Ingemar Björkhem

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: SCIENCE ADVANCES. 2024;10(4):eadj1354
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387
Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison
Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
Article: GLIA. 2023;71(6):1414-1428
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes
Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
Article: BRAIN SCIENCES. 2022;12(11):1450
Ventriculoperitoneal Shunt Treatment Increases 7 Alpha Hy-Droxy-3-Oxo-4-Cholestenoic Acid and 24-Hydroxycholesterol Concentrations in Idiopathic Normal Pressure Hydrocephalus
Porru E; Edstrom E; Arvidsson L; Elmi-Terander A; Fletcher-Sandersjoo A; Sandblom AL; Hansson M; Duell F; Bjorkhem I
Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076
Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204
Sex difference in flux of 27-hydroxycholesterol into the brain
Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):56
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
Sandebring-Matton A; Goikolea J; Bjorkhem I; Paternain L; Kemppainen N; Laatikainen T; Ngandu T; Rinne J; Soininen H; Cedazo-Minguez A; Solomon A; Kivipelto M
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2021;206:105794
Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates
Abdel-Khalik J; Hearn T; Dickson AL; Crick PJ; Yutuc E; Austin-Muttitt K; Bigger BW; Morris AA; Shackleton CH; Clayton PT; Iida T; Sircar R; Rohatgi R; Marschall H-U; Sjovall J; Bjorkhem I; Mullins JGL; Griffiths WJ; Wang Y
Article: JOURNAL OF LIPID RESEARCH. 2021;62:100065
Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)
Pedrelli M; Parini P; Kindberg J; Arnemo JM; Bjorkhem I; Aasa U; Westerstahl M; Walentinsson A; Pavanello C; Turri M; Calabresi L; Oorni K; Camejo G; Frobert O; Hurt-Camejo E
Article: AQUACULTURE. 2020;528:735552
Choline and phosphatidylcholine, but not methionine, cysteine, taurine and taurocholate, eliminate excessive gut mucosal lipid accumulation in Atlantic salmon (Salmo salar L)
Krogdahl A; Hansen AKG; Kortner TM; Bjorkhem I; Krasnov A; Berge GM; Denstadli V
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2020;80(5):395-400
Further evidence for a continuous flux of bile acids into the brain: trapping of bile acids in subdural hematomas
Porru E; Edstrom E; Saeed AA; Eggertsen G; Lovgren-Sandblom A; Roda A; Bjorkhem I
Article: BRITISH JOURNAL OF NUTRITION. 2020;123(10):1081-1093
Dose-response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater
Hansen AKG; Kortner TM; Denstadli V; Masoval K; Bjorkhem I; Grav HJ; Krogdahl A
Article: BMC VETERINARY RESEARCH. 2020;16(1):32
Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.)
Hansen AKG; Kortner TM; Krasnov A; Bjorkhem I; Penn M; Krogdahl A
Article: MOLECULAR THERAPY METHODS & CLINICAL DEVELOPMENT. 2019;15:359-370
mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5
Hauser S; Poenisch M; Schelling Y; Hoeflinger P; Schuster S; Teegler A; Betten R; Gustafsson J-A; Huebener-Schmid J; Schlake T; Chevessier-Tuennesen F; Horscroft N; Bjorkhem I; Schoels L
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;195:105475
Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse
Crick PJ; Yutuc E; Abdel-Khalik J; Saeed A; Betsholtz C; Genove G; Bjorkhem I; Wang Y; Griffiths WJ
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:115-125
First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods
Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Lovgren-Sandblom A; Geilenkeuser W-J; Ahrends R; Andrade I; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Becker S; Bretillon L; Browne RW; Caccia C; Ceglarek UH; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Gray R; Griffiths WJ; Gylling H; Harding S; Helmschrodt C; Iuliano L; Janssen H-G; Jones P; Kaipiainen L; Kannenberg F; Jesus Lagarda M; Leoni V; Lottenberg AM; MacKay DS; Matysik S; McDonald J; Menendez-Carreno M; Myrie SB; Nunes VS; Ostlund RE; Polisecki E; Ramos F; Rideout TC; Schaefer EJ; Schmitz G; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
Theofilopoulos S; de Oliveira WAA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Bjorkhem I; Wang Y; Griffiths WJ; Arenas E
Article: CEREBRAL CORTEX. 2019;29(1):429-446
27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
Article: BIOCHIMIE. 2018;153:26-32
International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods
Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Geilenkeuser W-J; Lovgren-Sandblom A; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Bretillon L; Browne RW; Caccia C; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Griffiths WJ; Iuliano L; Jesus Lagarda M; Leoni V; Lottenberg AM; Matysik S; McDonald J; Rideout TC; Schmitz G; Nunes VS; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(10):5151-5154
Evidence for sex difference in the CSF/plasma albumin ratio in ∼20 000 patients and 335 healthy volunteers
Parrado-Fernandez C; Blennow K; Hansson M; Leoni V; Cedazo-Minguez A; Bjorkhem I
Article: FRONTIERS IN NEUROLOGY. 2018;9:756
24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
Bjorkhem I; Patra K; Boxer AL; Svenningsson P
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2018;1863(9):968-979
Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium
Sun Y; Kopp S; Strutz J; Gali CC; Zandl-Lang M; Fanaee-Danesh E; Kirsch A; Cvitic S; Frank S; Saffery R; Bjorkhem I; Desoye G; Wadsack C; Panzenboeck U
Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2018;8(2):162-168
Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood
Johansson H; Mork L-M; Li M; Sandblom AL; Bjorkhem I; Hoijer J; Ericzon B-G; Jorns C; Gilg S; Sparrelid E; Isaksson B; Nowak G; Ellis E
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2018;1863(1):40-60
Regulatory effects of simvastatin and apoJ on APP processing and,amyloid-β clearance in blood-brain barrier endothelial cells
Zandl-Lang M; Fanaee-Danesh E; Sun Y; Albrecher NM; Gali CC; Cancar I; Kober A; Tam-Amersdorfer C; Stracke A; Storck SM; Saeed A; Stefulj J; Pietrzik CU; Wilson MR; Bjorkhem I; Panzenboeck U
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017;383:18-25
Clinical and molecular characterization of hereditary spastic paraplegias: A next-generation sequencing panel approach
Burguez D; Polese-Bonatto M; Jacinto Scudeiro LA; Bjorkhem I; Schols L; Jardim LB; Matte U; Saraiva-Pereira ML; Siebert M; Morales Saute JA
Article: BRAIN. 2017;140(12):3112-3127
Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial
Schoels L; Rattay TW; Martus P; Meisner C; Baets J; Fischer I; Jaegle C; Fraidakis MJ; Martinuzzi A; Saute JA; Scarlato M; Antenora A; Stendel C; Hoeflinger P; Lourenco CM; Abreu L; Smets K; Paucar M; Deconinck T; Bis DM; Wiethoff S; Bauer P; Arnoldi A; Marques W; Jardim LB; Hauser S; Criscuolo C; Filla A; Zuchner S; Bassi MT; Klopstock T; De Jonghe P; Bjorkhem I; Schuele R
Article: PLOS ONE. 2017;12(10):e0187168
Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
Mast N; Lin JB; Anderson KW; Bjorkhem I; Pikuleva IA
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2017;1862(6):573-588
Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier
Kober AC; Manavalan APC; Tam-Amersdorfer C; Holmer A; Saeed A; Fanaee-Danesh E; Zandl M; Albrecher NM; Bjorkhem I; Kostner GM; Dahlback B; Panzenboeck U
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2017;169:77-87
Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients
Griffiths WJ; Abdel-Khalik J; Crick PJ; Ogundare M; Shackleton CH; Tuschl K; Kwok MK; Bigger BW; Morris AA; Honda A; Xu L; Porter NA; Bjorkhem I; Clayton PT; Wang Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(12):4913-4924
Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum
Mast N; Anderson KW; Lin JB; Li Y; Turko IV; Tatsuoka C; Bjorkhem I; Pikuleva IA
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):699-717
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyas B; Olof-Wahlund L; Winblad B; Savitcheva I; Bjorkhem I; Cedazo-Minguez A
Article: JOURNAL OF LIPID RESEARCH. 2017;58(2):455-459
On the importance of albumin binding for the flux of 7α-hydroxy-3-oxo-4-cholestenoic acid in the brain
Saeed AA; Edstrom E; Pikuleva I; Eggertsen G; Bjorkhem I
Article: SCIENTIFIC REPORTS. 2017;7:40775
Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling
Urlep Z; Lorbek G; Perse M; Jeruc J; Juvan P; Matz-Soja M; Gebhardt R; Bjorkhem I; Hall JA; Bonneau R; Littman DR; Rozman D
Article: NEUROSCIENCE LETTERS. 2016;633:174-181
Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats
Kazkayasi I; Ismail M-A; Parrado-Fernandez C; Bjorkhem I; Pekiner C; Uma S; Cedazo-Minguez A; Burul-Bozkurt N
Article: BMC VETERINARY RESEARCH. 2016;12(1):190
Bile components and lecithin supplemented to plant based diets do not diminish diet related intestinal inflammation in Atlantic salmon
Kortner TM; Penn MH; Bjorkhem I; Masoval K; Krogdahl A
Article: SCIENTIFIC REPORTS. 2016;6:30928
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
Article: NEUROLOGY-GENETICS. 2016;2(4):e84
PROGRESSIVE BRAIN CALCIFICATIONS AND SIGNS IN A FAMILY WITH THE L9R MUTATION IN THE PDGFB GENE
Paucar M; Almqvist H; Saeed A; Bergendal G; Ygge J; Holmin S; Bjorkhem I; Svenningsson P
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(333):333ra50
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Zimmer S; Grebe A; Bakke SS; Bode N; Halvorsen B; Ulas T; Skjelland M; De Nardo D; Labzin LI; Kerksiek A; Hempel C; Heneka MT; Hawxhurst V; Fitzgerald ML; Trebicka J; Bjorkhem I; Gustafsson J-A; Westerterp M; Tall AR; Wright SD; Espevik T; Schultze JL; Nickenig G; Lutjohann D; Latz E
Article: JOURNAL OF LIPID RESEARCH. 2016;57(2):258-264
Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis
Lin JB; Mast N; Bederman IR; Li Y; Brunengraber H; Bjorkhem I; Pikuleva IA
Article: JOURNAL OF INHERITED METABOLIC DISEASE. 2016;39(1):75-83
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis
Mignarri A; Magni A; Del Puppo M; Gallus GN; Bjorkhem I; Federico A; Dotti MT
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2015;358(1-2):201-206
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.
