023;78(2):333-341
Genetic and Environmental Influences on Longitudinal Frailty Trajectories From Adulthood into Old Age
Mak JKL; Kuja-Halkola R; Bai G; Hassing LB; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Article: GEROSCIENCE. 2023;45(1):85-103
Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics
Kananen L; Hurme M; Buerkle A; Moreno-Villanueva M; Bernhardt J; Debacq-Chainiaux F; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dolle MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom E; Talbot D; Libert C; Raitanen J; Koskinen S; Harkanen T; Stenholm S; Ala-Korpela M; Lehtimaki T; Raitakari OT; Ukkola O; Kahonen M; Jylha M; Jylhava J
Article: PLOS ONE. 2023;18(3):e0283344
Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden
Kananen L; Hong X; Annetorp M; Mak JKL; Jylhava J; Eriksdotter M; Hagg S; Religa D
Article: GERONTOLOGY. 2023;69(4):396-405
Two Years with COVID-19: The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study
Mak JKL; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Hagg S; Religa D; Jylhava J
Article: GERONTOLOGY. 2023;69(12):1385-1393
Is Frailty Different in Younger Adults Compared to Old? Prevalence, Characteristics, and Risk Factors of Early-Life and Late-Life Frailty in Samples from Sweden and UK
Bai G; Wang Y; Mak JKL; Ericsson M; Hagg S; Jylhava J
Article: CLINICAL NUTRITION. 2022;41(12):2973-2979
Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19
Kananen L; Eriksdotter M; Bostrom AM; Kivipelto M; Annetorp M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Hagg S; Religa D; Jylhava J; Cederholm T
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2022;37(12):1261-1271
Adiposity and the risk of dementia: mediating effects from inflammation and lipid levels
Karlsson IK; Zhan Y; Wang Y; Li X; Jylhava J; Hagg S; Aslan AKD; Gatz M; Pedersen NL; Reynolds CA
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2311-2319
Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden
Mak JKL; Hagg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Bostrom A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engstrom M; Johnson P; Lundberg LG; Akesson E; Oberg CS; Olsson M; Cederholm T; Jylhava J; Religa D
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2022;77(11):2281-2287
Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age
Haapanen MJ; Jylhava J; Kortelainen L; Mikkola TM; Salonen M; Wasenius NS; Kajantie E; Eriksson JG; von Bonsdorff MB
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2022;20(10):2358-2365.e11
Prevalence and Implications of Frailty in Older Adults With Incident Inflammatory Bowel Diseases: A Nationwide Cohort Study
Kochar B; Jylhava J; Soderling J; Ritchie CS; Group SS; Ludvigsson JF; Khalili H; Olen O
Article: EPIGENOMICS. 2022;14(18):1105-1124
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
Marttila S; Tamminen H; Rajic S; Mishra PP; Lehtimaki T; Raitakari O; Kahonen M; Kananen L; Jylhava J; Hagg S; Delerue T; Peters A; Waldenberger M; Kleber ME; Marz W; Luoto R; Raitanen J; Sillanpaa E; Laakkonen EK; Heikkinen A; Ollikainen M; Raitoharju E
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2022;37(3):227-234
COVID-19 prevalence and mortality in longer-term care facilities
Levin AT; Jylhava J; Religa D; Shallcross L
Journal article: NPJ PARKINSON'S DISEASE. 2022;8(1):14
Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients
Meoni G; Tenori L; Schade S; Licari C; Pirazzini C; Bacalini MG; Garagnani P; Turano P; Trenkwalder C; Franceschi C; Mollenhauer B; Luchinat C
Article: SCIENTIFIC REPORTS. 2022;12(1):1330
Early downregulation of hsa-miR-144-3p in serum from drug-naive Parkinson's disease patients
Zago E; Dal Molin A; Dimitri GM; Xumerle L; Pirazzini C; Bacalini MG; Maturo MG; Azevedo T; Spasov S; Gomez-Garre P; Perinan MT; Jesus S; Baldelli L; Sambati L; Calandra-Buonaura G; Garagnani P; Provini F; Cortelli P; Mir P; Trenkwalder C; Mollenhauer B; Franceschi C; Lio P; Nardini C
Article: JOURNAL OF NUTRITION. 2022;152(1):269-275
Protein Nutritional Status and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Article: AGE AND AGEING. 2021;50(6):2174-2182
Frailty trajectories in three longitudinal studies of aging: Is the level or the rate of change more predictive of mortality?
Bai G; Szwajda A; Wang Y; Li X; Bower H; Karlsson IK; Johansson B; Aslan AKD; Pedersen NL; Hagg S; Jylhava J
Article: BMC MEDICINE. 2021;19(1):248
Frailty and the risk of dementia: is the association explained by shared environmental and genetic factors?
