John Inge Johnsen | Karolinska Institutet

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: CANCER LETTERS. 2024;605:217261
The ROCK-1/2 inhibitor RKI-1447 blocks N-MYC, promotes cell death, and emerges as a synergistic partner for BET inhibitors in neuroblastoma
Pepich A; Tummler C; Abu Ajamieh S; Treis D; Boje AS; Vellema Q; Tsea I; Akerlund E; Seashore-Ludlow B; Fard SS; Kogner P; Johnsen JI; Wickstrom M
Journal article: CANCER RESEARCH. 2024;84(17):b060
Clonal composition of αβ and γδ T cells in primary human neuroblastoma tumors - Is every child unique?
Verhoeven BM; Ye K; Stenman J; Kogner P; Johnsen JI; Reina OB; Kreslavskiy T; Baryawno N
Article: MOLECULAR CANCER. 2024;23(1):180
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
Article: NUCLEIC ACIDS RESEARCH (NAR). 2024;52(5):2648-2671
METTL3 drives telomere targeting of TERRA lncRNA through m⁶A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma
Vaid R; Thombare K; Mendez A; Burgos-Panadero R; Djos A; Jachimowicz D; Lundberg KI; Bartenhagen C; Kumar N; Tummler C; Sihlbom C; Fransson S; Johnsen JI; Kogner P; Martinsson T; Fischer M; Mondal T
Article: CANCERS. 2024;16(4):812
Recent Advances in Neuroblastoma Research
Johnsen JI; Kogner P
Article: JCI INSIGHT. 2024;9(6):e173337
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic
Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickstrom M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
Article: GENOME MEDICINE. 2024;16(1):1
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
Mei S; Alchahin AM; Tsea I; Kfoury Y; Hirz T; Jeffries NE; Zhao T; Xu Y; Zhang H; Sarkar H; Wu S; Subtelny AO; Johnsen JI; Zhang Y; Salari K; Wu C-L; Randolph MA; Scadden DT; Dahl DM; Shin J; Kharchenko PV; Saylor PJ; Sykes DB; Baryawno N
Article: CANCERS. 2023;15(18):4599
Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development
Yuan Y; Alzrigat M; Rodriguez-Garcia A; Wang X; Bexelius TS; Johnsen JI; Arsenian-Henriksson M; Liano-Pons J; Bedoya-Reina OC
Journal article: NEURO-ONCOLOGY. 2023;25(Suppl 1):i62
MDB-04. SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
Article: BRITISH JOURNAL OF CANCER. 2022;127(11):2060-2071
Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
Zhou X; Santos GS; Zhan Y; Oliveira MMS; Rezaei S; Singh M; Peuget S; Westerberg LS; Johnsen JI; Selivanova G
Article: JCI INSIGHT. 2022;7(17):e153836
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tummler C; Myrberg IH; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
Article: CELL REPORTS MEDICINE. 2022;3(6):100657
The immune cell atlas of human neuroblastoma
Verhoeven BM; Mei S; Olsen TK; Gustafsson K; Valind A; Lindstrom A; Gisselsson D; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1677
Abstract 1677: Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):6215
Abstract 6215: The immune cell atlas of human neuroblastoma
Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindström A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Article: LIFE SCIENCES. 2022;295:120394
Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E₂ and suppress tumor growth in medulloblastoma
Ljungblad L; Bergqvist F; Tummler C; Madawala S; Olsen TK; Andonova T; Jakobsson P-J; Johnsen JI; Pickova J; Strandvik B; Kogner P; Gleissman H; Wickstrom M
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(3):182-201
MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickstrom M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(7):3702
The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma
Rasheed K; Moens U; Policastro B; Johnsen JI; Koljonen V; Sihto H; Lui W-O; Sveinbjornsson B
Article: NATURE COMMUNICATIONS. 2022;13(1):1537
GIT1 protects against breast cancer growth through negative regulation of Notch
Zhang S; Miyakawa A; Wickstrom M; Dyberg C; Louhivuori L; Varas-Godoy M; Kemppainen K; Kanatani S; Kaczynska D; Ellstrom ID; Elfman L; Kronqvist P; Repo H; Mikoshiba K; Sahlgren C; Johnsen JI; Uhlen P
Article: BMC GENOMICS. 2022;23(1):149
TC-hunter: identification of the insertion site of a transgenic gene within the host genome
Borjesson V; Martinez-Monleon A; Fransson S; Kogner P; Johnsen JI; Milosevic J; Lopez MD
Article: JCO PRECISION ONCOLOGY. 2022;6:e2100271
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation
Treis D; Umapathy G; Fransson S; Guan J; Mendoza-Garcia P; Siaw JT; Wessman S; Murkes LG; Stenman JJE; Djos A; Elfman LHM; Johnsen JI; Hallberg B; Palmer RH; Martinsson T; Kogner P
Article: NEURO-ONCOLOGY ADVANCES. 2022;4(1):vdac028
Filamin A increases aggressiveness of human neuroblastoma
Bandaru S; Prajapati B; Juvvuna PK; Dosa S; Kogner P; Johnsen JI; Kanduri C; Akyurek LM
Article: CANCER DISCOVERY. 2021;11(12):3090-3105
Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity
Zhou X; Singh M; Santos GS; Guerlavais V; Carvajal LA; Aivado M; Zhan Y; Oliveira MMS; Westerberg LS; Annis DA; Johnsen JI; Selivanova G
Article: CANCERS. 2021;13(23):6042
PPM1D Is a Therapeutic Target in Childhood Neural Tumors
Milosevic J; Treis D; Fransson S; Gallo-Oller G; Sveinbjoernsson B; Eissler N; Tanino K; Sakaguchi K; Martinsson T; Wickstroem M; Kogner P; Johnsen JI
Article: CANCERS. 2021;13(21):5493
High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice
Milosevic J; Fransson S; Gulyas M; Olsen TK; Gallo-Oller G; Treis D; Elfman LHM; Wilhelm M; Martinsson T; Baryawno N; Kogner P; Johnsen JI
Article: CELL DEATH AND DISEASE. 2021;12(10):914
Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
Giovannucci TA; Salomons FA; Haraldsson M; Elfman LHM; Wickstroem M; Young P; Lundbaeck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma NP
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2021;169:102285
Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children.