Novakova L; Axelsson M; Malmeström C; Zetterberg H; Björkhem I; Karrenbauer VD; Lycke J
Article: STEROIDS. 2015;99(Pt B):183-188
Increased flux of the plant sterols campesterol and sitosterol across a disrupted blood brain barrier
Saeed AA; Genove G; Li T; Huelshorst F; Betsholtz C; Bjoerkhem I; Luejohann D
Article: SCIENTIFIC REPORTS. 2015;5:8777
Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
Lorbek G; Perse M; Jeruc J; Juvan P; Gutierrez-Mariscal FM; Lewinska M; Gebhardt R; Keber R; Horvat S; Bjorkhem I; Rozman D
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;278:356-359
27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice
Heverin M; Maioli S; Pham T; Mateos L; Camporesi E; Ali Z; Winblad B; Cedazo-Minguez A; Bjorkhem I
Article: MOLECULAR NEUROBIOLOGY. 2015;51(3):1489-1503
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells
Moutinho M; Nunes MJ; Gomes AQ; Gama MJ; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Rodrigues E
Article: JOURNAL OF IMMUNOLOGY. 2014;193(11):5637-5648
ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis
Baldan A; Gonen A; Choung C; Que X; Marquart TJ; Hernandez I; Bjorkhem I; Ford DA; Witztum JL; Tarling EJ
Article: PLOS ONE. 2014;9(11):e113619
Cholesterol, Oxysterol, Triglyceride, and Coenzyme Q Homeostasis in ALS. Evidence against the Hypothesis That Elevated 27-Hydroxycholesterol Is a Pathogenic Factor
Wuolikainen A; Acimovic J; Loevgren-Sandblom A; Parini P; Andersen PM; Bjoerkhem I
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(11):4829-4842
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S; Griffiths WJ; Crick PJ; Yang S; Meljon A; Ogundare M; Kitambi SS; Lockhart A; Tuschl K; Clayton PT; Morris AA; Martinez A; Reddy MA; Martinuzzi A; Bassi MT; Honda A; Mizuochi T; Kimura A; Nittono H; De Michele G; Carbone R; Criscuolo C; Yau JL; Seckl JR; Schuele R; Schoels L; Sailer AW; Kuhle J; Fraidakis MJ; Gustafsson J-A; Steffensen KR; Bjorkhem I; Ernfors P; Sjovall J; Arenas E; Wang Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(34):23712-23722
Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
Saeed AA; Genove G; Li T; Luetjohann D; Olin M; Mast N; Pikuleva IA; Crick P; Wang Y; Griffiths W; Betsholtz C; Bjorkhem I
Article: BRITISH JOURNAL OF NUTRITION. 2014;111(12):2089-2103
Dietary cholesterol supplementation to a plant-based diet suppresses the complete pathway of cholesterol synthesis and induces bile acid production in Atlantic salmon (Salmo salar L.)
Kortner TM; Bjorkhem I; Krasnov A; Timmerhaus G; Krogdahl A
Article: JOURNAL OF LIPID RESEARCH. 2014;55(6):1165-1172
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
Bjorkhem I; Diczfalusy U; Lovgren-Sandblom A; Starck L; Jonsson M; Tallman K; Schirmer H; Ousager LB; Crick PJ; Wang Y; Griffiths WJ; Guengerich FP
Article: JOURNAL OF LIPID RESEARCH. 2014;55(2):313-318
7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
Saeed A; Floris F; Andersson U; Pikuleva I; Lovgren-Sandblom A; Bjerke M; Paucar M; Wallin A; Svenningsson P; Bjorkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(52):36936-36947
Characterization of Cholesterol Homeostasis in Telomerase-immortalized Tangier Disease Fibroblasts Reveals Marked Phenotype Variability
Kannenberg F; Gorzelniak K; Jaeger K; Fobker M; Rust S; Repa J; Roth M; Bjorkhem I; Walter M
Article: PLOS ONE. 2013;8(11):e78550
Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
Ellis ECS; Nauglers S; Parini P; Mork L-M; Jorns C; Zemack H; Sandblom AL; Bjorkhem I; Ericzon B-G; Wilson EM; Strom SC; Grompe M
Article: NEUROSCIENCE LETTERS. 2013;555:102-105
Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease
Bjorkhem I; Lovgren-Sandblom A; Leoni V; Meaney S; Brodin L; Salveson L; Winge K; Palhagen S; Svenningsson P
Article: MOLECULES. 2013;18(9):11067-11085
Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice
Lorbek G; Perse M; Horvat S; Bjorkhem I; Rozman D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;36(4):739-747
Diagnostic Power of 24S-Hydroxycholesterol in Cerebrospinal Fluid: Candidate Marker of Brain Health
Leoni V; Solomon A; Lovgren-Sandblom A; Minthon L; Blennow K; Hansson O; Wahlund L-O; Kivipelto M; Bjorkhem I
Article: PLOS ONE. 2013;8(7):e68534
Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?