Bai G; Wang Y; Kuja-Halkola R; Li X; Tomata Y; Karlsson IK; Pedersen NL; Hagg S; Jylhava J
Article: NUTRIENTS. 2021;13(10):3539
Fatty Acids and Frailty: A Mendelian Randomization Study
Tomata Y; Wang Y; Hagg S; Jylhava J
Journal article: NPJ PARKINSON'S DISEASE. 2021;7(1):78
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
Baldelli L; Schade S; Jesus S; Schreglmann SR; Sambati L; Gomez-Garre P; Halsband C; Calandra-Buonaura G; Daniela Adarmes-Gomez A; Sixel-Doering F; Zenesini C; Pirazzini C; Garagnani P; Bacalini MG; Bhatia KP; Cortelli P; Mollenhauer B; Franceschi C; Mir P; Trenkwalder C; Provini F
Article: AGING CELL. 2021;20(9):e13459
A genome-wide association study of the frailty index highlights brain pathways in ageing
Atkins JL; Jylhava J; Pedersen NL; Magnusson PK; Lu Y; Wang Y; Hagg S; Melzer D; Williams DM; Pilling LC
Article: AGING. 2021;13(13):16990-17023
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak JKL; Reynolds CA; Hagg S; Li X; Ericsson M; Pedersen NL; Jylhava J; Kuja-Halkola R
Article: MOLECULAR PSYCHIATRY. 2021;26(6):2148-2162
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek FA; Suderman M; Roetman PJ; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty JD; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send TS; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran DL; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix JF; Bakermans-Kranenburg MJ; Campbell A; Czamara D; Binder E; Corpeleijn E; Gonzalez JR; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van IJzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma DI
Article: HUMAN GENETICS. 2021;140(6):849-861
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Article: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. 2021;69(5):1128-1139
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: The effect of sampling
Mak JKL; Kuja-Halkola R; Wang Y; Hagg S; Jylhava J
Article: CLINICAL EPIGENETICS. 2021;13(1):85
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AKD; Reynolds CA; Pedersen NL
Article: EBIOMEDICINE. 2021;66:103318
Clinical biomarkers and associations with healthspan and lifespan: Evidence from observational and genetic data
Li X; Ploner A; Wang Y; Zhan Y; Pedersen NL; Magnusson PK; Jylhava J; Hagg S
Article: SCIENTIFIC REPORTS. 2021;11(1):6139
Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains
Kananen L; Enroth L; Raitanen J; Jylhava J; Buerkle A; Moreno-Villanueva M; Bernhardt J; Toussaint O; Grubeck-Loebenstein B; Malavolta M; Basso A; Piacenza F; Collino S; Gonos ES; Sikora E; Gradinaru D; Jansen EHJM; Dolle MET; Salmon M; Stuetz W; Weber D; Grune T; Breusing N; Simm A; Capri M; Franceschi C; Slagboom PE; Talbot DCS; Libert C; Koskinen S; Bruunsgaard H; Hansen AM; Lund R; Hurme M; Jylha M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2021;194:111426
A geroscience approach for Parkinson ' s disease: Conceptual framework and design of PROPAG-AGEING project
Pirazzini C; Azevedo T; Baldelli L; Bartoletti-Stella A; Calandra-Buonaura G; Dal Molin A; Dimitri GM; Doykov I; Gomez-Garre P; Hagg S; Hallqvist J; Halsband C; Heywood W; Jesus S; Jylhava J; Kwiatkowska KM; Labrador-Espinosa MA; Licari C; Maturo MG; Mengozzi G; Meoni G; Milazzo M; Perinan-Tocino MT; Ravaioli F; Sala C; Sambati L; Schade S; Schreglmann S; Spasov S; Tenori L; Williams D; Xumerle L; Zago E; Bhatia KP; Capellari S; Cortelli P; Garagnani P; Houlden H; Lio P; Luchinat C; Delledonne M; Mills K; Mir P; Mollenhauer B; Nardini C; Pedersen NL; Provini F; Strom S; Trenkwalder C; Turano P; Bacalini MG; Franceschi C
Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2020;21(11):1555-1559.e2
Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care
Hagg S; Jylhava J; Wang Y; Xu H; Metzner C; Annetorp M; Garcia-Ptacek S; Khedri M; Bostrom A-M; Kadir A; Johansson A; Kivipelto M; Eriksdotter M; Cederholm T; Religa D
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(10):1943-1950
Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden
Raymond E; Reynolds CA; Aslan AKD; Finkel D; Ericsson M; Hagg S; Pedersen NL; Jylhava J
Article: SCIENTIFIC REPORTS. 2020;10(1):13809
Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey
Kananen L; Hurme M; Jylna M; Harkanen T; Koskinen S; Stenholm S; Kahonen M; Lehtimaki T; Ukkola O; Jylhava J
Article: AGING CELL. 2020;19(8):e13197
A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation
Reynolds CA; Tan Q; Munoz E; Jylhava J; Hjelmborg J; Christiansen L; Hagg S; Pedersen NL
Article: BMC PULMONARY MEDICINE. 2020;20(1):206
Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis
Nyberg A; Larsson A; Jylhava J; Hurme M; Sperber J; Lipcsey M; Castegren M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2020;44(6):1397-1405
Replicating associations between DNA methylation and body mass index in a longitudinal sample of older twins
Karlsson IK; Ericsson M; Wang Y; Jylhava J; Hagg S; Pedersen NL; Reynolds CA; Dahl Aslan AK
Article: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. 2020;46(3):316-320
Should we invest in biological age predictors to treat colorectal cancer in older adults?