Ljungblad L; Gleissman H; Hedberg G; Wickstrom M; Eissler N; Pickova J; Johnsen JI; Tedroff K; Strandvik B; Kogner P
Article: CANCER RESEARCH. 2021;81(6):1457-1471
Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma
Mitra S; Muralidharan SV; Di Marco M; Juvvuna PK; Kosalai ST; Reischl S; Jachimowicz D; Subhash S; Raimondi I; Kurian L; Huarte M; Kogner P; Fischer M; Johnsen JI; Mondal T; Kanduri C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(33):20127-20138
Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
Susanto E; Navarro AM; Zhou L; Sundstrom A; van Bree N; Stantic M; Moslem M; Tailor J; Rietdijk J; Zubillaga V; Huebner J-M; Weishaupt H; Wolfsberger J; Alafuzoff I; Nordgren A; Magnaldo T; Siesjo P; Johnsen JI; Kool M; Tammimies K; Darabi A; Swartling FJ; Falk A; Wilhelm M
Article: THE FASEB JOURNAL. 2020;34(8):11101-11114
Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting
Kock A; Bergqvist F; Steinmetz J; Elfman LHM; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P; Larsson K
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872
Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures
Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjoholm LK; Dahlstrom J; Sjoberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekstrom TJ; Bjorkholm M; Straat K
Article: CANCERS. 2019;12(1):E73-73
Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth
Dyberg C; Andonova T; Olsen TK; Brodin B; Kool M; Kogner P; Johnsen JI; Wickstrom M
Article: ONCOGENE. 2019;38(15):2800-2813
Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma
Hald OH; Olsen L; Gallo-Oller G; Elfman LHM; Lokke C; Kogner P; Sveinbjornsson B; Flaegstad T; Johnsen JI; Einvik C
Article: CANCERS. 2019;11(2):E202-202
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells In Vitro
Tummler C; Dumitriu G; Wickstrom M; Coopman P; Valkov A; Kogner P; Johnsen JI; Moens U; Sveinbjornsson B
Article: CANCER LETTERS. 2019;442:341-350
RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism
Azatyan A; Gallo-Oller G; Diao Y; Selivanova G; Johnsen JI; Zaphiropoulos PG
Article: EBIOMEDICINE. 2018;32:84-92
Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
Kock A; Larsson K; Bergqvist F; Eissler N; Elfman LHM; Raouf J; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P
Article: PHARMACOLOGICAL RESEARCH. 2018;131:164-176
Molecular mechanisms and therapeutic targets in neuroblastoma
Johnsen JI; Dyberg C; Fransson S; Wickstrom M
Article: ONCOTARGET. 2017;8(56):95135-95151
Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
Tummler C; Snapkov I; Wickstrom M; Moens U; Ljungblad L; Elfman LHM; Winberg J-O; Kogner P; Johnsen JI; Sveinbjornsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(32):E6603-E6612
Rho-associated kinase is a therapeutic target in neuroblastoma
Dyberg C; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Olsen TK; Forsberg D; Herlenius E; Martinsson T; Brodin B; Kogner P; Johnsen JI; Wickstrom M
Journal article: CANCER RESEARCH. 2017;77:687
Targeting tumor-promoting neuroblastoma microenvironment: inhibiton of tumor development and progression by targeting mPGES-1 expressed by cancer associated fibroblasts
Kock A; Larsson K; Eissler N; Bergqvist F; Rauf J; Korotkova M; Johnsen J-I; Jakobsson P-J; Kogner P
Journal article: CANCER RESEARCH. 2017;77:1945
PPM1D/Wip1, promising new target in childhood cancers neuroblastoma and medulloblastoma
Milosevic J; Eissler N; Treis D; Wicktrom M; Fransson S; Sveinbjornsson B; Baryawno N; Kosalai S; Kanduri C; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Article: SCIENTIFIC REPORTS. 2017;7:46366
Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation
Sanden E; Dyberg C; Krona C; Gallo-Oller G; Olsen TK; Perez JE; Wickstrom M; Estekizadeh A; Kool M; Visse E; Ekstrom TJ; Siesjo P; Johnsen JI; Darabi A
Article: CLINICAL CANCER RESEARCH. 2016;22(15):3849-3859
Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma
Mao Y; Eissler N; Le Blanc K; Johnsen JI; Kogner P; Kiessling R
Article: CELL REPORTS. 2016;16(4):979-993
Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients
Ribeiro D; Klarqvist MDR; Westermark UK; Oliynyk G; Dzieran J; Kock A; Banares CS; Hertwig F; Johnsen JI; Fischer M; Kogner P; Loven J; Henriksson MA
Article: BMC CANCER. 2016;16:490
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
Snapkov I; Oqvist CO; Figenschau Y; Kogner P; Johnsen JI; Sveinbjornsson B
Journal article: CANCER RESEARCH. 2016;76:761
Specific inhibition of prostaglandin E2 production in medulloblastoma
Bergqvist F; Ljungblad L; Wickstrom M; Larsson K; Kock A; Korotkova M; Johnsen JI; Kogner P; Jakobsson P-J
Journal article: CANCER RESEARCH. 2016;76:2454
Omega-3 fatty acids DHA and EPA decrease oncogenic PGE2 in medulloblastoma in vitro and in vivo
Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Kogner P; Wickstrom M
Journal article: CANCER RESEARCH. 2016;76:2465
Spleen tyrosine kinase (SYK) in neuroblastoma tumorigenesis
Tuemmler C; Dumitriu G; Cserna J; Moens UL; Kogner P; Johnsen JI; Sveinbjornsson B
Journal article: NEURO-ONCOLOGY. 2016;18(suppl_3):iii116
MB-83OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA
Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Gleissman H; Kogner P; Wickström M
Journal article: NEURO-ONCOLOGY. 2016;18(Suppl 3):iii116
MB-83OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA
Article: BMC CANCER. 2016;16:259
Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma
Dyberg C; Papachristou P; Haug BH; Lagercrantz H; Kogner P; Ringstedt T; Wickstrom M; Johnsen JI
Article: MOLECULAR & CELLULAR ONCOLOGY. 2016;3(2):e1131356
Wingless/β-catenin signaling as a modulator of chemoresistance in cancer.
