Jurga Laurencikiene

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler

Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E
Article: SCIENTIFIC REPORTS. 2023;13(1):10559

Mechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytes

Vavakova M; Hofwimmer K; Laurencikiene J; Goransson O
Article: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):84

Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4⁺ T cells

Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
Article: NATURE COMMUNICATIONS. 2023;14(1):1438

An integrated single cell and spatial transcriptomic map of human white adipose tissue

Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nankam PAN; Frendo-Cumbo S; Backdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Stahl PL; Viguerie N; Langin D; Wolfrum C; Blueher M; Ryden M; Mejhert N
Article: GUT. 2022;71(11):2179-2193

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance

Krieg L; Didt K; Karkossa I; Bernhart SH; Kehr S; Subramanian N; Lindhorst A; Schaudinn A; Tabei S; Keller M; Stumvoll M; Dietrich A; von Bergen M; Stadler PF; Laurencikiene J; Krueger M; Blueher M; Gericke M; Schubert K; Kovacs P; Chakaroun R; Massier L
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954

Sex-specific regulation of IL-10 production in human adipose tissue in obesity

Subramanian N; Tavira B; Hofwimmer K; Gutsmann B; Massier L; Abildgaard J; Juul A; Ryden M; Arner P; Laurencikiene J
Article: CIRCULATION. 2021;144(12):961-982

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Edgar L; Akbar N; Braithwaite AT; Krausgruber T; Gallart-Ayala H; Bailey J; Corbin AL; Khoyratty TE; Chai JT; Alkhalil M; Rendeiro AF; Ziberna K; Arya R; Cahill TJ; Bock C; Laurencikiene J; Crabtree MJ; Lemieux ME; Riksen NP; Netea MG; Wheelock CE; Channon KM; Ryden M; Udalova IA; Carnicer R; Choudhury RP
Article: ELIFE. 2021;10:e65996

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

Sanchez-Ceinos J; Guzman-Ruiz R; Alberto Rangel-Zuniga O; Lopez-Alcala J; Moreno-Cano E; Del Rio-Moreno M; Luis Romero-Cabrera J; Perez-Martinez P; Maymo-Masip E; Vendrell J; Fernandez-Veledo S; Manuel Fernandez-Real J; Laurencikiene J; Ryden M; Membrives A; Luque RM; Lopez-Miranda J; Malagon MM
Article: ENDOCRINOLOGY. 2021;162(7):bqab096

An RNAi Screening of Clinically Relevant Transcription Factors Regulating Human Adipogenesis and Adipocyte Metabolism

Bjork C; Subramanian N; Liu J; Acosta JR; Tavira B; Eriksson AB; Arner P; Laurencikiene J
Article: CELLULAR SIGNALLING. 2020;76:109786

JUP/plakoglobin is regulated by salt-inducible kinase 2, and is required for insulin-induced signalling and glucose uptake in adipocytes

Negoita F; Vavakova M; Saell J; Laurencikiene J; Goeransson O
Article: CELL METABOLISM. 2020;31(2):375-390.e11

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019;104(10):4552-4562

Human-Specific Function of IL-10 in Adipose Tissue Linked to Insulin Resistance

Acosta JR; Tavira B; Douagi I; Kulyte A; Arner P; Ryden M; Laurencikiene J
Article: CELLULAR SIGNALLING. 2019;55:73-80

Insulin induces Thr484 phosphorylation and stabilization of SIK2 in adipocytes

Sall J; Negoita F; Hansson B; Kopietz F; Linder W; Pettersson AML; Ekelund M; Laurencikiene J; Degerman E; Stenkula KG; Goransson O
Article: CELL REPORTS. 2018;25(3):551-560.e5

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue

Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
Article: DIABETES OBESITY & METABOLISM. 2018;20(10):2416-2425

Mapping of biguanide transporters in human fat cells and their impact on lipolysis

Arner P; Kulyte A; Batchelor K; Laurencikiene J; Livingston J; Ryden M
Article: JOURNAL OF ENDOCRINOLOGY. 2018;238(3):187-202

STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue

Sutt S; Cansby E; Paul A; Amrutkar M; Nunez-Duran E; Kulkarni NM; Stahlman M; Boren J; Laurencikiene J; Howell BW; Enerback S; Mahlapuu M
Article: STEM CELL RESEARCH & THERAPY. 2017;8(1):250

Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population

Acosta JR; Joost S; Karlsson K; Ehrlund A; Li X; Aouadi M; Kasper M; Arner P; Ryden M; Laurencikiene J
Article: SCIENTIFIC DATA. 2017;4:170164