Hagg S; Jylhava J
Article: ELIFE. 2020;9:e51507
Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up
Li X; Ploner A; Wang Y; Magnusson PK; Reynolds C; Finkel D; Pedersen NL; Jylhava J; Hagg S
Article: CLINICAL EPIGENETICS. 2019;11(1):187
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhava J; Hedman AK; Almqvist C; Karlsson IK; Pedersen NL; Almgren M; Hagg S
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(12):1980-1986
Functional Aging Index Complements Frailty in Prediction of Entry Into Care and Mortality
Finkel D; Sternang O; Jylhava J; Bai G; Pedersen NL
Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s222
CAUSES OF FRAILTY: GENETIC ANALYSIS IN 164,000 UK BIOBANK PARTICIPANTS
Atkins J; Pilling LC; Williams D; Jylhävä J; Melzer D
Article: PSYCHOSOMATIC MEDICINE. 2019;81(9):799-807
Neuroticism as a Predictor of Frailty in Old Age: A Genetically Informative Approach
Danielsdottir HB; Jylhava J; Hagg S; Lu Y; Colodro-Conde L; Martin NG; Pedersen NL; Mosing MA; Lehto K
Article: BIOGERONTOLOGY. 2019;20(3):321-329
Can markers of biological age predict dependency in old age?
Jylhava J; Jiang M; Foebel AD; Pedersen NL; Hagg S
Article: BMC MEDICINE. 2019;17(1):94
The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards: a large cohort study
Li X; Ploner A; Karlsson IK; Liu X; Magnusson PKE; Pedersen NL; Haegg S; Jylhava J
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2019;74(4):582-587
A Frailty Index for UK Biobank Participants
Williams DM; Jylhava J; Pedersen NL; Hagg S
Article: CELL REPORTS. 2019;26(10):2681-2691.e5
Fcμ receptor as a Costimulatory Molecule for T Cells
Meryk A; Pangrazzi L; Hagen M; Hatzmann F; Jenewein B; Jakic B; Hermann-Kleiter N; Baier G; Jylhava J; Hurme M; Trieb K; Grubeck-Loebenstein B
Article: EBIOMEDICINE. 2019;40:710-716
Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts
Jylhava J; Hjelmborg J; Soerensen M; Munoz E; Tan Q; Kuja-Halkola R; Mengel-From J; Christensen K; Christiansen L; Hagg S; Pedersen NL; Reynolds CA
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):418-426
Plasma cell-free DNA and qSOFA score predict 7-day mortality in 481 emergency department bacteraemia patients
Rannikko J; Seiskari T; Huttunen R; Tarkiainen I; Jylhava J; Hurme M; Syrjanen J; Aittoniemi J
Article: GENES. 2018;9(2):E78-78
DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins
Svane AM; Soerensen M; Lund J; Tan Q; Jylhava J; Wang Y; Pedersen NL; Hagg S; Debrabant B; Deary IJ; Christensen K; Christiansen L; Hjelmborg JB
Article: AGING. 2017;9(12):2629-2646
Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hagg S; Jylhava J
Article: EXPERIMENTAL GERONTOLOGY. 2017;97:60-63
Human endogenous retrovirus HERV-K(HML-2) env expression is not associated with markers of immunosenescence
Marttil S; Nevalainen T; Jylhava J; Kananen L; Jylha M; Hervonen A; Hurme M
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(11):1569-1574
Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+Study
Lisko I; Tiainen K; Raitanen J; Jylhava J; Hurme M; Hervonen A; Jylha M; Stenholm S
Article: CLINICAL EPIGENETICS. 2017;9:20
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals
Nevalainen T; Kananen L; Marttila S; Jylhava J; Mononen N; Kahonen M; Raitakari OT; Hervonen A; Jylha M; Lehtimaki T; Hurme M
Article: NEUROLOGY. 2016;87(22):2290-2299
FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
Lehtonen JM; Forsstrom S; Bottani E; Viscomi C; Baris OR; Isoniemi H; Hockerstedt K; Osterlund P; Hurme M; Jylhava J; Leppa S; Markkula R; Helio T; Mombelli G; Uusimaa J; Laaksonen R; Laaksovirta H; Auranen M; Zeviani M; Smeitink J; Wiesner RJ; Nakada K; Isohanni P; Suomalainen A
Article: AGE. 2016;38(3):65
The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies
Kananen L; Marttila S; Nevalainen T; Kummola L; Junttila I; Mononen N; Kahonen M; Raitakari OT; Hervonen A; Jylha M; Lehtimaki T; Hurme M; Jylhava J