Johnsen JI; Wickström M; Baryawno N
Article: DEVELOPMENTAL CELL. 2016;36(2):164-178
The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis
Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
Article: ONCOIMMUNOLOGY. 2016;5(12):e1232222
Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade
Eissler N; Mao Y; Brodin D; Reutersward P; Svahn HA; Johnsen JI; Kiessling R; Kogner P
Article: NATURE COMMUNICATIONS. 2015;6:8904
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
Wickstrom M; Dyberg C; Milosevic J; Einvik C; Calero R; Sveinbjornsson B; Sanden E; Darabi A; Siesjo P; Kool M; Kogner P; Baryawno N; Johnsen JI
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075
COX/mPGES-1/PGE₂ pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
Larsson K; Kock A; Idborg H; Henriksson MA; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J
Article: JOURNAL OF NEURO-ONCOLOGY. 2015;123(1):1-13
Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas
Sanden E; Dyberg C; Krona C; Visse E; Caren H; Northcott PA; Kool M; Stahl N; Persson A; Englund E; Johnsen JI; Siesjo P; Darabi A
Journal article: LINDBERGIA. 2015;38(1):30-38
Porella obtusata: distribution, ecology and threats at the west coast of Norway, the northern fringe of its European distribution
Hassel K; Johnsen JI; Jordal JB; Knutsen A
Article: BMC CANCER. 2014;14:600
The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling
Diao Y; Rahman MF-U; Villegas VE; Wickstrom M; Johnsen JI; Zaphiropoulos PG
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605
Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth
Marino A-M; Frijhoff J; Calero R; Baryawno N; Ostman A; Johnsen JI
Article: CANCER DISCOVERY. 2014;4(4):434-451
RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma
Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2014;106(3):djt459
Protective Role of Humanin on Bortezomib-Induced Bone Growth Impairment in Anticancer Treatment
Eriksson E; Wickstrom M; Perup LS; Johnsen JI; Eksborg S; Kogner P; Savendahl L
Journal article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2014;2(Suppl 3):p203
Immune suppression by myeloid-derived suppressor cells, MDSCs, in MYCN-driven neuroblastoma provides a potential target for cancer immunotherapy
Eissler N; Sveinbjörnsson B; Kock A; Johnsen JI; Kogner P
Article: PLOS ONE. 2014;9(4):e95628
Sunitinib Suppress Neuroblastoma Growth through Degradation of MYCN and Inhibition of Angiogenesis
Calero R; Morchon E; Johnsen JI; Serrano R
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(10):2351-2361
Frequent detection of human cytomegalovirus in neuroblastoma: A novel therapeutic target?
Wolmer-Solberg N; Baryawno N; Rahbar A; Fuchs D; Odeberg J; Taher C; Wilhelmi V; Milosevic J; Mohammad A-A; Martinsson T; Sveinbjornsson B; Johnsen JI; Kogner P; Soederberg-Naucler C
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;43(3):831-838
Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme
Jamil S; Cedervall J; Hultman I; Ali R; Margaryan NV; Rasmuson A; Johnsen JI; Sveinbjornsson B; Dalianis T; Kanter L; Orrego A; Strizzi L; Hendrix MJC; Sandstedt B; Kogner P; Ahrlund-Richter L
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):2751
Abstract 2751: Wnt/β-catenin regulates the expression of MGMT through TCF/LEF transcription: new strategy for DNA alkylators in cancer therapy.
Wickström M; Baryawno N; Dyberg C; Milosevic J; Sveinbjörnsson B; Northcott PA; Taylor M; Kool M; Kogner P; Johnsen JI
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):2746
Abstract 2746: Microsomal prostaglandin E2 synthase-1 may provide a novel specific therapeutic target in neuroblastoma.
Kock A; Rasmuson A; Korotkova M; Idborg H; Johnsen JI; Jakobsson P-J; Kogner P
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;42(4):1239-1248
Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis
Pettersen I; Baryawno N; Abel F; Bakkelund WH; Zykova SN; Winberg J-O; Moens U; Rasmuson A; Kogner P; Johnsen JI; Sveinbjornsson B
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
Wickstrom M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevag OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
Article: BMC MEDICAL GENETICS. 2012;13:83
Quantitative global and gene-specific promoter methylation in relation to biological properties of neuroblastomas
Kiss NB; Kogner P; Johnsen JI; Martinsson T; Larsson C; Geli J
Article: BRITISH JOURNAL OF CANCER. 2012;106(11):1807-1815
Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase
Hiyoshi H; Abdelhady S; Segerstrom L; Sveinbjornsson B; Nuriya M; Lundgren TK; Desfrere L; Miyakawa A; Yasui M; Kogner P; Johnsen JI; Andang M; Uhlen P
Article: PLOS ONE. 2012;7(12):e51297
Tumor Development, Growth Characteristics and Spectrum of Genetic Aberrations in the TH-MYCN Mouse Model of Neuroblastoma
Rasmuson A; Segerstrom L; Nethander M; Finnman J; Elfman LHM; Javanmardi N; Nilsson S; Johnsen JI; Martinsson T; Kogner P
Article: PLOS ONE. 2012;7(1):e29331
Autocrine Prostaglandin E₂ Signaling Promotes Tumor Cell Survival and Proliferation in Childhood Neuroblastoma
Rasmuson A; Kock A; Fuskevag OM; Kruspig B; Simon-Santamaria J; Gogvadze V; Johnsen JI; Kogner P; Sveinbjornsson B
Article: ONCOTARGET. 2011;2(12):1329-1338
Is human cytomegalovirus a target in cancer therapy?
Johnsen JI; Baryawno N; Soderberg-Naucler C
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;129(12):2958-2965
Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo
Segerstrom L; Baryawno N; Sveinbjornsson B; Wickstrom M; Elfman L; Kogner P; Johnsen JI
Article: CANCER LETTERS. 2011;310(2):222-231
Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+cell compartment and the in vitro tumorigenic capability of neuroblastoma cells
Schiapparelli P; Shahi MH; Enguita-German M; Johnsen JI; Kogner P; Lazcoz P; Castresana JS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):4043-4055
Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target
Baryawno N; Rahbar A; Wolmer-Solberg N; Taher C; Odeberg J; Darabi A; Khan Z; Sveinbjornsson B; Fuskevag O-M; Segerstrom L; Nordenskjold M; Siesjo P; Kogner P; Johnsen JI; Soderberg-Naucler C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):208-212
Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models
Marino A-M; Sofiadis A; Baryawno N; Johnsen JI; Larsson C; Vukojevic V; Ekstrom TJ
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(7):1703-1711
Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo
Gleissman H; Segerstrom L; Hamberg M; Ponthan F; Lindskog M; Johnsen JI; Kogner P
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(3):843-849
Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts
Philipova T; Baryawno N; Hartmann W; Pietsch T; Drud H; Johnsen JI; Ekstrom TJ
Article: CELL CYCLE. 2010;9(13):2548-2554
Medulloblastoma A disease with disorganized developmental signaling cascades
Baryawno N; Sveinbjornsson B; Kogner P; Johnsen JI
Journal article: CANCER RESEARCH. 2010;70(8_Supplement):4354
Abstract 4354: Celecoxib reduces MGMT expression and potentiates the effect of temozolomide in childhood medulloblastoma
Baryawno N; Milosevic J; Wickström M; Sveinbjörnsson B; Eksborg S; Kogner P; Johnsen JI
Article: THE FASEB JOURNAL. 2010;24(3):906-915
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates
Gleissman H; Yang R; Martinod K; Lindskog M; Serhan CN; Johnsen JI; Kogner P
Journal article: ECANCERMEDICALSCIENCE. 2010;4:156
Might salicylate exert benefits against childhood cancer?