The cell-type specific transcriptome in human adipose tissue and influence of obesity on adipocyte progenitors

Ehrlund A; Acosta JR; Bjork C; Heden P; Douagi I; Arner P; Laurencikiene J
Article: SCIENTIFIC REPORTS. 2017;7(1):10152

Epigenetic Regulation of PLIN1 in Obese Women and its Relation to Lipolysis

Bialesova L; Kulyte A; Petrus P; Sinha I; Laurencikiene J; Zhao C; Wright KD; Arner P; Dahlman I
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2017;312(6):E482-E494

Comprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women

Dahlman I; Belarbi Y; Laurencikiene J; Pettersson AM; Arner P; Kulyte A
Article: DIABETOLOGIA. 2017;60(2):314-323

Salt-inducible kinase 2 and-3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes

Sall J; Pettersson AML; Bjork C; Henriksson E; Wasserstrom S; Linder W; Zhou Y; Hansson O; Andersson DP; Ekelund M; Degerman E; Stenkula KG; Laurencikiene J; Goransson O
Article: DIABETES. 2017;66(1):218-230

Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution

Ehrlund A; Mejhert N; Bjork C; Andersson R; Kulyte A; Astrom G; Itoh M; Kawaji H; Lassmann T; Daub CO; Carninci P; Forrest ARR; Hayashizaki Y; Sandelin A; Ingelsson E; Ryden M; Laurencikiene J; Arner P; Arner E
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):4021-4029

Adipose and Circulating CCL18 Levels Associate With Metabolic Risk Factors in Women

Hogling DE; Petrus P; Gao H; Backdahl J; Dahlman I; Laurencikiene J; Acosta J; Ehrlund A; Naslund E; Kulyte A; Mejhert N; Andersson DP; Arner P; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(10):3765-3771

Circulating and Adipose Levels of Adipokines Associated With Insulin Sensitivity in Nonobese Subjects With Type 2 Diabetes

Andersson DP; Laurencikiene J; Acosta JR; Ryden M; Arner P
Article: DIABETOLOGIA. 2016;59(3):560-570

Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

Acosta JR; Douagi I; Andersson DP; Backdahl J; Ryden M; Arner P; Laurencikiene J
Article: PLOS ONE. 2016;11(12):e0168276

Functional Analyses of the Crohn's Disease Risk Gene LACC1

Assadi G; Vesterlund L; Bonfiglio F; Mazzurana L; Cordeddu L; Schepis D; Mjosberg J; Ruhrmann S; Fabbri A; Vukojevic V; Percipalle P; Salomons FA; Laurencikiene J; Torkvist L; Halfvarson J; D'Amato M
Article: NUTRITION & METABOLISM. 2016;13:4

Effects of selected bioactive food compounds on human white adipocyte function

Bjork C; Wilhelm U; Mandrup S; Larsen BD; Bordoni A; Heden P; Ryden M; Arner P; Laurencikiene J
Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(12):1733-1741

Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation

Karbiener M; Glantschnig C; Pisani DF; Laurencikiene J; Dahlman I; Herzig S; Amri E-Z; Scheideler M
Article: DIABETOLOGIA. 2015;58(9):2115-2123

MAFB as a novel regulator of human adipose tissue inflammation

Pettersson AML; Acosta JR; Bjork C; Kratzel J; Stenson B; Blomqvist L; Viguerie N; Langin D; Arner P; Laurencikiene J
Article: NATURE COMMUNICATIONS. 2015;6:7433

Cidea improves the metabolic profile through expansion of adipose tissue

Abreu-Vieira G; Fischer AW; Mattsson C; de Jong JMA; Shabalina IG; Ryden M; Laurencikiene J; Arner P; Cannon B; Nedergaard J; Petrovic N
Article: CELL METABOLISM. 2014;19(6):981-992

Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue

Gao H; Mejhert N; Fretz JA; Arner E; Lorente-Cebrian S; Ehrlund A; Dahlman-Wright K; Gong X; Stromblad S; Douagi I; Laurencikiene J; Dahlman I; Daub CO; Ryden M; Horowitz MC; Arner P
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(5):E494-E502

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis

Archer A; Laurencikiene J; Ahmed O; Steffensen KR; Parini P; Gustafsson J-A; Korach-Andre M
Article: PLOS ONE. 2014;9(3):e80274

Ceruloplasmin Is a Novel Adipokine Which Is Overexpressed in Adipose Tissue of Obese Subjects and in Obesity-Associated Cancer Cells