Maioli S; Bavner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Bjorkhem I
Article: PLOS ONE. 2013;8(7):e68031
Sulphatation Does Not Appear to Be a Protective Mechanism to Prevent Oxysterol Accumulation in Humans and Mice
Acimovic J; Lovgren-Sandblom A; Olin M; Ali Z; Heverin M; Schuele R; Schoels L; Fischler B; Fickert P; Trauner M; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 2013;54(4):1033-1043
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1^-/- mice
Ali Z; Heverin M; Olin M; Acimovic J; Lovgren-Sandblom A; Shafaati M; Bavner A; Meiner V; Leitersdorf E; Bjorkhem I
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2012;53(11):7026-7033
Single Nucleotide Polymorphism in the Cholesterol-24S-Hydroxylase (CYP46A1) Gene and Its Association with CFH and LOC387715 Gene Polymorphisms in Age-Related Macular Degeneration
Fourgeux C; Dugas B; Richard F; Bjorkhem I; Acar N; Bron AM; Korobelnik J-F; Leveziel N; Zerbib J; Puche N; Creuzot-Garcher CP; Souied E; Bretillon L
Article: NEUROSCIENCE LETTERS. 2012;510(2):121-126
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
Besga A; Cedazo-Minguez A; Kareholt I; Solomon A; Bjorkhem I; Winblad B; Leoni V; Hooshmand B; Spulber G; Gonzalez-Pinto A; Kivipelto M; Wahlund LO
Article: NEUROCHEMISTRY INTERNATIONAL. 2012;60(2):192-198
Marked change in the balance between CYP27A1 and CYP46A1 mediated elimination of cholesterol during differentiation of human neuronal cells
Milagre I; Olin M; Nunes MJ; Moutinho M; Lovgren-Sandblom A; Gama MJ; Bjorkhem I; Rodrigues E
Article: JOURNAL OF INTERNAL MEDICINE. 2011;270(4):377-387
Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo
Shafaati M; Olin M; Bavner A; Pettersson H; Rozell B; Meaney S; Parini P; Bjorkhem I
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(9):942-946
The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter
Zolotushko J; Flusser H; Markus B; Shelef I; Langer Y; Heverin M; Bjoerkhem I; Sivan S; Birk OS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(29):25574-25585
Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism
Mateos L; Ismail M-A; Gil-Bea F-J; Schuele R; Schoels L; Heverin M; Folkesson R; Bjorkhem I; Cedazo-Minguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2011;24(4):669-679
Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease
Mateos L; Ismail M-A; Gil-Bea F-J; Leoni V; Winblad B; Bjorkhem I; Cedazo-Minguez A
Article: JOURNAL OF LIPID RESEARCH. 2011;52(5):1004-1010
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
Shafaati M; Marutle A; Pettersson H; Lovgren-Sandblom A; Olin M; Pikuleva I; Winblad B; Nordberg A; Bjorkhem I
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2011;68(3):537-551
Sterol binding by OSBP-related protein 1L regulates late endosome motility and function
Vihervaara T; Uronen R-L; Wohlfahrt G; Bjorkhem I; Ikonen E; Olkkonen VM
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2011;52(1):594-603
Cholestenoic Acid Is an Important Elimination Product of Cholesterol in the Retina: Comparison of Retinal Cholesterol Metabolism with That in the Brain
Mast N; Reem R; Bederman I; Huang S; DiPatre PL; Bjorkhem I; Pikuleva IA
Article: JOURNAL OF LIPID RESEARCH. 2011;52(1):170-174
High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?
Bjorkhem I; Lovgren-Sandblom A; Piehl F; Khademi M; Pettersson H; Leoni V; Olsson T; Diczfalusy U
Article: DRUG METABOLISM AND DISPOSITION. 2011;39(1):39-46
Inhibition of Human Sterol Δ⁷-Reductase and Other Postlanosterol Enzymes by LK-980, a Novel Inhibitor of Cholesterol Synthesis
Acimovic J; Korosec T; Seliskar M; Bjorkhem I; Monostory K; Szabo P; Pascussi J-M; Belic A; Urleb U; Kocjan D; Rozman D
Article: JOURNAL OF LIPID RESEARCH. 2010;51(9):2722-2730
On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase
Bavner A; Shafaati M; Hansson M; Olin M; Shpitzen S; Meiner V; Leitersdorf E; Bjorkhem I
Article: BRAIN RESEARCH. 2010;1344:185-191
A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations
Keller L; Murphy C; Wang H-X; Fratiglioni L; Olin M; Gafvels M; Bjorkhem I; Graff C; Meaney S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(6):1174-1180
Impaired Development of Atherosclerosis in Abcg1^-/- Apoe^-/- Mice Identification of Specific Oxysterols That Both Accumulate in Abcg1^-/- Apoe^-/- Tissues and Induce Apoptosis
Tarling EJ; Bojanic DD; Tangirala RK; Wang X; Lovgren-Sandblom A; Lusis AJ; Bjorkhem I; Edwards PA
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(6):674-681
Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters
Mast N; Shafaati M; Zaman W; Zheng W; Prusak D; Wood T; Ansari GAS; Loevgren-Sandblom A; Olin M; Bjorkhem I; Pikuleva I
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):46-49
Cerebrotendinous xanthomatosis: An inborn error in bile acid synthesis with defined mutations but still a challenge
Bjorkhem I; Hansson M
Article: JOURNAL OF LIPID RESEARCH. 2010;51(4):819-823
Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
Schuele R; Siddique T; Deng H-X; Yang Y; Donkervoort S; Hansson M; Madrid RE; Siddique N; Schoels L; Bjorkhem I
Article: CURRENT ALZHEIMER RESEARCH. 2010;7(2):134-139
Platelet Alpha- and Beta-Secretase Activities are not Significantly Affected by Dementia or Mild Cognitive Impairment in Swedish Patients
Gorham P; Bark N; Meaney S; Bjorkhem I; Crisby M
Article: JOURNAL OF LIPID RESEARCH. 2010;51(2):318-323
The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
Shafaati M; Mast N; Beck O; Nayef R; Heo GY; Bjorkhem-Bergman L; Luetjohann D; Bjorkhem I; Pikuleva IA
Article: JOURNAL OF LIPID RESEARCH. 2010;51(1):169-181
Differential expression and function of ABCG1 and ABCG4 during development and aging
Bojanic DD; Tarr PT; Gale GD; Smith DJ; Bok D; Chen B; Nusinowitz S; Loevgren-Sandblom A; Bjoerkhem I; Edwards PA
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2009;50(12):5712-5717
Primary Open-Angle Glaucoma: Association with Cholesterol 24S-Hydroxylase (CYP46A1) Gene Polymorphism and Plasma 24-Hydroxycholesterol Levels
Fourgeux C; Martine L; Bjoerkhem I; Diczfalusy U; Joffre C; Acar N; Creuzot-Garcher C; Bron A; Bretillon L
Article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2009;47(12):709-715
4β-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man
Luetjohann D; Marinova M; Schneider B; Oldenburg J; von Bergmann K; Bieber T; Bjorkhem I; Diczfalusy U
Article: NEUROSCIENCE LETTERS. 2009;462(1):89-93
Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease
Solomon A; Leoni V; Kivipelto M; Besga A; Oksengard AR; Julin P; Svensson L; Wahlund L-O; Andreasen N; Winblad B; Soininen H; Bjorkhem I
Article: BMC GENOMICS. 2009;10:384
Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers
Rezen T; Viola T; Lovgren-Sandblom A; Bjorkhem I; Meyer UA; Rozman D
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2009;877(22):2081-2086
Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells
Acimovic J; Lovgren-Sandblom A; Monostory K; Rozman D; Golicnik M; Lutjohann D; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 2009;50(Suppl):S213-S218
Are side-chain oxidized oxysterols regulators also in vivo?