Morgan G; Johnsen J
Article: CANCER RESEARCH. 2010;70(1):266-276
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
Baryawno N; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen JI
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;124(5):1227-1234
Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo
Paimberg E; Johnsen JI; Paulsson J; Gleissman H; Wickstrom M; Edgren M; Ostman A; Kogner P; Lindskog M
Article: NEURO-ONCOLOGY. 2008;10(5):661-674
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E₂ pathway provides medulloblastoma therapeutic targets
Baryawno N; Sveinbjornsson B; Eksborg S; Orrego A; Segerstrom L; Oqvist CO; Holm S; Gustavsson B; Kagedal B; Kogner P; Johnsen JI
Article: THE FASEB JOURNAL. 2008;22(10):3525-3536
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
Sveinbjornsson B; Rasmuson A; Baryawno N; Wan M; Pettersen I; Ponthan F; Orrego A; Haeggstrom JZ; Johnsen JI; Kogner P
Article: ONCOGENE. 2008;27(20):2910-2922
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
Johnsen JI; Segerstrom L; Orrego A; Elfman L; Henriksson M; Kagedal B; Eksborg S; Sveinbjornsson B; Kogner P
Article: MOLECULAR CANCER THERAPEUTICS. 2007;6(9):2409-2417
The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo
Wickstrom M; Johnsen JI; Ponthan F; Segerstrom L; Sveinbjornsson B; Lindskog M; Lovborg H; Viktorsson K; Lewensohn R; Kogner P; Larsson R; Gullbo J
Article: CLINICAL CANCER RESEARCH. 2007;13(3):1036-1044
Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo
Ponthan F; Wickstroem M; Gleissman H; Fuskevag OM; Segerstroem L; Sveinbjoernsson B; Redfern CPF; Eksborg S; Kogner P; Johnsen JI
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;119(3):493-500
The antimicrobial peptide, Lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo
Eliassen LT; Berge G; Leknessund A; Wikman M; Lindin I; Lokke C; Ponthan F; Johnsen JI; Sveinbjornsson B; Kogner P; Flægstad T; Rekdal O
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;118(10):2584-2593
Neuroblastoma cell death in response to docosahexaenoic acid: Sensitization to chemotherapy and arsenic-induced oxidative stress
Lindskog M; Gleissman H; Ponthan F; Castro J; Kogner P; Johnsen JI
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;25(6):1849-1857
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-γ and TRAIL
Johnsen JI; Pettersen I; Ponthan F; Sveinbjornsson B; Flægstad T; Kogner P
Article: CANCER RESEARCH. 2004;64(20):7210-7215
Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo
Johnsen JI; Lindskog M; Ponthan F; Pettersen I; Elfman L; Orrego A; Sveinbjörnsson B; Kogner P
Article: JOURNAL OF MEDICAL VIROLOGY. 2003;70(1):14-19
Identification of a unique BK virus variant in the CNS of a patient with AIDS
Jorgensen GEK; Hammarin AL; Bratt G; Grandien M; Flægstad T; Johnsen JI
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;104(4):418-424
The synthetic retinoid Ro 13-6307 induces neuroblastoma differentiation in vitro and inhibits neuroblastoma tumour growth in vivo
Ponthan F; Johnsen JI; Klevenvall L; Castro J; Kogner P
Article: ANTICANCER RESEARCH. 2001;21(6A):3733-3738
Interferon-γ modulates TRAIL-mediated apoptosis in human colon carcinoma cells
Langaas V; Shahzidi S; Johnsen JI; Smedsrod B; Sveinbjornsson B
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;88(5):685-691
p53-mediated negative regulation of stathmin/Op18 expression is associated with G₂/M cell-cycle arrest
Johnsen JI; Aurelio ON; Kwaja Z; Jörgensen GE; Pellegata NS; Plattner R; Stanbridge EJ; Cajot JF
Article: CANCER RESEARCH. 1999;59(5):1160-1163
A possible contributory role of BK virus infection in neuroblastoma development
Flægstad T; Andresen PA; Johnsen JI; Asomani SK; Jorgensen GE; Vignarajan S; Kjuul A; Kogner P; Traavik T
Article: VIRUS RESEARCH. 1997;52(1):61-71
The human polyomavirus BK T antigen induces gene expression in human cytomegalovirus
Kristoffersen AK; Johnsen JI; Seternes OM; Rollag H; Degré M; Traavik T
Article: NUCLEIC ACIDS RESEARCH (NAR). 1996;24(11):2158-2165
Isolation and characterization of the QM promoter
Farmer AA; Johnsen JI; Loftus TM; Smith KP; Stanbridge EJ
Article: JOURNAL OF GENERAL VIROLOGY. 1995;76:1571-1581
SUBPOPULATIONS OF NONCODING CONTROL REGION VARIANTS WITHIN A CELL CULTURE-PASSAGED STOCK OF BK VIRUS - SEQUENCE COMPARISONS AND BIOLOGICAL CHARACTERISTICS
JOHNSEN JI; SETERNES OM; JOHANSEN T; MOENS U; MANTYJARVI R; TRAAVIK T
Journal article: JOURNAL OF IMMUNOLOGICAL METHODS. 1994;173(2):149-156
A 2-FUSION PARTNER SYSTEM FOR RAISING ANTIBODIES AGAINST SMALL IMMUNOGENS EXPRESSED IN BACTERIA
HEY AW; JOHNSEN JI; JOHANSEN B; TRAAVIK T
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Review: CANCERS. 2024;16(10):1863
The Neuroblastoma Microenvironment, Heterogeneity and Immunotherapeutic Approaches
Polychronopoulos PA; Bedoya-Reina OC; Johnsen JI
Preprint: BIORXIV. 2024
Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing
van Bree N; Oppelt A-S; Lindström S; Zhou L; Boutin L; Johnsen JI; Bräutigam L; Wilhelm M
Conference publication: NEURO-ONCOLOGY. 2023;25:i62
SINGLE-CELL TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT GENOMIC LANDSCAPES, CELL TRAJECTORIES, AND TUMOUR-MICROENVIRONMENT INTERACTIONS IN FOUR SUBTYPES OF MEDULLOBLASTOMA
Ruchiy Y; Tsea I; Verhoeven BM; Sinha I; Preka E; Olsen TK; Mei S; Blomgren K; Johnsen JI; Carlson L-M; Dyberg C; Baryawno N
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Materials and Methods, Figures 1-6 from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Supplementary Materials and Methods, Figures 1-6 from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from MYCMI-7: A Small MYC-Binding Compound that Inhibits MYC: MAX Interaction and Tumor Growth in a MYC-Dependent Manner
Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickström M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
Conference publication: CANCER SCIENCE. 2023;114:249
Pharmacological activation of p53 triggers viral mimicry response thereby promoting anti-tumor immunity
Selivanova G; Zhou X; Singh M; Sanz G; Guerlavais V; Carvajal LA; Aivado M; Annis A; Zhan Y; Oliveira M; Westerberg L; Johnsen JI
Conference publication: PEDIATRIC BLOOD AND CANCER. 2023;70:S107
EXPANSION OF VD1+GAMMA DELTA T CELLS IN HUMAN NEUROBLASTOMA TUMORS REVEALS NOVEL POSSIBILITIES FOR IMMUNOTHERAPY
Verhoeven BM; Ye K; Stenman J; Kogner P; Johnsen JI; Baryawno N; Kreslavskiy T
Preprint: BIORXIV. 2022
METTL3 drives telomere targeting of TERRA lncRNA through m⁶A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma
Vaid R; Thombare K; Mendez A; Burgos-Panadero R; Djos A; Jachimowicz D; Lundberg KI; Bartenhagen C; Kumar N; Tümmler C; Sihlbom C; Fransson S; Johnsen JI; Kogner P; Martinsson T; Fischer M; Mondal T
Review: CURRENT ONCOLOGY REPORTS. 2022;24(8):1053-1062
Neuroblastoma Heterogeneity, Plasticity, and Emerging Therapies
Lundberg KI; Treis D; Johnsen JI
Conference publication: CANCER RESEARCH. 2022;82(12)
Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
The immune cell atlas of human neuroblastoma
Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindstrom A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
The immune cell atlas of human neuroblastoma.