Article: ONCOTARGET. 2016;7(15):19228-19241
Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift
Jylhava J; Kananen L; Raitanen J; Marttila S; Nevalainen T; Hervonen A; Jylha M; Hurme M
Article: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2016;71(3):412-419
Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years
Enroth L; Raitanen J; Hervonen A; Lehtimaki T; Jylhava J; Hurme M; Jylha M
Article: BMC GENOMICS. 2016;17:103
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
Kananen L; Marttila S; Nevalainen T; Jylhava J; Mononen N; Kahonen M; Raitakari OT; Lehtimaki T; Hurme M
Article: NEUROLOGICAL RESEARCH. 2016;38(1):45-50
The concentration of cell-free DNA in video-EEG patients is dependent on the epilepsy syndrome and duration of epilepsy
Alapirtti T; Jylhava J; Raitanen J; Makinen R; Peltola J; Hurme MA; Liimatainen S
Article: PLOS ONE. 2016;11(11):e0167028
Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals
Nevalainen T; Kananen L; Marttila S; Jylhava J; Jylha M; Hervonen A; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2015;72:227-229
Cytomegalovirus infection accelerates epigenetic aging
Kananen L; Nevalainen T; Jylhava J; Marttila S; Hervonen A; Jylha M; Hurme M
Article: ONCOTARGET. 2015;6(31):30557-30567
Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny
Marttila S; Kananen L; Jylhava J; Nevalainen T; Hervonen A; Jylha M; Hurme M
Journal article: MITOCHONDRION. 2015;24:s45-s46
Mitochondrial myopathy biomarker Fibroblast growth factor 21 is induced by muscle mtDNA instability and translation defects
Lehtonen JM; Forsström S; Viscomi C; Zeviani M; Moraes C; Nakada K; Smeitink J; Wiesner RJ; Baris O; Isoniemi H; Höckerstedt K; Österlund P; Hurme M; Jylhävä J; Leppä S; Markkula R; Heliö T; Mombelli G; Suomalainen A
Article: AGE. 2015;37(4):9814
Transcriptomic and epigenetic analyses reveal a gender difference in aging- associated inflammation: the Vitality 90+study
Nevalainen T; Kananen L; Marttila S; Jylha M; Hervonen A; Hurme M; Jylhava J
Article: BMC GENOMICS. 2015;16(1):179
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
Marttila S; Kananen L; Hayrynen S; Jylhava J; Nevalainen T; Hervonen A; Jylha M; Nykter M; Hurme M
Article: SCIENTIFIC REPORTS. 2015;5:8631
Number of sons contributes to ageing-associated inflammation
Marttila S; Nevalainen T; Kananen L; Jylhava J; Jylha M; Hervonen A; Ilonen J; Hurme M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2014;143:1-8
Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy - A study with monozygotic twin pairs
Kangas R; Pollanen E; Rippo MR; Lanzarini C; Prattichizzo F; Niskala P; Jylhava J; Sipila S; Kaprio J; Procopio AD; Capri M; Franceschi C; Olivieri F; Kovanen V
Article: BMC MEDICAL GENOMICS. 2014;7:54
Identification of a prognostic signature for old-age mortality by integrating genome-wide transcriptomic data with the conventional predictors: the Vitality 90+Study
Jylhava J; Raitanen J; Marttila S; Hervonen A; Jylha M; Hurme M
Article: BLOOD COAGULATION AND FIBRINOLYSIS. 2014;25(6):612-617
Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia
Laine OK; Koskela SM; Outinen TK; Joutsi-Korhonen L; Huhtala H; Vaheri A; Hurme MA; Jylhava J; Makela SM; Mustonen JT
Article: CURRENT PHARMACEUTICAL DESIGN. 2014;20(38):6058-6070
Determinants of Longevity: Genetics, Biomarkers and Therapeutic Approaches
Jylhava J
Article: ATHEROSCLEROSIS. 2014;233(1):268-271
Circulating cell-free DNA is associated with cardiometabolic risk factors: The Health 2000 Survey
Jylhava J; Lehtimaki T; Jula A; Moilanen L; Kesaniemi YA; Nieminen MS; Kahonen M; Hurme M
Article: IMMUNITY AND AGEING. 2014;11(1):2
Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians
Marttila S; Jylhava J; Kananen L; Hervonen A; Jylha M; Hurme M
Journal article: CRITICAL CARE. 2014;18(Suppl 1):p292
Lung-protective ventilation suppresses plasma levels of cell-free DNA in porcine experimental postoperative sepsis