Arner E; Forrest ARR; Ehrlund A; Mejhert N; Itoh M; Kawaji H; Lassmann T; Laurencikiene J; Ryden M; Arner P
Article: PLOS ONE. 2014;9(1):e86800

MicroRNAs Regulate Human Adipocyte Lipolysis: Effects of miR-145 Are Linked to TNF-α

Lorente-Cebrian S; Mejhert N; Kulyte A; Laurencikiene J; Astrom G; Heden P; Ryden M; Arner P
Article: DIABETOLOGIA. 2013;56(9):2044-2054

LXR is a negative regulator of glucose uptake in human adipocytes

Pettersson AML; Stenson BM; Lorente-Cebrian S; Andersson DP; Mejhert N; Kratzel J; Astrom G; Dahlman I; Chibalin AV; Arner P; Laurencikiene J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(3):E503-E508

Characterization of the Wnt Inhibitors Secreted Frizzled-Related Proteins (SFRPs) in Human Adipose Tissue

Ehrlund A; Mejhert N; Lorente-Cebrian S; Astrom G; Dahlman I; Laurencikiene J; Ryden M
Article: DIABETES. 2012;61(8):1986-1993

Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

Arner E; Mejhert N; Kulyte A; Balwierz PJ; Pachkov M; Cormont M; Lorente-Cebrian S; Ehrlund A; Laurencikiene J; Heden P; Dahlman-Wright K; Tanti J-F; Hayashizaki Y; Ryden M; Dahlman I; van Nimwegen E; Daub CO; Arner P
Article: EUROPEAN JOURNAL OF NUTRITION. 2012;51(3):335-342

Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes

Lorente-Cebrian S; Eriksson A; Dunlop T; Mejhert N; Dahlman I; Astrom G; Sjolin E; Wahlen K; Carlberg C; Laurencikiene J; Heden P; Arner P; Ryden M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(12):E2045-E2049

Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

Laurencikiene J; Skurk T; Kulyte A; Heden P; Astrom G; Sjolin E; Ryden M; Hauner H; Arner P
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2011;301(1):E210-E222

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice

Korach-Andre M; Archer A; Gabbi C; Barros RP; Pedrelli M; Steffensen KR; Pettersson AT; Laurencikiene J; Parini P; Gustafsson J-A
Article: FEBS LETTERS. 2011;585(5):744-748

CIDEA interacts with liver X receptors in white fat cells

Kulyte A; Pettersson AT; Antonson P; Stenson BM; Langin D; Gustafsson J-A; Staels B; Ryden M; Arner P; Laurencikiene J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(1):370-379

Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis

Stenson BM; Ryden M; Venteclef N; Dahlman I; Pettersson AML; Mairal A; Astrom G; Blomqvist L; Wang V; Jocken JWE; Clement K; Langin D; Arner P; Laurencikiene J
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(1):133-141

Twist1 in Human White Adipose Tissue and Obesity

Pettersson AT; Mejhert N; Jernas M; Carlsson LMS; Dahlman I; Laurencikiene J; Arner P; Ryden M
Article: DIABETES. 2010;59(3):564-571

A Possible Inflammatory Role of Twist1 in Human White Adipocytes

Pettersson AT; Laurencikiene J; Mejhert N; Naslund E; Bouloumie A; Dahlman I; Arner P; Ryden M
Article: BMC ENDOCRINE DISORDERS. 2010;10:1

Role of Receptor-Interacting Protein 140 in human fat cells

Mejhert N; Laurencikiene J; Pettersson AT; Kaaman M; Stenson BM; Ryden M; Dahlman I
Article: DIABETES. 2009;58(12):2731-2740

Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance in Primary Human Skeletal Muscle Cells

Sell H; Laurencikiene J; Taube A; Eckardt K; Cramer A; Horrighs A; Arner P; Eckel J
Article: ENDOCRINOLOGY. 2009;150(9):4104-4113

Activation of Liver X Receptor Regulates Substrate Oxidation in White Adipocytes

Stenson BM; Ryden M; Steffensen KR; Wahlen K; Pettersson AT; Jocken JW; Arner P; Laurencikiene J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(27):18282-18291

Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes

Bezaire V; Mairal A; Ribet C; Lefort C; Girousse A; Jocken J; Laurencikiene J; Anesia R; Rodriguez A-M; Ryden M; Stenson BM; Dani C; Ailhaud G; Arner P; Langin D
Article: INTERNATIONAL JOURNAL OF OBESITY. 2009;33(1):67-74