Verhoeven BM; Mei S; Olsen TK; Gustafsson KK; Valind A; Lindstrom A; Nord DG; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S230
NOVEL DRUG COMBINATIONS FOR NEUROBLASTOMA THERAPY - EXPLORING THE FULL POTENTIAL OF THE ROCK2-SPECIFIC INHIBITOR KD025
Tummler C; Pepich A; Vellema Q; Abu Ajamieh S; Park SW; Ljungblad L; Seashore-Ludlow B; Karlsson K; Kogner P; Johnsen JI; Nasman MW
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S226
SCHWANN CELL PRECURSORS IS THE CELL-OF-ORIGIN IN HUMAN NEUROBLASTOMA
Otte J; Olsen T; Mei S; Kameneva P; Embaie BT; Bjorklund A; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Cheng H; Zachariadis V; Enge M; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S211-S212
SINGLE CELL ANALYSIS OF HUMAN BONE METASTATIC NEUROBLASTOMA UNRAVELS EMERGING IMMUNE CELL POPULATIONS IN THE BONE MARROW
Alchahin A; Embaie BT; Mei S; Verhoeven BM; Olsen T; Kharchenko P; Johnsen JI; Kogner P; Baryawno N
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S211
CHARACTERIZATION OF TENEURIN-4 AND ITS ROLE IN NEUROBLASTOMA TUMORIGENESIS
Abu Ajamieh S; Andonova T; Pepich A; Olsen T; Tummler C; Thankaswamy-Kosalai S; Kanduri C; Fransson S; Martinsson T; Baryawno N; Nasman A; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S227
COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH COMBINATIONAL TREATMENT WITH ROCK INHIBITOR RKI-1447 AND BET INHIBITORS SYNERGISTICALLY IMPAIRS NEUROBLASTOMA GROWTH
Pepich A; Tummler C; Abu Ajamieh S; Vellema Q; Akerlund E; Treis D; Seashore-Ludlow B; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S229-S230
INVESTIGATING THE INTERACTIONS OF DISTINCT TUMOR SUBPOPULATIONS IN HUMAN NEUROBLASTOMA USING SINGLE-CELL RNASEQ AND NOVEL SPATIAL MULTI-OMICS
Tsea I; Olsen T; Otte J; Mei S; Embaie BT; Kogner P; Johnsen JI; Baryawno N; Fard S
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S229
SYNERGISTIC EFFECT OF WIP1 INHIBITOR SL-176 AND H3K27 DEMETHYLASE INHIBITOR GSK-J4 ON NEUROBLASTOMA CELLS AND SPHEROIDS
Treis D; Tummler C; Kogner P; Johnsen JI; Nasman MW
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69
THE IMMUNE CELL ATLAS OF HUMAN NEUROBLASTOMA
Verhoeven BM; Mei S; Olsen T; Gustafsson K; Valind A; Nord DG; Fard S; Hagerling C; Kharchenko P; Kogner P; Johnsen JI; Baryawno N
Preprint: BIORXIV. 2021
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie B; Alchahin A; Milosevic J; Otte J; Tümmler C; Myrberg IH; Westerhout E; Koster J; Versteeg R; Kogner P; Johnsen JI; Sykes D; Baryawno N
Preprint: BIORXIV. 2021
Inhibition of the ubiquitin-proteasome system by a bioactivatable compound
Giovannucci T; Salomons F; Haraldsson M; Elfman L; Wickström M; Young P; Lundbäck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma N
Preprint: BIORXIV. 2020
PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors
Milosevic J; Fransson S; Gulyas M; Gallo-Oller G; Olsen T; Treis D; Wickström M; Elfman LHM; Sveinbjornsson B; Hertwig F; Bartenhagen C; Reinsbach S; Wilhelm M; Abel F; Javanmardi N; Thankaswamy-Kosalai S; Eissler N; Kock A; Shi Y; Tanino K; Hehir-Kwa J; Mensenkamp A; Tytgat GAM; Kanduri C; Holmberg J; Gisselsson D; Molenaar J; Jongmans M; Fischer M; Kool M; Sakaguchi K; Baryawno N; Martinsson T; Johnsen JI; Kogner P
Preprint: BIORXIV. 2020
Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma
Olsen T; Otte J; Mei S; Kameneva P; Björklund Å; Kryukov E; Hou Z; Johansson A; Sundström E; Martinsson T; Fransson S; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Preprint: SSRN ELECTRONIC JOURNAL. 2020
Inhibition of the Ubiquitin-Proteasome System by a Bioactivatable Prodrug
Giovannucci TA; Salomons FA; Martin Haraldsson M; Elfman LMH; Wickström M; Young P; Lundbäck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma N
Review: FRONTIERS IN ONCOLOGY. 2020;10:624079
MYCN Function in Neuroblastoma Development
Otte J; Dyberg C; Pepich A; Johnsen JI
Conference publication: PEDIATRIC BLOOD AND CANCER. 2020;67:S3
Malignant Schwann Cell Precursors Mediate Intratumoral Plasticity in Human Neuroblastoma
Olsen TK; Otte J; Mei S; Kameneva P; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:9
Neuroblastoma - A Neural Crest Derived Embryonal Malignancy
Johnsen JI; Dyberg C; Wickstrom M
Conference publication: CANCER RESEARCH. 2018;78(13):4145
Characterization of the ODZ receptor family in neuroblastoma
Andonova T; Kogner P; Johnsen JI; Wickstrom M