Bjorkhem I
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;378(4):689-694
Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors
Shafaati M; O'Driscoll R; Bjoerkhem I; Meaney S
Article: BRAIN PATHOLOGY. 2009;19(1):69-80
Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Diet in vivo and by 27-Hydroxycholesterol in vitro
Mateos L; Akterin S; Gil-Bea F-J; Spulber S; Rahman A; Bjorkhem I; Schultzberg M; Flores-Morales A; Cedazo-Minguez A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2008;376(1):206-210
CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver
Acimovic J; Fink M; Pompon D; Bjorkhem I; Hirayama J; Sassone-Corsi P; Golicnik M; Rozman D
Article: BRAIN. 2008;131(Pt 11):2851-2859
Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntingtons disease
Leoni V; Mariotti C; Tabrizi SJ; Valenza M; Wild EJ; Henley SMD; Hobbs NZ; Mandelli ML; Grisoli M; Bjorkhem I; Cattaneo E; Di Donato S
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2008;1781(8):383-390
Metabolism of a novel side chain modified Δ8(14)-15-ketosterol, a potential cholesterol lowering drug:: 28-hydroxylation by CYP27A1
Pettersson H; Norlin M; Andersson U; Pikuleva I; Bjorkhem I; Misharin AY; Wikvall K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(28):9546-9551
Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain
Mast N; Whitet MA; Bjorkhem I; Johnson EF; Stout CD; Pikuleva IA
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2008;64(Pt 5):487-495
Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1
White MA; Mast N; Bjorkhem I; Johnson EF; Stout CD; Pikuleva IA
Article: NEUROBIOLOGY OF DISEASE. 2007;28(1):133-142
Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease
Valenza M; Leoni V; Tarditi A; Mariotti C; Bjorkhem I; Di Donato S; Cattaneo E
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(10):2191-2197
Studies on the cholesterol-free mouse -: Strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol
Heverin M; Meaney S; Brafman A; Shafir M; Olin M; Shafaati M; von Bahr S; Larsson L; Loevgren-Sandblom A; Diczfalusy U; Parini P; Feinstein E; Bjoerkhem I
Article: NEUROSCIENCE LETTERS. 2007;425(2):78-82
Levels of ApoE in cerebrospinal fluid are correlated with Tau and 24S-hydroxycholesterol in patients with cognitive disorders
Shafaati M; Solomon A; Kivipelto M; Bjorkhem I; Leoni V
Article: HUMAN MOLECULAR GENETICS. 2007;16(18):2187-2198
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation
Valenza M; Carroll JB; Leoni V; Bertram LN; Bjorkhem I; Singaraja RR; Di Donato S; Lutjohann D; Hayden MR; Cattaneo E
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2007;856(1-2):15-19
Novel LC-MS/MS method for assay of 7α-hydroxy-4-cholesten-3-one in human plasma evidence for a significant extrahepatic metabolism
Lovgren-Sandblom A; Heverin M; Larsson H; Lundstrom E; Wahren J; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF INTERNAL MEDICINE. 2007;262(2):254-262
Cholestatic liver disease in adults may be due to an inherited defect in bile acid biosynthesis
Fischler B; Bodin K; Stjernman H; Olin M; Hansson M; Sjovall J; Bjorkhem I
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;359(1):46-50
Regulation of α- and β-secretase activity by oxysterols:: Cerebrosterol stimulates processing of APP via the α-secretase pathway
Famer D; Meaney S; Mousavi M; Nordberg A; Bjorkhem I; Crisby M
Article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS. 2007;45(7):377-384
Effects of high-dose itraconazole treatment on lipoproteins in men
Schneider B; Gerdsen R; Plat J; Dullens S; Bjorkhem I; Diczfalusy U; Neuvonen PJ; Bieber T; von Bergmann K; Lutjohann D
Article: JOURNAL OF INTERNAL MEDICINE. 2007;261(5):504-510
Unique patient with cerebrotendinous xanthomatosis.: Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase
Hansson M; Olin M; Floren C-H; von Bahr S; van't Hooft F; Meaney S; Eggertsen G; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 2007;48(5):1167-1174
On the mechanism of cerebral accumulation of cholestanol in patients with cerebrotendinous xanthomatosis
Panzenboeck U; Andersson U; Hansson M; Sattler W; Meaney S; Bjorkhem I
Article: CURRENT EYE RESEARCH. 2007;32(4):361-366
Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina
Bretillon L; Diczfalusy U; Bjoerkhem I; Maire MA; Martine L; Joffre C; Acar N; Bron A; Creuzot-Garcher C
Article: JOURNAL OF LIPID RESEARCH. 2007;48(4):944-951
Novel route for elimination of brain oxysterols across the blood-brain barrier:: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid
Meaney S; Heverin M; Panzenboeck U; Ekstrom L; Axelsson M; Andersson U; Diczfalusy U; Pikuleva I; Wahren J; Sattler W; Bjorkhem I
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2007;127(3):253-261
Differential hepatocellular zonation pattern of cholesterol 7α-hydroxylase (Cyp7a1) and sterol 12α-hydroxylase (Cyp8b1) in the mouse
Wang J; Olin M; Rozell B; Bjorkhem I; Einarsson C; Eggertsen G; Gafvels M
Article: JOURNAL OF LIPID RESEARCH. 2006;47(9):2020-2027
Two loci on chromosome 9 control bile acid composition:: evidence that a strong candidate gene, Cyp8b1, is not the culprit
Sehayek E; Hagey LR; Fung Y-Y; Duncan EM; Yu HJ; Eggertsen G; Bjorkhem I; Hofmann AF; Breslow JL
Article: CLINICAL NEUROLOGY AND NEUROSURGERY. 2006;108(5):456-460
Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis
Karrenbauer VD; Leoni V; Lim ET; Giovannoni G; Ingle GT; Sastre-Garriga J; Thompson AJ; Rashid W; Davies G; Miller DH; Bjorkhem I; Masterman T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;342(4):1382-1388
Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice
Wang J; Gåfvels M; Rudling M; Murphy C; Björkhem I; Einarsson C; Eggertsen G
Article: BIOCHEMISTRY. 2006;45(14):4396-4404
Distinct binding of cholesterol and 5-cholestane-3α,7α,12α-triol to cytochrome P450 27A1: Evidence from modeling and site-directed mutagenesis studies
Mast N; Murtazina D; Liu H; Graham SE; Bjorkhem I; Halpert JR; Peterson J; Pikuleva IA
Article: NEUROSCIENCE LETTERS. 2006;397(1-2):83-87
Are the CSF levels of 24S-hydroxychole sterol a sensitive biomarker for mild cognitive impairment?
Leoni V; Shafaati M; Salomon A; Kivipelto M; Björkhem I; Wahlund LO
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2006;316(3):1146-1152
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
Thelen KM; Rentsch KM; Gutteck U; Heverin M; Olin M; Andersson U; von Eckardstein A; Björkhem I; Lütjohann D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(7):3810-3820
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1) - Marked insensitivity toward different regulatory axes
Ohyama Y; Meaney S; Heverin M; Ekström L; Brafman A; Shafir M; Andersson U; Olin M; Eggertsen G; Diczfalusy U; Feinstein E; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2006;47(2):421-430
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
Wang J; Einarsson C; Murphy C; Parini P; Björkhem I; Gåfvels M; Eggertsen G
Article: UPSALA JOURNAL OF MEDICAL SCIENCES. 2006;111(1):131-136
Bile acid metabolism in extrahepatic biliary atresia: lithocholic acid in stored dried blood collected at neonatal screening.
