Jurga Laurencikiene
Researcher | Docent
E-mail: jurga.laurencikiene@ki.se
Visiting address: Blickagången 16 (byggnad NEO), 14183 Huddinge
Postal address: H7 Medicin, Huddinge, H7 GUT Laurencikiene, 171 77 Stockholm
About me
- The group focuses on the function of adipose tissue immune cells and their role in obesity-related complications such as insulin resistance and type 2 diabetes. In addition, we are interested in how signals coming from immune cells are influencing healthy vs unhealthy adipose tissue expansion and how sex differences influence these processes.
The transferability of research results between sexes has been questioned with great differences found both in human and murine metabolic and immune system research. Sex dimorphism is a well-known phenomena in development of obesity-related insulin resistance (IR) and type 2 diabetes (T2D) as well as in general immune response. Men have a higher risk of insulin resistance and metabolic complications compared to pre-menopausal
women even though obesity is more prevalent in women. Several sex-related differences in white adipose tissue (WAT) function have been defined, for example leptin secretion and adipocyte lipolysis. Therefore, it is apparent that WAT function contributes to metabolic differences observed between sexes. However, most of such studies focused on adipocyte phenotype, while also immune cells have a central role in regulation of metabolism and inflammation in WAT. Furthermore, immune cells also respond to insulin and can develop insulin resistance. Our hypothesis is that WAT immune cells possess sex differences in composition of populations and their functions, which affects WAT expansion and its phenotype.
Research
- Adipocytes, adipose tissue immune cells, obesity, type 2 diabetes, inflammation, sex differences.
Teaching
- - Director of studies for the Master’s programme in Biomedicine,
- Course director of the elective course in "Circulation, Metabolism and Endocrinology" in a Master's programme in Biomedicine,
- Co-ordinator of a doctoral program in Metabolism and Endocrinology (MetEndo),
- Board member of the graduate program in Metabolism and Endocrinology (MetEndo) at KI,
- Teacher in courses under Master's programme in Biomedicine and doctoral courses at KI.
- Teacher's representative in the Programme committee for Biomedicine programmes and Programme committee for undergraduate education at MedH.
Articles
- Article: NATURE COMMUNICATIONS. 2024;15(1):7957Hofwimmer K; de Paula Souza J; Subramanian N; Vujicic M; Rachid L; Mereau H; Zhao C; Dror E; Barreby E; Bjorkstrom NK; Wernstedt Asterholm I; Boni-Schnetzler M; Meier DT; Donath MY; Laurencikiene J
- Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2024;47(9):2249-2260Subramanian N; Wiik A; Rullman E; Melin M; Lundberg TR; Flanagan J; Holmberg M; Dekanski A; Dhejne C; Arver S; Gustafsson T; Laurencikiene J; Andersson DP
- Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E
- Article: SCIENTIFIC REPORTS. 2023;13(1):10559Vavakova M; Hofwimmer K; Laurencikiene J; Goransson O
- Article: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):84Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
- Article: NATURE COMMUNICATIONS. 2023;14(1):1438Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nankam PAN; Frendo-Cumbo S; Backdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Stahl PL; Viguerie N; Langin D; Wolfrum C; Blueher M; Ryden M; Mejhert N
- Article: GUT. 2022;71(11):2179-2193Krieg L; Didt K; Karkossa I; Bernhart SH; Kehr S; Subramanian N; Lindhorst A; Schaudinn A; Tabei S; Keller M; Stumvoll M; Dietrich A; von Bergen M; Stadler PF; Laurencikiene J; Krueger M; Blueher M; Gericke M; Schubert K; Kovacs P; Chakaroun R; Massier L
- Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954Subramanian N; Tavira B; Hofwimmer K; Gutsmann B; Massier L; Abildgaard J; Juul A; Ryden M; Arner P; Laurencikiene J
- Article: ELIFE. 2021;10:e65996Sanchez-Ceinos J; Guzman-Ruiz R; Alberto Rangel-Zuniga O; Lopez-Alcala J; Moreno-Cano E; Del Rio-Moreno M; Luis Romero-Cabrera J; Perez-Martinez P; Maymo-Masip E; Vendrell J; Fernandez-Veledo S; Manuel Fernandez-Real J; Laurencikiene J; Ryden M; Membrives A; Luque RM; Lopez-Miranda J; Malagon MM
