Julian Walfridsson

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: LEUKEMIA. 2023;37(3):593-605
The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes
Trempenau ML; Schuster MB; Pundhir S; Pereira MA; Kalvisa A; Tapia M; Su J; Ge Y; de Boer B; Balhuizen A; Bagger FO; Shliaha P; Sroczynska P; Walfridsson J; Gronbaek K; Theilgaard-Moench K; Jensen ONN; Helin K; Porse BTT
Article: BLOOD. 2022;139(20):3040-3057
Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression
Cai H; Kondo M; Sandhow L; Xiao P; Johansson A-S; Sasaki T; Zawacka-Pankau J; Tryggvason K; Ungerstedt J; Walfridsson J; Ekblom M; Qian H
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:880668
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
Pena-Perez L; Kharazi S; Frengen N; Krstic A; Bouderlique T; Hauenstein J; He M; Somuncular E; Li Wang X; Dahlberg C; Gustafsson C; Johansson A-S; Walfridsson J; Kadri N; Woll P; Kierczak M; Qian H; Westerberg L; Luc S; Mansson R
Article: CANCER RESEARCH. 2021;81(22):5733-5744
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Sanjiv K; Calderon-Montano JM; Pham TM; Erkers T; Tsuber V; Almlof I; Hoglund A; Heshmati Y; Seashore-Ludlow B; Danda AN; Gad H; Wiita E; Gokturk C; Rasti A; Friedrich S; Centio A; Estruch M; Vatsveen TK; Struyf N; Visnes T; Scobie M; Koolmeister T; Henriksson M; Wallner O; Sandvall T; Lehmann S; Theilgaard-Monch K; Garnett MJ; Ostling P; Walfridsson J; Helleday T; Berglund UW
Article: MOLECULAR CANCER RESEARCH. 2020;18(10):1522-1533
HCN Channel Activity Balances Quiescence and Proliferation in Neural Stem Cells and Is a Selective Target for Neuroprotection During Cancer Treatment
Johard H; Omelyanenko A; Fei G; Zilberter M; Dave Z; Abu-Youssef R; Schmidt L; Harisankar A; Vincent CT; Walfridsson J; Nelander S; Harkany T; Blomgren K; Andang M
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: SCIENTIFIC REPORTS. 2018;8(1):11202
The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation
Heshmati Y; Kharazi S; Turkoz G; Chang D; Dolatabadi EK; Bostrom J; Krstic A; Boukoura T; Wagner E; Kadri N; Mansson R; Altun M; Qian H; Walfridsson J
Article: HAEMATOLOGICA. 2018;103(7):1169-1181
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia
Heshmati Y; Turkoz G; Harisankar A; Kharazi S; Bostrom J; Dolatabadi EK; Krstic A; Chang D; Mansson R; Altun M; Qian H; Walfridsson J
Article: BLOOD ADVANCES. 2018;2(12):1480-1494
Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice
Xiao P; Sandhow L; Heshmati Y; Kondo M; Bouderlique T; Dolinska M; Johansson A-S; Sigvardsson M; Ekblom M; Walfridsson J; Qian H
Article: BLOOD ADVANCES. 2018;2(5):534-548
Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm
Xiao P; Dolinska M; Sandhow L; Kondo M; Johansson A-S; Bouderlique T; Zhao Y; Li X; Dimitriou M; Rassidakis GZ; Hellstrom-Lindberg E; Minato N; Walfridsson J; Scadden DT; Sigvardsson M; Qian H
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2018;117:247-257
Selenite and methylseleninic acid epigenetically affects distinct gene sets in myeloid leukemia: A genome wide epigenetic analysis
Khalkar P; Ali HA; Codo P; Diaz Argelich N; Martikainen A; Arzenani MK; Lehmann S; Walfridsson J; Ungerstedt J; Fernandes AP
Article: NATURE MEDICINE. 2017;23(2):256-263
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: DRUG DESIGN DEVELOPMENT AND THERAPY. 2016;10:2881-2897
Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design
Masoumi S; Harisankar A; Gracias A; Bachinger F; Fufa T; Chandrasekar G; Gaunitz F; Walfridsson J; Kitambi SS
Article: CYTOTHERAPY. 2015;17(12):1732-1745
Xeno-immunosuppressive properties of human decidual stromal cells in mouse models of alloreactivity in vitro and in vivo
Sadeghi B; Heshmati Y; Khoein B; Kaipe H; Uzunel M; Walfridsson J; Ringden O
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;171(4):478-490
Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts
Conte S; Katayama S; Vesterlund L; Karimi M; Dimitriou M; Jansson M; Mortera-Blanco T; Unneberg P; Papaemmanuil E; Sander B; Skoog T; Campbell P; Walfridsson J; Kere J; Hellstrom-Lindberg E