Conference publication: CANCER RESEARCH. 2018;78(13):5092
Establishment of an induction protocol for medulloblastoma during prenatal stages of a floxed-cre inducible model
Gallo-Oller G; Azatyan A; Baryawno N; Kogner P; Johnsen JI
Review: EXPERT OPINION ON DRUG DISCOVERY. 2017;12(8):801-811
Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project
Moreno L; Caron H; Geoerger B; Eggert A; Schleiermacher G; Brock P; Valteau-Couanet D; Chesler L; Schulte JH; De Preter K; Molenaar J; Schramm A; Eilers M; Van Maerken T; Johnsen JI; Garrett M; George SL; Tweddle DA; Kogner P; Berthold F; Koster J; Barone G; Tucker ER; Marshall L; Herold R; Sterba J; Norga K; Vassal G; Pearson ADJ
Conference publication: CANCER RESEARCH. 2017;77:5832
Rho-associated kinase is a therapeutic target in neuroblastoma
Dyberg CH; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Forsberg D; Herlenius E; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2017;64:S343
Omegachild - An Early Clinical Study Aiming at a Novel Approach to Treat Neural Tumors and Prevent Long-Term Side Effects
Ljungblad L; Wickstrom M; Eissler N; Pickova J; Johnsen JI; Tedroff K; Strandvik B; Gleissman H; Kogner P
Conference publication: PEDIATRIC BLOOD AND CANCER. 2017;64:S232
Complete Clinical Response in High-Risk Neuroblastoma After ALK-Inhibitor Mono-Therapy Specifically Targeting the Novel Activating I1171T ALK Mutation
Kogner P; Treis D; Siaw J; Fransson S; Guan J; Svenberg P; Hansson M; Wessman S; Gordon L; Stenman J; Svensson PJ; Johnsen JI; Martinsson T; Palmer RH; Hallberg B
Conference publication: NEURO-ONCOLOGY. 2016;18:116
OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA
Ljungblad L; Bergqvist F; Andonova T; Jakobsson P-J; Johnsen JI; Gleissman H; Kogner P; Wickstrom M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2016;63:S28
Combination Therapy of Anti-PD-1 Antibody and CSF-1R Inhibitor Reverses Induction of Suppressive Myeloid Cells and Controls Spontaneous Neuroblastoma Progression
Eissler N; Mao Y; Brodin D; Reutersward P; Svahn HA; Johnsen JI; Kiessling R; Kogner P
Conference publication: PEDIATRIC BLOOD AND CANCER. 2016;63:S82
The PPM1D-Encoded Wip1-Phosphatase is a Candidate Oncogene on 17q Contributing to Neuroblastoma Development and Providing a Novel Therapeutic Target
Milosevic J; Fransson S; Treis D; Tanino K; Wickstrom M; Sveinbjornsson B; Kosalai ST; Baryawno N; Johnsen JI; Sakaguchi K; Kanduri C; Martinsson T; Kogner P
Conference publication: PEDIATRIC BLOOD AND CANCER. 2016;63:S82-S83
Targeting the Benign to Kill the Malignant : Inhibition of Inflammatory Progression of Neuroblastoma by Targeting mPGES-1 in Cancer Associated Fibroblasts in the Tumour Microenvironment
Kock A; Larsson K; Eissler N; Bergqvist F; Elfman L; Raouf J; Korotkova M; Johnsen JI; Jakobsson PJ; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:3279
Expression of chemerin and chemerin receptors in neuroblastoma: implications in tumorigenesis
Tuemmler C; Snapkov I; Moens UL; Kogner P; Johnsen JI; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2015;75:3283
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
Snapkov I; Oqvist CO; Figenschau YA; Kogner P; Johnsen JI; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2015;75:1632
Microsomal prostaglandin E synthase 1: a novel therapeutic target of neuroblastoma
Kock A; Larsson K; Joan R; Korotkova M; Johnsen J-I; Jakobsson P-J; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:503
The PPM1D encoded phosphatase Wip1 is a novel oncogene and potential therapeutic target in neuroblastoma and medulloblastoma
Miloseyic J; Treis D; Wickstrom M; Fransson S; Eissler N; Syeinbjornsson B; Baryawno N; Tanino K; Selivanova G; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2015;75:3275
A novel approach to treat medulloblastoma: The omega-3 fatty acids DHA and EPA reduce medulloblastoma tumor growth in vitro and in vivo
Ljungblad LM; Johnsen J-I; Wickstrom M; Kogner P; Gleissman H
Conference publication: CANCER RESEARCH. 2015;75:3266
Inhibition of Rho-associated kinase 2 suppresses MYCN expression and induces differentiation of neuroblastoma
Dyberg C; Forsberg D; Fransson S; Palm JL; Haug BH; Sveinbjornsson B; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Review: WORLD JOURNAL OF EXPERIMENTAL MEDICINE. 2015;5(1):1-10
Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options.
