Jurga Laurencikiene
Researcher
| Docent
E-mail: jurga.laurencikiene@ki.se
Visiting address: Blickagången 16 (byggnad NEO), 14183 Huddinge
Postal address: H7 Medicin, Huddinge, H7 BioNut Laurencikiene, 171 77 Stockholm
About me
- The group focuses on the function of adipose tissue immune cells and their role in obesity-related complications such as insulin resistance and type 2 diabetes. In addition, we are interested in how signals coming from immune cells are influencing healthy vs unhealthy adipose tissue expansion and how sex differences influence these processes.
The transferability of research results between sexes has been questioned with great differences found both in human and murine metabolic and immune system research. Sex dimorphism is a well-known phenomena in development of obesity-related insulin resistance (IR) and type 2 diabetes (T2D) as well as in general immune response. Men have a higher risk of insulin resistance and metabolic complications compared to pre-menopausal
women even though obesity is more prevalent in women. Several sex-related differences in white adipose tissue (WAT) function have been defined, for example leptin secretion and adipocyte lipolysis. Therefore, it is apparent that WAT function contributes to metabolic differences observed between sexes. However, most of such studies focused on adipocyte phenotype, while also immune cells have a central role in regulation of metabolism and inflammation in WAT. Furthermore, immune cells also respond to insulin and can develop insulin resistance. Our hypothesis is that WAT immune cells possess sex differences in composition of populations and their functions, which affects WAT expansion and its phenotype.
Research
- Adipocytes, adipose tissue immune cells, obesity, type 2 diabetes, inflammation, sex differences.
Teaching
- - Director of studies for the Master’s programme in Biomedicine,
- Course director of the elective course in "Circulation, Metabolism and Endocrinology" in a Master's programme in Biomedicine,
- Co-ordinator of a doctoral program in Metabolism and Endocrinology (MetEndo),
- Board member of the graduate program in Metabolism and Endocrinology (MetEndo) at KI,
- Teacher in courses under Master's programme in Biomedicine and doctoral courses at KI.
- Teacher's representative in the Programme committee for Biomedicine programmes and Programme committee for undergraduate education at MedH.
Articles
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Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590
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Article: SCIENTIFIC REPORTS. 2023;13(1):10559
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Article: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):84
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Article: NATURE COMMUNICATIONS. 2023;14(1):1438
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Article: GUT. 2022;71(11):2179-2193
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Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954
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Article: CIRCULATION. 2021;144(12):961-982
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Article: ELIFE. 2021;10:e65996
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Article: ENDOCRINOLOGY. 2021;162(7):bqab096
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Article: CELLULAR SIGNALLING. 2020;76:109786
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Article: CELL METABOLISM. 2020;31(2):375-390.e11
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2019;104(10):4552-4562
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Article: CELLULAR SIGNALLING. 2019;55:73-80
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Article: CELL REPORTS. 2018;25(3):551-560.e5
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Article: DIABETES OBESITY & METABOLISM. 2018;20(10):2416-2425
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Article: JOURNAL OF ENDOCRINOLOGY. 2018;238(3):187-202
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Article: STEM CELL RESEARCH & THERAPY. 2017;8(1):250
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Article: SCIENTIFIC DATA. 2017;4:170164
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Article: SCIENTIFIC REPORTS. 2017;7(1):10152
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2017;312(6):E482-E494
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Article: DIABETES. 2017;66(1):218-230
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):4021-4029
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(10):3765-3771
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Article: DIABETOLOGIA. 2016;59(3):560-570
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Article: PLOS ONE. 2016;11(12):e0168276
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Article: NUTRITION & METABOLISM. 2016;13:4
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Article: INTERNATIONAL JOURNAL OF OBESITY. 2015;39(12):1733-1741
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Article: DIABETOLOGIA. 2015;58(9):2115-2123
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Article: NATURE COMMUNICATIONS. 2015;6:7433
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Article: CELL METABOLISM. 2014;19(6):981-992
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(5):E494-E502
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Article: PLOS ONE. 2014;9(3):e80274
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Article: PLOS ONE. 2014;9(1):e86800
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Article: DIABETOLOGIA. 2013;56(9):2044-2054
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(3):E503-E508
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Article: DIABETES. 2012;61(8):1986-1993
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Article: EUROPEAN JOURNAL OF NUTRITION. 2012;51(3):335-342
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(12):E2045-E2049
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2011;301(1):E210-E222
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Article: FEBS LETTERS. 2011;585(5):744-748
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(1):370-379
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Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(1):133-141
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Article: DIABETES. 2010;59(3):564-571
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Article: BMC ENDOCRINE DISORDERS. 2010;10:1
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Article: DIABETES. 2009;58(12):2731-2740
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Article: ENDOCRINOLOGY. 2009;150(9):4104-4113
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(27):18282-18291
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Article: INTERNATIONAL JOURNAL OF OBESITY. 2009;33(1):67-74
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Article: CANCER RESEARCH. 2008;68(22):9247-9254
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Article: CANCER. 2008;113(7):1695-1704
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Article: INTERNATIONAL JOURNAL OF OBESITY. 2008;32(9):1380-1387
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Article: CANCER RESEARCH. 2007;67(11):5531-5537
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Article: JOURNAL OF LIPID RESEARCH. 2007;48(5):1069-1077
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Article: BLOOD. 2007;109(1):159-167
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Article: EMBO REPORTS. 2006;7(3):303-307
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Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(4):576-582
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Article: JOURNAL OF IMMUNOLOGY. 2001;167(6):3257-3265
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Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;49(5):523-532
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Journal article:Adipose Tissue Vasculature Facilitates Immune Activation of Macrophages Via the CD200-CD200R Axis
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All other publications
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Corrigendum: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):229
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Conference publication: DIABETOLOGIA. 2019;62:S107
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Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502
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Thesis / dissertation: 2004
Grants
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The role of the immune component in human adipose tissue expansion in cardiometabolic diseases: does the sex matterKarolinska Institutet1 June 2024 - 1 June 2028
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Characterization of gender-specific differences in insulin sensitivity and type 2 diabetes through studies of human adipose tissue immune component.CIMED1 January 2024 - 31 December 2026
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Type 2 diabetes and adipose tissue morphology: dual role and sex- specificity of the immune componentEFSD and Novo Nordisk A/S Programme for Diabetes Research in Europe1 November 2023 - 1 November 2024
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Swedish Research Council1 January 2017 - 31 December 2022
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Swedish Research Council1 January 2013 - 31 December 2016
Employments
- Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Degrees and Education
- Docent, Karolinska Institutet, 2011
- Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2004