Article: STEM CELL REPORTS. 2014;3(3):502-515
Neural Stem Cell Differentiation Is Dictated by Distinct Actions of Nuclear Receptor Corepressors and Histone Deacetylases
Castelo-Branco GG; Lilja T; Wallenborg K; Falcao AM; Marques SC; Gracias A; Solum D; Paap R; Walfridsson J; Teixeira AI; Rosenfeld MG; Jepsen K; Hermanson O
Article: BLOOD. 2014;123(12):1870-1882
shRNA screening identifies JMJD1C as being required for leukemia maintenance
Sroczynska P; Cruickshank VA; Bukowski J-P; Miyagi S; Bagger FO; Walfridsson J; Schuster MB; Porse B; Helin K
Article: PLOS GENETICS. 2011;7(3):e1001334
The FUN30 Chromatin Remodeler, Fft3, Protects Centromeric and Subtelomeric Domains from Euchromatin Formation
Stralfors A; Walfridsson J; Bhuiyan H; Ekwall K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(39):29729-29737
A Chromatin-remodeling Protein Is a Component of Fission Yeast Mediator
Khorosjutina O; Wanrooij PH; Walfridsson J; Szilagyi Z; Zhu X; Baraznenok V; Ekwall K; Gustafsson CM
Article: NUCLEIC ACIDS RESEARCH. 2010;38(15):4958-4969
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.
Pasini D; Malatesta M; Jung HR; Walfridsson J; Willer A; Olsson L; Skotte J; Wutz A; Porse B; Jensen ON; Helin K
Article: NATURE. 2010;464(7286):306-310
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
Pasini D; Cloos PAC; Walfridsson J; Olsson L; Bukowski J-P; Johansen JV; Bak M; Tommerup N; Rappsilber J; Helin K
Article: CANCER RESEARCH. 2009;69(21):8491-8498
ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.
Ciró M; Prosperini E; Quarto M; Grazini U; Walfridsson J; McBlane F; Nucifero P; Pacchiana G; Capra M; Christensen J; Helin K
Article: EMBO JOURNAL. 2007;26(12):2868-2879
A genome-wide role for CHD remodelling factors and Nap1 in nucleosome disassembly
Walfridsson J; Khorosjutina O; Matikainen P; Gustafsson CM; Ekwall K
Article: PLOS ONE. 2007;2(4):e386
Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1
Opel M; Lando D; Bonilla C; Trewick SC; Boukaba A; Walfridsson J; Cauwood J; Werler PJH; Carr AM; Kouzarides T; Murzina NV; Allshire RC; Ekwall K; Laue ED
Article: GENETICS. 2007;175(4):1549-1560
Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe
Isaac S; Walfridsson J; Zohar T; Lazar D; Kahan T; Ekwall K; Cohen A
Article: EMBO JOURNAL. 2005;24(16):2906-2918
Genome wide analysis of nucleosome density histone acetylation and HDAC function in fission yeast
Wirén M; Silverstein RA; Sinha I; Walfridsson J; Lee HM; Laurenson P; Pillus L; Robyr D; Grunstein M; Ekwall K
Article: NUCLEIC ACIDS RESEARCH. 2005;33(9):2868-2879
The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres
Walfridsson J; Bjerling P; Thalen M; Yoo EJ; Park SD; Ekwall K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):16648-16653
Dicer is required for chromosome segregation and gene silencing in fission yeast cells
Provost P; Silverstein RA; Dishart D; Walfridsson J; Djupedal I; Kniola B; Wright A; Samuelsson B; Rådmark O; Ekwall K
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Corrigendum: NUCLEIC ACIDS RESEARCH. 2021;49(15):9000-9001
Correction to 'Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes'.
Pasini D; Malatesta M; Jung HR; Walfridsson J; Willer A; Olsson L; Skotte J; Wutz A; Porse B; Jensen ON; Helin K
Other: CELL. 2017;170(2):407
Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule (Retraction of Vol 157, Pg 313, 2014)
Kitambi SS; Toledo EM; Usoskin D; Wee S; Harisankar A; Svensson R; Sigmundsson K; Kalderen C; Niklasson M; Kundu S; Aranda S; Westermark B; Uhrbom L; Andang M; Damberg P; Nelander S; Arenas E; Artursson P; Walfridsson J; Nilsson KF; Hammarstrom LGJ; Ernfors P
Doctoral thesis: 2007
The CHD chromatin remodeling factors in Schizosaccharomyces pombe
Walfridsson J

Anställningar

Anknuten till Forskning, Medicin, Huddinge, Karolinska Institutet, 2025-2026
Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-2025

Examina och utbildning

Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2021
FILOSOFIE DOKTOR, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2007

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