Gustafsson J; Alvelius G; Björkhem I; Nemeth A
Article: JOURNAL OF LIPID RESEARCH. 2006;47(1):215-227
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α
Inoue Y; Yu AM; Yim SH; Ma XC; Krausz KW; Inoue J; Xiang CC; Brownstein MJ; Eggertsen G; Björkhem I; Gonzalez FJ
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2005;65(7):595-600
Polymorphism in the coding part of the sterol 12α-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile
Abrahamsson A; Gåfvels M; Reihnér E; Björkhem I; Einarsson C; Eggertsen G
Article: ATHEROSCLEROSIS. 2005;182(1):37-45
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration
Abrahamsson A; Krapivner S; Gustafsson U; Muhrbeck O; Eggertsen G; Johansson I; Persson I; Angelin B; Ingelman-Sundberg M; Björkhem I; Einarsson C; van't Hooft FM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1735(3):167-175
Cholic acid as key regulator of cholesterol synthesis, intestinal absorption and hepatic storage in mice
Murphy C; Parini P; Wang J; Björkhem I; Eggertsen G; Gåfvels M
Article: CLINICAL SCIENCE. 2005;108(6):507-513
Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study
Lu Q; Björkhem I; Wretlind B; Diczfalusy U; Henriksson P; Freyschuss A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;330(2):395-399
Feedback regulation of bile acid synthesis in human liver:: Importance of HNF-4α for regulation of CYP7A1
Abrahamsson A; Gustafsson U; Ellis E; Nilsson LM; Sahlin S; Björkhem I; Einarsson C
Article: JOURNAL OF LIPID RESEARCH. 2005;46(5):1047-1052
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
Heverin M; Meaney S; Lütjohann D; Diczfalusy U; Wahren J; Björkhem I
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(5):1057-1064
Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
Brousseau ME; Diffenderfer MR; Millar JS; Nartsupha C; Asztalos BF; Welty FK; Wolfe ML; Rudling M; Björkhem I; Angelin B; Mancuso JP; Digenio AG; Rader DJ; Schaefer EJ
Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2005;40(4):481-486
Mutation in the sterol 27-hydroxylase gene associated with fatal cholestasis in infancy
von Bahr S; Bjökhem I; van't Hooft F; Alvelius G; Nemeth T; Sjövall J; Fischler T
Article: BIOCHEMISTRY. 2005;44(9):3259-3271
Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis
Mast N; Graham SE; Andersson U; Bjorkhem I; Hill C; Peterson J; Pikuleva IA
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2005;65(5):365-375
Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid
Babiker A; Dzeletovic S; Wiklund B; Pettersson N; Salonen J; Nyyssönen K; Eriksson M; Diczfalusy U; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2004;45(12):2345-2353
Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1
Murtazina DA; Andersson U; Hahn IS; Bjorkhem I; Ansari GAS; Pikuleva IA
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;320(4):1204-1210
Mechanisms of cholesterol and sterol regulatory element binding protein regulation of the sterol 12α-hydroxylase gene (CYP8B1)
Yang YZ; Eggertsen G; Gåfvels M; Andersson U; Einarsson C; Björkhem I; Chiang JYL
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2004;428(1):99-108
Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N- and C-terminal modifications
Mast N; Andersson U; Nakayama K; Bjorkhem I; Pikuleva IA
Article: STEROIDS. 2004;69(6):431-438
High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
Lütjohann D; Stroick M; Bertsch T; Kühl S; Lindenthal B; Thelen K; Andersson U; Björkhem I; von Bergmann K; Fassbender K
Article: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2004;42(2):186-191
Diagnostic use of cerebral and extracerebral oxysterols
Leoni V; Masterman T; Mousavi FS; Wretlind B; Wahlund LO; Diczfalusy U; Hillert J; Björkhem I
Article: JOURNAL OF HEPATOLOGY. 2004;40(1):8-13
Studies on the mechanism of accumulation of cholesterol in the gallbladder mucosa.: Evidence that sterol 27-hydroxylase is not a pathogenetic factor
Strömsten A; von Bahr S; Bringman S; Saeki M; Sahlin S; Björkhem I; Einarsson C
Article: JOURNAL OF LIPID RESEARCH. 2004;45(1):186-193
Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
Heverin M; Bogdanovic N; Lütjohann D; Bayer T; Pikuleva I; Bretillon L; Diczfalusy U; Winblad B; Björkhem I
Article: SCIENCE. 2003;302(5653):2087
Generation of viable cholesterol-free mice
Wechsler A; Brafman A; Shafir M; Heverin M; Gottlieb H; Damari G; Gozlan-Kelner S; Spivak I; Moshkin O; Fridman E; Becker Y; Skaliter R; Einat P; Faerman A; Björkhem I; Feinstein E
Article: BIOCHEMISTRY. 2003;42(48):14284-14292
Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain
Mast N; Norcross R; Andersson U; Shou MG; Nakayama K; Bjorkhem I; Pikuleva IA
Article: HEPATOLOGY. 2003;38(4):930-938
Feedback regulation of bile acid synthesis in primary human hepatocytes:: Evidence that CDCA is the strongest inhibitor
Ellis E; Axelson M; Abrahamsson A; Eggertsen G; Thörne A; Nowak G; Ericzon BG; Björkhem I; Einarsson C
Article: STEROIDS. 2003;68(7-8):595-601
On the origin of the cholestenoic acids in human circulation
Meaney S; Babiker A; Lütjohann D; Diczfalusy U; Axelson M; Bjrökhem I
Article: JOURNAL OF LIPID RESEARCH. 2003;44(8):1515-1522
On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation
Norlin M; von Bahr S; Björkhem I; Wikvall K
Article: JOURNAL OF LIPID RESEARCH. 2003;44(4):793-799
Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers
Leoni V; Masterman T; Patel P; Meaney S; Diczfalusy U; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2002;43(12):2130-2135
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation:: critical importance of the position of the oxygen function
Meaney S; Bodin K; Diczfalusy U; Björkhem I
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2002;113(2):183-189
Simvastatin treatment in the SLO syndrome:: A safe approach?
Starck L; Lövgren-Sandblom A; Björkhem I
Article: NEUROSCIENCE LETTERS. 2002;331(3):163-166
Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
Leoni V; Masterman T; Diczfalusy U; De Luca G; Hillert J; Björkhem I
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;110(8):1191-1200
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
Li-Hawkins J; Gåfvels M; Olin M; Lund EG; Andersson U; Schuster G; Björkhem I; Russell DW; Eggertsen G
Article: JOURNAL OF INTERNAL MEDICINE. 2002;252(4):314-321
Cholesterol treatment forever? The first Scandinavian trial of cholesterol supplementation in the cholesterol-synthesis defect Smith-Lemli-Opitz syndrome
Starck L; Lövgren-Sandblom A; Björkhem I
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;110(6):725-730
Do oxysterols control cholesterol homeostasis?
Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(37):34036-34041
Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model -: Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis
Meir K; Kitsberg D; Alkalay I; Szafer F; Rosen H; Shpitzen S; Ben Avi L; Staels B; Fievet C; Meiner V; Björkhem I; Leitersdorf E
Article: JOURNAL OF INTERNAL MEDICINE. 2002;252(3):259-264
Cerebrotendinous xanthomatosis:: molecular characterization of two Scandinavian sisters
Rystedt E; Olin M; Seyama Y; Buchmann M; Berstad A; Eggertsen G; Björkhem I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2002;87(9):4307-4313
Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7α-hydroxylase mRNAs in human liver
Rudling M; Angelin B; Ståhle L; Reihnér E; Sahlin S; Olivecrona H; Björkhem I; Einarsson C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(35):31534-31540
Metabolism of 4β-hydroxycholesterol in Humans
Bodin K; Andersson U; Rystedt E; Ellis E; Norlin M; Pikuleva I; Eggertsen G; Björkhem I; Diczfalusy U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(30):26804-26807
Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver -: No coordinate regulation of CYP7A1 and CYP27A1
Björkhem I; Araya Z; Rudling M; Angelin B; Einarsson C; Wikvall K
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2002;32(7):528-534
Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism
Hillebrant CG; Nyberg B; Gustafsson U; Sahlin S; Björkhem I; Rudling M; Einarsson C
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2002;22(7):1129-1135
Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1)
von Bahr S; Movin T; Papadogiannakis N; Pikuleva I; Rönnow P; Diczfalusy U; Björkhem I
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2002;22(5):734-742
Oxysterols -: Friends, foes, or just fellow passengers?