Nyberg A; Sperber J; Lipcsey M; Jylhävä J; hurme M; Castegren M
Article: PLOS ONE. 2014;9(2):e87741
High Cell-Free DNA Predicts Fatal Outcome among Staphylococcus aureus Bacteraemia Patients with Intensive Care Unit Treatment
Forsblom E; Aittoniemi J; Ruotsalainen E; Helmijoki V; Huttunen R; Jylhava J; Hurme M; Jarvinen A
Article: EPILEPSY RESEARCH. 2013;105(3):292-298
The concentration of cell-free DNA in focal epilepsy
Liimatainen SP; Jylhava J; Raitanen J; Peltola JT; Hurme MA
Article: AGING CELL. 2013;12(3):388-397
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty
Jylhava J; Nevalainen T; Marttila S; Jylha M; Hervonen A; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2013;48(3):305-312
Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: A transcriptomic analysis
Kuparinen T; Marttila S; Jylhava J; Tserel L; Peterson P; Jylha M; Hervonen A; Hurme M
Article: PLOS ONE. 2013;8(6):e66229
Transcriptional Analysis Reveals Gender-Specific Changes in the Aging of the Human Immune System
Marttila S; Jylhava J; Nevalainen T; Nykter M; Jylha M; Hervonen A; Tserel L; Peterson P; Hurme M
Article: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2012;12(5):363-365
Indoleamine 2,3-Dioxygenase Activity and Expression in Patients With Chronic Lymphocytic Leukemia
Lindstrom V; Aittoniemi J; Jylhava J; Eklund C; Hurme M; Paavonen T; Oja SS; Itala-Remes M; Sinisalo M
Article: EXPERIMENTAL GERONTOLOGY. 2012;47(5):372-378
Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: The Vitality 90+Study
Jylhava J; Jylha M; Lehtimaki T; Hervonen A; Hurme M
Article: GENES AND IMMUNITY. 2012;13(2):184-190
Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response
Kuparinen T; Seppala I; Jylhava J; Marttila S; Aittoniemi J; Kettunen J; Viikari J; Kahonen M; Raitakari O; Lehtimaki T; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;167(2):309-316
Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study
Haarala A; Kahonen M; Lehtimaki T; Aittoniemi J; Jylhava J; Hutri-Kahonen N; Taittonen L; Laitinen T; Juonala M; Viikari J; Raitakari OT; Hurme M
Article: PLOS ONE. 2012;7(2):e31455
Plasma Cell-Free DNA Levels Are Elevated in Acute Puumala Hantavirus Infection
Outinen TK; Kuparinen T; Jylhava J; Leppanen S; Mustonen J; Makela S; Porsti I; Syrjanen J; Vaheri A; Hurme M
Article: PLOS ONE. 2012;7(4):e35426
A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
Jylhava J; Lyytikainen L-P; Kahonen M; Hutri-Kahonen N; Kettunen J; Viikari J; Raitakari OT; Lehtimaki T; Hurme M
Article: EXPERIMENTAL GERONTOLOGY. 2011;46(12):1000-1002
IL-7 concentration is increased in nonagenarians but is not associated with markers of T cell immunosenescence
Marttila S; Jylhava J; Pesu M; Hamalainen S; Jylha M; Hervonen A; Hurme M
Article: IMMUNITY AND AGEING. 2011;8:9
Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
Marttila S; Jylhava J; Eklund C; Hervonen A; Jylha M; Hurme M
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2011;41(9):951-957
Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study
Haarala A; Kahonen M; Eklund C; Jylhava J; Koskinen T; Taittonen L; Huupponen R; Lehtimaki T; Viikari J; Raitakari OT; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2011;164(2):211-217
Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey
Jylhava J; Haarala A; Kahanen M; Lehtimaki T; Jula A; Moilanen L; Kesaniemi YA; Nieminen MS; Hurme M
Article: PLOS ONE. 2011;6(3):e17653
High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study
Huttunen R; Hurme M; Aittoniemi J; Huhtala H; Vuento R; Laine J; Jylhava J; Syrjanen J
Article: PLOS ONE. 2011;6(7):e21700
Fatal Outcome in Bacteremia is Characterized by High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation: A Prospective Cohort Study
Huttunen R; Kuparinen T; Jylhava J; Aittoniemi J; Vuento R; Huhtala H; Laine J; Syrjanen J; Hurme M