Söderberg-Nauclér C; Johnsen JI
Conference publication: PEDIATRIC BLOOD AND CANCER. 2015;62:S332
THE PPM1D ENCODED PHOSPHATASE WIP1 IS A NOVEL ONCOGENE AND POTENTIAL THERAPEUTIC TARGET IN NEUROBLASTOMA AND MEDULLOBLASTOMA
Milosevic J; Treis D; Malin M; Fransson S; Sveinbjornsson B; Eissler N; Baryawno N; Tanino K; Selivanova G; Sakaguchi K; Martinsson T; Johnsen JI; Kogner P
Conference publication: PEDIATRIC BLOOD AND CANCER. 2015;62:S149
NEUROBLASTOMA IMMUNOTHERAPY TARGETING CSF-1R REVERSES INDUCTION OF SUPPRESSIVE MYELOID CELLS AND CONTROLS AGGRESSIVE TUMOR PROGRESSION
Eissler N; Mao Y; Johnsen JI; Kiessling R; Kogner P
Conference publication: PEDIATRIC BLOOD AND CANCER. 2015;62:S328-S329
INHIBITION OF RHO-ASSOCIATED KINASE 2 INHIBITS MALIGNANT PROGRESSION IN NEUROBLASTOMA BY INDUCING DIFFERENTIATION AND MYCN DEGRADATION
Dyberg C; Forsberg D; Fransson S; Lannerholm-Palm J; Sveinbjornsson B; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:135
RNA helicase A is essential for 1p36 gene KIF1 Bβ tumor suppression in neuroblastomas
Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Choo Z; Hellman U; Sandberg R; Kenchappa RS; Martinsson T; Johnsen JI; Kogner P; Schlisio S
Conference publication: CANCER RESEARCH. 2014;74(20):a84
Stereotactic injections of primary medulloblastomas as a representative model of the different subgroups for preclinical drug screening
Krona C; Dyberg C; Sanden E; Darabi A; Wickstrom M; Northcott P; Johnsen JI; Siesjo P
Conference publication: CANCER RESEARCH. 2014;74(19):3976
Expression of formyl peptide receptor 1 (FPR1) in neuroblastoma: Implications in tumorigenesis
Snapkov I; Kogner P; Johnsen J-I; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2014;74(19):3986
Characterization of prostaglandin signaling in primary neuroblastoma
Kock A; Larsson K; Ljungblad L; Idborg H; Korotkova M; Elfman L; Johnsen J-I; Jakobsson P-J; Kogner P
Conference publication: CANCER RESEARCH. 2014;74(19):3971
PPM1D/WIP1, a potential target in neuroblastoma
Milosevic J; Wickstrom M; Treis D; Nordegren HS; Elfman L; Baryawno N; Fransson S; Sveinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2014;74(19):3988
The omega-3 fatty acids DHA and EPA inhibit medulloblastoma growth
Ljungblad LM; Wickstrom M; Johnsen J-I; Kogner P; Gleissman H
Meeting abstract: CANCER RESEARCH. 2014;74(19):3110
Targeting the Wnt/PCP signaling through ROCK: A new neuroblastoma drug target
Dyberg C; Forsberg D; Papachristou P; Lannerholm-Palm J; Haug BH; Sveinbjoernsson B; Lagercrantz H; Kogner P; Johnsen JI; Wickstrom M
Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191
Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer
Hiyoshi H; Johnsen JI; Andang M; Uhlen P
Meeting abstract: CANCER RESEARCH. 2013;73(8):3795
Vangl2 and Pricklel expression, interaction and regulation of Wnt/PCP signaling in medulloblastoma and neuroblastoma
Dyberg CH; Papachristou P; Lagercrantz H; Johnsen JI; Wickstrom M
Conference publication: CANCER RESEARCH. 2013;73(8):3817
The potential oncogenic significance of Wip1 in neuroblastoma
Milosevic J; Wickstrom M; Elfman L; Baryawno N; Sveinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2013;15:18
EXPERIMENTAL COMBINATION THERAPY: HISTONE DEACETYLASE AND DNA METHYL TRANSFERASE INHIBITORS IN BRAIN CANCER CELL MODEL
Marino A-M; Baryawno N; Johnsen J-I; Ostman A
Editorial comment: ONCOIMMUNOLOGY. 2012;1(5):739-740
Cytomegalovirus infection in brain tumors A potential new target for therapy?
Soderberg-Naucler C; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:1420
Microsomal prostaglandin E2 synthase 1 (mPGES-1) is expressed in neuroblastoma and may represent a novel target for therapy
Kock A; Rasmuson A; Idborg H; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2012;72:4725
Inhibition of the Hedgehog signaling pathway - a new target in treatment for children with neuroblastoma
Wickstrom M; Dyberg C; Shimokawa T; Baryawno N; Milosevic J; Fuskevag OM; Larsson R; Zaphiropoulos PG; Kogner P; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:825
Wnt/beta-catenin signaling regulates the expression of O6-methylguanine DNA-methyltransferase in cancer cells: a new strategy to overcome resistance for DNA alkylators in cancer therapy
Dyberg CH; Baryawno N; Milosevic J; Wickstrom M; Sveinbjornsson B; Northcott PA; Taylor MD; Kool M; Kogner P; Johnsen JI
Conference publication: CANCER RESEARCH. 2012;72:2499
The significance of Wip1 in neuroblastoma and medulloblastoma
Milosevic J; Baryawno N; Syeinbjornsson B; Martinsson T; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2012;14:102
THE POTENTIAL ONCOGENIC SIGNIFICANCE OF WIP1 IN MEDULLOBLASTOMA
Milosevic J; Baryawno N; Sveinbjornsson B; Martinsson T; Grotzer M; Johnsen JI; Kogner P
Conference publication: NEURO-ONCOLOGY. 2012;14:99-100
ANTINEOPLASTIC ACTION OF 5-AZA-2′DEOXYCYTIDINE AND SODIUM 4-PHENYLBUTYRATE ON MEDULLOBLASTOMA CELL MODELS
Marino A-M; Baryawno N; Ekstrom TP; Ostman A; Johnsen J-I
Conference publication: CANCER RESEARCH. 2011;71:lb-209-lb-209
Expression of O6-methylguanine DNA-methyltransferase is regulated by Wnt/β-catenin signalling in cancer cells: A new strategy for DNA alkylators in cancer therapy
Milosevic J; Baryawno N; Dyberg C; Wickstrom M; Sveinbjornsson B; Northcott PA; Taylor MD; Kool M; Kogner P; Johnsen JI
Conference publication: NEURO-ONCOLOGY. 2011;13:I9
COMBINED EFFECTS OF 5-AZA-2′DEOXYCYTIDINE AND 4-PHENYLBUTYRATE ON MEDULLOBLASTOMA
Marino AM; Johnsen J-I; Ekstrom TJ; Zaphiropoulos P; Ostman A
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1365-1373
Omega-3 fatty acids in cancer, the protectors of good and the killers of evil?