- Article: CIRCULATION. 2021;144(12):961-982Edgar L; Akbar N; Braithwaite AT; Krausgruber T; Gallart-Ayala H; Bailey J; Corbin AL; Khoyratty TE; Chai JT; Alkhalil M; Rendeiro AF; Ziberna K; Arya R; Cahill TJ; Bock C; Laurencikiene J; Crabtree MJ; Lemieux ME; Riksen NP; Netea MG; Wheelock CE; Channon KM; Ryden M; Udalova IA; Carnicer R; Choudhury RP
- Article: ENDOCRINOLOGY. 2021;162(7):bqab096Bjork C; Subramanian N; Liu J; Acosta JR; Tavira B; Eriksson AB; Arner P; Laurencikiene J
- Article: CELLULAR SIGNALLING. 2020;76:109786Negoita F; Vavakova M; Saell J; Laurencikiene J; Goeransson O
- Article: CELL METABOLISM. 2020;31(2):375-390.e11Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019;104(10):4552-4562Acosta JR; Tavira B; Douagi I; Kulyte A; Arner P; Ryden M; Laurencikiene J
- Article: CELLULAR SIGNALLING. 2019;55:73-80Sall J; Negoita F; Hansson B; Kopietz F; Linder W; Pettersson AML; Ekelund M; Laurencikiene J; Degerman E; Stenkula KG; Goransson O
- Article: CELL REPORTS. 2018;25(3):551-560.e5Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
- Article: DIABETES OBESITY & METABOLISM. 2018;20(10):2416-2425Arner P; Kulyte A; Batchelor K; Laurencikiene J; Livingston J; Ryden M
- Article: JOURNAL OF ENDOCRINOLOGY. 2018;238(3):187-202Sutt S; Cansby E; Paul A; Amrutkar M; Nunez-Duran E; Kulkarni NM; Stahlman M; Boren J; Laurencikiene J; Howell BW; Enerback S; Mahlapuu M
- Article: STEM CELL RESEARCH & THERAPY. 2017;8(1):250Acosta JR; Joost S; Karlsson K; Ehrlund A; Li X; Aouadi M; Kasper M; Arner P; Ryden M; Laurencikiene J
- Article: SCIENTIFIC DATA. 2017;4:170164Ehrlund A; Acosta JR; Bjork C; Heden P; Douagi I; Arner P; Laurencikiene J
- Show more
All other publications
- Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S116-S117Hofwimmer K; Souza JDP; Subramanian N; Vujicic M; Asterholm IW; Ryden M; Boni-Schnetzler M; Meier DT; Donath MY; Laurencikiene J
- Corrigendum: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):229Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
- Preprint: BIORXIV. 2021Sánchez-Ceinos J; Guzmán-Ruiz R; Rangel-Zúñiga OA; López-Alcalá J; Moreno-Caño E; del Río-Moreno M; Romero-Cabrera JL; Pérez-Martínez P; Maymo-Masip E; Vendrell J; Fernández-Veledo S; Fernández-Real JM; Laurencikiene J; Rydén M; Membrives A; Luque RM; López-Miranda J; Malagón MM
- Preprint: SSRN ELECTRONIC JOURNAL. 2020Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mahú I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; Näslund E; Laurencikiene J; Bleriot C; Rydén M; Ginhoux F; Aouadi M
- Conference publication: DIABETOLOGIA. 2019;62:S107Laurencikiene J; Hofwimmer K; Tavira B; Acosta J; Ryden M
- Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502Laurencikiene J; Ryden M
- Conference publication: JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS. 2010;3(2-3):97Pettersson A; Mejhert N; Naslund E; Bouloumie A; Dahlman I; Laurencikiene J; Amer P; Ryden M
- Conference publication: INTERNATIONAL JOURNAL OF OBESITY. 2007;31:S67Pettersson A; Laurencikiene J; Arvidsson Nordstroem E; Dahlman I; Murphy C; Dungner E; Leijonhufvud B-M; Ryden M; Arner P
- Conference publication: JOURNAL OF IMMUNOLOGY. 2007;178Severinson E; Laurencikiene J
- Doctoral thesis: 2004Laurencikiene J
- Conference publication: FASEB JOURNAL. 2003;17(7):C101Laurencikiene J; Severinson E
Grants
- The role of the immune component in human adipose tissue expansion in cardiometabolic diseases: does the sex matterKarolinska Institutet1 June 2024 - 1 June 2028
- Characterization of gender-specific differences in insulin sensitivity and type 2 diabetes through studies of human adipose tissue immune component.CIMED1 January 2024 - 31 December 2026
- Type 2 diabetes and adipose tissue morphology: dual role and sex- specificity of the immune componentEFSD and Novo Nordisk A/S Programme for Diabetes Research in Europe1 November 2023 - 1 November 2024
- Teasing out gender-specific differences in insulin sensitivity and type 2 diabetes through studies of human adipose tissue immune componentNovo Nordisk Foundation15 October 2021 - 31 December 2025
- Swedish Research Council1 January 2017 - 31 December 2022
- Swedish Research Council1 January 2013 - 31 December 2016
Employments
- Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Degrees and Education
- Docent, Karolinska Institutet, 2011
- Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2004