Article: MECHANISMS OF AGEING AND DEVELOPMENT. 2011;132(1-2):20-26
Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ study
Jylhava J; Kotipelto T; Raitala A; Jylha M; Hervonen A; Hurme M
Article: BIOGERONTOLOGY. 2010;11(6):671-677
Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study
Jylhava J; Eklund C; Jylha M; Hervonen A; Hurme M
Article: PFLUGERS ARCHIV EUROPEAN JOURNAL OF PHYSIOLOGY. 2010;459(2):239-246
Gene variants as determinants of longevity: focus on the inflammatory factors
Jylhava J; Hurme M
Article: JOURNAL OF RHEUMATOLOGY. 2009;36(11):2487-2490
Serum Amyloid A and C-Reactive Protein Concentrations Are Differently Associated with Markers of Autoimmunity in Patients with Primary Sjogren's Syndrome
Pertovaara M; Jylhava J; Uusitalo H; Pukander J; Helin H; Hurme M
Article: JOURNAL OF INTERNAL MEDICINE. 2009;266(3):286-295
Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study
Jylhava J; Haarala A; Eklund C; Pertovaara M; Kahonen M; Hutri-Kahonen N; Levula M; Lehtimaki T; Huupponen R; Jula A; Juonala M; Viikari J; Raitakari O; Hurme M
Article: PLOS ONE. 2009;4(6):e5948
Parvovirus Induced Alterations in Nuclear Architecture and Dynamics
Ihalainen TO; Niskanen EA; Jylhava J; Paloheimo O; Dross N; Smolander H; Langowski J; Timonen J; Vihinen-Ranta M
Article: EXPERIMENTAL GERONTOLOGY. 2009;44(4):297-299
Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: The Vitality 90+study
Jylhava J; Eklund C; Jylha M; Hervonen A; Lehtimaki T; Karhunen P; Hurme M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;155(1):53-58
Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: The Cardiovascular Risk in Young Finns Study
Jylhava J; Eklund C; Pessi T; Raitakari OT; Juonala M; Kahonen M; Viikari JSA; Lehtimaki T; Hurme M
Article: CELLULAR MICROBIOLOGY. 2007;9(8):1946-1959
Dynamics and interactions of parvoviral NS1 protein in the nucleus
Ihalainen TO; Niskanen EA; Jylhava J; Turpeinen T; Rinne J; Timonen J; Vihinen-Ranta M
Article: BMC BIOTECHNOLOGY. 2007;7:1
Internalization of novel non-viral vector TAT-streptavidin into human cells
Rinne J; Albarran B; Jylhava J; Ihalainen TO; Kankaanpaa P; Hytonen VP; Stayton PS; Kulomaa MS; Vihinen-Ranta M
Journal article: MOLECULAR THERAPY. 2006;13:s73
188. Internalization of Novel Delivery Vector TAT-Streptavidin into Human Cells
Rinne J; Albarran B; Jylhävä J; Ihalainen TO; Kankaanpää P; Hytönen VP; Stayton PS; Kulomaa MS; Vihinen-Ranta M
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Review: THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(10):glad251
Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age
Mak JKL; Karlsson IK; Tang B; Wang Y; Pedersen NL; Hagg S; Jylhava J; Reynolds CA
Review: AGEING RESEARCH REVIEWS. 2023;91:102082
Recent developments in frailty identification, management, risk factors and prevention: A narrative review of leading journals in geriatrics and gerontology
Dent E; Hanlon P; Sim M; Jylhava J; Liu Z; Vetrano DL; Stolz E; Perez-Zepeda MU; Crabtree DR; Nicholson C; Job J; Ambagtsheer RC; Ward PR; Shi SM; Huynh Q; Hoogendijk EO
Editorial comment: AGING. 2023;15(11):4571-4573
Automated frailty scores: towards clinical implementation
Mak JKL; Religa D; Jylhava J
Review: CLINICAL INTERVENTIONS IN AGING. 2023;18:2171-2183
Use of Electronic Medical Records (EMR) in Gerontology: Benefits, Considerations and a Promising Future
Bednorz A; Mak JKL; Jylhaevae J; Religa D
Preprint: BIORXIV. 2022
Methylation status of VTRNA2-1/nc886 is stable across human populations, monozygotic twin pairs and in majority of somatic tissues
Marttila S; Tamminen H; Rajić S; Mishra P; Lehtimäki T; Raitakari O; Kähönen M; Kananen L; Jylhävä J; Hägg S; Delerue T; Peters A; Waldenberger M; Kleber M; März W; Luoto R; Raitanen J; Sillanpää E; Laakkonen E; Heikkinen A; Ollikainen M; Raitoharju E
Preprint: MEDRXIV. 2021