Björkhem I; Diczfalusy U
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2002;62(7):537-539
Post-occlusive reactive hyperemia in single nutritive capillaries of the nail fold:: methodological considerations
Lu Q; Freyschuss A; Jonsson AM; Björkhem I; Henriksson P
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2002;36(1):27-32
24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
Papassotiropoulos A; Lütjohann D; Bagli M; Locatelli S; Jessen F; Buschfort R; Ptok U; Björkhem I; von Bergmann K; Heun R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1534(2-3):129-138
On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions
Freyschuss A; Al-Schurbaji A; Björkhem B; Babiker A; Diczfalusy U; Berglund L; Henriksson P
Article: NEUROSCIENCE LETTERS. 2001;314(1-2):45-48
On the turnover of brain cholesterol in patients with Alzheimer's disease.: Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
Bogdanovica N; Bretillon L; Lund EG; Diczfalusy U; Lannfelt L; Winblad B; Russell DW; Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(40):37004-37010
From brain to bile -: Evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
Björkhem I; Andersson U; Ellis E; Alvelius G; Ellegård L; Diczfalusy U; Sjövall J; Einarsson C
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2001;69(2):278-290
Two genes that map to the STSL locus cause sitosterolemia:: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
Lu KM; Lee MH; Hazard S; Brooks-Wilson A; Hidaka H; Kojima H; Ose L; Stalenhoef AFH; Mietinnen T; Bjorkhem I; Bruckert E; Pandya A; Brewer HB; Salen G; Dean M; Srivastava A; Patel SB
Article: CLINICAL CARDIOLOGY. 2001;24(7):511-515
N-acetylcysteine improves microcirculatory flow during smoking: New effects of an old drug with possible benefits for smokers
Lu Q; Björkhem I; Xiu RJ; Henriksson P; Freyschuss A
Article: JOURNAL OF LIPID RESEARCH. 2001;42(7):1025-1032
Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans
Diczfalusy MA; Björkhem I; Einarsson C; Hillebrant CG; Alexson SEH
Article: BIOCHEMISTRY. 2001;40(25):7621-7629
Putative helix F contributes to regioselectivity of hydroxylation in mitochondrial cytochrome P450 27A1
Pikuleva IA; Puchkaev A; Björkhem I
Article: ACTA PAEDIATRICA. 2001;90(6):652-657
Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol
Lütjohann D; Björkhem I; Locatelli S; Dame C; Schmolling J; von Bergmann K; Fahnenstich H
Article: GASTROENTEROLOGY. 2001;120(7):1801-1809
Expression of sterol 12α-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo
Pandak WM; Bohdan P; Franklund C; Mallonee DH; Eggertsen G; Björkhem I; Gil G; Vlahcevic ZR; Hylemon PB
Article: JOURNAL OF LIPID RESEARCH. 2001;42(3):366-371
Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome:: abnormal levels of 24S-and 27-hydroxycholesterol
Björkhem I; Starck L; Andersson U; Lütjohann D; von Bahr S; Pikuleva I; Babiker A; Diczfalusy U
Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;107(5):565-573
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice
Alberti S; Schuster G; Parini P; Feltkamp D; Diczfalusy U; Rudling M; Angelin B; Björkhem I; Pettersson S; Gustafsson J
Article: JOURNAL OF LIPID RESEARCH. 2001;42(1):70-78
Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol:: a stable isotope study
Meaney S; Hassan M; Sakinis A; Lütjohann D; von Bergmann K; Wennmalm Å; Diczfalusy U; Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(44):34046-34053
Oxysterol 7α-hydroxylase activity by cholesterol 7α-hydroxylase (CYP7A)
Norlin M; Andersson U; Björkhem I; Wikvall K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2000;106(9):1175-1184
The bile acid synthetic gene 3β-hydroxy-Δ⁵-C₂₇-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
Schwarz M; Wright AC; Davis DL; Nazer H; Björkhem I; Russell DW
Article: NEUROSCIENCE LETTERS. 2000;293(2):87-90
Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
Bretillon L; Sidén Å; Wahlund LO; Lütjohann D; Minthon L; Crisby M; Hillert J; Groth CG; Diczfalusy U; Björkhem I
Article: JOURNAL OF LIPID RESEARCH. 2000;41(10):1629-1639
24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
Norlin M; Toll A; Björkhem I; Wikvall K
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2000;6(4):522-525
Bile acid formation in primary human hepatocytes
Einarsson C; Ellis E; Abrahamsson A; Ericzon BG; Björkhem I; Axelson M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2000;1486(2-3):293-298
Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique:: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice
Meaney S; Lütjohann D; Diczfalusy U; Björkhem I
Article: NEUROREPORT. 2000;11(9):1959-1962
Plasma 24S-hydroxycholesterol:: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease
Papassotiropoulos A; Lütjohann D; Bagli M; Locatelli S; Jessen F; Rao ML; Maier W; Björkhem I; von Bergmann K; Heun R
Article: HEPATOLOGY. 2000;31(6):1305-1312
Bile acid synthesis in cultured human hepatocytes:: Support for an alternative biosynthetic pathway to cholic acid
Axelson M; Ellis E; Mörk B; Garmark K; Abrahamsson A; Björkhem I; Ericzon BG; Einarsson C
Article: JOURNAL OF LIPID RESEARCH. 2000;41(5):840-845
Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
Bretillon L; Lütjohann D; Ståhle L; Widhe T; Bindl L; Eggertsen G; Diczfalusy U; Björkhem I
Article: GASTROENTEROLOGY. 2000;118(3):599-607
Regulation of sterol 12α-hydroxylase and cholic acid biosynthesis in the rat
Vlahcevic ZR; Eggertsen G; Björkhem I; Hylemon PB; Redford K; Pandak WM
Article: JOURNAL OF LIPID RESEARCH. 2000;41(2):195-198
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients
Lütjohann D; Papassotiropoulos A; Björkhem I; Locatelli S; Bagli M; Oehring RD; Schlegel U; Jessen F; Rao ML; von Bergmann K; Heun R
Article: MICROVASCULAR RESEARCH. 1999;58(3):305-311
A single high dose of vitamin C counteracts the acute negative effect on microcirculation induced by smoking a cigarette
Zhang J; Ying X; Lu Q; Kallner A; Xiu RJ; Henriksson P; Björkhem I
Article: JOURNAL OF INTERNAL MEDICINE. 1999;246(4):399-407
Deoxycholic acid treatment in patients with cholesterol gallstones:: failure to detect a suppression of cholesterol 7α-hydroxylase activity
Hillebrant CG; Nyberg B; Angelin B; Axelson M; Björkhem I; Rudling M; Einarsson C
Article: JOURNAL OF LIPID RESEARCH. 1999;40(8):1417-1425
Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase:: evidence that most of this steroid in the circulation is of pulmonary origin
Babiker A; Andersson O; Lindblom D; van der Linden J; Wiklund B; Lütjohann D; Diczfalusy U; Björkhem I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1439(1):40-46
Microsomal long-chain acyl-CoA thioesterase (carboxylesterase ES-4) is regulated by thyroxine
Diczfalusy MA; Andersson U; Björkhem I; Einarsson C; Alexson SEH
Article: ACTA PAEDIATRICA. 1999;88(7):729-733
Beneficial effects of dietary supplementation in a disorder with defective synthesis of cholesterol.: A case report of a girl with Smith-Lemli-Opitz syndrome, polyneuropathy and precocious puberty
Starck L; Björkhem I; Ritzén EM; Nilsson BY; von Döbeln U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1438(2):167-174
Thyroid hormone suppresses hepatic sterol 12α-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver:: Failure to define known thyroid hormone response elements in the gene
Andersson U; Yang YZ; Björkhem I; Einarsson C; Eggertsen G; Gåfvels M
Article: JOURNAL OF INTERNAL MEDICINE. 1999;245(3):247-252
Studies in hypertriglyceridaemia - VI: serum lathosterol concentration is raised in hypertriglyceridaemic non-diabetic males with hyperinsulinaemia
Asplund-Carlson A; Lund E; Björkhem I; Carlson LA
Article: GENOMICS. 1999;56(2):184-196
Structure and chromosomal assignment of the sterol 12α-hydroxylase gene (CYP8B1) in human and mouse:: Eukaryotic cytochrome P-450 gene devoid of introns
Gåfvels M; Olin M; Chowdhary BP; Raudsepp T; Andersson U; Persson B; Jansson M; Björkhem I; Eggertsen G
Article: BRAIN RESEARCH. 1999;818(1):171-175
The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells
Kölsch H; Lütjohann D; Tulke A; Björkhem I; Rao ML
Article: FEBS JOURNAL. 1999;259(1-2):404-411
Formation of fatty acid ethyl esters in rat liver microsomes -: Evidence for a key role for acyl-CoA:: ethanol O-acyltransferase
Diczfalusy MA; Björkhem I; Einarsson C; Alexson SEH
Article: JOURNAL OF LIPID RESEARCH. 1999;40(1):17-23
The bile acid-inducible baiF gene from Eubacterium sp. strain VPI 12708 encodes a bile acid-coenzyme A hydrolase