Gleissman H; Johnsen JI; Kogner P
Corrigendum: CANCER RESEARCH. 2010;70(5):2138-2139
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth (vol 70, pg 266, 2010)
Baryawno N; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen JI
Review: ADVANCES IN CANCER RESEARCH. 2010;107:163-224
MYC in Oncogenesis and as a Target for Cancer Therapies
Albihn A; Johnsen JI; Henriksson MA
Review: APOPTOSIS : AN INTERNATIONAL JOURNAL ON PROGRAMMED CELL DEATH. 2009;14(4):424-438
Embryonal neural tumours and cell death
Johnsen JI; Kogner P; Albihn A; Henriksson MA
Conference publication: CANCER RESEARCH. 2009;69
Novel tyrosine kinase inhibitors are effective in in vitro models of high risk neuroblastoma
Palmberg E; Rickardson L; Johnsen JI; Kogner P; Lindskog M
Conference publication: CANCER RESEARCH. 2009;69
Neuroblastoma cells produce PGE₂ and express all four PGE₂ receptors: Implications for tumorigenesis
Rasmuson A; Johnsen JI; Koshnevis M; Simon-SantaMaria J; Elfman L; Fuskevag OM; Orrego A; Kogner P; Sveinbjornsson B
Conference publication: CANCER RESEARCH. 2009;69
The cyclooxygenase-2 prostaglandin E2 pathway is expressed in childhood medulloblastoma providing novel therapeutic targets as indicated by promising response to Celecoxib-therapy in vitro, in vivo and pilot clinical experience
Milosevic J; Baryawno N; Sveinbjornsson B; Eksborg S; Holm S; Johnsen J-I; Kogner P
Conference publication: CANCER RESEARCH. 2009;69
Small molecule inhibitors of PI3K/Akt signaling inhibit WntA#946;-catenin pathway crosstalk and suppress medulloblastoma growth
Ninib B; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2009;53(5):807
OMEGA-3 FATTY ACIDS IN CHILDHOOD CANCER: ELUCIDATION OF THE DOCOSAHEXAENOIC ACID METABOLIC PATHWAY IN NEUROBLASTOMA AND DEFINITION OF CYTOTOXIC INTERMEDIATES
Kogner P; Gleissman H; Serhan CN; Hamberg M; Segerstrom L; Lindskog M; Johnsen JI
Conference publication: NEURO-ONCOLOGY. 2008;10(3):515
The cyclooxygenase-2 prostaglandin E2 pathway is expressed in childhood medulloblastoma providing novel therapeutic targets as indicated by promising response to NSAID-therapy in vitro, in vivo and pilot clinical experience
Baryawno N; Sveinbjbornsson B; Eksborg S; Orrego A; Segerstrom L; Oqvist CO; Holm S; Gustavsson B; Kagedal B; Kogner P; Johnsen JI
Conference publication: NEURO-ONCOLOGY. 2008;10(3):506
A novel celecoxib derivate, OSU03012, suppresses medulloblastoma growth by inhibiting catenin function and MYC expression
Baryawno N; Sveinbjornsson B; Eksborg S; Kogner P; Johnsen JI
Meeting abstract: CYTOKINE. 2007;39(1):33
Expression of TWEAK and Fn-14 in neuroblastoma, and their implications in tumorigenesis
Pettersen I; Bakkelund WH; Winberg J-O; Johnsen JI; Kogner P; Sveinbjornsson B
Conference publication: NEURO-ONCOLOGY. 2007;9(2):197
Cyclooxygenase 2 is abundantly expressed in medulloblastoma tumors and cell lines:: Nonsteroidal anti-inflammatory drugs are potent inhibitors of medulloblastoma growth
Baryawno N; Sveinbjornsson B; Holm S; Orrego A; Gustavsson B; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2006;66(8)
COX inhibitors as a potential adjuvant therapy in childhood medulloblastoma
Baryawno N; Sveinbjornsson B; Holm S; Orrego A; Gustavsson B; Kogner P; Johnsen JI
Conference publication: CANCER RESEARCH. 2006;66(8)
Omega-3 docosahexaenoic acid inhibits neuroblastoma cell growth in vivo
Gleissman H; Lindskog M; Ponthan F; Elfman L; Johnsen JI; Kogner P
Conference publication: CANCER RESEARCH. 2006;66(8)
Neuroblastoma cells express all four PGE₂ receptor subtypes and specific receptor antagonists may inhibit tumor growth
Rasmuson A; Johnsen JI; Orrego A; Kogner P; Sveinbjornsson B
Conference publication: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2006;79(1-2):185
Expression of 5-lipoxygenase in human neuroblastoma and effects of its inhibitors on neuroblastoma cell proliferation and apoptosis
Sveinbjörnsson B; Johnsen JI; Rasmuson A; Pettersen I; Orrego A; Phontan F; Elfnan L; Kogner P
Review: CANCER LETTERS. 2005;228(1-2):195-201
NSAIDs in neuroblastoma therapy
Johnsen JI; Lindskog M; Ponthan F; Pettersen I; Elfman L; Orrego A; Sveinbjörnsson B; Kogner P
Review: CANCER LETTERS. 2005;228(1-2):247-255
Proton magnetic resonance spectroscopy in neuroblastoma:: Current status, prospects and limitations
Lindskog M; Spenger C; Klason T; Jarvet J; Gräslund A; Johnsen JI; Ponthan F; Douglas L; Nordell B; Kogner P
Published conference paper: PEDIATRIC BLOOD AND CANCER. 2000;35(6):593-596
Human polyomavirus BK (BKV) and neuroblastoma:: Mechanisms of oncogenic action and possible strategy for novel treatment
Jorgensen GEK; Johnsen JI; Ponthan F; Kogner P; Flægstad T; Traavik T
Review: VIRUS GENES. 1995;10(3):261-275
NONCODING CONTROL REGION OF NATURALLY-OCCURRING BK VIRUS VARIANTS - SEQUENCE COMPARISON AND FUNCTIONAL-ANALYSIS
MOENS U; JOHANSEN T; JOHNSEN JI; SETERNES OM; TRAAVIK T
Visa fler

Forskningsbidrag

Identifying and overcoming mechanisms of treatment resistance in patients with neuroblastoma
Barncancerfonden
1 January 2023 - 31 December 2023
Johnsen, John Inge – New treatment options for childhood neural tumours
Swedish Cancer Society
1 January 2022
New therapy for medulloblastoma and neuroblastoma
Swedish Cancer Society
1 January 2018
New therapy for medulloblastoma and neuroblastoma
Swedish Cancer Society
1 January 2017
New therapy for medulloblastoma and neuroblastoma
Swedish Cancer Society
1 January 2016
Novel Neuroblastoma Biomarkers of Clinical Relevance
Swedish Foundation for Strategic Research
1 January 2015 - 31 December 2019
New therapy for medulloblastoma and neuroblastoma
Swedish Cancer Society
1 January 2015
Targeted therapy for children with medulloblastoma
Swedish Cancer Society
1 January 2014
Novel targeted therapy for childhood cancer with emphasis on Wip-1 in medulloblastoma and neuroblastoma
Swedish Research Council
1 January 2009 - 31 December 2011
BK virus and neuroblastoma
Stiftelsen Dam
31 December 2000 - 31 July 2002

Anställningar

Senior Forskare, Kvinnors och barns hälsa, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Tumörbiologi, Karolinska Institutet, 2010

Nyheter från KI

Kalenderhändelser från KI