Using an electronic frailty index to predict adverse outcomes in geriatric COVID-19 patients: data from the Stockholm GeroCovid study
Mak J; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Hägg S; Religa D; Jylhävä J
Preprint: MEDRXIV. 2021
Development of an electronic frailty index for hospitalized geriatric patients in Sweden
Mak J; Hägg S; Eriksdotter M; Annetorp M; Kuja-Halkola R; Kananen L; Boström A-M; Kivipelto M; Metzner C; Jerlardtz VB; Engström M; Johnson P; Lundberg LG; Åkesson E; Öberg CS; Olsson M; Cederholm T; Jylhävä J; Religa D
Corrigendum: HUMAN GENETICS. 2021;140(6):863
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance (Dec, 10.1007/s00439-020-02249-w, 2020)
Hagg S; Jylhava J; Wang Y; Czene K; Grassmann F
Review: ELIFE. 2021;10:e63425
Sex differences in biological aging with a focus on human studies
Hagg S; Jylhava J
Preprint: RESEARCH SQUARE. 2021
Epigenome-wide association study of level and change in cognitive abilities from midlife through late-life
Karlsson I; Ericsson M; Wang Y; Jylhävä J; Hägg S; Aslan AD; Reynolds C; Pedersen N
Preprint: MEDRXIV. 2020
Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education
Mak J; Reynolds C; Hägg S; Li X; Ericsson M; Pedersen N; Jylhävä J; Kuja-Halkola R
Preprint: MEDRXIV. 2020
Frailty and comorbidity in predicting community COVID-19 mortality in the UK Biobank: the effect of sampling
Mak J; Kuja-Halkola R; Wang Y; Hägg S; Jylhävä J
Preprint: BIORXIV. 2020
Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance
Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Preprint: BIORXIV. 2020
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek F; Suderman M; Roetman P; Sugden K; Chiocchetti A; Ismail K; Mulder R; Hafferty J; Adams M; Walker R; Morris S; Lahti J; Küpers L; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip H; Jansen R; Baselmans B; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhävä J; Wang Y; Mishra PP; Colins O; Corcoran D; Poulton R; Mill J; Hannon E; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; González JR; Grazuleviciene R; Gutzkow K; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; BIOS Consortium; Kluft C; Davies G; Hakulinen C; Keltikangas-Järvinen L; Franke B; Freitag C; Konrad K; Hervas A; Fernández-Rivas A; Vetro A; Raitakari O; Lehtimäki T; Vermeiren R; Strandberg T; Räikkönen K; Snieder H; Witt S; Deuschle M; Pedersen N; Hägg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt T; Tiemeier H; van Ijzendoorn M; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans K; McIntosh A; Bartels M; Boomsma D
Conference publication: BEHAVIOR GENETICS. 2020;50(6):485-487
DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan
van Dongen J; Hagenbeek FA; Suderman M; Roetman P; Sugden K; Chiocchetti AG; Ismail K; Mulder RH; Hafferty J; Adams MJ; Walker RM; Morris SW; Lahti J; Kupers LK; Escaramis G; Alemany S; Bonder MJ; Meijer M; Ip HF; Jansen R; Baselmans BML; Parmar P; Lowry E; Streit F; Sirignano L; Send T; Frank J; Jylhava J; Wang Y; Mishra PP; Colins OF; Corcoran D; Poulton R; Mill J; Hannon EJ; Arseneault L; Korhonen T; Vuoksimaa E; Felix J; Bakermans-Kranenburg M; Campbell A; Czamara D; Binder E; Corpeleijn E; Ramon Gonzalez J; Grazuleviciene R; Gutzkow KB; Evandt J; Vafeiadi M; Klein M; van der Meer D; Ligthart L; Kluft C; Davies GE; Hakulinen C; Keltikangas-Jarvinen L; Franke B; Freitag CM; Konrad K; Hervas A; Fernandez-Rivas A; Vetro A; Raitakari O; Lehtimaki T; Vermeiren R; Strandberg T; Raikkonen K; Snieder H; Witt SH; Deuschle M; Pedersen NL; Hagg S; Sunyer J; Franke L; Kaprio J; Ollikainen M; Moffitt TE; Tiemeier H; van Ijzendoorn MH; Relton C; Vrijheid M; Sebert S; Jarvelin M-R; Caspi A; Evans KL; McIntosh AM; Bartels M; Boomsma D
Preprint: RESEARCH SQUARE. 2019
Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis
Nyberg A; Larsson A; Jylhävä J; Hurme M; Sperber J; Lipcsey M; Castegren M
Preprint: MEDRXIV. 2019