Ye HQ; Mallonee DH; Wells JE; Björkhem I; Hylemon PB
Article: JOURNAL OF LIPID RESEARCH. 1998;39(8):1594-1600
Cholesterol homeostasis in human brain:: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
Björkhem I; Lütjohann D; Diczfalusy U; Ståhle L; Ahlborg G; Wahren J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(29):18153-18160
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
Pikuleva IA; Babiker A; Waterman MR; Bjorkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(24):14805-14812
Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
Rosen H; Reshef A; Maeda N; Lippoldt A; Shpizen S; Triger L; Eggertsen G; Björkhem I; Leitersdorf E
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 1998;58(2):155-160
Determination of low levels of total mercury in blood and plasma by cold vapour atomic fluorescence spectrometry
Sandborgh-Englund G; Björkhem I; Björkman L; Valtersson C
Article: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 1998;28(4):324-328
Effects of short-term treatment with pravastatin on the hepatic synthesis of cholesterol and bile acids in gallstone patients
Hillebrant CG; Axelson M; Björkhem I; Wang FH; Nyberg B; Einarsson C
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1998;18(4):554-561
Sterol 27-hydroxylase- and ApoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages - Evidence for an inverse relation between the two mechanisms
Westman J; Kallin B; Björkhem I; Nilsson J; Diczfalusy U
Article: HEPATOLOGY. 1998;27(2):615-620
Bile acid synthesis in primary cultures of rat and human hepatocytes
Ellis E; Goodwin B; Abrahamsson A; Liddle C; Mode A; Rudling M; Bjorkhem I; Einarsson C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1389(2):150-154
Rabbit liver contains one major sterol 12α-hydroxylase with broad substrate specificity
Andersson U; Eggertsen G; Björkhem I
Article: PROTEIN JOURNAL. 1998;17(1):1-7
Phosphatidate phosphatase - A key enzyme in glycerolipid biosynthesis, studies on the yeast enzyme
Stark M; Humble E; Jörnvall H; Björkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(48):30178-30184
Importance of a novel oxidative mechanism for elimination of brain cholesterol - Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with O-18(2) techniques in vivo and in vitro
Bjorkhem I; Lutjohann D; Breuer O; Sakinis A; Wennmalm A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(42):26253-26261
Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism - Comparison with high density lipoprotein-mediated reverse cholesterol transport
Babiker A; Andersson O; Lund E; Xiu RJ; Deeb S; Reshef A; Leitersdorf E; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 1997;38(10):2049-2061
Ca2+ channel blockers verapamil and nifedipine inhibit apoptosis induced by 25-hydroxycholesterol in human aortic smooth muscle cells
Ares MPS; PornAres MI; Thyberg J; JunttiBerggren L; Berggren PO; Diczfalusy U; Kallin B; Bjorkhem I; Orrenius S; Nilsson J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(38):23995-24001
Identification and characterization of a mouse oxysterol 7 alpha-hydroxylase cDNA
Schwarz M; Lund EG; Lathe R; Bjorkhem I; Russell DW
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(29):18481-18489
Molecular cloning and expression of cDNA encoding 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-CoA oxidase from rabbit liver
Pedersen JI; Eggertsen G; Hellman U; Andersson U; Bjorkhem I
Article: JOURNAL OF HEPATOLOGY. 1997;27(1):150-155
Circulating markers for biosynthesis of cholesterol and bile acids are not depressed in asymptomatic gallstone subjects
Muhrbeck O; Wang FH; Bjorkhem I; Axelson M; Einarsson K
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1997;343(1):123-130
Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27)
Pikuleva IA; Bjorkhem I; Waterman MR
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1997;17(6):1178-1184
Vitamin C reduces cholesterol-induced microcirculatory changes in rabbits
Freyschuss A; Xiu RJ; Zhang J; Ying XY; Diczfalusy U; Joestrand T; Henriksson P; Bjorkhem I
Article: HEPATOLOGY. 1997;25(6):1447-1450
Hepatic cholesterol metabolism in human obesity
Stahlberg D; Rudling M; Angelin B; Bjorkhem I; Forsell P; Nilsell K; Einarsson K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(10):4925-4930
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7 alpha-hydroxy dehydroepiandrosterone and 7 alpha-hydroxy pregnenolone
Rose KA; Stapleton G; Dott K; Kieny MP; Best R; Schwarz M; Russell DW; Bjorkhem I; Seckl J; Lathe R
Article: BIOCHEMICAL JOURNAL. 1997;323(Pt 3):853-858
Transformation of subcutaneous nitric oxide into nitrate in the rat
Benthin G; Bjorkhem I; Breuer O; Sakinis A; Wennmalm A
Article: JOURNAL OF LIPID RESEARCH. 1997;38(5):870-879
Novel homozygous and compound heterozygous mutations of sterol 27-hydroxylase gene (CYP27) cause cerebrotendinous xanthomatosis in three Japanese patients from two unrelated families
Chen W; Kubota S; Kim KS; Cheng J; Kuriyama M; Eggertsen G; Bjorkhem I; Seyama Y
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 1997;689(2):349-355
Gas chromatographic-mass spectrometric determination of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations
Cui JF; Bjorkhem I; Eneroth P
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1997;1344(3):278-285
Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
Crisby M; Nilsson J; Kostulas V; Bjorkhem I; Diczfalusy U
Article: CIRCULATION. 1997;95(4):840-845
Lipoprotein oxidation and progression of carotid atherosclerosis
Salonen JT; Nyyssonen K; Salonen R; PorkkalaSarataho E; Tuomainen TP; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(50):32269-32275
Molecular cloning and expression of rabbit sterol 12 alpha-hydroxylase
Eggertsen G; Olin M; Andersson U; Ishida H; Kubota S; Hellman U; KyuIchiro O; Bjorkhem I
Article: JOURNAL OF CHROMATOGRAPHY. B, BIOMEDICAL APPLICATIONS. 1996;687(1):55-59
Increased urinary testosterone epitestosterone ratios found in Swedish athletes in connection with a national control program - Evaluation of 28 cases
Garle M; Ocka R; Palonek E; Bjorkhem I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1996;1317(2):119-126
Genetic analysis of a Japanese cerebrotendinous xanthomatosis family: Identification of a novel mutation in the adrenodoxin binding region of the CYP 27 gene
Chen WG; Kubota S; Nishimura Y; Nozaki S; Yamashita S; Nakagawa T; KamedaTakemura K; Menju M; Matsuzawa Y; Bjorkhem I; Eggertsen G; Seyama Y
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1996;334(2):183-192
Studies of distant members of the P450 superfamily (P450scc and P450c27) by random chimeragenesis
Pikuleva IA; Bjorkhem I; Waterman MR
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1996;1317(1):19-26
Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: Evidence that lithocholic acid does not down regulate the hepatic cholesterol 7 alpha-hydroxylase activity in gallstone patients
Einarsson K; Alvelius G; Hillebrant CG; Reihner E; Bjorkhem I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(18):9799-9804
Cholesterol homeostasis in human brain: Evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation
Lutjohann D; Breuer O; Ahlborg G; Nennesmo I; Siden A; Diczfalusy U; Bjorkhem I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(30):18024-18031
Disruption of cholesterol 7 alpha-hydroxylase gene in mice .2. Bile acid deficiency is overcome by induction of oxysterol 7 alpha-hydroxylase
Schwarz M; Lund EG; Setchell KDR; Kayden HJ; Zerwekh JE; Bjorkhem I; Herz J; Russell DW
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;224(1):37-42
Substrate stereospecificity in oxidation of (25S)-3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoyl-CoA by peroxisomal trihydroxy-5 beta-cholestanoyl-CoA oxidase
Pedersen JI; Veggan T; Bjorkhem I
Article: JOURNAL OF LIPID RESEARCH. 1996;37(6):1258-1267
Expression and characterization of a C-24 bile acid 7 alpha-dehydratase from Eubacterium sp strain VPI 12708 in Escherichia coli
Dawson JA; Mallonee DH; Bjorkhem I; Hylemon PB
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 1996;56(3):229-240
Phytosterolaemia in a Norwegian family: Diagnosis and characterization of the first Scandinavian case
Lutjohann D; Bjorkhem I; Ose L
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 1996;56(3):211-217
Studies on the degradation of [U-3H]-phytanic acid and [U-3H]-pristanic acid in cultured fibroblasts from children with peroxisomal disorders.