Endothelin-1 stimulates human adipocyte lipolysis through the ET_A receptor

Eriksson AKS; van Harmelen V; Stenson BM; Astrom G; Wahlen K; Laurencikiene J; Ryden M
Article: CANCER RESEARCH. 2008;68(22):9247-9254

Evidence for an Important Role of CIDEA in Human Cancer Cachexia

Laurencikiene J; Stenson BM; Nordstrom EA; Agustsson T; Langin D; Isaksson B; Permert J; Ryden M; Arner P
Article: CANCER. 2008;113(7):1695-1704

Lipolysis -: Not inflammation, cell death, or lipogenesis -: Is involved in adipose tissue loss in cancer cachexia

Ryden M; Agustsson T; Laurencikiene J; Britton T; Sjoelin E; Isaksson B; Permert J; Arner P
Article: INTERNATIONAL JOURNAL OF OBESITY. 2008;32(9):1380-1387

Characterization of the human CIDEA promoter in fat cells

Pettersson AT; Laurencikiene J; Nordstrom EA; Stenson BM; van Harmelen V; Murphy C; Dahlman I; Ryden M
Article: CANCER RESEARCH. 2007;67(11):5531-5537

Mechanism of increased lipolysis in cancer cachexia

Agustsson T; Ryden M; Hoffstedt J; van Harmelen V; Dicker A; Laurencikiene J; Isaksson B; Permert J; Arner P
Article: JOURNAL OF LIPID RESEARCH. 2007;48(5):1069-1077

NF-κB is important for TNF-α-induced lipolysis in human adipocytes

Laurencikiene J; van Harmelen V; Nordstrom EA; Dicker A; Blomqvist L; Naslund E; Langin D; Arner P; Ryden M
Article: BLOOD. 2007;109(1):159-167

Regulation of ε germline transcription and switch region mutations by IgH locus 3′ enhancers in transgenic mice

Laurencikiene J; Tamosiunas V; Severinson E
Article: EMBO REPORTS. 2006;7(3):303-307

RNA editing and alternative splicing: the importance of co-transcriptional coordination.

Laurencikiene J; Källman AM; Fong N; Bentley DL; Ohman M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(4):576-582

Differential activation of signal transducer and activator of transcription 6 in B cells from allergic children and their non-allergic siblings

Deveikaite V; Fila C; Laurencikiene J; Klein E; Kihlström A; Lilja G; Ekström ES; Severinson E
Article: JOURNAL OF IMMUNOLOGY. 2001;167(6):3257-3265

HS1,2 enhancer regulation of germline ε and γ2b promoters in murine B lymphocytes:: Evidence for specific promoter-enhancer interactions

Laurencikiene J; Deveikaite V; Severinson E
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;49(5):523-532

Characterization of CD40-dependent immunoglobulin class switching

Ström L; Laurencikiené J; Miskiniené A; Severinson E
Journal article:

Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis

Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
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Alla övriga publikationer

Corrigendum: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):229

Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4⁺T cells (vol 22, 84, 2023)

Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
Conference publication: DIABETOLOGIA. 2019;62:S107

Role of IL-1beta in human adipose tissue remodelling in obesity and type 2 diabetes

Laurencikiene J; Hofwimmer K; Tavira B; Acosta J; Ryden M
Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502

Liver X receptors and fat cell metabolism

Laurencikiene J; Ryden M
Thesis / dissertation: 2004

Regulation of germline transcription in the immunoglobulin heavy chain locus

Laurencikiene, Jurga

Forskningsbidrag

The role of the immune component in human adipose tissue expansion in cardiometabolic diseases: does the sex matter

Karolinska Institutet

1 June 2024 - 1 June 2028
Characterization of gender-specific differences in insulin sensitivity and type 2 diabetes through studies of human adipose tissue immune component.

Centrum för Innovativ Medicin

1 January 2024 - 31 December 2026
Type 2 diabetes and adipose tissue morphology: dual role and sex- specificity of the immune component

EFSD and Novo Nordisk A/S Programme for Diabetes Research in Europe

1 November 2023 - 1 November 2024
Novel regulatory networks of human adipose tissue expansion and remodeling in health and disease: a role of adipogenesis and fat cell progenitors

Swedish Research Council

1 January 2017 - 31 December 2022
Novel Transcriptional Networks Controlling Human Fat Cell Metabolism in Health and Disease

Swedish Research Council

1 January 2013 - 31 December 2016

Anställningar

Forskare, Medicin, Huddinge, Karolinska Institutet, 2024-

Examina och utbildning

Docent, Experimentell endokrinologi, Karolinska Institutet, 2011
MEDICINE DOKTORSEXAMEN, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2004

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

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