Drivers of Frailty from Adulthood into Old Age: Results from a 27-year Longitudinal Population-Based Study in Sweden
Raymond E; Reynolds C; Dahl Aslan A; Finkel D; Ericsson M; Hägg S; Pedersen N; Jylhävä J
Preprint: BIORXIV. 2019
A decade of epigenetic change in aging twins: genetic and environmental contributions to longitudinal DNA methylation
Reynolds C; Tan Q; Munoz E; Jylhävä J; Hjelmborg J; Christiansen L; Hägg S; Pedersen N
Preprint: MEDRXIV. 2019
A Genome-Wide Association Study of the Frailty Index Highlights Synaptic Pathways in Aging
Atkins J; Jylhävä J; Pedersen N; Magnusson P; Lu Y; Wang Y; Hägg S; Melzer D; Williams D; Pilling L
Preprint: BIORXIV. 2019
Comprehensive longitudinal study of epigenetic mutations in aging
Wang Y; Karlsson R; Jylhävä J; Hedman Å; Almqvist C; Karlsson I; Pedersen N; Almgren M; Hägg S
Preprint: BIORXIV. 2019
Neuroticism as a predictor of frailty in old age: a genetically informative approach
Danielsdottir HB; Jylhävä J; Hägg S; Lu Y; Colodro-Conde L; Martin N; Pedersen N; Mosing M; Lehto K
Conference publication: BEHAVIOR GENETICS. 2019;49(6):527
10-year epigenetic change: age-associated CpGs are differentially heritable
Reynolds C; Tan Q; Munoz E; Jylhava J; Hjelmborg J; Christiansen L; Hagg S; Pedersen NL
Conference publication: BEHAVIOR GENETICS. 2019;49(6):516
Genome-wide association study of a frailty Index in UK Biobank and TwinGene
Jylhava J; Pilling L; Williams D; Lu Y; Pedersen NL; Melzer D; Atkins J
Conference publication: BEHAVIOR GENETICS. 2019;49(6):523
Frailty and mortality: sex differences and socioeconomic influences in Swedish twins
Ericsson M; Pedersen NL; Fors S; Kuja-Halkola R; Mosing M; Jylhava J; Aslan AD
Conference publication: BEHAVIOR GENETICS. 2019;49(6):515
Neuroticism as a predictor of frailty in old age: a genetically informative approach
Bjork H; Jylhava J; Hagg S; Lu Y; Colodro-Conde L; Martin N; Pedersen NL; Mosing M; Lehto K
Conference publication: BEHAVIOR GENETICS. 2019;49(6):503
DNA methylation and change in late-life cognitive abilities
Karlsson I; Ericsson M; Wang Y; Jylhava J; Hagg S; Aslan AD; Reynolds C; Pedersen NL
Preprint: BIORXIV. 2018
The frailty index is a predictor of cause-specific mortality independent of familial effects from midlife onwards
Li X; Ploner A; Karlsson I; Liu X; Magnusson PKE; Pedersen N; Hägg S; Jylhävä J
Preprint: BIORXIV. 2017
A frailty index for UK Biobank participants
Williams D; Jylhävä J; Pedersen N; Hägg S
Preprint: BIORXIV. 2017
The frailty index is associated with the need for care in an aging Swedish population
Jylhävä J; Jiang M; Foebel AD; Pedersen NL; Hägg S
Preprint: BIORXIV. 2017
Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort
Jiang M; Foebel AD; Kuja-Halkola R; Karlsson I; Pedersen NL; Hägg S; Jylhävä J
Review: EBIOMEDICINE. 2017;21:29-36
Biological Age Predictors
Jylhava J; Pedersen NL; Hagg S
Conference publication: BEHAVIOR GENETICS. 2017;47(6):706
Longitudinal variance components of the Horvath clock and its contributing CpGs
Jylhava J; Reynolds C; Hjelmborg J; Munoz E; Tan Q; Christiansen L; Hagg S; Pedersen NL
Review: ANTIVIRAL RESEARCH. 2013;100(3):589-604
The pathogenesis of nephropathia epidemica: New knowledge and unanswered questions
Mustonen J; Makela S; Outinen T; Laine O; Jylhava J; Arstila PT; Hurme M; Vaheri A
Meeting abstract: EXPERIMENTAL GERONTOLOGY. 2013;48(7):689
The quantity of cell-free mitochondrial DNA in plasma as an indicator of frailty in nonagenarians
Nevalainen T; Jylhava J; Marttila S; Jylha M; Hervonen A; Hurme M
Book chapter: ENCYCLOPEDIA OF LIFE SCIENCES. 2012;p.
Genetic Determinants of Human Life‐Span
Jylhävä J; Hurme M
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Senior Forskare, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2022-

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Docent, Epidemiologi, Karolinska Institutet, 2021

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