Kase BF; Björkhem I
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;221(1):107-110
Dietary cholesterol induces transient changes in plasma nitrate levels in rabbits that are correlated to microcirculatory changes
Freyschuss A; Xiu RJ; Benthin G; Henriksson P; Bjorkhem I; Wennmalm A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1996;16(4):606-610
Acyl-coenzyme A: Cholesterol O-acyltransferase is not identical to liver microsomal carboxylesterase
Diczfalusy MA; Bjorkhem I; Einarsson K; Alexson SEH
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 1996;56(2):151-160
Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng
Cui JF; Garle M; Bjorkhem I; Eneroth P
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1996;16(2):208-212
Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans
Lund E; Andersson O; Zhang J; Babiker A; Ahlborg G; Diczfalusy U; Einarsson K; Sjovall J; Bjorkhem I
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(2):461-468
Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages
Hulten LM; Lindmark H; Diczfalusy U; Bjorkhem I; Ottosson M; Liu Y; Bondjers G; Wiklund O
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 1995;55(1):121-127
SERUM AND URINARY MARKERS OF EXOGENOUS TESTOSTERONE ADMINISTRATION
PALONEK E; GOTTLIEB C; GARLE M; BJORKHEM I; CARLSTROM K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(35):20278-20284
USE OF AN O-18(2) INHALATION TECHNIQUE AND MASS ISOTOPOMER DISTRIBUTION ANALYSIS TO STUDY OXYGENATION OF CHOLESTEROL IN RAT - EVIDENCE FOR IN-VIVO FORMATION OF 7-OXOCHOLESTEROL, 7-BETA-HYDROXYCHOLESTEROL, 24-HYDROXYCHOLESTEROL, AND 24-HYDROXYCHOLESTEROL
BREUER O; BJORKHEM I
Article: JOURNAL OF LIPID RESEARCH. 1995;36(8):1763-1773
STEROL ABSORPTION AND STEROL BALANCE IN PHYTOSTEROLEMIA EVALUATED BY DEUTERIUM-LABELED STEROLS - EFFECT OF SITOSTANOL TREATMENT
LUTJOHANN D; BJORKHEM I; BEIL UF; VONBERGMANN K
Article: FEBS JOURNAL. 1995;228(1):144-148
IMMUNOCHEMICAL DETERMINATION OF HUMAN CHOLESTEROL 7-ALPHA-HYDROXYLASE
MAEDA Y; EGGERTSEN G; NYBERG B; SETOGUCHI T; OKUDA KI; EINARSSON K; BJORKHEM I
Article: FEBS JOURNAL. 1995;227(3):715-722
HEPATIC FATTY-ACID METABOLISM AS A DETERMINANT OF PLASMA AND LIVER TRIACYLGLYCEROL LEVELS - STUDIES ON TETRADECYLTHIOACETIC AND TETRADECYLTHIOPROPIONIC ACIDS
ASIEDU DK; ALSHURBAJI A; RUSTAN AC; BJORKHEM I; BERGLUND L; BERGE RK
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Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene
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Olsson AG; Angelin B; Assmann G; Binder CJ; Bjoerkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Mueller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
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Letter: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017;375:245-247
A SLC20A2 gene mutation carrier displaying ataxia and increased levels of cerebrospinal fluid phosphate
Paucar M; Almqvist H; Jelic V; Hagman G; Jorneskog G; Holmin S; Bjorkhem I; Svenningsson P
Review: CURRENT OPINION IN LIPIDOLOGY. 2013;24(4):283-287
Cerebrotendinous xanthomatosis
Bjorkhem I
Review: BIOCHIMIE. 2013;95(3):448-454
Five decades with oxysterols
Bjorkhem I
Editorial: JOURNAL OF LIPID RESEARCH. 2011;52(8):1447-1449
Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol
Diczfalusy U; Bjorkhem I
Letter: NATURE IMMUNOLOGY. 2011;12(7):577
Detecting oxysterols in the human circulation
Bjorkhem I; Diczfalusy U; Olsson T; Russell DW; McDonald JG; Wang Y; Griffiths WJ
Review: JOURNAL OF LIPID RESEARCH. 2010;51(9):2489-2503
Genetic connections between neurological disorders and cholesterol metabolism
Bjorkhem I; Leoni V; Meaney S
Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2010;163:S12-S13
Sterol binding by OSBP-related protein 1L (ORP1 L) regulates late endosome motility and function
Vihervaara T; Uronen R-L; Wohlfahrt G; Bjoerkhem I; Ikonen E; Olkkonen VM
Meeting abstract: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2009;283(1-2):246
Is 27-hydroxycholesterol the missing link between hypercholesterolemia and Alzheimer's disease?
Bjorkhem I
Review: MOLECULAR ASPECTS OF MEDICINE. 2009;30(3):171-179
Oxysterols and neurodegenerative diseases
Bjorkhem I; Cedazo-Minguez A; Leoni V; Meaney S
Published conference paper: LIPIDS. 2007;42(1):5-14
Rediscovery of cerebrosterol
Bjorkhem I
Review: JOURNAL OF INTERNAL MEDICINE. 2006;260(6):493-508
Crossing the barrier:: oxysterols as cholesterol transporters and metabolic modulators in the brain
Bjorkhem I
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):582
Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin
Thelen KM; Rentsch KM; Gutteck U; Heverin M; Olin M; Andersson U; von Eckardstein A; Bjoerkhem I; Luetjohann D
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):562
Effects of high-dosage itraconazole treatment on synthesis, transport and metabolism of cholesterol in men
Schneider B; Plat J; Gerdsen R; Diczfalusy U; Björkhem I; Neuvonen PJ; Bieber T; Von Bergmann K; L tjohann D
Published conference paper: ACTA NEUROLOGICA SCANDINAVICA, SUPPLEMENT. 2006;114:43-49
Oxysterols and Alzheimer's disease
Bjorkhem I; Heverin M; Leoni V; Meaney S; Diczfalusy U
Editorial: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2004;24(12):2209-2210
24(S),25-epoxycholesterol - A potential friend
Bjorkhem I; Diczfalusy U
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S526
Activities of cytochrome P450 46A1, a key enzyme in cholesterol degradation in the brain
Pikuleva IA; Mast N; Norcross R; Andersson U; Shou M; Nakayama K; Bjorkhem I
Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2004;24(5):806-815
Brain cholesterol: Long secret life behind a barrier
Björkhem I; Meaney S
Review: CURRENT OPINION IN LIPIDOLOGY. 2002;13(3):247-253
Oxysterols in human circulation:: which role do they have?
Björkhem I; Meaney S; Diczfalusy U
Published conference paper: JOURNAL OF LIPID RESEARCH. 2001;42(10):1571-1577
Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick disease, type C
Alvelius G; Hjalmarson O; Griffiths WJ; Björkhem I; Sjövall J
Review: CURRENT OPINION IN LIPIDOLOGY. 2001;12(2):97-103
Genes involved in initial steps of bile acid synthesis
Björkhem I; Eggertsen G
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2000;11(5):180-183
Sterol 27-hydroxylase deficiency:: A rare cause of xanthomas in normocholesterolemic humans
Björkhem I; Leitersdorf E
Meeting abstract: ATHEROSCLEROSIS. 1999;144:121
The lung is the major source of 27-oxygenated cholesterol in the human circulation
Babiker A; Björkhem I; Diczfalusy U
Review: CURRENT OPINION IN LIPIDOLOGY. 1999;10(2):161-165
Removal of cholesterol from extrahepatic sources by oxidative mechanisms
Björkhem I; Diczfalusy U; Lütjohann D
Meeting abstract: GASTROENTEROLOGY. 1998;114(4):a523
The effect of combined treatment with ursodeoxycholic acid and pravastatin on hepatic cholesterol metabolism and biliary lipids in gallstone patients.
Hillebrant CG; Björkhem I; Eiarsson C; Rudling M; Nyberg B
Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):217
Lipid peroxidation and progression of carotid atherosclerosis: A prospective 3-year follow-up study
Salonen JT; Nyyssonen K; Salonen R; Luoma J; YlaHerttuala S; Diczfalusy U; Bjorkhem I
Review: SUB-CELLULAR BIOCHEMISTRY. 1997;28:23-55
Coordinate regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in the liver.
Björkhem I; Lund E; Rudling M
Published conference paper: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION, SUPPLEMENT. 1996;56:9-17
Novel pathways for elimination of cholesterol by extrahepatic formation of side-chain oxidized oxysterols
Diczfalusy U; Lund E; Lutjohann D; Bjorkhem I
Review: LAKARTIDNINGEN. 1995;92(37):3325-3329
[New possibilities for children with Smith-Lemli-Opitz syndrome. A cholesterol synthesis defect discovered].
Starck L; Björkhem I; Lund E; von Döbeln U
Review: ACCOUNTS OF CHEMICAL RESEARCH. 1995;28(6):241-249
ROLE OF OXYSTEROLS IN THE REGULATION OF CHOLESTEROL HOMEOSTASIS - A CRITICAL-EVALUATION
LUND E; BJORKHEM I
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Anställningar

Professor Emeritus/Emerita, Laboratoriemedicin, Karolinska Institutet, 2023-2026
Professor, Senior, Laboratoriemedicin, Karolinska Institutet, 2019-2020
Professor, Senior, Laboratoriemedicin, Karolinska Institutet, 2012-2018
Professor/Överläkare, Laboratoriemedicin, Karolinska Institutet, 2003-2008
Professor, Kliniskt forskningscentrum (H6), Karolinska Institutet, 1994-2004
Professor/Överläkare, Inst f Med labratorievet & teknik (H3), Karolinska Institutet, 1996-2002
Professor, Inst f Med labratorievet & teknik (H3), Karolinska Institutet, 1995-1995

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Docent, 1969

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